Fc gamma receptor glycosylation modulates the binding of IgG glycoforms: A requirement for stable antibody interactions

Journal of Proteome Research

Volumn 13, Issue 12, 2014, Pages 5471-5485

  Hayes, Jerrard M ^a,f   Frostell, Asa ^b   Cosgrave, Eoin F J ^c   Struwe, Weston B ^d   Potter, Oscar ^e   Davey, Gavin P ^a   Karlsson, Robert ^b   Anneren, Cecilia ^b   Rudd, Pauline M ^f  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b BIACORE AB   (Sweden)

^c WATERS CORPORATION   (United States)

^d UNIVERSITY OF OXFORD   (United Kingdom)

^e AGILENT TECHNOLOGIES   (United States)

^f NATIONAL INSTITUTE FOR BIOPROCESSING RESEARCH AND TRAINING   (Ireland)

Author keywords

antibody; Fc receptors; glycan analysis; Glycosylation; rituximab; surface plasmon resonance

Indexed keywords

FC RECEPTOR; FC RECEPTOR IA; FC RECEPTOR IIA; FC RECEPTOR IIB; FC RECEPTOR IIIA; GLYCAN DERIVATIVE; IMMUNOGLOBULIN G ANTIBODY; PHENYLALANINE; RITUXIMAB; UNCLASSIFIED DRUG; VALINE; FCGR1A PROTEIN, HUMAN; FCGR2B PROTEIN, HUMAN; FCGR3A PROTEIN, HUMAN; FCGR3B PROTEIN, HUMAN; GLYCOSYLPHOSPHATIDYLINOSITOL ANCHORED PROTEIN; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY; POLYSACCHARIDE; PROTEIN BINDING; RECOMBINANT PROTEIN;

ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING KINETICS; CONTROLLED STUDY; DEGLYCOSYLATION; DISSOCIATION; FUCOSYLATION; GLYCOSYLATION; HEK293 CELL LINE; HUMAN; HUMAN CELL; HYDROPHILIC INTERACTION CHROMATOGRAPHY; MASS SPECTROMETRY; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RECEPTOR BINDING; STEADY STATE; SURFACE PLASMON RESONANCE; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; METABOLISM; MUTATION; POLYACRYLAMIDE GEL ELECTROPHORESIS; TANDEM MASS SPECTROMETRY;

ANTIBODIES, MONOCLONAL, MURINE-DERIVED; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; GLYCOSYLATION; GPI-LINKED PROTEINS; HEK293 CELLS; HUMANS; IMMUNOGLOBULIN G; KINETICS; MUTATION; POLYSACCHARIDES; PROTEIN BINDING; RECEPTORS, IGG; RECOMBINANT PROTEINS; SURFACE PLASMON RESONANCE; TANDEM MASS SPECTROMETRY;

EID: 84915747782     PISSN: 15353893     EISSN: 15353907     Source Type: Journal    
DOI: 10.1021/pr500414q     Document Type: Article

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