Which patients with Parkinson's disease participate in clinical trials? One centre's experiences with a new cell based therapy trial (TRANSEURO)

Journal of Parkinson's Disease

Volumn 4, Issue 4, 2014, Pages 671-676

  Moore, Sarah F ^a   Guzman, Natalie Valle ^a   Mason, Sarah L ^a   Williams Gray, Caroline H ^a   Barker, Roger A ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

cell and tissue based therapy; clinical trials as topic; neurodegenerative diseases; Parkinson disease; patient participation

Indexed keywords

DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA;

ADDENBROOKE COGNITIVE EXAMINATION REVISED SCORE; ADULT; AGE DISTRIBUTION; APATHY EVALUATION SCALE; ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; EDUCATIONAL STATUS; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MOTOR PERFORMANCE; MULTICENTER STUDY; NAMED INVENTORIES, QUESTIONNAIRES AND RATING SCALES; NEUROPSYCHOLOGICAL TEST; OPEN STUDY; PARKINSON DISEASE; PARKINSON DISEASE QUESTIONNAIRE 39; PATIENT PARTICIPATION; PATIENT SELECTION; QUALITY OF LIFE; STEM CELL TRANSPLANTATION; UNIFIED PARKINSON DISEASE RATING SCALE; AGED; BIOLOGICAL THERAPY; CLINICAL TRIAL; COHORT ANALYSIS; COMPLICATION; MIDDLE AGED; MOTOR ACTIVITY; NONPARAMETRIC TEST; PHYSIOLOGY; PROCEDURES; PSYCHOLOGICAL RATING SCALE; RANDOMIZED CONTROLLED TRIAL; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

ADULT; AGED; CELL- AND TISSUE-BASED THERAPY; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; MOTOR ACTIVITY; NEUROPSYCHOLOGICAL TESTS; PARKINSON DISEASE; PSYCHIATRIC STATUS RATING SCALES; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME;

EID: 84914697822     PISSN: 18777171     EISSN: 1877718X     Source Type: Journal    
DOI: 10.3233/JPD-140432     Document Type: Article

References (15)

1. Kim SYH, Wilson RM, Kim HM, Holloway RG, De Vries RG, Frank SA,&Kieburtz K (2012) Comparison of enrollees and decliners of parkinson disease sham surgery trials. Mov Disord, 27, 506-511.
2. Albert SM, Sano M, Marder K, Jacobs DM, Brandt J, Albert M, & Stern Y (1997) Participation in clinical trials and long-term outcomes in Alzheimer's disease. Neurology, 49, 38-43.
3. Unger JM, Hershman DL, Albain KS, Moinpour CM, Petersen JA, Burg K, & Crowley JJ (2013) Patient Income Level and Cancer Clinical Trial Participation. J Clin Oncol, 10, 536-542.
4. Kaplan CP, Nápoles AM, Dohan D, Hwang S, Melisko M, Nickleach D, Quinn JA, & Haas J (2013) Clinical trial discussion, referral, and recruitment: Physician, patient, and system factors. Cancer Causes Control, 24, 979-988.
5. Petit GH, Olsson TT, & Brundin P (2014) Review: The future of cell therapies and brain repair: Parkinson's disease leads the way: Parkinson cell therapy. Neuropathol Appl Neurobiol, 40, 60-70.
6. Foltynie T, Brayne CEG, Robbins TW, & Barker RA (2004) The cognitive ability of an incident cohort of Parkinson's patients in the UK. The CamPaIGN study. Brain, 127, 550-560.
7. IBM Corporation (2012) IBM SPSS Statistics for Macintosh, Version 21.0. IBM Corp., Armonk, NY.
8. OnePoll (2012) NIHR Consumer Survey. National Institute for Health Research, London.
9. Fallowfield L, Ratcliffe D, & Souhami R (1997) Clinicians' attitudes to clinical trials of cancer therapy. Eur J Cancer, 33, 2221-2229.
10. Grunfeld E, Zitzelsberger L, Coristine M, & Aspelund F (2002) Barriers and facilitators to enrollment in cancer clinical trials: Qualitative study of the perspectives of clinical research associates. Cancer, 95, 1577-1583.
11. Grosset KA,&Grosset DG (2005) Patient-perceived involvement and satisfaction in Parkinson's disease: Effect on therapy decisions and quality of life. Mov Disord, 20, 616-619.
12. Van der Eijk M, Frouke AP, Nijhuis M, Faber J, & Bloem BR (2013) Moving from physician-centered care towards patientcentered care for Parkinson's disease patients. Parkinsonism Relat Disord, 19, 923-927.
13. Nisenzon AN, Robinson ME,Bowers D, Banou E, Malaty I,& Okun MS (2011) Measurement of patient-centered outcomes in Parkinson's disease: What do patients reallywant from their treatment Parkinsonism Relat Disord, 17, 89-94.
14. Spaar A, Frey M, Turk A, Karrer W, & Puhan MA (2009) Recruitment barriers in a randomized controlled trial from the physicians' perspective-a postal survey. BMC Med Res Methodol, 9, 14.
15. Pagonabarraga J, Garcá-Sánchez C, Llebaria G, Pascual-Sedano B, Gironell A,&Kulisevsky J (2007) Controlled study of decision-making and cognitive impairment in Parkinson's disease. Mov Disord, 30, 1430-1435.