Xylose phosphorylation functions as a molecular switch to regulate proteoglycan biosynthesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 44, 2014, Pages 15723-15728

  Wen, Jianzhong ^a   Xiao, Junyu ^a,d   Rahdar, Meghdad ^a   Choudhury, Biswa P ^b   Cui, Jixin ^a   Taylor, Gregory S ^a   Esko, Jeffrey D ^b,c   Dixon, Jack E ^a  

^a San Diego   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California San Diego   (United States)

^d PEKING UNIVERSITY   (China)

Author keywords

Fam20B; GalT II; Proteoglycan; Secretory kinase; Xylose phosphorylation

Indexed keywords

ENZYME; GALACTOSYLTRANSFERASE; GLYCOSAMINOGLYCAN; PHOSPHOTRANSFERASE; PROTEOGLYCAN; SIALIC ACID; TETRASACCHARIDE; XYLOSE; B3GALT6 PROTEIN, HUMAN; SIALIC ACID DERIVATIVE;

ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; EHLERS DANLOS SYNDROME; ENZYME ACTIVITY; GENE DELETION; GENE LOSS; GENE MUTATION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; GENE SILENCING; GENETICS; HEK293 CELL LINE; METABOLISM; PHOSPHORYLATION;

EUKARYOTA;

EHLERS-DANLOS SYNDROME; GALACTOSYLTRANSFERASES; GENE KNOCKDOWN TECHNIQUES; HEK293 CELLS; HUMANS; PHOSPHORYLATION; PROTEOGLYCANS; SIALIC ACIDS; XYLOSE;

EID: 84914689918     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1417993111     Document Type: Article

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