Recruitment of rat diaphragm motor units across motor behaviors with different levels of diaphragm activation

Journal of Applied Physiology

Volumn 117, Issue 11, 2014, Pages 1308-1316

  Seven, Yasin B ^a   Mantilla, Carlos B ^a,b   Sieck, Gary C ^a,b  

^a MAYO GRADUATE SCHOOL   (United States)

^b DEPARTMENT OF UROLOGY   (United States)

Author keywords

Discharge rates; Doublets; Electromyography; Motor unit recruitment order; Neuromotor control; Recruitment reversal

Indexed keywords

AIRWAY OBSTRUCTION; ANIMAL; ANOXIA; BREATHING MECHANICS; DIAPHRAGM; ELECTROMYOGRAPHY; MALE; MOTOR ACTIVITY; NEUROPHYSIOLOGICAL RECRUITMENT; PATHOPHYSIOLOGY; PHYSIOLOGY; SNEEZING; SPRAGUE DAWLEY RAT;

AIRWAY OBSTRUCTION; ANIMALS; ANOXIA; DIAPHRAGM; ELECTROMYOGRAPHY; MALE; MOTOR ACTIVITY; RATS, SPRAGUE-DAWLEY; RECRUITMENT, NEUROPHYSIOLOGICAL; RESPIRATORY MECHANICS; SNEEZING;

EID: 84914132636     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.01395.2013     Document Type: Article

References (44)

1. Adrian ED, Bronk DW. The discharge of impulses in motor nerve fibres. II. The frequency of discharge in reflex and voluntary contractions. J Physiol 67: I3-151, 1929.
2. Altose MD, Kelsen SG, Stanley NN, Levinson RS, Cherniack NS, Fishman AP. Effects of hypercapnia on mouth pressure during airway occlusion in conscious man. J Appl Physiol 40: 338-344, 1976.
3. Arita H, Bishop B. Firing profile of diaphragm single motor unit during hypercapnia and airway occlusion. J Appl Physiol 55: 1203-1210, 1983.
4. Bawa P, Calancie B. Repetitive doublets in human flexor carpi radialis muscle. J Physiol 339: 123-132, 1983.
5. Berger AJ. Phrenic motoneurons in the cat: Subpopulations and nature of respiratory drive potentials. J Neurophysiol 42: 76-90, 1979.
6. Bishop B, Settle S, Hirsch J. Single motor unit activity in the diaphragm of cat during pressure breathing. J Appl Physiol 50: 348-357, 1981.
7. Butler JE. Drive to the human respiratory muscles. Respir Physiol Neurobiol 159: 115-126, 2007.
8. Butler JE, McKenzie DK, Gandevia SC. Discharge properties and recruitment of human diaphragmatic motor units during voluntary inspiratory tasks. J Physiol 518: 907-920, 1999.
9. Cohen MI, Piercey MF, Gootman PM, Wolotosky P. Synaptic connections between medullary inspiratory neurons and phrenic motoneurons as revealed by cross-correlation. Brain Res 81: 319-324, 1974.
10. Davies JG, Kirkwood PA, Sears TA. The distribution of monosynaptic connexions from inspiratory bulbospinal neurones to inspiratory motoneurones in the cat. J Physiol 368: 63-87, 1985.
11. Desmedt JE, Godaux E. Ballistic contractions in fast or slow human muscles: Discharge patterns of single motor units. J Physiol 285: 185-196, 1978.
12. Desmedt JE, Godaux E. Ballistic contractions in man: Characteristic recruitment pattern of single motor units of the tibialis anterior muscle. J Physiol 264: 673-693, 1977.
13. Dick TE, Kong FJ, Berger AJ. Correlation of recruitment order with axonal conduction velocity for supraspinally driven diaphragmatic motor units. J Neurophysiol 57: 245-259, 1987.
14. Gandevia SC, Leeper JB, McKenzie DK, De Troyer A. Discharge frequencies of parasternal intercostal and scalene motor units during breathing in normal and COPD subjects. Am J Respir Crit Care Med 153: 622-628, 1996.
15. Henneman E. Relation between size of neurons and their susceptibility to discharge. Science 126: 1345-1346, 1957.
16. Henneman E, Somjen G, Carpenter DO. Functional significance of cell size in spinal motoneurons. J Neurophysiol 28: 560-580, 1965.
17. Hwang JC, St. John WM. Facilitation and inhibition of phrenic motoneuronal activities by lung inflation. J Appl Physiol 74: 2485-2492, 1993.
18. Iscoe S, Dankoff J, Migicovsky R, Polosa C. Recruitment and discharge frequency of phrenic motoneurones during inspiration. Respir Physiol Neurobiol 26: 113-128, 1976.
19. Jodkowski JS, Viana F, Dick TE, Berger AJ. Electrical properties of phrenic motoneurons in the cat: Correlation with inspiratory drive. J Neurophysiol 58: 105-124, 1987.
20. Kong FJ, Berger AJ. Firing properties and hypercapnic responses of single phrenic motor axons in the rat. J Appl Physiol 61: 1999-2004, 1986.
21. Lederer DH, Altose MD, Kelsen SG, Cherniack NS. Comparison of occlusion pressure and ventilatory responses. Thorax 32: 212-220, 1977.
22. Lopata M, Evanich MJ, Lourenco RV. Quantification of diaphragmatic EMG response to CO2 rebreathing in humans. J Appl Physiol 43: 262-270, 1977.
23. Mantilla CB, Greising SM, Zhan WZ, Seven YB, Sieck GC. Prolonged C2 spinal hemisection-induced inactivity reduces diaphragm muscle specific force with modest, selective atrophy of type IIx and/or IIb fibers. J Appl Physiol 114: 380-386, 2013.
24. Mantilla CB, Seven YB, Hurtado-Palomino JN, Zhan WZ, Sieck GC. Chronic assessment of diaphragm muscle EMG activity across motor behaviors. Respir Physiol Neurobiol 177: 176-182, 2011.
25. Mantilla CB, Seven YB, Zhan WZ, Sieck GC. Diaphragm motor unit recruitment in rats. Respir Physiol Neurobiol 173: 101-106, 2010.
26. Mantilla CB, Sieck GC. Phrenic motor unit recruitment during ventilatory and non-ventilatory behaviors. Respir Physiol Neurobiol 179: 57-63, 2011.
27. McPhedran AM, Wuerker RB, Henneman E. Properties of motor units in a homogeneous red muscle (soleus) of the cat. J Neurophysiol 28: 71-84, 1965.
28. Milano S, Grelot L, Bianchi AL, Iscoe S. Discharge patterns of phrenic motoneurons during fictive coughing and vomiting in decerebrate cats. J Appl Physiol 73: 1626-1636, 1992.
29. Milner-Brown HS, Stein RB, Yemm R. The orderly recruitment of human motor units during voluntary isometric contractions. J Physiol 230: 359-370, 1973.
30. Prakash YS, Mantilla CB, Zhan WZ, Smithson KG, Sieck GC. Phrenic motoneuron morphology during rapid diaphragm muscle growth. J Appl Physiol 89: 563-572, 2000.
31. Quinn GP, Keough MJ. Experimental Design and Data Analysis for Biologists. Cambridge Univ. Press, 2002.
32. Saboisky JP, Gorman RB, De Troyer A, Gandevia SC, Butler JE. Differential activation among five human inspiratory motoneuron pools during tidal breathing. J Appl Physiol 102: 772-780, 2007.
33. Seven YB, Mantilla CB, Zhan WZ, Sieck GC. Non-stationarity and power spectral shifts in EMG activity reflect motor unit recruitment in rat diaphragm muscle. Respir Physiol Neurobiol 185: 400-409, 2013.
34. Sieck GC, Fournier M. Diaphragm motor unit recruitment during ventilatory and nonventilatory behaviors. J Appl Physiol 66: 2539-2545, 1989.
35. Sieck GC, Trelease RB, Harper RM. Sleep influences on diaphragmatic motor unit discharge. Exp Neurol 85: 316-335, 1984.
36. St. John WM, Bartlett D, Jr. Comparison of phrenic motoneuron responses to hypercapnia and isocapnic hypoxia. J Appl Physiol Respir Environ Exercise Physiol 46: 1096-1102, 1979.
37. Stein RB, Gossen ER, Jones KE. Neuronal variability: Noise or part of the signal? Nat Rev Neurosci 6: 389-397, 2005.
38. Tansey KE, Botterman BR. Activation of type-identified motor units during centrally evoked contractions in the cat medial gastrocnemius muscle. I. Motor-unit recruitment. J Neurophysiol 75: 26-37, 1996.
39. Torikai H, Hayashi F, Tanaka K, Chiba T, Fukuda Y, Moriya H. Recruitment order and dendritic morphology of rat phrenic motoneurons. J Comp Neurol 366: 231-243, 1996.
40. Twisk JWR. Applied Longitudinal Data Analysis for Epidemiology: A Practical Guide. Cambridge Univ. Press, 2003.
41. von Euler C, Hayward JN, Marttila I, Wyman RJ. The spinal connections of the inspiratory neurones of the ventrolateral nucleus of the cat's tractus solitarius. Brain Res 61: 23-33, 1973.
42. Whitelaw WA, Derenne JP, Milic-Emili J. Occlusion pressure as a measure of respiratory center output in conscious man. Respir Physiol Neurobiol 23: 181-199, 1975.
43. Wuerker RB, McPhedran M, Henneman E. Properties of motor units in a heterogeneous pale muscle (m. gastrocnemius) of the cat. J Neurophysiol 28: 85-99, 1965.
44. Zajac FE, Faden JS. Relationship among recruitment order, axonal conduction velocity, and muscle-unit properties of type-identified motor units in cat plantaris muscle. J Neurophysiol 53: 1303-1322, 1985.