The plexiform spindle cell nevus nevi and atypical variants: Report of 128 cases

Human Pathology

Volumn 45, Issue 12, 2014, Pages 2369-2378

  Hung, Tawny ^a   Yang, Aparche ^b,c   Mihm, Martin C ^d   Barnhill, Raymond L ^b,c  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c INSTITUT CURIE   (France)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Atypical deep penetrating nevus; Atypical plexiform spindle cell nevus; Combined nevus; Deep penetrating nevus; Melanocytic lesion of undetermined malignant potential (MELTUMP); Plexiform spindle cell nevus

Indexed keywords

ADOLESCENT; ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BLUE NEVUS; CELL COMPOSITION; CHILD; CLINICAL FEATURE; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOLOGY; DEATH; DISEASE COURSE; DYSPLASTIC NEVUS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; HISTOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; INFANT; MAJOR CLINICAL STUDY; MALE; MELANOMA; MITOSIS RATE; NEUROTROPISM; NEVUS; PHENOTYPE; PLEXIFORM SPINDLE CELL NEVUS; RECURRENT DISEASE; SENTINEL LYMPH NODE METASTASIS; SPINDLE CELL CARCINOMA; TUMOR RECURRENCE; TUMOR VOLUME; VERY ELDERLY; MIDDLE AGED; PATHOLOGY; PRESCHOOL CHILD; SKIN TUMOR; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFANT; MALE; MIDDLE AGED; NEVUS, SPINDLE CELL; SKIN NEOPLASMS; YOUNG ADULT;

EID: 84913606316     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2014.08.009     Document Type: Article

References (19)

1. R.L. Barnhill, M.A. Barnhill, and M. Berwick The histologic spectrum of pigmented spindle cell nevus: a review of 120 cases with emphasis on atypical variants Hum Pathol 22 1991 52 58
2. R.L. Barnhill, M.C. Mihm, and C.M. Magro Plexiform spindle cell nevus: a distinctive variant of plexiform melanocytic nevus Histopathology 18 1991 243 247
3. J. Seab, J. Graham, and E. Helwig Deep penetrating nevus Am J Surg Pathol 13 1989 39 44
4. P.H. Cooper Deep penetrating (plexiform spindle cell) nevus: a frequent participant in combined nevus J Cutan Pathol 19 1992 172 180
5. D.A. Mehregan, and A.H. Mehregan Deep penetrating nevus Arch Dermatol 129 1993 328 331
6. A. Robson, M. Morley-Quante, and H. Hempel Deep penetrating nevus: clinicopathological study of 31 cases with further delineation of histological features allowing distinction from other pigmented benign melanocytic lesions and melanoma Histopathology 43 2003 529 537
7. R.L. Barnhill, H. Kiryu, and A.J. Sober Frequency of dysplastic nevi amongnevomelanocytic lesions submitted for histopathologic examination: time trends over a 37-year period Arch Dermatol 126 1990 463 465
8. R.A. Scolyer, L. Zhuang, and A.A. Palmer Combined naevus: a benign lesion frequently misdiagnosed both clinically and pathologically as melanoma Pathology 36 2004 419 427
9. D.R. Pulitzer, P.C. Martin, and A.P. Cohen Histologic classification of the combined nevus: analysis of the variable expression of melanocytic nevi Am J Surg Pathol 15 1991 1111 1122
10. J.L. Baran, and L.M. Duncan Combined melanocytic nevi: histologic variants and melanoma mimics Am J Surg Pathol 35 2011 1540 1548
11. A. Spatz, S. Peterse, and C.D.M. Fletcher Plexiform Spitz nevus: an intradermal Spitz nevus with plexiform growth pattern Am J Dermatopathol 21 1999 542 546
12. L. Cerroni, R. Barnhill, and D. Elder Melanocytic tumors of uncertain malignant potential: results of a tutorial held at the XXIX symposium of the International Society of Dermatopathology in Graz, October 2008 Am J Surg Pathol 34 2010 314 326
13. A. Cochran, S. Binder, and D. Morton The role of lymphatic mapping and sentinel lymph node biopsy in the management of atypical and anomalous melanocytic lesions J Cutan Pathol 37 2010 54 59
14. R.M. Abraham, M.E. Ming, and D.E. Elder An atypical melanocytic lesion without genomic abnormalities shows locoregional metastasis J Cutan Pathol 39 2012 21 24
15. T. Hung, A. Piris, and A. Lobo Sentinel lymph node metastasis is not predictive of poor outcome in patients with problematic spitzoid melanocytic tumors Hum Pathol 44 2012 87 94
16. L. Raskin, M. Ludgate, and R. Lyer Copy number variations and clinical outcome in atypical spitz tumors Am J Surg Pathol 35 2011 243 252
17. T.H. McCalmont, and B.C. Bastian An unconventional deep penetrating melanocytic nevus with microscopic involvement of regional lymph nodes J Cutan Pathol 39 2012 25 28
18. S. Luo, A. Sepehr, and H. Tsao Spitz nevi and other Spitzoid lesions part II. Natural history and management J Am Acad Dermatol 65 2011 1087 1092
19. C.M. Lohmann, D.G. Coit, and M.S. Brady Sentinel lymph node biopsy in patients with diagnostically controversial spitzoid melanocytic tumors Am J Surg Pathol 26 2002 47 55