In vivo imaging of Lgr5-positive cell populations using confocal laser endomicroscopy during early colon tumorigenesis

Endoscopy

Volumn 46, Issue 12, 2014, Pages 1110-1115

  Choi, Jin Woo ^a,b   Kim, Jun Ki ^c   Choi, Myunghwan ^a   Kim, Yi Rang ^a   Yun, Seok Hyun ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b Wonkwang University   (South Korea)

^c University of Ulsan College of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AZOXYMETHANE; DEXTRAN SULFATE; ENHANCED GREEN FLUORESCENT PROTEIN; LGR5 PROTEIN; MOLECULAR MARKER; TUMOR MARKER; UNCLASSIFIED DRUG; G PROTEIN COUPLED RECEPTOR; LGR5 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL POPULATION; COLON ADENOMA; COLON CARCINOGENESIS; COLON POLYP; COLONOSCOPY; CONFOCAL LASER MICROSCOPY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DESCENDING COLON; EARLY CANCER; GENE EXPRESSION; IN VIVO STUDY; INFANT; MARKER GENE; MOLECULAR IMAGING; MOUSE; MOUSE MODEL; NONHUMAN; TUMOR GROWTH; TUMOR MODEL; WHITE LIGHT ENDOSCOPY; ANIMAL; CARCINOGENESIS; CELL TRANSFORMATION; COLON; COLON TUMOR; COLORECTAL NEOPLASMS; DIAGNOSTIC IMAGING; EARLY DIAGNOSIS; EXPERIMENTAL NEOPLASM; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PROCEDURES;

ANIMALS; BIOMARKERS, TUMOR; CARCINOGENESIS; CELL TRANSFORMATION, NEOPLASTIC; COLON; COLONIC NEOPLASMS; COLONOSCOPY; COLORECTAL NEOPLASMS; DIAGNOSTIC IMAGING; EARLY DIAGNOSIS; MICE; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; NEOPLASMS, EXPERIMENTAL; RECEPTORS, G-PROTEIN-COUPLED;

EID: 84913596527     PISSN: 0013726X     EISSN: 14388812     Source Type: Journal    
DOI: 10.1055/s-0034-1377631     Document Type: Article

References (13)

1. Hill M. J., Morson B. C., Bussey H. J. Aetiology of adenoma - carcinoma sequence in large bowel. Lancet: 1978; 1 245 247
2. Kim C. Y., Fleischer D. E. Colonic chromoscopy. A new perspective on polyps and flat adenomas. Gastrointest Endosc Clin North Am: 1997; 7 423 437
3. Eaden J. A., Mayberry J. F. British Society for Gastroenterology; Association of Coloproctology for Great Britain and Ireland Guidelines for screening and surveillance of asymptomatic colorectal cancer in patients with inflammatory bowel disease. Gut: 2002; 51 V10 12
4. Machida H., Sano Y., Hamamoto Y. et al. Narrow-band imaging in the diagnosis of colorectal mucosal lesions: a pilot study. Endoscopy: 2004; 36 1094 1098
5. Ragunath K. Autofluorescence endoscopy - not much gain after all? Endoscopy: 2007; 39 1021 1022
6. Hurlstone D. P., Baraza W., Brown S. et al. In vivo real-time confocal laser scanning endomicroscopic colonoscopy for the detection and characterization of colorectal neoplasia. Br J Surg: 2008; 95 636 645
7. Sanduleanu S., Driessen A., Gomez-Garcia E. et al. In vivo diagnosis and classification of colorectal neoplasia by chromoendoscopy-guided confocal laser endomicroscopy. Clin Gastroenterol Hepatol: 2010; 8 371 378
8. Barker N., van Es J. H., Kuipers J. et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature: 2007; 449 1003 1007
9. Barker N., Ridgway R. A., van Es J. H. et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature: 2009; 457 608 611
10. Kim P., Chung E., Yamashita H. et al. In vivo wide-area cellular imaging by side-view endomicroscopy. Nat Methods: 2010; 7 303 305
11. Parra S. G., Chia T. H., Zinter J. P. et al. Multiphoton microscopy of cleared mouse organs. J Biomed Optics: 2010; 15 036017
12. Bird R. P. Observation and quantification of aberrant crypts in the murine colon treated with a colon carcinogen: preliminary findings. Cancer letters: 1987; 37 147 151
13. Tanaka T., Kohno H., Suzuki R. et al. A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate. Cancer Sci: 2003; 94 965 973