Desmosomal defects in acantholytic squamous cell carcinomas

Journal of Cutaneous Pathology

Volumn 41, Issue 11, 2014, Pages 873-879

  O'Shea, Charlene ^a   Fitzpatrick, James E ^a   Koch, Peter J ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Acantholytic squamous cell carcinomas; Desmocollin; Desmoglein; Desmoplakin; Desmosomes

Indexed keywords

ACANTHOLYSIS; AGED; DESMOSOME; FEMALE; HUMAN; MALE; MIDDLE AGED; PATHOLOGY; RETROSPECTIVE STUDY; SKIN TUMOR; SQUAMOUS CELL CARCINOMA; VERY ELDERLY;

ACANTHOLYSIS; AGED; AGED, 80 AND OVER; CARCINOMA, SQUAMOUS CELL; DESMOSOMES; FEMALE; HUMANS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; SKIN NEOPLASMS;

EID: 84913586616     PISSN: 03036987     EISSN: 16000560     Source Type: Journal    
DOI: 10.1111/cup.12390     Document Type: Article

References (22)

1. Driemel O, Muller-Richter UD, Hakim SG, et al. Oral acantholytic squamous cell carcinoma shares clinical and histological features with angiosarcoma. Head Face Med 2008; 4: 17.
2. Kerawala CJ,. Acantholytic squamous cell carcinoma of the oral cavity: a more aggressive entity? Br J Oral Maxillofac Surg 2009; 47: 123.
3. Nappi O, Pettinato G, Wick MR,. Adenoid (acantholytic) squamous cell carcinoma of the skin. J Cutan Pathol 1989; 16: 114.
4. Cassarino DS, Derienzo DP, Barr RJ,. Cutaneous squamous cell carcinoma: a comprehensive clinicopathologic classification. Part one. J Cutan Pathol 2006; 33: 191.
5. Papadopoulou E, Tosios KI, Nikitakis N, Papadogeorgakis N, Sklavounou-Andrikopoulou A,. Acantholytic squamous cell carcinoma of the gingiva: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2010; 109: e67.
6. Cherpelis BS, Marcusen C, Lang PG,. Prognostic factors for metastasis in squamous cell carcinoma of the skin. Dermatol Surg 2002; 28: 268.
7. Ganeshan R, Chen J, Koch PJ,. Mouse models for blistering skin disorders. Dermatol Res Pract 2010; 2010: 584353.
8. Petrof G, Mellerio JE, McGrath JA,. Desmosomal genodermatoses. Br J Dermatol 2012; 166: 36.
9. Neuber S, Muhmer M, Wratten D, Koch PJ, Moll R, Schmidt A,. The desmosomal plaque proteins of the plakophilin family. Dermatol Res Pract 2010; 2010: 101452.
10. Koch PJ, Franke WW,. Desmosomal cadherins: another growing multigene family of adhesion molecules. Curr Opin Cell Biol 1994; 6: 682.
11. Vasioukhin V, Bowers E, Bauer C, Degenstein L, Fuchs E,. Desmoplakin is essential in epidermal sheet formation. Nat Cell Biol 2001; 3: 1076.
12. Samuelov L, Sarig O, Harmon RM, et al. Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting. Nat Genet 2013; 45: 1244.
13. Tanaka A, Lai-Cheong JE, Cafe ME, et al. Novel truncating mutations in PKP1 and DSP cause similar skin phenotypes in two Brazilian families. Br J Dermatol 2009; 160: 692.
14. Kurzen H, Moll I, Moll R, et al. Compositionally different desmosomes in the various compartments of the human hair follicle. Differentiation 1998; 63: 295.
15. Kurzen H, Munzing I, Hartschuh W,. Expression of desmosomal proteins in squamous cell carcinomas of the skin. J Cutan Pathol 2003; 30: 621.
16. Griffin JR, Wriston CC, Peters MS, Lehman JS,. Decreased expression of intercellular adhesion molecules in acantholytic squamous cell carcinoma compared with invasive well-differentiated squamous cell carcinoma of the skin. Am J Clin Pathol 2013; 139: 442.
17. Bayer-Garner IB, Smoller BR,. The expression of syndecan-1 is preferentially reduced compared with that of E-cadherin in acantholytic squamous cell carcinoma. J Cutan Pathol 2001; 28: 83.
18. Moreno-Maldonado R, Ramirez A, Navarro M, et al. IKKalpha enhances human keratinocyte differentiation and determines the histological variant of epidermal squamous cell carcinomas. Cell Cycle 2008; 7: 2021.
19. Koch PJ, Mahoney MG, Cotsarelis G, Rothenberger K, Lavker RM, Stanley JR,. Desmoglein 3 anchors telogen hair in the follicle. J Cell Sci 1998; 111: 2529.
20. Koch PJ, Mahoney MG, Ishikawa H, et al. Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol 1997; 137: 1091.
21. Chen J, Den Z, Koch PJ,. Loss of desmocollin 3 in mice leads to epidermal blistering. J Cell Sci 2008; 121: 2844.
22. Brennan D, Mahoney MG,. Increased expression of Dsg2 in malignant skin carcinomas: a tissue-microarray based study. Cell Adh Migr 2009; 3: 148.