메뉴 건너뛰기




Volumn 61, Issue 1, 2014, Pages S91-S97

Antiviral therapy with nucleotide polymerase inhibitors for chronic hepatitis C

Author keywords

Hepatitis C; Nucleoside nucleotide polymerase inhibitors; Sofosbuvir

Indexed keywords

ANTIVIRUS AGENT; NONSTRUCTURAL PROTEIN 5B; NUCLEOTIDE POLYMERASE INHIBITOR; PEGINTERFERON; RIBAVIRIN; RNA DIRECTED RNA POLYMERASE INHIBITOR; SIMEPREVIR; SOFOSBUVIR; UNCLASSIFIED DRUG; NUCLEIC ACID SYNTHESIS INHIBITOR; URIDINE PHOSPHATE; VIRUS DNA;

EID: 84913584398     PISSN: 01688278     EISSN: 16000641     Source Type: Journal    
DOI: 10.1016/j.jhep.2014.09.006     Document Type: Review
Times cited : (25)

References (49)
  • 1
    • 59149085501 scopus 로고    scopus 로고
    • The global burden of hepatitis C
    • D. Lavanchy The global burden of hepatitis C Liver Int 29 2009 74 81
    • (2009) Liver Int , vol.29 , pp. 74-81
    • Lavanchy, D.1
  • 3
    • 0033060563 scopus 로고    scopus 로고
    • Global surveillance and control of hepatitis C
    • Global surveillance and control of hepatitis C J Viral Hepatol 6 1999 35 47
    • (1999) J Viral Hepatol , vol.6 , pp. 35-47
  • 4
    • 4444365401 scopus 로고    scopus 로고
    • The natural history of hepatitis C
    • N.H. Afdhal The natural history of hepatitis C Semin Liver Dis 24 2004 3 8
    • (2004) Semin Liver Dis , vol.24 , pp. 3-8
    • Afdhal, N.H.1
  • 5
    • 77958487999 scopus 로고    scopus 로고
    • New insights into structure and replication of the hepatitis C virus and clinical implications
    • M. Poenisch, and R. Bartenschlager New insights into structure and replication of the hepatitis C virus and clinical implications Semin Liver Dis 30 2010 333 347
    • (2010) Semin Liver Dis , vol.30 , pp. 333-347
    • Poenisch, M.1    Bartenschlager, R.2
  • 6
    • 84880309916 scopus 로고    scopus 로고
    • Understanding the hepatitis C virus life cycle paves the way for highly effective therapies
    • T.K.H. Scheel, and C.M. Rice Understanding the hepatitis C virus life cycle paves the way for highly effective therapies Nat Med 19 2013 837 849
    • (2013) Nat Med , vol.19 , pp. 837-849
    • Scheel, T.K.H.1    Rice, C.M.2
  • 8
    • 77956268467 scopus 로고    scopus 로고
    • Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): An open-label, randomised, multicentre phase 2 trial
    • P.Y. Kwo, E.J. Lawitz, J. McCone, E.R. Schiff, J.M. Vierling, and D. Pound Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial Lancet 376 2010 705 716
    • (2010) Lancet , vol.376 , pp. 705-716
    • Kwo, P.Y.1    Lawitz, E.J.2    McCone, J.3    Schiff, E.R.4    Vierling, J.M.5    Pound, D.6
  • 9
    • 84882908504 scopus 로고    scopus 로고
    • Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) - NCT01514890
    • C. Hézode, H. Fontaine, C. Dorival, D. Larrey, F. Zoulim, and V. Canva Triple therapy in treatment-experienced patients with HCV-cirrhosis in a multicentre cohort of the French Early Access Programme (ANRS CO20-CUPIC) - NCT01514890 J Hepatol 59 2013 434 441
    • (2013) J Hepatol , vol.59 , pp. 434-441
    • Hézode, C.1    Fontaine, H.2    Dorival, C.3    Larrey, D.4    Zoulim, F.5    Canva, V.6
  • 10
    • 34548285424 scopus 로고    scopus 로고
    • Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
    • U. Koch, and F. Narjes Recent progress in the development of inhibitors of the hepatitis C virus RNA-dependent RNA polymerase Curr Top Med Chem 7 2007 1302 1329
    • (2007) Curr Top Med Chem , vol.7 , pp. 1302-1329
    • Koch, U.1    Narjes, F.2
  • 12
    • 41349083638 scopus 로고    scopus 로고
    • Antiviral activity, pharmacokinetics, safety and tolerability of R7128, a novel nucleoside HCV RNA polymerase inhibitor, following multiple, ascending, oral doses in patients with HCV genotype 1 infection who have failed prior interferon therapy
    • R.K. Reddy, M. Rodriguez-Torres, E.J. Gane, R. Robson, J. Lalezari, and G.T. Everson Antiviral activity, pharmacokinetics, safety and tolerability of R7128, a novel nucleoside HCV RNA polymerase inhibitor, following multiple, ascending, oral doses in patients with HCV genotype 1 infection who have failed prior interferon therapy Hepatology 46 2007 862A
    • (2007) Hepatology , vol.46 , pp. 862A
    • Reddy, R.K.1    Rodriguez-Torres, M.2    Gane, E.J.3    Robson, R.4    Lalezari, J.5    Everson, G.T.6
  • 13
    • 46249112617 scopus 로고    scopus 로고
    • Potent antiviral activity of the HCV nucleoside polymerase inhibitor R7128 with PEG-IFN and ribavirin: Interim results of R7128 500 mg BID for 28 days
    • J. Lalezari, E. Gane, M. Rodriguez-Torres, E. DeJesus, D.R. Nelson, and G.T. Everson Potent antiviral activity of the HCV nucleoside polymerase inhibitor R7128 with PEG-IFN and ribavirin: interim results of R7128 500 mg BID for 28 days J Hepatol 48 2008 S29
    • (2008) J Hepatol , vol.48 , pp. 29
    • Lalezari, J.1    Gane, E.2    Rodriguez-Torres, M.3    Dejesus, E.4    Nelson, D.R.5    Everson, G.T.6
  • 14
    • 77958162291 scopus 로고    scopus 로고
    • Sustained virologic response (SVR) following RG7128 1500 mg BID/PEG-IFN/RBV for 28 days in HCV genotype 2/3 prior non-responders
    • E.J. Gane, M. Rodriguez-Torres, D.E. Nelson, I.M. Jacobson, J.G. McHutchison, and A. Duca Sustained virologic response (SVR) following RG7128 1500 mg BID/PEG-IFN/RBV for 28 days in HCV genotype 2/3 prior non-responders J Hepatol 52 2010 S16
    • (2010) J Hepatol , vol.52 , pp. 16
    • Gane, E.J.1    Rodriguez-Torres, M.2    Nelson, D.E.3    Jacobson, I.M.4    McHutchison, J.G.5    Duca, A.6
  • 15
    • 78049527728 scopus 로고    scopus 로고
    • Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): A randomised, double-blind, placebo-controlled, dose-escalation trial
    • E.J. Gane, S.K. Roberts, C.A.M. Stedman, P.W. Angus, B. Ritchie, and R. Elston Oral combination therapy with a nucleoside polymerase inhibitor (RG7128) and danoprevir for chronic hepatitis C genotype 1 infection (INFORM-1): a randomised, double-blind, placebo-controlled, dose-escalation trial Lancet 376 2010 1467 1475
    • (2010) Lancet , vol.376 , pp. 1467-1475
    • Gane, E.J.1    Roberts, S.K.2    Stedman, C.A.M.3    Angus, P.W.4    Ritchie, B.5    Elston, R.6
  • 16
    • 84913555490 scopus 로고    scopus 로고
    • Favorable preclinical profile of Idx21437, a novel uridine nucleotide prodrug, for use in a direct-acting antiviral (DAA) regimen for HCV
    • K. Gupta, M. Seifer, I. Serra, H. Rashidzadeh, S. Luo, and M. La Colla Favorable preclinical profile of Idx21437, a novel uridine nucleotide prodrug, for use in a direct-acting antiviral (DAA) regimen for HCV J Hepatol 60 2014 S504
    • (2014) J Hepatol , vol.60 , pp. 504
    • Gupta, K.1    Seifer, M.2    Serra, I.3    Rashidzadeh, H.4    Luo, S.5    La Colla, M.6
  • 17
    • 84892718437 scopus 로고    scopus 로고
    • Pretransplant sofosbuvir and ribavirin to prevent recurrence of HCV infection after liver transplantation
    • M.P. Curry, X. Forns, R.T. Chung, N. Terrault, R.S. Brown, and J.M. Fenkel Pretransplant sofosbuvir and ribavirin to prevent recurrence of HCV infection after liver transplantation Hepatology 58 2013 314A 315A
    • (2013) Hepatology , vol.58 , pp. 314A-315A
    • Curry, M.P.1    Forns, X.2    Chung, R.T.3    Terrault, N.4    Brown, R.S.5    Fenkel, J.M.6
  • 18
    • 84891735608 scopus 로고    scopus 로고
    • New concepts of sofosbuvir-based treatment regimens in patients with hepatitis C
    • Z. Mariño, F. van Bömmel, X. Forns, and T. Berg New concepts of sofosbuvir-based treatment regimens in patients with hepatitis C Gut 63 2014 207 215
    • (2014) Gut , vol.63 , pp. 207-215
    • Mariño, Z.1    Van Bömmel, F.2    Forns, X.3    Berg, T.4
  • 19
    • 84899621215 scopus 로고    scopus 로고
    • Interferon-free strategies with a nucleoside/nucleotide analogue
    • J.J. Feld Interferon-free strategies with a nucleoside/nucleotide analogue Semin Liver Dis 34 2014 37 46
    • (2014) Semin Liver Dis , vol.34 , pp. 37-46
    • Feld, J.J.1
  • 22
    • 84878976866 scopus 로고    scopus 로고
    • Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): An open-label, randomised, multicentre phase 2 trial
    • K.V. Kowdley, E. Lawitz, I. Crespo, T. Hassanein, M.N. Davis, and M. DeMicco Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial Lancet 381 2013 2100 2107
    • (2013) Lancet , vol.381 , pp. 2100-2107
    • Kowdley, K.V.1    Lawitz, E.2    Crespo, I.3    Hassanein, T.4    Davis, M.N.5    Demicco, M.6
  • 23
    • 84876740954 scopus 로고    scopus 로고
    • Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: A randomised, double-blind, phase 2 trial
    • E. Lawitz, J.P. Lalezari, T. Hassanein, K.V. Kowdley, F.F. Poordad, and A.M. Sheikh Sofosbuvir in combination with peginterferon alfa-2a and ribavirin for non-cirrhotic, treatment-naive patients with genotypes 1, 2, and 3 hepatitis C infection: a randomised, double-blind, phase 2 trial Lancet Infect Dis 13 2013 401 408
    • (2013) Lancet Infect Dis , vol.13 , pp. 401-408
    • Lawitz, E.1    Lalezari, J.P.2    Hassanein, T.3    Kowdley, K.V.4    Poordad, F.F.5    Sheikh, A.M.6
  • 25
    • 84897084133 scopus 로고    scopus 로고
    • Once daily sofosbuvir plus ribavirin for 12 and 24 weeks in treatment-naïve patients with HCV infection: The QUANTUM study
    • J.P. Lalezari, D.R. Nelson, R.H. Hyland, M. Lin, S.J. Rossi, and W.T. Symonds Once daily sofosbuvir plus ribavirin for 12 and 24 weeks in treatment-naïve patients with HCV infection: the QUANTUM study J Hepatol 58 2013 S346
    • (2013) J Hepatol , vol.58 , pp. 346
    • Lalezari, J.P.1    Nelson, D.R.2    Hyland, R.H.3    Lin, M.4    Rossi, S.J.5    Symonds, W.T.6
  • 26
    • 84883089005 scopus 로고    scopus 로고
    • Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: A randomized clinical trial
    • A. Osinusi, E.G. Meissner, Y.-J. Lee, D. Bon, L. Heytens, and A. Nelson Sofosbuvir and ribavirin for hepatitis C genotype 1 in patients with unfavorable treatment characteristics: a randomized clinical trial JAMA 310 2013 804 811
    • (2013) JAMA , vol.310 , pp. 804-811
    • Osinusi, A.1    Meissner, E.G.2    Lee, Y.-J.3    Bon, D.4    Heytens, L.5    Nelson, A.6
  • 27
    • 84892737595 scopus 로고    scopus 로고
    • All-oral therapy with sofosbuvir plus ribavirin for the treatment of HCV genotype 1, 2, and 3 infection in patients co-infected with HIV (PHOTON-1)
    • M.S. Sulkowski, M. Rodriguez-Torres, J. Lalezari, W.J. Fessel, K. Mounzer, and M.C. Shuhart All-oral therapy with sofosbuvir plus ribavirin for the treatment of HCV genotype 1, 2, and 3 infection in patients co-infected with HIV (PHOTON-1) Hepatology 58 2013 313A 314A
    • (2013) Hepatology , vol.58 , pp. 313A-314A
    • Sulkowski, M.S.1    Rodriguez-Torres, M.2    Lalezari, J.3    Fessel, W.J.4    Mounzer, K.5    Shuhart, M.C.6
  • 28
    • 84874644131 scopus 로고    scopus 로고
    • Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life
    • J. Guedj, H. Dahari, L. Rong, N.D. Sansone, R.E. Nettles, and S.J. Cotler Modeling shows that the NS5A inhibitor daclatasvir has two modes of action and yields a shorter estimate of the hepatitis C virus half-life Proc Natl Acad Sci USA 110 2013 3991 3996
    • (2013) Proc Natl Acad Sci USA , vol.110 , pp. 3991-3996
    • Guedj, J.1    Dahari, H.2    Rong, L.3    Sansone, N.D.4    Nettles, R.E.5    Cotler, S.J.6
  • 29
    • 84878475234 scopus 로고    scopus 로고
    • Sofosbuvir and daclatasvir combination therapy in a liver transplant recipient with severe recurrent cholestatic hepatitis C
    • R.J. Fontana, E.A. Hughes, and M. Bifano Sofosbuvir and daclatasvir combination therapy in a liver transplant recipient with severe recurrent cholestatic hepatitis C Am J Transplant 13 2013 1601 1605
    • (2013) Am J Transplant , vol.13 , pp. 1601-1605
    • Fontana, R.J.1    Hughes, E.A.2    Bifano, M.3
  • 30
    • 84880271996 scopus 로고    scopus 로고
    • All-oral sofosbuvir-based 12-week regimens for the treatment of chronic HCV infection: The ELECTRON study
    • E.J. Gane, C.A. Stedman, R.H. Hyland, P.S. Pang, X. Ding, and W.T. Symonds All-oral sofosbuvir-based 12-week regimens for the treatment of chronic HCV infection: the ELECTRON study J Hepatol 58 2013 S6 S7
    • (2013) J Hepatol , vol.58 , pp. 6-S7
    • Gane, E.J.1    Stedman, C.A.2    Hyland, R.H.3    Pang, P.S.4    Ding, X.5    Symonds, W.T.6
  • 31
    • 84894621765 scopus 로고    scopus 로고
    • Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): An open-label, randomised, phase 2 trial
    • E. Lawitz, F.F. Poordad, P.S. Pang, R.H. Hyland, X. Ding, and H. Mo Sofosbuvir and ledipasvir fixed-dose combination with and without ribavirin in treatment-naive and previously treated patients with genotype 1 hepatitis C virus infection (LONESTAR): an open-label, randomised, phase 2 trial Lancet 383 2014 515 523
    • (2014) Lancet , vol.383 , pp. 515-523
    • Lawitz, E.1    Poordad, F.F.2    Pang, P.S.3    Hyland, R.H.4    Ding, X.5    Mo, H.6
  • 32
  • 34
    • 84907525692 scopus 로고    scopus 로고
    • Sofosbuvir/ledipasvir fixed dose combination is safe and effective in difficult-to-treat populations including genotype-3 patients, decompensated genotype-1 patients, and genotype-1 patients with prior sofosbuvir treatment experience
    • E.J. Gane, R.H. Hyland, D. An, P.S. Pang, W.T. Symonds, and J.G. Mchutchison Sofosbuvir/ledipasvir fixed dose combination is safe and effective in difficult-to-treat populations including genotype-3 patients, decompensated genotype-1 patients, and genotype-1 patients with prior sofosbuvir treatment experience J Hepatol 60 2014 S3 S4
    • (2014) J Hepatol , vol.60 , pp. 3-S4
    • Gane, E.J.1    Hyland, R.H.2    An, D.3    Pang, P.S.4    Symonds, W.T.5    McHutchison, J.G.6
  • 36
    • 84895736477 scopus 로고    scopus 로고
    • SVR results of a once-daily regimen of simeprevir (SMV, TMC435) plus sofosbuvir (SOF, GS-7977) with or without ribavirin in cirrhotic and non-cirrhotic HCV genotype 1 treatment-naïve and prior null responder patients: The COSMOS study
    • LB3
    • I.M. Jacobson, R. Ghalib, M. Rodriguez-Torres, Z. Younossi, A. Corregidor, and M.S. Sulkowski SVR results of a once-daily regimen of simeprevir (SMV, TMC435) plus sofosbuvir (SOF, GS-7977) with or without ribavirin in cirrhotic and non-cirrhotic HCV genotype 1 treatment-naïve and prior null responder patients: the COSMOS study Hepatology 58 2013 LB3
    • (2013) Hepatology , vol.58
    • Jacobson, I.M.1    Ghalib, R.2    Rodriguez-Torres, M.3    Younossi, Z.4    Corregidor, A.5    Sulkowski, M.S.6
  • 37
    • 84906053496 scopus 로고    scopus 로고
    • Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): A phase 3, randomised, double-blind, placebo-controlled trial
    • I.M. Jacobson, G.J. Dore, G.R. Foster, M.W. Fried, M. Radu, and V.V. Rafalsky Simeprevir with pegylated interferon alfa 2a plus ribavirin in treatment-naive patients with chronic hepatitis C virus genotype 1 infection (QUEST-1): a phase 3, randomised, double-blind, placebo-controlled trial Lancet 384 2 2014 403 413
    • (2014) Lancet , vol.384 , Issue.2 , pp. 403-413
    • Jacobson, I.M.1    Dore, G.J.2    Foster, G.R.3    Fried, M.W.4    Radu, M.5    Rafalsky, V.V.6
  • 38
    • 65449136656 scopus 로고    scopus 로고
    • Diagnosis, management, and treatment of hepatitis C: An update
    • M.G. Ghany, D.B. Strader, D.L. Thomas, and L.B. Seeff Diagnosis, management, and treatment of hepatitis C: an update Hepatology 49 2009 1335 1374
    • (2009) Hepatology , vol.49 , pp. 1335-1374
    • Ghany, M.G.1    Strader, D.B.2    Thomas, D.L.3    Seeff, L.B.4
  • 41
    • 84896710685 scopus 로고    scopus 로고
    • Sofosbuvir in combination with PEGIFN and ribavirin for 12 weeks provides high SVR rates in HCV infected genotype 2 or 3 treatment experienced patients with and without compensated cirrhosis: Results from the LONESTAR-2 study
    • Lawitz E, Poordad F, Brainard D, Hyland RH, An D, Symonds WT, et al. Sofosbuvir in combination with PEGIFN and ribavirin for 12 weeks provides high SVR rates in HCV infected genotype 2 or 3 treatment experienced patients with and without compensated cirrhosis: results from the LONESTAR-2 study. In: 64th annual meeting of the American Association for the study of liver diseases; 2013. p. LB4.
    • (2013) 64th Annual Meeting of the American Association for the Study of Liver Diseases , pp. LB4
    • Lawitz, E.1    Poordad, F.2    Brainard, D.3    Hyland, R.H.4    An, D.5    Symonds, W.T.6
  • 42
    • 84907521748 scopus 로고    scopus 로고
    • Successful retreatment with sofosbuvir-containing regimens for HCV genotype 2 or 3 infected patients who failed prior sofosbuvir plus ribavirin therapy
    • R. Esteban, L. Nyberg, J. Lalezari, L. Ni, B. Doehle, and B. Kanwar Successful retreatment with sofosbuvir-containing regimens for HCV genotype 2 or 3 infected patients who failed prior sofosbuvir plus ribavirin therapy J Hepatol 60 2014 S4 S5
    • (2014) J Hepatol , vol.60 , pp. 4-S5
    • Esteban, R.1    Nyberg, L.2    Lalezari, J.3    Ni, L.4    Doehle, B.5    Kanwar, B.6
  • 43
    • 84907567738 scopus 로고    scopus 로고
    • Safety and efficacy of treatment with the interferon-free, ribavirin-free combination of sofosbuvir + GS-5816 for 12 weeks in treatment naive patients with genotype 1-6 HCV infection
    • G.T. Everson, T.T. Tran, W.J. Towner, M.N. Davis, D. Wyles, and R. Nahass Safety and efficacy of treatment with the interferon-free, ribavirin-free combination of sofosbuvir + GS-5816 for 12 weeks in treatment naive patients with genotype 1-6 HCV infection J Hepatol 60 2014 S46
    • (2014) J Hepatol , vol.60 , pp. 46
    • Everson, G.T.1    Tran, T.T.2    Towner, W.J.3    Davis, M.N.4    Wyles, D.5    Nahass, R.6
  • 44
    • 84908086002 scopus 로고    scopus 로고
    • Sofosbuvir plus ribavirin, an interferon-free regimen, in the treatment of treatment-naive and treatment-experienced patients with chronic genotype 4 HCV infection
    • P.J. Ruane, D. Ain, R. Meshrekey, J. Riad, M. Soliman, and S. Mikhail Sofosbuvir plus ribavirin, an interferon-free regimen, in the treatment of treatment-naive and treatment-experienced patients with chronic genotype 4 HCV infection J Hepatol 60 2014 S503 S504
    • (2014) J Hepatol , vol.60 , pp. 503-S504
    • Ruane, P.J.1    Ain, D.2    Meshrekey, R.3    Riad, J.4    Soliman, M.5    Mikhail, S.6
  • 45
    • 84913573505 scopus 로고    scopus 로고
    • Integrated safety analysis of sofosbuvir-based HCV treatment regimens from phase 3 studies
    • S.C. Gordon, W. Towner, A. Aggarwal, J. Ma, J. McNally, and L.M. Stamm Integrated safety analysis of sofosbuvir-based HCV treatment regimens from phase 3 studies Gastroenterology 146 2014 S921
    • (2014) Gastroenterology , vol.146 , pp. 921
    • Gordon, S.C.1    Towner, W.2    Aggarwal, A.3    Ma, J.4    McNally, J.5    Stamm, L.M.6
  • 47
    • 84879602208 scopus 로고    scopus 로고
    • Comprehensive resistance testing in patients who relapsed after treatment with sofosbuvir (GS-7977)-containing regimens in phase 2 studies
    • E. Svarovskaia, H. Dvory-Sobol, V. Gontcharova, S. Chiu, C. Hebner, and R.H. Hyland Comprehensive resistance testing in patients who relapsed after treatment with sofosbuvir (GS-7977)-containing regimens in phase 2 studies Hepatology 56 2012 551A
    • (2012) Hepatology , vol.56 , pp. 551A
    • Svarovskaia, E.1    Dvory-Sobol, H.2    Gontcharova, V.3    Chiu, S.4    Hebner, C.5    Hyland, R.H.6
  • 48
    • 84913603634 scopus 로고    scopus 로고
    • Retreatment of relapsers to sofosbuvir/ribavirin with sofosbuvir/ledipasvir: Complete and rapid virologic suppression by week 4
    • A. Osinusi, M. Marti, K. Townsend, A. Nelson, A. Kohli, and R. Silk Retreatment of relapsers to sofosbuvir/ribavirin with sofosbuvir/ledipasvir: complete and rapid virologic suppression by week 4 J Hepatol 60 2014 S5 S6
    • (2014) J Hepatol , vol.60 , pp. 5-S6
    • Osinusi, A.1    Marti, M.2    Townsend, K.3    Nelson, A.4    Kohli, A.5    Silk, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.