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Volumn 16, Issue 10, 2014, Pages 1036-1039

The dipeptidyl peptidase-4 inhibitor linagliptin lowers postprandial glucose and improves measures of β-cell function in type 2 diabetes

Author keywords

Beta cell; DPP IV inhibitor; Drug mechanism; Glycaemic control; Type 2 diabetes

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; LINAGLIPTIN; PLACEBO; ANTIDIABETIC AGENT; PURINE DERIVATIVE; QUINAZOLINE DERIVATIVE;

EID: 84912520644     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/dom.12312     Document Type: Letter
Times cited : (11)

References (13)
  • 1
    • 0028817815 scopus 로고
    • Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group
    • U.K. Prospective Diabetes Study 16.
    • U.K. Prospective Diabetes Study 16. Overview of 6 years' therapy of type II diabetes: a progressive disease. U.K. Prospective Diabetes Study Group. Diabetes 1995; 44: 1249-1258.
    • (1995) Diabetes , vol.44 , pp. 1249-1258
  • 2
    • 79959484802 scopus 로고    scopus 로고
    • Effects of rosiglitazone, glyburide, and metformin on beta-cell function and insulin sensitivity in ADOPT
    • Kahn SE, Lachin JM, Zinman B et al. Effects of rosiglitazone, glyburide, and metformin on beta-cell function and insulin sensitivity in ADOPT. Diabetes 2011; 60: 1552-1560.
    • (2011) Diabetes , vol.60 , pp. 1552-1560
    • Kahn, S.E.1    Lachin, J.M.2    Zinman, B.3
  • 3
    • 78650753885 scopus 로고    scopus 로고
    • Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications
    • Nauck MA. Incretin-based therapies for type 2 diabetes mellitus: properties, functions, and clinical implications. Am J Med 2011; 124: S3-S18.
    • (2011) Am J Med , vol.124 , pp. S3-S18
    • Nauck, M.A.1
  • 4
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    • Xu G, Stoffers DA, Habener JF, Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999; 48: 2270-2276.
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 5
    • 84871179173 scopus 로고    scopus 로고
    • Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus
    • Rauch T, Graefe-Mody U, Deacon CF et al. Linagliptin increases incretin levels, lowers glucagon, and improves glycemic control in type 2 diabetes mellitus. Diabetes Ther 2012; 3: 10.
    • (2012) Diabetes Ther , vol.3 , pp. 10
    • Rauch, T.1    Graefe-Mody, U.2    Deacon, C.F.3
  • 6
    • 84866303239 scopus 로고    scopus 로고
    • The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves beta-cell mass in non-obese diabetic mice
    • Jelsing J, Vrang N, van Witteloostuijn SB, Mark M, Klein T. The DPP4 inhibitor linagliptin delays the onset of diabetes and preserves beta-cell mass in non-obese diabetic mice. J Endocrinol 2012; 214: 381-387.
    • (2012) J Endocrinol , vol.214 , pp. 381-387
    • Jelsing, J.1    Vrang, N.2    van Witteloostuijn, S.B.3    Mark, M.4    Klein, T.5
  • 7
    • 84879919203 scopus 로고    scopus 로고
    • The DPP-4 inhibitor linagliptin restores beta-cell function and survival in human isolated islets through GLP-1 stabilization
    • Shah P, Ardestani A, Dharmadhikari G et al. The DPP-4 inhibitor linagliptin restores beta-cell function and survival in human isolated islets through GLP-1 stabilization. J Clin Endocrinol Metab 2013; 98: E1163-E1172.
    • (2013) J Clin Endocrinol Metab , vol.98 , pp. E1163-E1172
    • Shah, P.1    Ardestani, A.2    Dharmadhikari, G.3
  • 9
    • 79960915742 scopus 로고    scopus 로고
    • Beta cell function following 1 year vildagliptin or placebo treatment and after 12 week washout in drug-naive patients with type 2 diabetes and mild hyperglycaemia: a randomised controlled trial
    • Foley JE, Bunck MC, Moller-Goede DL et al. Beta cell function following 1 year vildagliptin or placebo treatment and after 12 week washout in drug-naive patients with type 2 diabetes and mild hyperglycaemia: a randomised controlled trial. Diabetologia 2011; 54: 1985-1991.
    • (2011) Diabetologia , vol.54 , pp. 1985-1991
    • Foley, J.E.1    Bunck, M.C.2    Moller-Goede, D.L.3
  • 10
    • 79960767310 scopus 로고    scopus 로고
    • Effects of saxagliptin on beta-cell stimulation and insulin secretion in patients with type 2 diabetes
    • Henry RR, Smith SR, Schwartz SL et al. Effects of saxagliptin on beta-cell stimulation and insulin secretion in patients with type 2 diabetes. Diabetes Obes Metab 2011; 13: 850-858.
    • (2011) Diabetes Obes Metab , vol.13 , pp. 850-858
    • Henry, R.R.1    Smith, S.R.2    Schwartz, S.L.3
  • 11
    • 52249090472 scopus 로고    scopus 로고
    • Robust improvements in fasting and prandial measures of beta-cell function with vildagliptin in drug-naive patients: analysis of pooled vildagliptin monotherapy database
    • Pratley RE, Schweizer A, Rosenstock J et al. Robust improvements in fasting and prandial measures of beta-cell function with vildagliptin in drug-naive patients: analysis of pooled vildagliptin monotherapy database. Diabetes Obes Metab 2008; 10: 931-938.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 931-938
    • Pratley, R.E.1    Schweizer, A.2    Rosenstock, J.3
  • 12
    • 38149110484 scopus 로고    scopus 로고
    • The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose
    • Utzschneider KM, Tong J, Montgomery B et al. The dipeptidyl peptidase-4 inhibitor vildagliptin improves beta-cell function and insulin sensitivity in subjects with impaired fasting glucose. Diabetes Care 2008; 31: 108-113.
    • (2008) Diabetes Care , vol.31 , pp. 108-113
    • Utzschneider, K.M.1    Tong, J.2    Montgomery, B.3
  • 13
    • 55449096196 scopus 로고    scopus 로고
    • Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on beta-cell function in patients with type 2 diabetes: a model-based approach
    • Xu L, Man CD, Charbonnel B et al. Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on beta-cell function in patients with type 2 diabetes: a model-based approach. Diabetes Obes Metab 2008; 10: 1212-1220.
    • (2008) Diabetes Obes Metab , vol.10 , pp. 1212-1220
    • Xu, L.1    Man, C.D.2    Charbonnel, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.