Osteoporosis markers on low-dose lung cancer screening chest computed tomography scans predict all-cause mortality

European Radiology

Volumn 25, Issue 1, 2015, Pages 132-139

  Buckens, C F ^a   van der Graaf, Y ^a   Verkooijen, H M ^a   Mali, W P ^a   Isgum, I ^b   Mol, C P ^b   Verhaar, H J ^a   Vliegenthart, R ^c   Oudkerk, M ^c   van Aalst, C M ^d   de Koning, H J ^d   de Jong, P A ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c Medical Center   (Netherlands)

^d ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

Bone density; Computed tomography; Lung cancer screening; Mortality; Vertebral fracture

Indexed keywords

ADULT; ALL CAUSE MORTALITY; ARTICLE; BONE DENSITY; CANCER SCREENING; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; CONE BEAM COMPUTED TOMOGRAPHY; DISEASE MARKER; FEMALE; FOLLOW UP; HUMAN; LOW ENERGY RADIATION; LUNG CANCER; LUNG EMPHYSEMA; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; MORTALITY; MULTIDETECTOR COMPUTED TOMOGRAPHY; OSTEOPOROSIS; PREDICTION; PREVALENCE; SMOKING; SPINE FRACTURE; SURVIVOR; TRABECULAR BONE; ADVERSE EFFECTS; AGED; BLOOD; CLINICAL TRIAL; CONTROLLED STUDY; EARLY DIAGNOSIS; FRAGILITY FRACTURE; LUNG TUMOR; MIDDLE AGED; MULTICENTER STUDY; PHOTON ABSORPTIOMETRY; PHYSIOLOGY; PROPORTIONAL HAZARDS MODEL; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL;

BIOLOGICAL MARKER;

ABSORPTIOMETRY, PHOTON; AGED; BIOLOGICAL MARKERS; BONE DENSITY; EARLY DETECTION OF CANCER; FEMALE; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; OSTEOPOROSIS; OSTEOPOROTIC FRACTURES; PROPORTIONAL HAZARDS MODELS; SMOKING; SPINAL FRACTURES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84912133420     PISSN: 09387994     EISSN: 14321084     Source Type: Journal    
DOI: 10.1007/s00330-014-3361-0     Document Type: Article

References (56)

1. Team NLSTR, Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD et al (2011) Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 365:395–409
2. Bach PB, Mirkin JN, Oliver TK, Azzoli CG, Berry DA, Brawley OW et al (2012) Benefits and harms of CT screening for lung cancer: a systematic review. JAMA J Am Med Assoc 307:2418–2429
3. Mets OM, de Jong PA, Prokop M (2012) Computed tomographic screening for lung cancer: an opportunity to evaluate other diseases. JAMA J Am Med Assoc 308:1433–1434
4. Mets OM, Buckens CFM, Zanen P, Isgum I, van Ginneken B, Prokop M et al (2011) Identification of chronic obstructive pulmonary disease in lung cancer screening computed tomographic scans. JAMA J Am Med Assoc 306:1775–1781
5. Mets OM, Vliegenthart R, Gondrie MJ, Viergever MA, Oudkerk M, de Koning HJ et al (2013) Lung cancer screening CT-based prediction of cardiovascular events. JACC Cardiovasc Imaging 6:899–907. doi:10.1016/j.jcmg.2013.02.008
6. McEvoy JW, Blaha MJ, Rivera JJ, Budoff MJ, Khan AN, Shaw LJ et al (2012) Mortality rates in smokers and nonsmokers in the presence or absence of coronary artery calcification. JACC Cardiovasc Imaging 5:1037–1045
7. Xie X, Zhao Y, de Bock GH, de Jong PA, Mali WP, Oudkerk M et al (2013) Validation and prognosis of coronary artery calcium scoring in non-triggered thoracic computed tomography: systematic review and meta-analysis. Circ Cardiovasc Imaging 6:514–521. doi:10.1161/CIRCIMAGING.113.000092
8. Centers for Disease Control and Prevention (CDC) (2005) Annual smoking-attributable mortality, years of potential life lost, and productivity losses--United States, 1997–2001. MMWR Morb Mortal Wkly Rep 54:625–628
9. Gan WQ, Man SFP, Senthilselvan A, Sin DD (2004) Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 59:574–580
10. Pickhardt PJ, Pooler BD, Lauder T, del Rio AM, Bruce RJ, Binkley N (2013) Opportunistic screening for osteoporosis using abdominal computed tomography scans obtained for other indications. Ann Intern Med 158:588–595
11. Romme EAPM, Murchison JT, Phang KF, Jansen FH, Rutten EPA, Wouters EFM et al (2012) Bone attenuation on routine chest CT correlates with bone mineral density on DXA in patients with COPD. J Bone Miner Res Off J Am Soc Bone Miner Res 27:2338–2343
12. Johansson C, Black D, Johnell O, Odén A, Mellström D (1998) Bone mineral density is a predictor of survival. Calcif Tissue Int 63:190–196
13. Buckens CF, de Jong PA, Mol C, Bakker E, Stallman HP, Mali WP et al (2013) Intra and interobserver reliability and agreement of semiquantitative vertebral fracture assessment on chest computed tomography. Woloschak GE, ed. PLoS ONE 8:e71204
14. Jalava T, Sarna S, Pylkkänen L, Mawer B, Kanis JA, Selby P et al (2003) Association between vertebral fracture and increased mortality in osteoporotic patients. J Bone Miner Res Off J Am Soc Bone Miner Res 18:1254–1260
15. Hasserius R, Karlsson MK, Nilsson BE, Redlund-Johnell I, Johnell O (2003) Prevalent vertebral deformities predict increased mortality and increased fracture rate in both men and women: a 10-year population-based study of 598 individuals from the Swedish cohort in the European Vertebral Osteoporosis Study. Osteoporos Int J Establ Result Coop Eur Found Osteoporos Natl Osteoporos Found USA 14:61–68
16. Trone DW, Kritz-Silverstein D, von Mühlen DG, Wingard DL, Barrett-Connor E (2007) Is radiographic vertebral fracture a risk factor for mortality? Am J Epidemiol 166:1191–1197
17. Puisto V, Rissanen H, Heliövaara M, Knekt P, Helenius I (2008) Mortality in the presence of a vertebral fracture, scoliosis, or Scheuermann’s disease in the thoracic spine. Ann Epidemiol 18:595–601
18. Ikeda Y, Sudo A, Yamada T, Uchida A (2010) Mortality after vertebral fractures in a Japanese population. J Orthop Surg Hong Kong 18:148–152
19. Waterloo S, Ahmed LA, Center JR, Eisman JA, Morseth B, Nguyen ND et al (2012) Prevalence of vertebral fractures in women and men in the population-based Tromsø Study. BMC Musculoskelet Disord 13:3
20. Buckens C, de Jong P, Mali W, Verhaar H, van der Graaf Y, Verkooijen H (2014) Prevalent vertebral fractures on chest CT: higher risk for future hip fracture. J Bone Miner Res Off J Am Soc Bone Miner Res 29:392–398. doi:10.1002/jbmr.2028
21. Woo EK, Mansoubi H, Alyas F (2008) Incidental vertebral fractures on multidetector CT images of the chest: prevalence and recognition. Clin Radiol 63:160–164
22. Bartalena T, Giannelli G, Rinaldi MF, Rimondi E, Rinaldi G, Sverzellati N et al (2009) Prevalence of thoracolumbar vertebral fractures on multidetector CT: underreporting by radiologists. Eur J Radiol 69:555–559
23. Williams AL, Al-Busaidi A, Sparrow PJ, Adams JE, Whitehouse RW (2009) Under-reporting of osteoporotic vertebral fractures on computed tomography. Eur J Radiol 69:179–183
24. Müller D, Bauer JS, Zeile M, Rummeny EJ, Link TM (2008) Significance of sagittal reformations in routine thoracic and abdominal multislice CT studies for detecting osteoporotic fractures and other spine abnormalities. Eur Radiol 18:1696–1702
25. Chan PL, Reddy T, Milne D, Bolland MJ (2012) Incidental vertebral fractures on computed tomography. N Z Med J 125:45–50
26. Bolland MJ, Grey AB, Gamble GD, Reid IR (2010) Effect of osteoporosis treatment on mortality: a meta-analysis. J Clin Endocrinol Metab 95:1174–1181
27. Van Iersel CA, de Koning HJ, Draisma G, Mali WPTM, Scholten ET, Nackaerts K et al (2007) Risk-based selection from the general population in a screening trial: selection criteria, recruitment and power for the Dutch-Belgian randomised lung cancer multi-slice CT screening trial (NELSON). Int J Cancer J Int Cancer 120:868–874
28. Onland-Moret NC, van der A DL, van der Schouw YT, Buschers W, Elias SG, van Gils CH et al (2007) Analysis of case-cohort data: a comparison of different methods. J Clin Epidemiol 60:350–355
29. Van Rikxoort EM, de Hoop B, Viergever MA, Prokop M, van Ginneken B (2009) Automatic lung segmentation from thoracic computed tomography scans using a hybrid approach with error detection. Med Phys 36:2934–2947
30. Schilham AMR, van Ginneken B, Gietema H, Prokop M (2006) Local noise weighted filtering for emphysema scoring of low-dose CT images. IEEE Trans Med Imaging 25:451–463
31. Gevenois PA, De Vuyst P, de Maertelaer V, Zanen J, Jacobovitz D, Cosio MG et al (1996) Comparison of computed density and microscopic morphometry in pulmonary emphysema. Am J Respir Crit Care Med 154:187–192
32. Newell JD Jr, Hogg JC, Snider GL (2004) Report of a workshop: quantitative computed tomography scanning in longitudinal studies of emphysema. Eur Respir J 23:769–775
33. Isgum I, Rutten A, Prokop M, Staring M, Klein S, Pluim JPW et al (2010) Automated aortic calcium scoring on low-dose chest computed tomography. Med Phys 37:714–723
34. Isgum I, Prokop M, Niemeijer M, Viergever MA, van Ginneken B (2012) Automatic coronary calcium scoring in low-dose chest computed tomography. IEEE Trans Med Imaging 31:2322–2334
35. Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res Off J Am Soc Bone Miner Res 8:1137–1148
36. Siris ES, Genant HK, Laster AJ, Chen P, Misurski DA, Krege JH (2007) Enhanced prediction of fracture risk combining vertebral fracture status and BMD. Osteoporos Int J Establ Result Coop Eur Found Osteoporos Natl Osteoporos Found USA 18:761–770
37. De Bruin A, Karduan J, Gast F, De Bruin E, van Sijl M, Verweij G (2004) Record linkage of hospital discharge register with population register: experiences at Statistics Netherlands. Stat J United Nations Econ Comm Eur 1:23–32
38. Tromp M, Ravelli AC, Bonsel GJ, Hasman A, Reitsma JB (2011) Results from simulated data sets: probabilistic record linkage outperforms deterministic record linkage. J Clin Epidemiol 64:565–572
39. Prentice R (1986) A case-cohort design for epidemiologic cohort studies and disease prevention trials. Biometrika 73:1–11
40. R Core Team (2013) R: a language and environment for statistical computing [Internet]. Vienna, Austria: R Foundation for Statistical Computing. Available from: http://www.R-project.org/
41. Pongchaiyakul C, Nguyen ND, Jones G, Center JR, Eisman JA, Nguyen TV (2005) Asymptomatic vertebral deformity as a major risk factor for subsequent fractures and mortality: a long-term prospective study. J Bone Miner Res Off J Am Soc Bone Miner Res 20:1349–1355
42. Nasto LA, Fusco A, Colangelo D, Mormando M, Di Giacomo G, Rossi B et al (2012) Clinical predictors of vertebral osteoporotic fractures in post-menopausal women: a cross-sectional analysis. Eur Rev Med Pharmacol Sci 16:1227–1234
43. Adler RA (2011) Osteoporosis in men: insights for the clinician. Ther Adv Musculoskelet Dis 3:191–200
44. Kiyokawa H, Muro S, Oguma T, Sato S, Tanabe N, Takahashi T et al (2012) Impact of COPD exacerbations on osteoporosis assessed by chest CT scan. COPD 9:235–242
45. Sennerby U, Melhus H, Gedeborg R, Byberg L, Garmo H, Ahlbom A et al (2009) Cardiovascular diseases and risk of hip fracture. JAMA J Am Med Assoc 302:1666–1673
46. Nuti R, Siviero P, Maggi S, Guglielmi G, Caffarelli C, Crepaldi G et al (2009) Vertebral fractures in patients with chronic obstructive pulmonary disease: the EOLO Study. Osteoporos Int J Establ Result Coop Eur Found Osteoporos Natl Osteoporos Found USA 20:989–998
47. Ensrud KE, Thompson DE, Cauley JA, Nevitt MC, Kado DM, Hochberg MC et al (2000) Prevalent vertebral deformities predict mortality and hospitalization in older women with low bone mass. Fracture Intervention Trial Research Group. J Am Geriatr Soc 48:241–249
48. Puisto V, Rissanen H, Heliövaara M, Impivaara O, Jalanko T, Kröger H et al (2011) Vertebral fracture and cause-specific mortality: a prospective population study of 3,210 men and 3,730 women with 30 years of follow-up. Eur Spine J Off Publ Eur Spine Soc Eur Spinal Deform Soc Eur Sect Cerv Spine Res Soc 20:2181–2186
49. Masunari N, Fujiwara S, Kasagi F, Takahashi I, Yamada M, Nakamura T (2012) Height loss starting in middle age predicts increased mortality in the elderly. J Bone Miner Res Off J Am Soc Bone Miner Res 27:138–145
50. Wannamethee SG, Shaper AG, Lennon L, Whincup PH (2006) Height loss in older men: associations with total mortality and incidence of cardiovascular disease. Arch Intern Med 166:2546–2552
51. Hillier TA, Lui L-Y, Kado DM, LeBlanc ES, Vesco KK, Bauer DC et al (2012) Height loss in older women: risk of hip fracture and mortality independent of vertebral fractures. J Bone Miner Res Off J Am Soc Bone Miner Res 27:153–159
52. Kovalchik SA, Tammemagi M, Berg CD, Caporaso NE, Riley TL, Korch M et al (2013) Targeting of low-dose CT screening according to the risk of lung-cancer death. N Engl J Med 369:245–254
53. Young RP, Hopkins RJ (2012) Chronic obstructive pulmonary disease detection during lung cancer screening. JAMA J Am Med Assoc 307:664, author reply 664–665
54. Young RP, Hopkins RJ, Midthun DE (2012) Computed tomographic screening for lung cancer. JAMA J Am Med Assoc 308:1320, author reply 1320–1321
55. Bazzocchi A, Spinnato P, Albisinni U et al (2012) A careful evaluation of scout CT lateral radiograph may prevent unreported vertebral fractures. Eur J Radiol 81:2353–2357
56. Bazzocchi A, Fuzzi F, Garzillo G et al (2013) Reliability and accuracy of scout CT in the detection of vertebral fractures. Br J Radiol 86:20130373