Competing risks analyses: Objectives and approaches

European Heart Journal

Volumn 35, Issue 42, 2014, Pages 2936-2941

  Wolbers, Marcel ^a,b   Koller, Michael T ^c   Stel, Vianda S ^d   Schaer, Beat ^e   Jager, Kitty J ^d   Leffondre, Karen ^f   Heinze, Georg ^g  

^a OXFORD UNIVERSITY CLINICAL RESEARCH UNIT   (Viet Nam)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY HOSPITAL BASEL   (Switzerland)

^d UNIVERSITY OF AMSTERDAM   (Netherlands)

^e UNIVERSITY HOSPITAL BASEL   (Switzerland)

^f UNIVERSITÉ DE BORDEAUX   (France)

^g MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cause specific hazard function; Combined endpoints; Cumulative incidence function; Multiple failure causes; Survival analysis

Indexed keywords

CARDIOVASCULAR RISK; COMPETING RISKS ANALYSIS; HUMAN; IMPLANTABLE CARDIOVERTER DEFIBRILLATOR; KAPLAN MEIER METHOD; MEDICAL DECISION MAKING; PROBABILITY; REVIEW; RISK ASSESSMENT; SECONDARY PREVENTION; STATISTICAL ANALYSIS; CARDIOLOGY; CARDIOVASCULAR DISEASE; INCIDENCE; MORTALITY; PROCEDURES; REGRESSION ANALYSIS; STATISTICS AND NUMERICAL DATA; SURVIVAL RATE;

CARDIOLOGY; CARDIOVASCULAR DISEASES; HUMANS; INCIDENCE; REGRESSION ANALYSIS; RISK ASSESSMENT; SURVIVAL RATE;

EID: 84912098010     PISSN: 0195668X     EISSN: 15229645     Source Type: Journal    
DOI: 10.1093/eurheartj/ehu131     Document Type: Review

References (17)

1. Koller MT, Leening MJ, Wolbers M, Steyerberg EW, Hunink MG, Schoop R, Hofman A, Bucher HC, Psaty BM, Lloyd-Jones DM, Witteman JC. Development and validation of a coronary risk prediction model for older U. S. and European persons in the Cardiovascular Health Study and the Rotterdam Study. Ann Intern Med 2012;157:389-397.
2. Lim E, Brown A, Helmy A, Mussa S, Altman DG. Composite outcomes in cardiovascular research: a survey of randomized trials. Ann Intern Med 2008;149: 612-617.
3. Kleinbaum DG, Klein M. Survival Analysis: A Self-Learning Text. 3rd ed. New york: Springer, 2011.
4. Bland JM, Altman DG. Survival probabilities (the Kaplan-Meier method). BMJ 1998; 317:1572.
5. Koller MT, Schaer B, Wolbers M, Sticherling C, Bucher HC, Osswald S. Death without prior appropriate implantable cardioverter-defibrillator therapy:acompet-ing risk study. Circulation 2008;117:1918-1926.
6. Putter H, Fiocco M, Geskus RB. Tutorial in biostatistics: competing risks and multi-state models. Stat Med 2007;26:2389-2430.
7. Grunkemeier GL, Jin R, Eijkemans MJ, Takkenberg JJ. Actual and actuarial probabilities of competing risks: apples and lemons. Ann Thorac Surg 2007;83: 1586-1592.
8. Koller MT, Raatz H, Steyerberg EW, Wolbers M. Competing risks and the clinical community: irrelevance or ignorance? Stat Med 2012;31:1089-1097.
9. Andersen PK, Geskus RB, de Witte T, Putter H. Competing risks in epidemiology: possibilities and pitfalls. Int J Epidemiol 2012;41:861-870.
10. Wolbers M, Koller MT, Witteman JC, Steyerberg EW. Prognostic models with competing risks: methods and application to coronary risk prediction. Epidemiology 2009; 20:555-561.
11. Latouche A, Allignol A, Beyersmann J, Labopin M, Fine JP. A competing risks analysis should report results on all cause-specific hazards and cumulative incidence functions. J Clin Epidemiol 2013;66:648-653.
12. Fine JP, Gray RJ. Aproportional hazards model for the subdistributionofacompeting Risk. J Am Stat Assoc 1999;94:496-509.
13. Gray B. Subdistribution Analysis of Competing Risks. The cmprsk library (v 2. 2-6). 2013. http://cran.r-project.org.
14. Kohl M, Plischke M, Leffondré K, Heinze G. PSHREG: A SAS macro for proportional and nonproportional substribution hazards regression with competing riskdata. 2013. http://cemsiis.meduniwien.ac.at/kb/wf/software/statistische-software/pshreg/(submitted).
15. Ferreira-Gonzalez I, Permanyer-Miralda G, Busse JW, Bryant DM, Montori VM, Alonso-Coello P, Walter SD, Guyatt GH. Methodologic discussions for using and interpreting composite endpoints are limited, but still identify major concerns. J Clin Epidemiol 2007;60:651-657 (discussion 658-62).
16. Freemantle N, Calvert M, Wood J, Eastaugh J, Griffin C. Composite outcomes in randomized trials: greater precision but with greater uncertainty? JAMA 2003;289: 2554-2559.
17. Anker SD, McMurray JJ. Time to move on from 'time-to-first': should all events be included in the analysis of clinical trials? Eur Heart J 2012;33:2764-2765.