Multicenter study of intravitreal dexamethasone implant in noninfectious uveitis: Indications, outcomes, and reinjection frequency

American Journal of Ophthalmology

Volumn 158, Issue 6, 2014, Pages 1136-1145.e5

  Zarranz Ventura, Javier ^a,b,d   Carreño, Ester ^a   Johnston, Robert L ^b   Mohammed, Quresh ^b   Ross, Adam H ^a   Barker, Carl ^a   Fonollosa, Alex ^c   Artaraz, Joseba ^c   Pelegrin, Laura ^d   Adan, Alfredo ^d   Lee, Richard W ^a,e,f   Dick, Andrew D ^a,e,f   Sallam, Ahmed ^b  

^a BRISTOL EYE HOSPITAL   (United Kingdom)

^b GLOUCESTERSHIRE HOSPITALS NHS FOUNDATION TRUST   (United Kingdom)

^c HOSPITAL DE CRUCES   (Spain)

^d HOSPITAL CLÍNIC   (Spain)

^e MOORFIELDS EYE HOSPITAL   (United Kingdom)

^f UNIVERSITY HOSPITALS BRISTOL NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ABATACEPT; ADALIMUMAB; AZATHIOPRINE; BETA INTERFERON; CYCLOSPORIN; DEXAMETHASONE; GOLIMUMAB; IMMUNOMODULATING AGENT; METHOTREXATE; MYCOPHENOLIC ACID; PREDNISOLONE; STEROID; TACROLIMUS; TRIAMCINOLONE; VASCULOTROPIN; DRUG IMPLANT; GLUCOCORTICOID;

ADULT; APHAKIA; ARTICLE; CENTRAL RETINAL THICKNESS; CHORIORETINOPATHY; COHORT ANALYSIS; DRUG IMPLANT; DRUG MEGADOSE; ENDOPHTHALMITIS; FEMALE; FOLLOW UP; HUMAN; IMMUNOMODULATION; IMPLANT DISLOCATION; INTERMEDIATE UVEITIS; INTRAOCULAR PRESSURE; LOCAL THERAPY; MAJOR CLINICAL STUDY; MALE; MEDICAL DEVICE CONTAMINATION; MULTICENTER STUDY; OPTICAL COHERENCE TOMOGRAPHY; OUTCOME ASSESSMENT; RETROSPECTIVE STUDY; SARCOIDOSIS; SIDE EFFECT; SYSTEMIC THERAPY; TREATMENT INDICATION; UVEITIS; VISUAL ACUITY; VITREOUS HEMORRHAGE; VITRITIS; AGED; CLINICAL TRIAL; DRUG EFFECTS; INTRAVITREAL DRUG ADMINISTRATION; MIDDLE AGED; PATHOLOGY; RETINA; RETREATMENT; TREATMENT OUTCOME; VITREOUS BODY;

ADULT; AGED; COHORT STUDIES; DEXAMETHASONE; DRUG IMPLANTS; FEMALE; GLUCOCORTICOIDS; HUMANS; INTRAOCULAR PRESSURE; INTRAVITREAL INJECTIONS; MALE; MIDDLE AGED; RETINA; RETREATMENT; RETROSPECTIVE STUDIES; TREATMENT OUTCOME; UVEITIS; VISUAL ACUITY; VITREOUS BODY;

EID: 84912089124     PISSN: 00029394     EISSN: 18791891     Source Type: Journal    
DOI: 10.1016/j.ajo.2014.09.003     Document Type: Article

References (22)

1. Q.D. Nguyen, D. Callanan, P. Dugel, D.G. Godfrey, D.A. Goldstein, and J.T. Wilensky Treating chronic noninfectious posterior segment uveitis: the impact of cumulative damage. Proceedings of an expert panel roundtable discussion Retina 26 Suppl 8 2006 1 16
2. M.D. de Smet Corticosteroid intravitreal implants Dev Ophthalmol 51 2012 122 133
3. J.B. Christoforidis, S. Chang, A. Jiang, J. Wang, and C.M. Cebulla Intravitreal devices for the treatment of vitreous inflammation Mediators Inflamm 2012 2012 126463
4. J. Wang, A. Jiang, M. Joshi, and J. Christoforidis Drug delivery implants in the treatment of vitreous inflammation Mediators Inflamm 2013 2013 780634
5. G.J. Jaffe, J. Ben-Nun, H. Guo, J.P. Dunn, and P. Ashton Fluocinolone acetonide sustained drug delivery device to treat severe uveitis Ophthalmology 107 11 2000 2024 2033
6. F.E. Kane, J. Burdan, A. Cutino, and K.E. Green Iluvien: a new sustained delivery technology for posterior eye disease Expert Opin Drug Delivery 5 9 2008 1039 1046
7. N.J. London, A. Chiang, and J.A. Haller The dexamethasone drug delivery system: indications and evidence Adv Ther 28 5 2011 351 366
8. J.E. Chang-Lin, M. Attar, and A.A. Acheampong Pharmacokinetics and pharmacodynamics of a sustained-release dexamethasone intravitreal implant Invest Ophthalmol Vis Sci 52 1 2011 80 86
9. J.A. Haller, F. Bandello, and R. Belfort Jr. Randomized, sham-controlled trial of dexamethasone intravitreal implant in patients with macular edema due to retinal vein occlusion Ophthalmology 117 6 2010 1134 1146.e3
10. J.A. Haller, F. Bandello, and R. Belfort Jr. Dexamethasone intravitreal implant in patients with macular edema related to branch or central retinal vein occlusion twelve-month study results Ophthalmology 118 12 2011 2453 2460
11. D.S. Boyer, D. Faber, and S. Gupta Dexamethasone intravitreal implant for treatment of diabetic macular edema in vitrectomized patients Retina 31 5 2011 915 923
12. C. Lowder, R. Belfort Jr., and S. Lightman Dexamethasone intravitreal implant for noninfectious intermediate or posterior uveitis Arch Ophthalmol 129 5 2011 545 553
13. A. Adan, L. Pelegrin, and A. Rey Dexamethasone intravitreal implant for treatment of uveitic persistent cystoid macular edema in vitrectomized patients Retina 33 7 2013 1435 1440
14. C.A. Arcinue, O.M. Ceron, and C.S. Foster A comparison between the fluocinolone acetonide (Retisert) and dexamethasone (Ozurdex) intravitreal implants in uveitis J Ocul Pharmacol Ther 29 5 2013 501 507
15. O. Tomkins-Netzer, S.R. Taylor, and A. Bar Treatment with repeat dexamethasone implants results in long-term disease control in eyes with noninfectious uveitis Ophthalmology 121 8 2014 1649 1654
16. C. Lange, N. Feltgen, B. Junker, K. Schulze-Bonsel, and M. Bach Resolving the clinical acuity categories "hand motion" and "counting fingers" using the Freiburg Visual Acuity Test (FrACT) Graefes Arch Clin Exp Ophthalmol 247 1 2009 137 142
17. R.B. Nussenblatt, A.G. Palestine, C.C. Chan, and F. Roberge Standardization of vitreal inflammatory activity in intermediate and posterior uveitis Ophthalmology 92 4 1985 467 471
18. E. Kaplan, and P. Meier Nonparametric estimation from incomplete observations J Am Stat Assoc 53 1958 457 481
19. D.A. Jabs, R.B. Nussenblatt, and J.T. Rosenbaum Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop Am J Ophthalmol 140 3 2005 509 516
20. J.H. Cao, M. Mulvalhill, L. Zhang, B.C. Joondeph, and M.S. Dacey Dexamethasone intravitreal implant in the treatment of persistent uveitic macular edema in the absence of active inflammation Ophthalmology 2014 10.1016/j.ophtha.2014.04.012
21. J.E. Chang-Lin, J.A. Burke, and Q. Peng Pharmacokinetics of a sustained-release dexamethasone intravitreal implant in vitrectomized and nonvitrectomized eyes Invest Ophthalmol Vis Sci 52 7 2011 4605 4609
22. H. Kok, C. Lau, N. Maycock, P. McCluskey, and S. Lightman Outcome of intravitreal triamcinolone in uveitis Ophthalmology 112 11 2005 1916 e1-7