Identification of IL12RB1 as a Novel Systemic Sclerosis Susceptibility Locus

Arthritis and Rheumatology

Volumn 66, Issue 12, 2014, Pages 3521-3523

  Lõpez Isac, Elena ^a   Bossini Castillo, Lara ^a   Guerra, Sandra G ^b   Denton, Christopher ^b   Fonseca, Carmen ^b   Assassi, Shervin ^c   Zhou, Xiaodong ^c   Mayes, Maureen D ^c   Simeõn, Carmen Pilar ^d   Ortego Centeno, Norberto ^e   Castellví, Iván ^f   Carreira, Patricia ^g,h   Gorlova, Olga ⁱ   Beretta, Lorenzo ^j   Santaniello, Alessandro ^j   Lunardi, Claudio ^k   Hesselstrand, Roger ^l   Nordin, Annika ^m   Riemekasten, Gabriela ⁿ   Witte, Torsten ^o   Hunzelmann, Nicolas ^p   Kreuter, Alexander ^q   Distler, Jörg H W ^r   Voskuyl, Alexandre E ^s   De Vries Bouwstra, Jeska ^t   Koeleman, Bobby P ^u   Herrick, Ariane ^v   Worthington, Jane ^v   Radstake, Timothy R D J ^u   Martin, Javier ^a   more..

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^c UNIVERSITY OF TEXAS   (United States)

^d HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^e HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

^f HOSPITAL DE LA SANTA CREU I SANT PAU   (Spain)

^g HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^h Multiple Institutions Throughout Spain ^*  (Spain)

ⁱ DARTMOUTH COLLEGE   (United States)

^j FONDAZIONE IRCCS CA GRANDA OSPEDALE MAGGIORE POLICLINICO   (Italy)

^k UNIVERSITY OF VERONA   (Italy)

^l LUND UNIVERSITY   (Sweden)

^m KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

ⁿ CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^o HANNOVER MEDICAL SCHOOL   (Germany)

^p UNIVERSITY OF COLOGNE   (Germany)

^q St Elisabeth Hospital   (Germany)

^r UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^s VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^t LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^u UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^v UNIVERSITY OF MANCHESTER   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 12 RECEPTOR BETA1; IL12RB1 PROTEIN, HUMAN; INTERLEUKIN 12 RECEPTOR;

ALLELE; AUTOIMMUNITY; COMPUTER MODEL; FOLLOW UP; GENE EXPRESSION; GENE IDENTIFICATION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; INFLAMMATION; LETTER; NATURAL KILLER CELL; PROMOTER REGION; RISK FACTOR; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC SCLEROSIS; TH1 CELL; CASE CONTROL STUDY; GENE FREQUENCY; GENETIC PREDISPOSITION; GENETICS; STATISTICAL MODEL;

CASE-CONTROL STUDIES; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LOGISTIC MODELS; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, INTERLEUKIN-12; SCLERODERMA, SYSTEMIC;

EID: 84912051014     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38870     Document Type: Letter

References (5)

1. Martin JE, Bossini-Castillo L, Martin J,. Unraveling the genetic component of systemic sclerosis. Hum Genet 2012; 131: 1023-37.
2. Radstake TR, Gorlova O, Rueda B, Martin JE, Alizadeh BZ, Palomino-Morales R, et al. Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus. Nat Genet 2010; 42: 426-9.
3. Vignali DA, Kuchroo VK,. IL-12 family cytokines: immunological playmakers. Nat Immunol 2012; 13: 722-8.
4. Mayes MD, Bossini-Castillo L, Gorlova O, Martin JE, Zhou X, Chen WV, et al. Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis. Am J Hum Genet 2014; 94: 47-61.
5. Bossini-Castillo L, Martin JE, Broen J, Gorlova O, Simeon CP, Beretta L, et al. A GWAS follow-up study reveals the association of the IL12RB2 gene with systemic sclerosis in Caucasian populations. Hum Mol Genet 2012; 21: 926-33.