Malarial anemia: digestive vacuole of Plasmodium falciparum mediates complement deposition on bystander cells to provoke hemophagocytosis

Medical Microbiology and Immunology

Volumn 203, Issue 6, 2014, Pages 383-393

  Dasari, Prasad ^a   Fries, Anja ^a   Heber, Sophia D ^a   Salama, Abdulgabar ^b   Blau, Igor Wolfgang ^b   Lingelbach, Klaus ^c   Bhakdi, Sebastian Chakrit ^d   Udomsangpetch, Rachanee ^d   Torzewski, Michael ^e   Reiss, Karina ^f   Bhakdi, Sucharit ^a  

^a UNIVERSITY MEDICAL CENTER MAINZ   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c PHILIPPS UNIVERSITY MARBURG   (Germany)

^d MAHIDOL UNIVERSITY   (Thailand)

^e ROBERT BOSCH HOSPITAL   (Germany)

^f UNIVERSITY OF KIEL   (Germany)

Author keywords

Bystander attack; Complement activation; Digestive vacuole; Hemophagocytosis; Malarial anemia; P. falciparum

Indexed keywords

CD59 ANTIGEN; CLASSICAL COMPLEMENT PATHWAY C3 C5 CONVERTASE; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C3D; COMPLEMENT COMPONENT C5; COMPLEMENT COMPONENT C5B; DECAY ACCELERATING FACTOR; REACTIVE OXYGEN METABOLITE; COMPLEMENT;

ANEMIA; ARTICLE; BRAIN MALARIA; BYSTANDER EFFECT; CELL VACUOLE; CELLULAR DISTRIBUTION; COMPLEMENT ACTIVATION; COMPLEMENT DEPOSITION; CONTROLLED STUDY; ERYTHROCYTE; ERYTHROPHAGOCYTOSIS; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; MALARIA; MALARIA FALCIPARUM; MALARIAL ANEMIA; OPSONIZATION; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA; POLARIZATION MICROSCOPY; TWO DIMENSIONAL ELECTROPHORESIS; WESTERN BLOTTING; BRAIN; IMMUNOLOGY; METABOLISM; PATHOLOGY; PHAGOCYTOSIS; PLASMODIUM FALCIPARUM;

BRAIN; BYSTANDER EFFECT; COMPLEMENT SYSTEM PROTEINS; ERYTHROCYTES; HUMANS; IMMUNOHISTOCHEMISTRY; PHAGOCYTOSIS; PLASMODIUM FALCIPARUM; VACUOLES;

EID: 84912012908     PISSN: 03008584     EISSN: 14321831     Source Type: Journal    
DOI: 10.1007/s00430-014-0347-0     Document Type: Article

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