Detecting monoclonal light chains in urine: MicroLC-ESI-Q-TOF mass spectrometry compared to immunofixation electrophoresis

British Journal of Haematology

Volumn 167, Issue 3, 2014, Pages 437-438

  Botz, Chad M ^a   Barnidge, David R ^a   Murray, David L ^a   Katzmann, Jerry A ^a  

^a MAYO CLINIC   (United States)

Author keywords

Laboratory haematology; Mass spectrometry; Methodology; Myeloma

Indexed keywords

IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; PARAPROTEIN; MONOCLONAL ANTIBODY;

DISULFIDE BOND; ELECTROSPRAY MASS SPECTROMETRY; HUMAN; IMMUNOELECTROPHORESIS; IMMUNOFIXATION ELECTROPHORESIS; INTERMETHOD COMPARISON; LETTER; MEDICAL HISTORY; MOLECULAR WEIGHT; MONOCLONAL IMMUNOGLOBULIN RAPID ACCURATE MOLECULAR MASS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ELECTROPHORESIS; TIME OF FLIGHT MASS SPECTROMETRY; URINALYSIS; WALDENSTROEM MACROGLOBULINEMIA; CHEMISTRY; COMPARATIVE STUDY; ECONOMICS; EVALUATION STUDY; IMMUNOLOGY; OSMOLARITY; PROCEDURES; PROTEINURIA; URINE;

ANTIBODIES, MONOCLONAL; HUMANS; IMMUNOELECTROPHORESIS; IMMUNOGLOBULIN LIGHT CHAINS; MICROCHEMISTRY; MOLECULAR WEIGHT; OSMOLAR CONCENTRATION; PROTEINURIA; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; URINALYSIS; WALDENSTROM MACROGLOBULINEMIA;

EID: 84912008917     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.13003     Document Type: Letter

References (4)

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2. International Myeloma Working Group. (2003) Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. British Journal of Haematology, 121, 749-757.
3. Keren, D.F. (1998) Detection and characterization of monoclonal components in serum and urine. Clinical Chemistry, 44(6 pt 1), 1143-1145.
4. Roden, A.C., Lockington, K.S., Tostrud, L.J. & Katzmann, J.A. (2008) Urine protein electrophoresis and immunoelectrophoresis using unconcentrated or minimally concentrated urine samples. American Journal of Clinical Pathology, 130, 141-145.