Association of rs7260002 of chorionic gonadotrophin β5 with idiopathic recurrent spontaneous abortion in Chinese population

Journal of Assisted Reproduction and Genetics

Volumn 31, Issue 11, 2014, Pages 1497-1500

  Sun, Yong ^a   Ji, Xuan ^a  

^a LINYI PEOPLE'S HOSPITAL   (China)

Author keywords

Chorionic gonadotrophin 5; Genetic association study; Genotype; Recurrent spontaneous abortion

Indexed keywords

ADULT; ARTICLE; CHINESE; CHORIONIC GONADOTROPIN BETA5 GENE; CONTROLLED STUDY; DOMINANT INHERITANCE; FEMALE; GENE; GENE EXPRESSION; GENE FREQUENCY; GENE FUNCTION; GENE IDENTIFICATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HUMAN; IDIOPATHIC DISEASE; MAJOR CLINICAL STUDY; PROMOTER REGION; RECESSIVE INHERITANCE; RECURRENT ABORTION; RISK REDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SPONTANEOUS ABORTION; ASIAN CONTINENTAL ANCESTRY GROUP; GENETICS; REGRESSION ANALYSIS;

CHORIONIC GONADOTROPIN BETA SUBUNIT;

ABORTION, HABITUAL; ASIAN CONTINENTAL ANCESTRY GROUP; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; POLYMORPHISM, SINGLE NUCLEOTIDE; REGRESSION ANALYSIS;

EID: 84911974374     PISSN: 10580468     EISSN: 15737330     Source Type: Journal    
DOI: 10.1007/s10815-014-0321-1     Document Type: Article

References (21)

1. Li T, Makris M, Tomsu M, Tuckerman E, Laird S. Recurrent miscarriage: aetiology, management and prognosis. Hum Reprod Update. 2002;8(5):463–81.
2. Branch DW, Gibson M, Silver RM. Recurrent miscarriage. N Engl J Med. 2010;363(18):1740–7.
3. Christiansen OB, Mathiesen O, Lauritsen JG, Grunnet N. Idiopathic recurrent spontaneous abortion: evidence of a familial predisposition. Acta Obstet Gynecol Scand. 1990;69(7–8):597–601.
4. Rull K, Nagirnaja L, Laan M. Genetics of recurrent miscarriage: challenges, current knowledge, future directions. Front Genet. 2012;3:34.
5. Rull K, Nagirnaja L, Ulander VM, Kelgo P, Margus T, Kaare M, et al. Chorionic gonadotropin beta-gene variants are associated with recurrent miscarriage in two European populations. J Clin Endocrinol Metab. 2008;93(12):4697–706.
6. Rull K, Laan M. Expression of β-subunit of HCG genes during normal and failed pregnancy. Hum Reprod. 2005;20(12):3360–8.
7. Poikkeus P, Hiilesmaa V, Tiitinen A. Serum HCG 12 days after embryo transfer in predicting pregnancy outcome. Hum Reprod. 2002;17(7):1901–5.
8. Letterie GS, Hibbert M. Serial serum human chorionic gonadotropin (hCG) levels in ectopic pregnancy and first trimester miscarriage. Arch Gynecol Obstet. 2000;263(4):168–9.
9. CACCIATORE B, STENMAN UH, YLÖSTALO P. Diagnosis of ectopic pregnancy by vaginal ultrasonography in combination with a discriminatory serum hCG level of 1000 IU/1 (IRP). BJOG Int J Obstet Gynaecol. 1990;97(10):904–8.
10. Cole LA, Sutton JM. Selecting an appropriate hCG test for managing gestational trophoblastic disease and cancer. J Reprod Med. 2004;49(7):545–53.
11. Miller-Lindholm AK, LaBenz C, Ramey J, Bedows E, Ruddon RW. Human chorionic gonadotropin-β gene expression in first trimester placenta 1. Endocrinology. 1997;138(12):5459–65.
12. Nagirnaja L, Rull K, Uusküla L, Hallast P, Grigorova M, Laan M. Genomics and genetics of gonadotropin beta-subunit genes: unique FSHB and duplicated LHB/CGB loci. Mol Cell Endocrinol. 2010;329(1):4–16.
13. Chen Y, Kibriya MG, Jasmine F, Santella RM, Senie RT, Ahsan H. Do placental genes affect maternal breast cancer? Association between offspring’s CGB5 and CSH1 gene variants and maternal breast cancer risk. Cancer Res. 2008;68(23):9729–34.
14. Rull K, Hallast P, Uusküla L, Jackson J, Punab M, Salumets A, et al. Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues. Mol Hum Reprod. 2008;14(1):23–31.
15. Rull K, Christiansen OB, Nagirnaja L, Steffensen R, Margus T, Laan M. A modest but significant effect of CGB5 gene promoter polymorphisms in modulating the risk of recurrent miscarriage. Fertil Steril. 2013;99(7):1930–6. e1936.
16. Licht P, Fluhr H, Neuwinger J, Wallwiener D, Wildt L. Is human chorionic gonadotropin directly involved in the regulation of human implantation? Mol Cell Endocrinol. 2007;269(1):85–92.
17. Toth P, Lukacs H, Gimes G, Sebestyen A, Pasztor N, Paulin F, et al. Clinical importance of vascular LH/hCG receptors–a review. Reprod Biol. 2001;1(2):5–11.
18. Herr F, Baal N, Reisinger K, Lorenz A, McKinnon T, Preissner K, et al. hCG in the regulation of placental angiogenesis. Results of an in vitro study. Placenta. 2007;28:S85–93.
19. Kayisli UA, Selam B, Guzeloglu-Kayisli O, Demir R, Arici A. Human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating Fas-Fas ligand system. J Immunol. 2003;171(5):2305–13.
20. Miller-Lindholm AK, Bedows E, Bartels CF, Ramey J, Maclin V, Ruddon RW. A naturally occurring genetic variant in the human chorionic gonadotropin-β gene 5 is assembly inefficient 1. Endocrinology. 1999;140(8):3496–506.
21. Wen B, Li H, Lu D, Song X, Zhang F, He Y, et al. Genetic evidence supports demic diffusion of Han culture. Nature. 2004;431(7006):302–5.