Proteomic analysis of 4-hydroxynonenal (4-HNE) modified proteins in liver mitochondria from chronic ethanol-fed rats

Redox Biology

Volumn 2, Issue , 2014, Pages 1038-1047

  Andringa, Kelly K ^a,b   Udoh, Uduak S ^c   Landar, Aimee ^c   Bailey, Shannon M ^b,c  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

4 Hydroxynonenal; Alcohol; Liver; Mitochondria; Posttranslational modification; Proteome

Indexed keywords

4 HYDROXYNONENAL; ALCOHOL; CHOLINE DEHYDROGENASE; CYTOCHROME C; CYTOCHROME C1; DIMETHYLGLYCINE DEHYDROGENASE; ELECTRON TRANSFERRING FLAVOPROTEIN; ELECTRON TRANSFERRING FLAVOPROTEIN ALPHA; ENOYL COENZYME A HYDRATASE; MITOCHONDRIAL PROTEIN; MITOFILIN; UNCLASSIFIED DRUG; 4-HYDROXY-2-NONENAL; ALDEHYDE;

ALCOHOL CONSUMPTION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLUE NATIVE POLYACRYLAMIDE GEL ELECTROPHORESIS; CONTROLLED STUDY; IMMUNOREACTIVITY; ISOELECTRIC FOCUSING; LIVER MITOCHONDRION; MALE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN ANALYSIS; PROTEIN MODIFICATION; PROTEIN TARGETING; PROTEOMICS; RAT; ALCOHOL LIVER DISEASE; ANIMAL; CHRONIC DISEASE; DRUG EFFECTS; METABOLISM; PATHOLOGY; PROTEIN PROCESSING; SPRAGUE DAWLEY RAT;

RATTUS;

ALDEHYDES; ANIMALS; CHRONIC DISEASE; ETHANOL; LIVER DISEASES, ALCOHOLIC; MALE; MITOCHONDRIA, LIVER; MITOCHONDRIAL PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOMICS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84911974338     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2014.09.006     Document Type: Article

References (41)

1. An L., Wang X., Cederbaum A.I. Cytokines in alcoholic liver disease. Archives of Toxicology 2012, 86:1337-1348. http://www.ncbi.nlm.nih.gov/pubmed/22367091, 10.1007/s00204-012-0814-6.
2. Feldstein A.E., Bailey S.M. Emerging role of redox dysregulation in alcoholic and nonalcoholic fatty liver disease. Antioxidants & Redox Signaling 2011, 15:421-424. http://www.ncbi.nlm.nih.gov/pubmed/21254858, 10.1089/ars.2011.3897.
3. Szabo G., Bala S. Alcoholic liver disease and the gut-liver axis. World Journal of Gastroenterology: WJG 2010, 16:1321-1329. http://www.ncbi.nlm.nih.gov/pubmed/20238398, 10.3748/wjg.v16.i11.1321.
4. Cunningham C.C., Bailey S.M. Ethanol consumption and liver mitochondria function. Neurosignals 2001, 10:271-282. 10.1159/000046892.
5. Cunningham C.C., Van Horn C.G. Energy availability and alcohol-related liver pathology. Alcohol Research & Health: Journal of the National Institute on Alcohol Abuse and Alcoholism 2003, 27:291-299. http://www.ncbi.nlm.nih.gov/pubmed/15540800.
6. Young T.A., Bailey S.M., Van Horn C.G., Cunningham C.C. Chronic ethanol consumption decreases mitochondrial and glycolytic production of ATP in liver. Alcohol and Alcoholism 2006, 41:254-260. http://www.ncbi.nlm.nih.gov/pubmed/16571619, 10.1093/alcalc/agl017.
7. Bailey S.M., Cunningham C.C. Acute and chronic ethanol increases reactive oxygen species generation and decreases viability in fresh, isolated rat hepatocytes. Hepatology 1998, 28:1318-1326. http://www.ncbi.nlm.nih.gov/pubmed/9794917, 10.1002/hep.510280521.
8. Bailey S.M., Robinson G., Pinner A., Chamlee L., Ulasova E., Pompilius M., Page G.P., Chhieng D., Jhala N., Landar A., Kharbanda K.K., Ballinger S., Darley-Usmar V. S-adenosylmethionine prevents chronic alcohol-induced mitochondrial dysfunction in the rat liver. American Journal of Physiology. Gastrointestinal and Liver Physiology 2006, 291:G857-G867. http://www.ncbi.nlm.nih.gov/pubmed/16825707, 10.1152/ajpgi.00044.2006.
9. Fritz K.S., Petersen D.R. An overview of the chemistry and biology of reactive aldehydes. Free Radical Biology & Medicine 2013, 59:85-91. http://www.ncbi.nlm.nih.gov/pubmed/22750507, 10.1016/j.freeradbiomed.2012.06.025.
10. Hartley D.P., Ruth J.A., Petersen D.R. The hepatocellular metabolism of 4-hydroxynonenal by alcohol dehydrogenase, aldehyde dehydrogenase, and glutathione S-transferase. Archives of Biochemistry and Biophysics 1995, 316:197-205. http://www.ncbi.nlm.nih.gov/pubmed/7840616, 10.1006/abbi.1995.1028.
11. Wall S.B., Smith M.R., Ricart K., Zhou F., Vayalil P.K., Oh J.Y., Landar A. Detection of electrophile-sensitive proteins. Biochimica et Biophysica Acta 2014, 1840:913-922. http://www.ncbi.nlm.nih.gov/pubmed/24021887, 10.1016/j.bbagen.2013.09.003.
12. Vasil'ev Y.V., Tzeng S.C., Huang L., Maier C.S. Protein modifications by electrophilic lipoxidation products: adduct formation, chemical strategies and tandem mass spectrometry for their detection and identification. Mass Spectrometry Reviews 2014, 33:157-182. http://www.ncbi.nlm.nih.gov/pubmed/24818247, 10.1002/mas.21389.
13. Doorn J.A., Petersen D.R. Covalent modification of amino acid nucleophiles by the lipid peroxidation products 4-hydroxy-2-nonenal and 4-oxo-2-nonenal. Chemical Research in Toxicology 2002, 15:1445-1450. http://www.ncbi.nlm.nih.gov/pubmed/12437335, 10.1021/tx025590o.
14. Isom A.L., Barnes S., Wilson L., Kirk M., Coward L., Darley-Usmar V. Modification of cytochrome c by 4-hydroxy- 2-nonenal: evidence for histidine, lysine, and arginine-aldehyde adducts. Journal of the American Society for Mass Spectrometry 2004, 15:1136-1147. http://www.ncbi.nlm.nih.gov/pubmed/15276160, 10.1016/j.jasms.2004.03.013.
15. Fritz K.S., Galligan J.J., Smathers R.L., Roede J.R., Shearn C.T., Reigan P., Petersen D.R. 4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification. Chemical Research in Toxicology 2011, 24:651-662. http://www.ncbi.nlm.nih.gov/pubmed/21449565, 10.1021/tx100355a.
16. Chacko B.K., Srivastava A., Johnson M.S., Benavides G.A., Chang M.J., Ye Y.Z., Jhala N., Murphy M.P., Kalyanaraman B., Darley-Usmar V.M. Mitochondria-targeted ubiquinone (mitoq) decreases ethanol-dependent micro and macro hepatosteatosis. Hepatology 2011, 54:153-163. http://www.ncbi.nlm.nih.gov/pubmed/21520201, 10.1002/hep.24377.
17. Carbone D.L., Doorn J.A., Kiebler Z., Ickes B.R., Petersen D.R. Modification of heat shock protein 90 by 4-hydroxynonenal in a rat model of chronic alcoholic liver disease. Journal of Pharmacology and Experimental Therapeutics 2005, 315:8-15. http://www.ncbi.nlm.nih.gov/pubmed/15951401, 10.1124/jpet.105.088088.
18. Sampey B.P., Carbone D.L., Doorn J.A., Drechsel D.A., Petersen D.R. 4-Hydroxy-2-nonenal adduction of extracellular signal-regulated kinase (Erk) and the inhibition of hepatocyte Erk-Est-like protein-1-activating protein-1 signal transduction. Molecular Pharmacology 2007, 71:871-883. http://www.ncbi.nlm.nih.gov/pubmed/17164404, 10.1124/mol.106.029686.
19. Sampey B.P., Korourian S., Ronis M.J., Badger T.M., Petersen D.R. Immunohistochemical characterization of hepatic malondialdehyde and 4-hydroxynonenal modified proteins during early stages of ethanol-induced liver injury. Alcoholism, Clinical and Experimental Research 2003, 27:1015-1022. http://www.ncbi.nlm.nih.gov/pubmed/12824824, 10.1111/j.1530-0277.2003.tb04430.x.
20. Smathers R.L., Galligan J.J., Shearn C.T., Fritz K.S., Mercer K., Ronis M., Orlicky D.J., Davidson N.O., Petersen D.R. Susceptibility of L-FABP-/- mice to oxidative stress in early-stage alcoholic liver. Journal of Lipid Research 2013, 54:1335-1345. http://www.ncbi.nlm.nih.gov/pubmed/23359610, 10.1194/jlr.M034892.
21. Smathers R.L., Galligan J.J., Stewart B.J., Petersen D.R. Overview of lipid peroxidation products and hepatic protein modification in alcoholic liver disease. Chemico-Biological Interactions 2011, 192:107-112. http://www.ncbi.nlm.nih.gov/pubmed/21354120, 10.1016/j.cbi.2011.02.021.
22. Venkatraman A., Landar A., Davis A.J., Chamlee L., Sanderson T., Kim H., Page G., Pompilius M., Ballinger S., Darley-Usmar V., Bailey S.M. Modification of the mitochondrial proteome in response to the stress of ethanol-dependent hepatotoxicity. Journal of Biological Chemistry 2004, 279:22092-22101. http://www.ncbi.nlm.nih.gov/pubmed/15033988, 10.1074/jbc.M402245200.
23. Lieber C.S., DeCarli L.M. The feeding of alcohol in liquid diets: two decades of applications and 1982 update. Alcoholism, Clinical and Experimental Research 1982, 6:523-531. http://www.ncbi.nlm.nih.gov/pubmed/6758624, 10.1111/j.1530-0277.1982.tb05017.x.
24. Bailey S.M., Patel V.B., Young T.A., Asayama K., Cunningham C.C. Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver. Alcoholism, Clinical and Experimental Research 2001, 25:726-733. http://www.ncbi.nlm.nih.gov/pubmed/11371722, 10.1111/j.1530-0277.2001.tb02273.x.
25. Towbin H., Staehelin T., Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proceedings of the National Academy of Sciences of the United of States of America 1979, 76:4350-4354. 10.1073/pnas.76.9.4350.
26. Uchida K., Szweda L.I., Chae H.Z., Stadtman E.R. Immunochemical detection of 4-hydroxynonenal protein adducts in oxidized hepatocytes. Proceedings of the National Academy of Sciences of the United of States of America 1993, 90:8742-8746. 10.1073/pnas.90.18.8742.
27. Uchida K., Itakura K., Kawakishi S., Hiai H., Toyokuni S., Stadtman E.R. Characterization of epitopes recognized by 4-hydroxy-2-nonenal specific antibodies. Archives of Biochemistry and Biophysics 1995, 324:241-248. http://www.ncbi.nlm.nih.gov/pubmed/8554315, 10.1006/abbi.1995.0036.
28. Loehr J.P., Goodman S.I., Frerman F.E. Glutaric acidemia type ii: Heterogeneity of clinical and biochemical phenotypes. Pediatric Research 1990, 27:311-315. http://www.ncbi.nlm.nih.gov/pubmed/2320399, 10.1203/00006450-199003000-00024.
29. Venkatraman A., Landar A., Davis A.J., Ulasova E., Page G., Murphy M.P., Darley-Usmar V., Bailey S.M. Oxidative modification of hepatic mitochondria protein thiols: Effect of chronic alcohol consumption. American Journal of Physiology. Gastrointestinal and Liver Physiology 2004, 286:G521-G527. http://www.ncbi.nlm.nih.gov/pubmed/14670822, 10.1152/ajpgi.00399.2003.
30. Andringa K., King A., Bailey S. Blue native-gel electrophoresis proteomics. Methods in Molecular Biology 2009, 519:241-258. http://www.ncbi.nlm.nih.gov/pubmed/19381587, 10.1007/978-1-59745-281-6_15.
31. Brookes P.S., Pinner A., Ramachandran A., Coward L., Barnes S., Kim H., Darley-Usmar V.M. High throughput two-dimensional blue-native electrophoresis: a tool for functional proteomics of mitochondria and signaling complexes. Proteomics 2002, 2:969-977. http://www.ncbi.nlm.nih.gov/pubmed/12203892, 10.1002/1615-9861(200208)2:8<969::AID-PROT969>3.0.CO;2-3.
32. Bailey S.M., Landar A., Darley-Usmar V. Mitochondrial proteomics in free radical research. Free Radical Biology & Medicine 2005, 38:175-188. http://www.ncbi.nlm.nih.gov/pubmed/15607901, 10.1016/j.freeradbiomed.2004.10.011.
33. Fischer M., You M., Matsumoto M., Crabb D.W. Peroxisome proliferator-activated receptor alpha (PPARalpha) agonist treatment reverses PPARalpha dysfunction and abnormalities in hepatic lipid metabolism in ethanol-fed mice. Journal of Biological Chemistry 2003, 278:27997-28004. http://www.ncbi.nlm.nih.gov/pubmed/12791698, 10.1074/jbc.M302140200.
34. Mato J.M., Martínez-Chantar M.L., Lu S.C. Methionine metabolism and liver disease. Annual Review of Nutrition 2008, 28:273-293. http://www.ncbi.nlm.nih.gov/pubmed/18331185, 10.1146/annurev.nutr.28.061807.155438.
35. Kharbanda K.K. Alcoholic liver disease and methionine metabolism. Seminars in Liver Disease 2009, 29:155-165. 10.1055/s-0029-1214371.
36. Allen R.H., Stabler S.P., Lindenbaum J. Serum betaine, N,N-dimethylglycine and N-methylglycine levels in patients with cobalamin and folate deficiency and related inborn errors of metabolism. Metabolism: Clinical and Experimental 1993, 42:1448-1460. http://www.ncbi.nlm.nih.gov/pubmed/7694037, 10.1016/0026-0495(93)90198-W.
37. Ji C., Shinohara M., Vance D., Than T.A., Ookhtens M., Chan C., Kaplowitz N. Effect of transgenic extrahepatic expression of betaine-homocysteine methyltransferase on alcohol or homocysteine-induced fatty liver. Alcoholism, Clinical and Experimental Research 2008, 32:1049-1058. http://www.ncbi.nlm.nih.gov/pubmed/18498552, 10.1111/j.1530-0277.2008.00666.x.
38. Bailey S.M., Cunningham C.C. Contribution of mitochondria to oxidative stress associated with alcoholic liver disease. Free Radical Biology & Medicine 2002, 32:11-16. http://www.ncbi.nlm.nih.gov/pubmed/11755312, 10.1016/S0891-5849(01)00769-9.
39. Patel V.B., Spencer C.H., Young T.A., Lively M.O., Cunningham C.C. Effects of 4-hydroxynonenal on mitochondrial 3-hydroxy-3-methylglutaryl (HMG-CoA) synthase. Free Radical Biology & Medicine 2007, 43:1499-1507. http://www.ncbi.nlm.nih.gov/pubmed/17964421, 10.1016/j.freeradbiomed.2007.08.004.
40. Waeg G., Dimsity G., Esterbauer H. Monoclonal antibodies for detection of 4-hydroxynonenal modified proteins. Free Radical Research 1996, 25:149-159. http://www.ncbi.nlm.nih.gov/pubmed/8885333, 10.3109/10715769609149920.
41. Chen J.J., Robinson N.C., Schenker S., Frosto T.A., Henderson G.I. Formation of 4-hydroxynonenal adducts with cytochrome c oxidase in rats following short-term ethanol intake. Hepatology 1999, 29:1792-1798. http://www.ncbi.nlm.nih.gov/pubmed/10347122, 10.1002/hep.510290611.