Optimizing hospital infection control: The role of mathematical modeling

Infection Control and Hospital Epidemiology

Volumn 35, Issue 12, 2014, Pages 1521-1530

  Doan, Tan N ^a   Kong, David C M ^a   Kirkpatrick, Carl M J ^a   McBryde, Emma S ^b  

^a MONASH UNIVERSITY   (Australia)

^b ROYAL MELBOURNE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ANTIBIOTIC THERAPY; BACTERIAL COLONIZATION; BACTERIUM CONTAMINATION; DISEASE TRANSMISSION; HAND WASHING; HOSPITAL ADMISSION; HOSPITAL INFECTION; HUMAN; INFECTION CONTROL; MATHEMATICAL MODEL; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MULTIDRUG RESISTANCE; NONHUMAN; REVIEW; SCREENING; VANCOMYCIN RESISTANT ENTEROCOCCUS; CROSS INFECTION; ORGANIZATION AND MANAGEMENT; OUTCOME ASSESSMENT; PREVENTION AND CONTROL; PROCEDURES; STATISTICS AND NUMERICAL DATA; THEORETICAL MODEL;

CROSS INFECTION; DISEASE TRANSMISSION, INFECTIOUS; HUMANS; INFECTION CONTROL; MODELS, THEORETICAL; OUTCOME ASSESSMENT (HEALTH CARE);

EID: 84911900661     PISSN: 0899823X     EISSN: 15596834     Source Type: Journal    
DOI: 10.1086/678596     Document Type: Review

References (40)

1. De Angelis G, Murthy A, Beyersmann J, Harbarth S. Estimating the impact of healthcare-associated infections on length of stay and costs. Clin Microbiol Infect 2010; 16: 1729-1735.
2. Hawkey PM, Jones AM. The changing epidemiology of resistance. J Antimicrob Chemother 2009; 64: i3-i10.
3. Alanis AJ. Resistance to antibiotics: are we in the post-antibiotic era? Arch Med Res 2005; 36: 697-705.
4. Grundmann H, Hellriegel B. Mathematical modelling: a tool for hospital infection control. Lancet Infect Dis 2006; 6: 39-45.
5. Stangl DK. Bridging the gap between statistical analysis and decision making in public health research. Stat Med 2005; 24: 503-511.
6. van Kleef E, Robotham JV, Jit M, Deeny SR, Edmunds WJ. Modelling the transmission of healthcare associated infections: a systematic review. BMC Infect Dis 2013; 13: 1-13.
7. Vynnycky E, White RG. An Introduction to Infectious Disease Modelling. New York: Oxford University Press, 2010.
8. Bailey N. The Biomathematics of Malaria. London: Charles Griffin, 1975.
9. Cooper BS, Medley GF, Scott GM. Preliminary analysis of the transmission dynamics of nosocomial infections: stochastic and management effects. J Hosp Infect 1999; 43: 131-147.
10. Pelupessy I, Bonten MJ, Diekmann O. How to assess the relative importance of different colonization routes of pathogens within hospital settings. Proc Natl Acad Sci USA 2002; 99: 5601-5605.
11. McBryde ES, Pettitt AN, McElwain DL. A stochastic mathematical model of methicillin resistant Staphylococcus aureus transmission in an intensive care unit: predicting the impact of interventions. J Theor Biol 2007; 245: 470-481.
12. McBryde ES, Pettitt AN, Cooper BS, McElwain DL. Characterizing an outbreak of vancomycin-resistant enterococci using hidden Markov models. J R Soc Interface 2007; 4: 745-754.
13. Cooper B, Lipsitch M. The analysis of hospital infection data using hidden Markov models. Biostatistics 2004; 5: 223-237.
14. Mishra S, Fisman DN, Boily MC. The ABC of terms used in mathematical models of infectious diseases. J Epidemiol Community Health 2011; 65: 87-94.
15. Keeling MJ, Danon L. Mathematical modelling of infectious diseases. Br Med Bull 2009; 92: 33-42.
16. Chamchod F, Ruan S. Modeling methicillin-resistant Staphylococcus aureus in hospitals: transmission dynamics, antibiotic usage and its history. Theor Biol Med Model 2012; 9: 1-14.
17. Austin DJ, Bonten MJ, Weinstein RA, Slaughter S, Anderson RM. Vancomycin-resistant enterococci in intensive-care hospital settings: transmission dynamics, persistence, and the impact of infection control programs. Proc Natl Acad Sci USA 1999; 96: 6908-6913.
18. Bonten MJ, Austin DJ, Lipsitch M. Understanding the spread of antibiotic resistant pathogens in hospitals: mathematical models as tools for control. Clin Infect Dis 2001; 33: 1739-1746.
19. Raboud J, Saskin R, Simor A, et al. Modeling transmission of methicillin-resistant Staphylococcus aureus among patients admitted to a hospital. Infect Control Hosp Epidemiol 2005; 26: 607-615.
20. Wang J, Wang L, Magal P, et al. Modelling the transmission dynamics of meticillin-resistant Staphylococcus aureus in Beijing Tongren hospital. J Hosp Infect 2011; 79: 302-308.
21. Wang X, Xiao Y, Wang J, Lu X. A mathematical model of effects of environmental contamination and presence of volunteers on hospital infections in China. J Theor Biol 2012; 293: 161-173.
22. Pressley J, D'Agata EM, Webb GF. The effect of co-colonization with community-acquired and hospital-acquired methicillinresistant Staphylococcus aureus strains on competitive exclusion. J Theor Biol 2010; 264: 645-656.
23. D'Agata EM, Horn MA, Webb GF. The impact of persistent gastrointestinal colonization on the transmission dynamics of vancomycin-resistant enterococci. J Infect Dis 2002; 185: 766-773.
24. D'Agata EM, Webb G, Horn M. A mathematical model quantifying the impact of antibiotic exposure and other interventions on the endemic prevalence of vancomycin-resistant enterococci. J Infect Dis 2005; 192: 2004-2011.
25. Perencevich EN, Fisman DN, Lipsitch M, Harris AD, Morris JG Jr, Smith DL. Projected benefits of active surveillance for vancomycin-resistant enterococci in intensive care units. Clin Infect Dis 2004; 38: 1108-1115.
26. Grima DT, Webb GF, D'Agata EM. Mathematical model of the impact of a nonantibiotic treatment for Clostridium difficile on the endemic prevalence of vancomycin-resistant enterococci in a hospital setting. Comput Math Methods Med 2012; 2012: 605861.
27. Chamchod F, Ruan S. Modeling the spread of methicillinresistant Staphylococcus aureus in nursing homes for elderly. PLoS ONE 2012; 7: 1-9.
28. D'Agata EM, Magal P, Olivier D, Ruan S, Webb GF. Modeling antibiotic resistance in hospitals: the impact of minimizing treatment duration. J Theor Biol 2007; 249: 487-499.
29. McBryde ES, McElwain DL. A mathematical model investigating the impact of an environmental reservoir on the prevalence and control of vancomycin-resistant enterococci. J Infect Dis 2006; 193: 1473-1474.
30. Pittet D, Allegranzi B, Sax H, et al. Evidence-based model for hand transmission during patient care and the role of improved practices. Lancet Infect Dis 2006; 6: 641-652.
31. Marra AR, Camargo TZ, Cardoso VJ, et al. Hand hygiene compliance in the critical care setting: a comparative study of 2 different alcohol handrub formulations. Am J Infect Control 2013; 41: 136-139.
32. Martin-Madrazo C, Soto-Diaz S, Canada-Dorado A, et al. Cluster randomized trial to evaluate the effect of a multimodal hand hygiene improvement strategy in primary care. Infect Control Hosp Epidemiol 2012; 33: 681-688.
33. Dos Santos RP, Konkewicz LR, Nagel FM, et al. Changes in hand hygiene compliance after a multimodal intervention and seasonality variation. Am J Infect Control 2013; 41: 1012-1016.
34. Kaier K, Mutters NT, Frank U. Bed occupancy rates and hospital-acquired infections-should beds be kept empty? Clin Microbiol Infect 2012; 18: 941-945.
35. Patel M, Weinheimer JD, Waites KB, Baddley JW. Active surveillance to determine the impact of methicillin-resistant Staphylococcus aureus colonization on patients in intensive care units of a Veterans Affairs medical center. Infect Control Hosp Epidemiol 2008; 29: 503-509.
36. Willing BP, Russell SL, Finlay BB. Shifting the balance: antibiotic effects on host-microbiota mutualism. Nat Rev Microbiol 2011; 9: 233-243.
37. Gonzales R, Anderer T, McCulloch CE, et al. A cluster randomized trial of decision support strategies for reducing antibiotic use in acute bronchitis. JAMA Intern Med 2013; 173: 267-273.
38. Boyce JM. Environmental contamination makes an important contribution to hospital infection. J Hosp Infect 2007; 2: 50-54.
39. Jit M, Brisson M. Modelling the epidemiology of infectious diseases for decision analysis: a primer. Pharmacoeconomics 2011; 29: 371-386.
40. Hollingsworth TD. Controlling infectious disease outbreaks: lessons from mathematical modelling. J Public Health Policy 2009; 30: 328-341.