The effects of PEG-based surface modification of PDMS microchannels on long-term hemocompatibility

Journal of Biomedical Materials Research - Part A

Volumn 102, Issue 12, 2014, Pages 4195-4205

  Kovach, Kyle M ^a   Capadona, Jeffrey R ^a,b   Gupta, Anirban Sen ^b   Potkay, Joseph A ^c,d,e  

^a LOUIS STOKES CLEVELAND VA MEDICAL CENTER   (United States)

^b Case Western Reserve University   (United States)

^c VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^d Case Western Reserve University   (United States)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Hemocompatibility; Microfluidics; Polydimethylsiloxane; Polyethylene glycol; Surface modification

Indexed keywords

ADSORPTION; BLOOD; COATINGS; GRAFTING (CHEMICAL); MICROFLUIDICS; PLATELETS; POLYDIMETHYLSILOXANE; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; SILICONES; SURFACE TREATMENT;

FIBRINOGEN ADSORPTION; HEMOCOMPATIBILITY; INCREASE IN PRESSURE; MICRO-FLUIDIC DEVICES; MICROFLUIDIC NETWORKS; OXYGEN PLASMA PRETREATMENT; POLYDIMETHYLSILOXANE PDMS; SURFACE MODIFICATION OF PDMS;

MICROCHANNELS;

DIMETICONE; FIBRINOGEN; MACROGOL; OXYGEN; BIOMATERIAL; MACROGOL DERIVATIVE;

ADSORPTION; AGING; ARTICLE; BLOOD COMPATIBILITY; BLOOD FLOW; CHEMICAL MODIFICATION; HUMAN; MICROFLUIDICS; MICROTECHNOLOGY; THROMBOCYTE ADHESION; THROMBOCYTE RICH PLASMA; X RAY PHOTOELECTRON SPECTROSCOPY; CHEMISTRY; CYTOLOGY; MATERIALS TESTING; METABOLISM; MICROFLUIDIC ANALYSIS; THROMBOCYTE;

ADSORPTION; BLOOD PLATELETS; COATED MATERIALS, BIOCOMPATIBLE; DIMETHYLPOLYSILOXANES; FIBRINOGEN; HUMANS; MATERIALS TESTING; MICROFLUIDIC ANALYTICAL TECHNIQUES; PLATELET ADHESIVENESS; POLYETHYLENE GLYCOLS;

EID: 84911807836     PISSN: 15493296     EISSN: 15524965     Source Type: Journal    
DOI: 10.1002/jbm.a.35090     Document Type: Article

References (57)

1. Sia SK, Whitesides GM. Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies. Electrophoresis 2003;24: 3563-576.
2. Duffy DC, McDonald JC, Schueller OJ, Whitesides GM. Rapid prototyping of microfluidic systems in poly(dimethylsiloxane). Anal Chem 1998;70:4974-4984.
3. Zhou J, Ellis AV, Voelcker NH. Recent developments in PDMS surface modification for microfluidic devices. Electrophoresis 2010; 31:2-16.
4. Curtis J, Colas A. Medical applications of silicone. In: Ratner B, Hoffman A, Schoen F, Lemons J, editors. Biomaterials Science: An Introduction to Materials in Medicine, 2nd ed. San Diego: Elsevier Academic Press; 2004. p 697-707.
5. Slentz B, Penner N, Lugowska E, Regnier F. Nanoliter capillary electrochromatography columns based on collocated monolithic support structures molded in poly(dimethyl siloxane). Electrophoresis 2001;22:3736-3743.
6. Lowe A, Ozer B, Wiepz G, Bertics P, Abbott N. Engineering of PDMS surfaces for use in microsystems for capture and isolation of biomedically important proteins: Epidermal growth factor receptor as a model system. Lab Chip 2008;8:1357-1364.
7. Matsubara Y, Murakami Y, Kobayashi M, Morita Y, Tamiya E. Application of on-chip cell cultures for the detection of allergic response. Biosensors Bioelectron 2004;19:741-747.
8. Wu JM, Chung Y, Belford KJ, Smith GD, Takayama S, Lahann J. A surface-modified sperm sorting device with long-term stability. Biomed Microdevices 2006;8:99-107.
9. Kniazeva T, Hsiao JC, Charest JL, Borenstein JT. A microfluidic respiratory assist device with high gas permeance for artificial lung applications. Biomed Microdevices 2011;13:315-323.
10. Potkay JA, Magnetta M, Vinson A, Cmolik B. Bio-inspired, efficient, artificial lung employing air as the ventilating gas. Lab Chip 2011;11:2901-2909.
11. Elam JH, Nygren H. Adsorption of coagulation proteins from whole blood on to polymer materials: Relation to platelet activation. Biomaterials 1992;13:3-8.
12. Absolom D, Zingg W, Neumann A. Protein adsorption to polymer particles: Role of surface properties. J Biomed Mater Res 2004;21: 161-171.
13. Lyman D, Brash J, Chaikin S, Klein K, Carini M. The effect of chemical Structure and surface properties of synthetic polymers on the coagulation of blood. II. Protein and platelet interaction with polymer surface. ASAIO J 1968;14:250-255.
14. Zhang Z, Borenstein JT, Guiney L, Miller R, Sukavaneshvar S, Loose C. Polybetaine modification of PDMS microfluidic devices to resist thrombus formation in whole blood. Lab Chip 2013;13: 1963-1968.
15. Thorslund S, Sanchez J, Larsson R, Nikolajeff F, Bergquist J. Functionality and stability of heparin immobilized onto poly (dimethylsiloxane). Colloids Surf B: Biointerfaces 2005;45:76-81.
16. Lee S, Vörös J. An aqueous-based surface modification of poly(dimethylsiloxane) with poly(ethylene glycol) to prevent biofouling. Langmuir 2005;21:11957-11962.
17. Raynor JE, Capadona JR, Collard DM, Petrie TA, Garciá AsJ. Polymer brushes and self-assembled monolayers: Versatile platforms to control cell adhesion to biomaterials (Review). Biointerphases 2009;4:FA3.
18. Kuo W-H, Wang M-J, Chang C-W, Wei T-C, Lai J-Y, Tsai W-B, Lee C. Improvement of hemocompatibility on materials by photoimmobilization of poly(ethylene glycol). J Mater Chem 2012;22:9991.
19. Chen H, Yuan L, Song W, Wu Z, Li D. Biocompatible polymer materials: Role of protein-surface interactions. Prog Polym Sci 2008;33:1059-1087.
20. Wong I, Ho CM. Surface molecular property modifications for poly (dimethylsiloxane)(PDMS) based microfluidic devices. Microfluid Nanofluid 2009;7:291-306.
21. Bodas D, Khan-Malek C. Hydrophilization and hydrophobic recovery of PDMS by oxygen plasma and chemical treatment-An SEM investigation. Sensor Actuat B: Chem 2007;123:368-373.
22. Chen I-J, Lindner E. The stability of radio-frequency plasmatreated polydimethylsiloxane surfaces. Langmuir 2007;23:3118-3122.
23. Zhang Z, Wang J, Tu Q, Nie N, Sha J, Liu W, Liu R, Zhang Y, Wang J. Surface modification of PDMS by surface-initiated atom transfer radical polymerization of water-soluble dendronized PEG methacrylate. Colloids Surf B: Biointerfaces 2011;88:85-92.
24. Berdichevsky Y. UV/ozone modification of poly(dimethylsiloxane) microfluidic channels. Sensor Actuat B: Chem 2004;97:402-408.
25. Sharma V, Dhayal M, Shivaprasad S, Jain S. Surface characterization of plasma-treated and PEG-grafted PDMS for micro fluidic applications. Vacuum 2007;81:1094-1100.
26. Hellmich W, Regtmeier J, Duong TT, Ros R, Anselmetti D, Ros A. Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels. Langmuir 2005;21:7551-7557.
27. Pinto S, Alves P, Matos C, Santos A, Rodrigues L, Teixeira J, Gil M. Poly(dimethyl siloxane) surface modification by low pressure plasma to improve its characteristics towards biomedical applications. Colloids Surf B: Biointerfaces 2010;81:20-26.
28. Wu CC, Yuan CY, Ding SJ. Effect of polydimethylsiloxane surfaces silanized with different nitrogen-containing groups on the adhesion progress of epithelial cells. Surf Coat Technol 2011;205: 3182-3189.
29. Wang A-J, Feng J-J, Fan J. Covalent modified hydrophilic polymer brushes onto poly(dimethylsiloxane) microchannel surface for electrophoresis separation of amino acids. J Chromatogr A 2008;1192:173-179.
30. Papra A, Bernard A, Juncker D, Larsen NB, Michel B, Delamarche E. Microfluidic networks made of poly(dimethylsiloxane), Si, and Au coated with polyethylene glycol for patterning proteins onto surfaces. Langmuir 2001;17:1090-4095.
31. Hemmilä S, Cauich-Rodríguez JV, Kreutzer J, Kallio P. Rapid, simple, and cost-effective treatments to achieve long-term hydrophilic PDMS surfaces. Appl Surf Sci 2012;258: 9864-9875.
32. Priest C. Surface patterning of bonded microfluidic channels. Biomicrofluidics 2010;4:32206.
33. Ebara M, Hoffman J, Stayton P, Hoffman A. Surface modification of microfluidic channels by UV-mediated graft polymerization of non-fouling and 'smart' polymers. Radiat Phys Chem 2007;76: 1409-1413.
34. Zhang Z, Feng X, Luo Q, Liu B-F. Environmentally friendly surface modification of PDMS using PEG polymer brush. Electrophoresis 2009;30:3174-3180.
35. Makamba H, Hsieh Y-Y, Sung W-C, Chen S-H. Stable permanently hydrophilic protein-resistant thin-film coatings on poly(dimethylsiloxane) substrates by electrostatic self-assembly and chemical cross-linking. Anal Chem 2005;77:3971-3978.
36. Thorslund S, Sanchez J, Larsson R, Nikolajeff F, Bergquist J. Bioactive heparin immobilized onto microfluidic channels in poly(dimethylsiloxane) results in hydrophilic surface properties. Colloids Surf B: Biointerfaces 2005;46:240-247.
37. Chen H, Zhang Z, Chen Y, Brook MA, Sheardown H. Protein repellant silicone surfaces by covalent immobilization of poly (ethylene oxide). Biomaterials 2005;26:2391-2399.
38. Sui G, Wang J, Lee C-C, Lu W, Lee SP, Leyton JV, Wu AM, Tseng H-R. Solution-phase surface modification in intact poly(dimethylsiloxane) microfluidic channels. Anal Chem 2006;78:5543-5551.
39. Microchem. SU-8 2000 (100-150) Negative Photoresist Datasheet. Volume 2012. Newton, MA: Microchem; 2012.
40. Bhattacharya S, Datta A, Berg J, Gangopadhyay S. Studies on surface wettability of poly(dimethyl) siloxane (PDMS) and glass under oxygen-plasma treatment and correlation with bond strength. J Microelectromech Syst 2005;14:590-597.
41. Moulder J, Stickle W, Sobol P, Bomben K. Handbook of Photoelectron Spectroscopy. ULVAC-PHI: Physical Electronics; 1995.
42. U.S. National Library of Medicine and National Institutes of Health. Fibrinogen. [Website] 2011 [cited 2013 3/14/13]. Available from: http://www.nlm.nih.gov/medlineplus/ency/article/003650.htm.
43. Ochoa C, Wu S, Stevens T. New developments in lung endothelial heterogeneity: von Willebrand factor, P-selectin, and the Weibel-Palade Body. Semin Thromb Hemost 2 2010;36:301-308.
44. Kim B, Peterson E, Papautsky I. Long-term stability of plasma oxidized PDMS surfaces. Proceedings of the 26 Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Vol. 2; 2004. p 5013-5016.
45. Lee JN, Park C, Whitesides GM. Solvent compatibility of poly (dimethylsiloxane)-based microfluidic devices. Anal Chem 2003; 75:6544-6554.
46. Furukawa K, Ushida T, Sugano H, Tamaki T, Ohshima N, Tateishi T. Effect of shear stress on platelet adhesion to expanded polytetrafluoroethylene, a silicone sheet, and an endothelial cell monolayer. ASAIO J 2000;46:696-701.
47. Di Stasio E, De Cristofaro R. The effect of shear stress on protein conformation: Physical forces operating on biochemical systems: The case of von Willebrand factor. Biophys Chem 2010;153:1-8.
48. Keefe AJ, Brault ND, Jiang S. Suppressing surface reconstruction of superhydrophobic PDMS using a superhydrophilic zwitterionic polymer. Biomacromolecules 2012;13:1683-1697.
49. Ruggeri ZM, Mendolicchio GL. Adhesion mechanisms in platelet function. Circ Res 2007;100:1673-1685.
50. Wu Y, Simonovsky FI, Ratner BD, Horbett TA. The role of adsorbed fibrinogen in platelet adhesion to polyurethane surfaces: A comparison of surface hydrophobicity, protein adsorption, monoclonal antibody binding, and platelet adhesion. J Biomed Mater Res Part A 2005;74A:722-738.
51. Gorbet MB, Sefton MV. Biomaterial-associated thrombosis: Roles of coagulation factors, complement, platelets, and leukocytes. Biomaterials 2004;25:5681-5703.
52. Wilson CJ, Clegg RE, Leavesley DI, Pearcy MJ. Mediation of biomaterial-cell interactions by adsorbed proteins: a review. Tissue Eng 2005;11:1-18.
53. Capadona JR, Petrie TA, Fears KP, Latour RA, Collard DM, García AJ. Surface-Nucleated assembly of fibrillar extracellular matrices. Adv Mater 2005;17:2604-2608.
54. Capadona JR, Collard DM, García AJ. Fibronectin adsorption and cell adhesion to mixed monolayers of tri(ethylene glycol)- and methyl-terminated alkanethiols. Langmuir 2003;19:1847-1852.
55. Lee K, Kim D, Min B, Lee S. Polymeric nanofiber web-based artificial renal microfluidic chip. Biomed Microdevices 2007;9:435-442.
56. Spiller D, Losi P, Briganti E, Sbrana S, Kull S, Martinelli I, Soldani G. PDMS content affects in vitro hemocompatibility of synthetic vascular grafts. J Mater Sci: Mater Med 2007;18:1097-1104.
57. VanDelinder V, Groisman A. Separation of plasma from whole human blood in a continuous cross-flow in a molded microfluidic device. Anal Chem 2006;78:3765-3771.