-
1
-
-
79952232216
-
Global cancer statistics
-
PMID: 21296855
-
Jemal A, Bray F, Center MM, Ferlay J, Ward E, Forman D. Global cancer statistics. CA Cancer J Clin 2011; 61: 69-90 [PMID: 21296855 DOI: 10.3322/caac.20107]
-
(2011)
CA Cancer J Clin
, vol.61
, pp. 69-90
-
-
Jemal, A.1
Bray, F.2
Center, M.M.3
Ferlay, J.4
Ward, E.5
Forman, D.6
-
2
-
-
0035256698
-
Untangling the ERBB signalling network
-
PMID: 11252954
-
Yarden Y, Sliwkowski MX. Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2001; 2: 127-137 [PMID: 11252954 DOI: 10.1038/35052073]
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 127-137
-
-
Yarden, Y.1
Sliwkowski, M.X.2
-
3
-
-
0028176477
-
A neu acquaintance for erbB3 and erbB4: A role for receptor heterodimerization in growth signaling
-
PMID: 8033211
-
Carraway KL, Cantley LC. A neu acquaintance for erbB3 and erbB4: A role for receptor heterodimerization in growth signaling. Cell 1994; 78: 5-8 [PMID: 8033211]
-
(1994)
Cell
, vol.78
, pp. 5-8
-
-
Carraway, K.L.1
Cantley, L.C.2
-
4
-
-
0031900740
-
Signal transduction through MAP kinase cascades
-
PMID: 9561267
-
Lewis TS, Shapiro PS, Ahn NG. Signal transduction through MAP kinase cascades. Adv Cancer Res 1998; 74: 49-139 [PMID: 9561267]
-
(1998)
Adv Cancer Res
, vol.74
, pp. 49-139
-
-
Lewis, T.S.1
Shapiro, P.S.2
Ahn, N.G.3
-
5
-
-
0031936410
-
Specificity within the EGF family/ERBB receptor family signaling network
-
PMID: 9504046
-
Riese DJ, Stern DF. Specificity within the EGF family/ErbB receptor family signaling network. Bioessays 1998; 20: 41-48 [PMID: 9504046]
-
(1998)
Bioessays
, vol.20
, pp. 41-48
-
-
Riese, D.J.1
Stern, D.F.2
-
6
-
-
0032860819
-
Controlled dimerization of ERBB receptors provides evidence for differential signaling by homo-And heterodimers
-
PMID: 10490623
-
Muthuswamy SK, Gilman M, Brugge JS. Controlled dimerization of ErbB receptors provides evidence for differential signaling by homo-And heterodimers. Mol Cell Biol 1999; 19: 6845-6857 [PMID: 10490623]
-
(1999)
Mol Cell Biol
, vol.19
, pp. 6845-6857
-
-
Muthuswamy, S.K.1
Gilman, M.2
Brugge, J.S.3
-
7
-
-
0024822342
-
Epidermal growth factor receptors in breast cancer: Association with early relapse and death, poor response to hormones and interactions with neu
-
PMID: 2576295
-
Harris AL, Nicholson S, Sainsbury JR, Farndon J, Wright C. Epidermal growth factor receptors in breast cancer: Association with early relapse and death, poor response to hormones and interactions with neu. J Steroid Biochem 1989; 34: 123-131 [PMID: 2576295]
-
(1989)
J Steroid Biochem
, vol.34
, pp. 123-131
-
-
Harris, A.L.1
Nicholson, S.2
Sainsbury, J.R.3
Farndon, J.4
Wright, C.5
-
8
-
-
20244378677
-
Phase i clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer
-
PMID: 15699478
-
Agus DB, Gordon MS, Taylor C, Natale RB, Karlan B, Mendelson DS, Press MF, Allison DE, Sliwkowski MX, Lieberman G, Kelsey SM, Fyfe G. Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer. J Clin Oncol 2005; 23: 2534-2543 [PMID: 15699478 DOI: 10.1200/JCO.2005.03.184]
-
(2005)
J Clin Oncol
, vol.23
, pp. 2534-2543
-
-
Agus, D.B.1
Gordon, M.S.2
Taylor, C.3
Natale, R.B.4
Karlan, B.5
Mendelson, D.S.6
Press, M.F.7
Allison, D.E.8
Sliwkowski, M.X.9
Lieberman, G.10
Kelsey, S.M.11
Fyfe, G.12
-
9
-
-
84875204170
-
Trastuzumab emtansine (T-DM1) for HER2-positive breast cancer
-
PMID: 23402224
-
Boyraz B, Sendur MA, Aksoy S, Babacan T, Roach EC, Kizilarslanoglu MC, Petekkaya I, Altundag K. Trastuzumab emtansine (T-DM1) for HER2-positive breast cancer. Curr Med Res Opin 2013; 29: 405-414 [PMID: 23402224 DOI: 10.118 5/03007995.2013.775113]
-
(2013)
Curr Med Res Opin
, vol.29
, pp. 405-414
-
-
Boyraz, B.1
Sendur, M.A.2
Aksoy, S.3
Babacan, T.4
Roach, E.C.5
Kizilarslanoglu, M.C.6
Petekkaya, I.7
Altundag, K.8
-
10
-
-
2942592008
-
Dual kinase inhibition in the treatment of breast cancer: Initial experience with the EGFR/ERBB-2 inhibitor lapatinib
-
PMID: 15163842
-
Burris HA. Dual kinase inhibition in the treatment of breast cancer: initial experience with the EGFR/ErbB-2 inhibitor lapatinib. Oncologist 2004; 9 Suppl 3: 10-15 [PMID: 15163842]
-
(2004)
Oncologist
, vol.9
, Issue.3
, pp. 10-15
-
-
Burris, H.A.1
-
11
-
-
26844536978
-
Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer
-
PMID: 16236738
-
Romond EH, Perez EA, Bryant J, Suman VJ, Geyer CE, Davidson NE, Tan-Chiu E, Martino S, Paik S, Kaufman PA, Swain SM, Pisansky TM, Fehrenbacher L, Kutteh LA, Vogel VG, Visscher DW, Yothers G, Jenkins RB, Brown AM, Dakhil SR, Mamounas EP, Lingle WL, Klein PM, Ingle JN, Wolmark N. Trastuzumab plus adjuvant chemotherapy for operable HER2-positive breast cancer. N Engl J Med 2005; 353: 1673-1684 [PMID: 16236738
-
(2005)
N Engl J Med
, vol.353
, pp. 1673-1684
-
-
Romond, E.H.1
Perez, E.A.2
Bryant, J.3
Suman, V.J.4
Geyer, C.E.5
Davidson, N.E.6
Tan-Chiu, E.7
Martino, S.8
Paik, S.9
Kaufman, P.A.10
Swain, S.M.11
Pisansky, T.M.12
Fehrenbacher, L.13
Kutteh, L.A.14
Vogel, V.G.15
Visscher, D.W.16
Yothers, G.17
Jenkins, R.B.18
Brown, A.M.19
Dakhil, S.R.20
Mamounas, E.P.21
Lingle, W.L.22
Klein, P.M.23
Ingle, J.N.24
Wolmark, N.25
more..
-
12
-
-
80052728749
-
Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: Joint analysis of data from NCCTG N9831 and NSABP B-31
-
PMID: 21768458
-
Perez EA, Romond EH, Suman VJ, Jeong JH, Davidson NE, Geyer CE, Martino S, Mamounas EP, Kaufman PA, Wolmark N. Four-year follow-up of trastuzumab plus adjuvant chemotherapy for operable human epidermal growth factor receptor 2-positive breast cancer: joint analysis of data from NCCTG N9831 and NSABP B-31. J Clin Oncol 2011; 29: 3366-3373 [PMID: 21768458 DOI: 10.1200/JCO.2011.35.0868]
-
(2011)
J Clin Oncol
, vol.29
, pp. 3366-3373
-
-
Perez, E.A.1
Romond, E.H.2
Suman, V.J.3
Jeong, J.H.4
Davidson, N.E.5
Geyer, C.E.6
Martino, S.7
Mamounas, E.P.8
Kaufman, P.A.9
Wolmark, N.10
-
13
-
-
84879927236
-
Trastuzumab plus adjuvant chemotherapy for HER2-positive breast cancer: Final planned joint analysis of overall survival (OS) from NSABP B-31 and NCCTG N9831
-
National Surgical Adjuvant Breast and Bowel Project (NSABP) Operations and Biostatistical Centers
-
Romond E, Suman V, Jeong J, Sledge G, Geyer C, Martino S, Rastogi P, Gralow J, Swain S, Winer E, Colon-Otero G, Hudis C, Paik S, Davidson N, Mamounas E, Zujewski J, Wolmark N, Perez E, National Surgical Adjuvant Breast and Bowel Project (NSABP) Operations and Biostatistical Centers, . Trastuzumab plus adjuvant chemotherapy for HER2-positive breast cancer: Final planned joint analysis of overall survival (OS) from NSABP B-31 and NCCTG N9831. Cancer Research 2012; 72: S5-5 [DOI: 10.1158/0008-5472. SABCS12-S5-5]
-
(2012)
Cancer Research
, vol.72
, pp. S5-5
-
-
Romond, E.1
Suman, V.2
Jeong, J.3
Sledge, G.4
Geyer, C.5
Martino, S.6
Rastogi, P.7
Gralow, J.8
Swain, S.9
Winer, E.10
Colon-Otero, G.11
Hudis, C.12
Paik, S.13
Davidson, N.14
Mamounas, E.15
Zujewski, J.16
Wolmark, N.17
Perez, E.18
-
14
-
-
83355163400
-
Sequential versus concurrent trastuzumab in adjuvant chemotherapy for breast cancer
-
PMID: 22042958
-
Perez EA, Suman VJ, Davidson NE, Gralow JR, Kaufman PA, Visscher DW, Chen B, Ingle JN, Dakhil SR, Zujewski J, Moreno-Aspitia A, Pisansky TM, Jenkins RB. Sequential versus concurrent trastuzumab in adjuvant chemotherapy for breast cancer. J Clin Oncol 2011; 29: 4491-4497 [PMID: 22042958 DOI: 10.1200/JCO.2011.36.7045]
-
(2011)
J Clin Oncol
, vol.29
, pp. 4491-4497
-
-
Perez, E.A.1
Suman, V.J.2
Davidson, N.E.3
Gralow, J.R.4
Kaufman, P.A.5
Visscher, D.W.6
Chen, B.7
Ingle, J.N.8
Dakhil, S.R.9
Zujewski, J.10
Moreno-Aspitia, A.11
Pisansky, T.M.12
Jenkins, R.B.13
-
15
-
-
26844503270
-
Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer
-
PMID: 16236737
-
Piccart-Gebhart MJ, Procter M, Leyland-Jones B, Goldhirsch A, Untch M, Smith I, Gianni L, Baselga J, Bell R, Jackisch C, Cameron D, Dowsett M, Barrios CH, Steger G, Huang CS, Andersson M, Inbar M, Lichinitser M, Lng I, Nitz U, Iwata H, Thomssen C, Lohrisch C, Suter TM, Rschoff J, Suto T, Greatorex V, Ward C, Straehle C, McFadden E, Dolci MS, Gelber RD. Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer. N Engl J Med 2005; 353: 1659-1672 [PMID: 16236737 DOI: 10.1056/NEJMoa052306]
-
(2005)
N Engl J Med
, vol.353
, pp. 1659-1672
-
-
Piccart-Gebhart, M.J.1
Procter, M.2
Leyland-Jones, B.3
Goldhirsch, A.4
Untch, M.5
Smith, I.6
Gianni, L.7
Baselga, J.8
Bell, R.9
Jackisch, C.10
Cameron, D.11
Dowsett, M.12
Barrios, C.H.13
Steger, G.14
Huang, C.S.15
Andersson, M.16
Inbar, M.17
Lichinitser, M.18
Lng, I.19
Nitz, U.20
Iwata, H.21
Thomssen, C.22
Lohrisch, C.23
Suter, T.M.24
Rschoff, J.25
Suto, T.26
Greatorex, V.27
Ward, C.28
Straehle, C.29
McFadden, E.30
Dolci, M.S.31
Gelber, R.D.32
more..
-
16
-
-
84884418164
-
2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): An open-label, randomised controlled trial
-
PMID: 23871490
-
Goldhirsch A, Gelber RD, Piccart-Gebhart MJ, de Azambuja E, Procter M, Suter TM, Jackisch C, Cameron D, Weber HA, Heinzmann D, Dal Lago L, McFadden E, Dowsett M, Untch M, Gianni L, Bell R, Köhne CH, Vindevoghel A, Andersson M, Brunt AM, Otero-Reyes D, Song S, Smith I, Leyland-Jones B, Baselga J. 2 years versus 1 year of adjuvant trastuzumab for HER2-positive breast cancer (HERA): An open-label, randomised controlled trial. Lancet 2013; 382: 1021-1028 [PMID: 23871490 DOI: 10.1016/S0140-6736(13)61094-6]
-
(2013)
Lancet
, vol.382
, pp. 1021-1028
-
-
Goldhirsch, A.1
Gelber, R.D.2
Piccart-Gebhart, M.J.3
De Azambuja, E.4
Procter, M.5
Suter, T.M.6
Jackisch, C.7
Cameron, D.8
Weber, H.A.9
Heinzmann, D.10
Dal Lago, L.11
McFadden, E.12
Dowsett, M.13
Untch, M.14
Gianni, L.15
Bell, R.16
Köhne, C.H.17
Vindevoghel, A.18
Andersson, M.19
Brunt, A.M.20
Otero-Reyes, D.21
Song, S.22
Smith, I.23
Leyland-Jones, B.24
Baselga, J.25
more..
-
17
-
-
33344478381
-
Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer
-
PMID: 16495393
-
Joensuu H, Kellokumpu-Lehtinen PL, Bono P, Alanko T, Kataja V, Asola R, Utriainen T, Kokko R, Hemminki A, Tarkkanen M, Turpeenniemi-Hujanen T, Jyrkkiö S, Flander M, Helle L, Ingalsuo S, Johansson K, Jskelinen AS, Pajunen M, Rauhala M, Kaleva-Kerola J, Salminen T, Leinonen M, Elomaa I, Isola J. Adjuvant docetaxel or vinorelbine with or without trastuzumab for breast cancer. N Engl J Med 2006; 354: 809-820 [PMID: 16495393 DOI: 10.1056/NEJMoa053028]
-
(2006)
N Engl J Med
, vol.354
, pp. 809-820
-
-
Joensuu, H.1
Kellokumpu-Lehtinen, P.L.2
Bono, P.3
Alanko, T.4
Kataja, V.5
Asola, R.6
Utriainen, T.7
Kokko, R.8
Hemminki, A.9
Tarkkanen, M.10
Turpeenniemi-Hujanen, T.11
Jyrkkiö, S.12
Flander, M.13
Helle, L.14
Ingalsuo, S.15
Johansson, K.16
Jskelinen, A.S.17
Pajunen, M.18
Rauhala, M.19
Kaleva-Kerola, J.20
Salminen, T.21
Leinonen, M.22
Elomaa, I.23
Isola, J.24
more..
-
18
-
-
73349115249
-
Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: Final results of the FinHer Trial
-
PMID: 19884557
-
Joensuu H, Bono P, Kataja V, Alanko T, Kokko R, Asola R, Utriainen T, Turpeenniemi-Hujanen T, Jyrkkiö S, Möykkynen K, Helle L, Ingalsuo S, Pajunen M, Huusko M, Salminen T, Auvinen P, Leinonen H, Leinonen M, Isola J, Kellokumpu-Lehtinen PL. Fluorouracil, epirubicin, and cyclophosphamide with either docetaxel or vinorelbine, with or without trastuzumab, as adjuvant treatments of breast cancer: final results of the FinHer Trial. J Clin Oncol 2009; 27: 5685-5692 [PMID: 19884557 DOI: 10.1200/JCO.2008.21.4577]
-
(2009)
J Clin Oncol
, vol.27
, pp. 5685-5692
-
-
Joensuu, H.1
Bono, P.2
Kataja, V.3
Alanko, T.4
Kokko, R.5
Asola, R.6
Utriainen, T.7
Turpeenniemi-Hujanen, T.8
Jyrkkiö, S.9
Möykkynen, K.10
Helle, L.11
Ingalsuo, S.12
Pajunen, M.13
Huusko, M.14
Salminen, T.15
Auvinen, P.16
Leinonen, H.17
Leinonen, M.18
Isola, J.19
Kellokumpu-Lehtinen, P.L.20
more..
-
19
-
-
80053539103
-
Adjuvant trastuzumab in HER2-positive breast cancer
-
PMID: 21991949
-
Slamon D, Eiermann W, Robert N, Pienkowski T, Martin M, Press M, Mackey J, Glaspy J, Chan A, Pawlicki M, Pinter T, Valero V, Liu MC, Sauter G, von Minckwitz G, Visco F, Bee V, Buyse M, Bendahmane B, Tabah-Fisch I, Lindsay MA, Riva A, Crown J. Adjuvant trastuzumab in HER2-positive breast cancer. N Engl J Med 2011; 365: 1273-1283 [PMID: 21991949 DOI: 10.1056/NEJMoa0910383]
-
(2011)
N Engl J Med
, vol.365
, pp. 1273-1283
-
-
Slamon, D.1
Eiermann, W.2
Robert, N.3
Pienkowski, T.4
Martin, M.5
Press, M.6
Mackey, J.7
Glaspy, J.8
Chan, A.9
Pawlicki, M.10
Pinter, T.11
Valero, V.12
Liu, M.C.13
Sauter, G.14
Von Minckwitz, G.15
Visco, F.16
Bee, V.17
Buyse, M.18
Bendahmane, B.19
Tabah-Fisch, I.20
Lindsay, M.A.21
Riva, A.22
Crown, J.23
more..
-
20
-
-
74949141693
-
Trastuzumab for patients with axillarynode-positive breast cancer: Results of the FNCLCC-PACS 04 trial
-
PMID: 19917839
-
Spielmann M, Roch H, Delozier T, Canon JL, Romieu G, Bourgeois H, Extra JM, Serin D, Kerbrat P, Machiels JP, Lortholary A, Orfeuvre H, Campone M, Hardy-Bessard AC, Coudert B, Maerevoet M, Piot G, Kramar A, Martin AL, Penault-Llorca F. Trastuzumab for patients with axillarynode-positive breast cancer: results of the FNCLCC-PACS 04 trial. J Clin Oncol 2009; 27: 6129-6134 [PMID: 19917839 DOI: 10.1200/JCO.2009.23.0946]
-
(2009)
J Clin Oncol
, vol.27
, pp. 6129-6134
-
-
Spielmann, M.1
Roch, H.2
Delozier, T.3
Canon, J.L.4
Romieu, G.5
Bourgeois, H.6
Extra, J.M.7
Serin, D.8
Kerbrat, P.9
Machiels, J.P.10
Lortholary, A.11
Orfeuvre, H.12
Campone, M.13
Hardy-Bessard, A.C.14
Coudert, B.15
Maerevoet, M.16
Piot, G.17
Kramar, A.18
Martin, A.L.19
Penault-Llorca, F.20
more..
-
21
-
-
84879780559
-
6 months versus 12 months of adjuvant trastuzumab for patients with HER2-positive early breast cancer (PHARE): A randomised phase 3 trial
-
PMID: 23764181
-
Pivot X, Romieu G, Debled M, Pierga JY, Kerbrat P, Bachelot T, Lortholary A, Espi M, Fumoleau P, Serin D, Jacquin JP, Jouannaud C, Rios M, Abadie-Lacourtoisie S, Tubiana-Mathieu N, Cany L, Catala S, Khayat D, Pauport I, Kramar A. 6 months versus 12 months of adjuvant trastuzumab for patients with HER2-positive early breast cancer (PHARE): A randomised phase 3 trial. Lancet Oncol 2013; 14: 741-748 [PMID: 23764181 DOI: 10.1016/S1470-2045(13)70225-0]
-
(2013)
Lancet Oncol
, vol.14
, pp. 741-748
-
-
Pivot, X.1
Romieu, G.2
Debled, M.3
Pierga, J.Y.4
Kerbrat, P.5
Bachelot, T.6
Lortholary, A.7
Espi, M.8
Fumoleau, P.9
Serin, D.10
Jacquin, J.P.11
Jouannaud, C.12
Rios, M.13
Abadie-Lacourtoisie, S.14
Tubiana-Mathieu, N.15
Cany, L.16
Catala, S.17
Khayat, D.18
Pauport, I.19
Kramar, A.20
more..
-
22
-
-
84871712684
-
Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: A randomised, controlled, phase 3 trial
-
PMID: 23234763
-
Goss PE, Smith IE, OShaughnessy J, Ejlertsen B, Kaufmann M, Boyle F, Buzdar AU, Fumoleau P, Gradishar W, Martin M, Moy B, Piccart-Gebhart M, Pritchard KI, Lindquist D, Chavarri-Guerra Y, Aktan G, Rappold E, Williams LS, Finkelstein DM. Adjuvant lapatinib for women with early-stage HER2-positive breast cancer: A randomised, controlled, phase 3 trial. Lancet Oncol 2013; 14: 88-96 [PMID: 23234763 DOI: 10.1016/S1470-2045(12)70508-9]
-
(2013)
Lancet Oncol
, vol.14
, pp. 88-96
-
-
Goss, P.E.1
Smith, I.E.2
OShaughnessy, J.3
Ejlertsen, B.4
Kaufmann, M.5
Boyle, F.6
Buzdar, A.U.7
Fumoleau, P.8
Gradishar, W.9
Martin, M.10
Moy, B.11
Piccart-Gebhart, M.12
Pritchard, K.I.13
Lindquist, D.14
Chavarri-Guerra, Y.15
Aktan, G.16
Rappold, E.17
Williams, L.S.18
Finkelstein, D.M.19
-
23
-
-
78149483057
-
Triple-negative breast cancer
-
PMID: 21067385
-
Foulkes WD, Smith IE, Reis-Filho JS. Triple-negative breast cancer. N Engl J Med 2010; 363: 1938-1948 [PMID: 21067385 DOI: 10.1056/NEJMra1001389]
-
(2011)
N Engl J Med
, vol.363
, pp. 1938-1948
-
-
Foulkes, W.D.1
Smith, I.E.2
Reis-Filho, J.S.3
-
24
-
-
20544460650
-
Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: Results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer
-
PMID: 15738535
-
Buzdar AU, Ibrahim NK, Francis D, Booser DJ, Thomas ES, Theriault RL, Pusztai L, Green MC, Arun BK, Giordano SH, Cristofanilli M, Frye DK, Smith TL, Hunt KK, Singletary SE, Sahin AA, Ewer MS, Buchholz TA, Berry D, Hortobagyi GN. Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer. J Clin Oncol 2005; 23: 3676-3685 [PMID: 15738535 DOI: 10.1200/JCO.2005.07.032]
-
(2005)
J Clin Oncol
, vol.23
, pp. 3676-3685
-
-
Buzdar, A.U.1
Ibrahim, N.K.2
Francis, D.3
Booser, D.J.4
Thomas, E.S.5
Theriault, R.L.6
Pusztai, L.7
Green, M.C.8
Arun, B.K.9
Giordano, S.H.10
Cristofanilli, M.11
Frye, D.K.12
Smith, T.L.13
Hunt, K.K.14
Singletary, S.E.15
Sahin, A.A.16
Ewer, M.S.17
Buchholz, T.A.18
Berry, D.19
Hortobagyi, G.N.20
more..
-
25
-
-
33846297680
-
Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: An update of the initial randomized study population and data of additional patients treated with the same regimen
-
PMID: 17200359
-
Buzdar AU, Valero V, Ibrahim NK, Francis D, Broglio KR, Theriault RL, Pusztai L, Green MC, Singletary SE, Hunt KK, Sahin AA, Esteva F, Symmans WF, Ewer MS, Buchholz TA, Hortobagyi GN. Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: An update of the initial randomized study population and data of additional patients treated with the same regimen. Clin Cancer Res 2007; 13: 228-233 [PMID: 17200359 DOI: 10.1158/1078-0432.CCR-06-1345]
-
(2007)
Clin Cancer Res
, vol.13
, pp. 228-233
-
-
Buzdar, A.U.1
Valero, V.2
Ibrahim, N.K.3
Francis, D.4
Broglio, K.R.5
Theriault, R.L.6
Pusztai, L.7
Green, M.C.8
Singletary, S.E.9
Hunt, K.K.10
Sahin, A.A.11
Esteva, F.12
Symmans, W.F.13
Ewer, M.S.14
Buchholz, T.A.15
Hortobagyi, G.N.16
-
26
-
-
75149145066
-
Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): A randomised controlled superiority trial with a parallel HER2-negative cohort
-
PMID: 20113825
-
Gianni L, Eiermann W, Semiglazov V, Manikhas A, Lluch A, Tjulandin S, Zambetti M, Vazquez F, Byakhow M, Lichinitser M, Climent MA, Ciruelos E, Ojeda B, Mansutti M, Bozhok A, Baronio R, Feyereislova A, Barton C, Valagussa P, Baselga J. Neoadjuvant chemotherapy with trastuzumab followed by adjuvant trastuzumab versus neoadjuvant chemotherapy alone, in patients with HER2-positive locally advanced breast cancer (the NOAH trial): A randomised controlled superiority trial with a parallel HER2-negative cohort. Lancet 2010; 375: 377-384 [PMID: 20113825 DOI: 10.1016/S0140-6736(09)61964-4]
-
(2011)
Lancet
, vol.375
, pp. 377-384
-
-
Gianni, L.1
Eiermann, W.2
Semiglazov, V.3
Manikhas, A.4
Lluch, A.5
Tjulandin, S.6
Zambetti, M.7
Vazquez, F.8
Byakhow, M.9
Lichinitser, M.10
Climent, M.A.11
Ciruelos, E.12
Ojeda, B.13
Mansutti, M.14
Bozhok, A.15
Baronio, R.16
Feyereislova, A.17
Barton, C.18
Valagussa, P.19
Baselga, J.20
more..
-
27
-
-
79957601951
-
Pathologic complete response after neoadjuvant chemotherapy plus trastuzumab predicts favorable survival in human epidermal growth factor receptor 2-overexpressing breast cancer: Results from the TECHNO trial of the AGO and GBG study groups
-
PMID: 21788566
-
Untch M, Fasching PA, Konecny GE, Hasmller S, Lebeau A, Kreienberg R, Camara O, Mller V, du Bois A, Khn T, Stickeler E, Harbeck N, Höss C, Kahlert S, Beck T, Fett W, Mehta KM, von Minckwitz G, Loibl S. Pathologic complete response after neoadjuvant chemotherapy plus trastuzumab predicts favorable survival in human epidermal growth factor receptor 2-overexpressing breast cancer: results from the TECHNO trial of the AGO and GBG study groups. J Clin Oncol 2011; 29: 3351-3357 [PMID: 21788566 DOI: 10.1200/JCO.2010.31.4930]
-
(2011)
J Clin Oncol
, vol.29
, pp. 3351-3357
-
-
Untch, M.1
Fasching, P.A.2
Konecny, G.E.3
Hasmller, S.4
Lebeau, A.5
Kreienberg, R.6
Camara, O.7
Mller, V.8
Du Bois, A.9
Khn, T.10
Stickeler, E.11
Harbeck, N.12
Höss, C.13
Kahlert, S.14
Beck, T.15
Fett, W.16
Mehta, K.M.17
Von Minckwitz, G.18
Loibl, S.19
-
28
-
-
84888131377
-
Fluorouracil, epirubicin, and cyclophosphamide (FEC-75) followed by paclitaxel plus trastuzumab versus paclitaxel plus trastuzumab followed by FEC-75 plus trastuzumab as neoadjuvant treatment for patients with HER2-positive breast cancer (Z1041): A randomised, controlled, phase 3 trial
-
PMID: 24239210
-
Buzdar AU, Suman VJ, Meric-Bernstam F, Leitch AM, Ellis MJ, Boughey JC, Unzeitig G, Royce M, McCall LM, Ewer MS, Hunt KK. Fluorouracil, epirubicin, and cyclophosphamide (FEC-75) followed by paclitaxel plus trastuzumab versus paclitaxel plus trastuzumab followed by FEC-75 plus trastuzumab as neoadjuvant treatment for patients with HER2-positive breast cancer (Z1041): A randomised, controlled, phase 3 trial. Lancet Oncol 2013; 14: 1317-1325 [PMID: 24239210 DOI: 10.1016/S1470-2045(13)70502-3]
-
(2013)
Lancet Oncol
, vol.14
, pp. 1317-1325
-
-
Buzdar, A.U.1
Suman, V.J.2
Meric-Bernstam, F.3
Leitch, A.M.4
Ellis, M.J.5
Boughey, J.C.6
Unzeitig, G.7
Royce, M.8
McCall, L.M.9
Ewer, M.S.10
Hunt, K.K.11
-
29
-
-
77951624086
-
Neoadjuvant treatment with trastuzumab in HER2-positive breast cancer: Results from the GeparQuattro study
-
PMID: 20308670
-
Untch M, Rezai M, Loibl S, Fasching PA, Huober J, Tesch H, Bauerfeind I, Hilfrich J, Eidtmann H, Gerber B, Hanusch C, Khn T, du Bois A, Blohmer JU, Thomssen C, Dan Costa S, Jackisch C, Kaufmann M, Mehta K, von Minckwitz G. Neoadjuvant treatment with trastuzumab in HER2-positive breast cancer: results from the GeparQuattro study. J Clin Oncol 2010; 28: 2024-2031 [PMID: 20308670 DOI: 10.1200/JCO.2009.23.8451]
-
(2011)
J Clin Oncol
, vol.28
, pp. 2024-2031
-
-
Untch, M.1
Rezai, M.2
Loibl, S.3
Fasching, P.A.4
Huober, J.5
Tesch, H.6
Bauerfeind, I.7
Hilfrich, J.8
Eidtmann, H.9
Gerber, B.10
Hanusch, C.11
Khn, T.12
Du Bois, A.13
Blohmer, J.U.14
Thomssen, C.15
Dan Costa, S.16
Jackisch, C.17
Kaufmann, M.18
Mehta, K.19
Von Minckwitz, G.20
more..
-
30
-
-
84865532999
-
Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I-III breast cancer (HannaH study): A phase 3, open-label, multicentre, randomised trial
-
PMID: 22884505
-
Ismael G, Hegg R, Muehlbauer S, Heinzmann D, Lum B, Kim SB, Pienkowski T, Lichinitser M, Semiglazov V, Melichar B, Jackisch C. Subcutaneous versus intravenous administration of (neo)adjuvant trastuzumab in patients with HER2-positive, clinical stage I-III breast cancer (HannaH study): A phase 3, open-label, multicentre, randomised trial. Lancet Oncol 2012; 13: 869-878 [PMID: 22884505 DOI: 10.1016/S1470-2045(12)70329-7]
-
(2012)
Lancet Oncol
, vol.13
, pp. 869-878
-
-
Ismael, G.1
Hegg, R.2
Muehlbauer, S.3
Heinzmann, D.4
Lum, B.5
Kim, S.B.6
Pienkowski, T.7
Lichinitser, M.8
Semiglazov, V.9
Melichar, B.10
Jackisch, C.11
-
31
-
-
84856444501
-
Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-Taxane-based chemotherapy (GeparQuinto, GBG 44): A randomised phase 3 trial
-
PMID: 22257523
-
Untch M, Loibl S, Bischoff J, Eidtmann H, Kaufmann M, Blohmer JU, Hilfrich J, Strumberg D, Fasching PA, Kreienberg R, Tesch H, Hanusch C, Gerber B, Rezai M, Jackisch C, Huober J, Khn T, Nekljudova V, von Minckwitz G. Lapatinib versus trastuzumab in combination with neoadjuvant anthracycline-Taxane-based chemotherapy (GeparQuinto, GBG 44): A randomised phase 3 trial. Lancet Oncol 2012; 13: 135-144 [PMID: 22257523 DOI: 10.1016/S1470-2045(11)70397-7]
-
(2012)
Lancet Oncol
, vol.13
, pp. 135-144
-
-
Untch, M.1
Loibl, S.2
Bischoff, J.3
Eidtmann, H.4
Kaufmann, M.5
Blohmer, J.U.6
Hilfrich, J.7
Strumberg, D.8
Fasching, P.A.9
Kreienberg, R.10
Tesch, H.11
Hanusch, C.12
Gerber, B.13
Rezai, M.14
Jackisch, C.15
Huober, J.16
Khn, T.17
Nekljudova, V.18
Von Minckwitz, G.19
-
32
-
-
84857236823
-
Lapatinib with trastuzumab for HER2-positive early breast cancer (Neo-ALTTO): A randomised, open-label, multicentre, phase 3 trial
-
PMID: 22257673
-
Baselga J, Bradbury I, Eidtmann H, Di Cosimo S, de Azambuja E, Aura C, Gmez H, Dinh P, Fauria K, Van Dooren V, Aktan G, Goldhirsch A, Chang TW, Horvth Z, Coccia-Portugal M, Domont J, Tseng LM, Kunz G, Sohn JH, Semiglazov V, Lerzo G, Palacova M, Probachai V, Pusztai L, Untch M, Gelber RD, Piccart-Gebhart M. Lapatinib with trastuzumab for HER2-positive early breast cancer (Neo-ALTTO): A randomised, open-label, multicentre, phase 3 trial. Lancet 2012; 379: 633-640 [PMID: 22257673 DOI: 10.1016/S0140-6736(11)61847-3]
-
(2012)
Lancet
, vol.379
, pp. 633-640
-
-
Baselga, J.1
Bradbury, I.2
Eidtmann, H.3
Di Cosimo, S.4
De Azambuja, E.5
Aura, C.6
Gmez, H.7
Dinh, P.8
Fauria, K.9
Van Dooren, V.10
Aktan, G.11
Goldhirsch, A.12
Chang, T.W.13
Horvth, Z.14
Coccia-Portugal, M.15
Domont, J.16
Tseng, L.M.17
Kunz, G.18
Sohn, J.H.19
Semiglazov, V.20
Lerzo, G.21
Palacova, M.22
Probachai, V.23
Pusztai, L.24
Untch, M.25
Gelber, R.D.26
Piccart-Gebhart, M.27
more..
-
33
-
-
84886721495
-
Lapatinib as a component of neoadjuvant therapy for HER2-positive operable breast cancer (NSABP protocol B-41): An open-label, randomised phase 3 trial
-
PMID: 24095300
-
Robidoux A, Tang G, Rastogi P, Geyer CE, Azar CA, Atkins JN, Fehrenbacher L, Bear HD, Baez-Diaz L, Sarwar S, Margolese RG, Farrar WB, Brufsky AM, Shibata HR, Bandos H, Paik S, Costantino JP, Swain SM, Mamounas EP, Wolmark N. Lapatinib as a component of neoadjuvant therapy for HER2-positive operable breast cancer (NSABP protocol B-41): An open-label, randomised phase 3 trial. Lancet Oncol 2013; 14: 1183-1192 [PMID: 24095300 DOI: 10.1016/S1470-2045(13)70411-X]
-
(2013)
Lancet Oncol
, vol.14
, pp. 1183-1192
-
-
Robidoux, A.1
Tang, G.2
Rastogi, P.3
Geyer, C.E.4
Azar, C.A.5
Atkins, J.N.6
Fehrenbacher, L.7
Bear, H.D.8
Baez-Diaz, L.9
Sarwar, S.10
Margolese, R.G.11
Farrar, W.B.12
Brufsky, A.M.13
Shibata, H.R.14
Bandos, H.15
Paik, S.16
Costantino, J.P.17
Swain, S.M.18
Mamounas, E.P.19
Wolmark, N.20
more..
-
34
-
-
84855297353
-
Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (Neo-Sphere): A randomised multicentre, open-label, phase 2 trial
-
PMID: 22153890
-
Gianni L, Pienkowski T, Im YH, Roman L, Tseng LM, Liu MC, Lluch A, Staroslawska E, de la Haba-Rodriguez J, Im SA, Pedrini JL, Poirier B, Morandi P, Semiglazov V, Srimuninnimit V, Bianchi G, Szado T, Ratnayake J, Ross G, Valagussa P. Efficacy and safety of neoadjuvant pertuzumab and trastuzumab in women with locally advanced, inflammatory, or early HER2-positive breast cancer (Neo-Sphere): A randomised multicentre, open-label, phase 2 trial. Lancet Oncol 2012; 13: 25-32 [PMID: 22153890 DOI: 10.1016/S1470-2045(11)70336-9]
-
(2012)
Lancet Oncol
, vol.13
, pp. 25-32
-
-
Gianni, L.1
Pienkowski, T.2
Im, Y.H.3
Roman, L.4
Tseng, L.M.5
Liu, M.C.6
Lluch, A.7
Staroslawska, E.8
De La Haba-Rodriguez, J.9
Im, S.A.10
Pedrini, J.L.11
Poirier, B.12
Morandi, P.13
Semiglazov, V.14
Srimuninnimit, V.15
Bianchi, G.16
Szado, T.17
Ratnayake, J.18
Ross, G.19
Valagussa, P.20
more..
-
35
-
-
84856700379
-
S5-6: Neoadjuvant Pertuzumab and Trastuzumab Concurrent or Sequential with an Anthracycline-Containing or Concurrent with an Anthracycline-Free Standard Regimen: A Randomized Phase II Study (TRYPHAENA
-
Schneeweiss A, Chia S, Hickish T, Harvey V, Eniu A, Hegg R, Tausch C, Seo J, Tsai Y, Ackrill A, Ross G, Cortes J . S5-6: Neoadjuvant Pertuzumab and Trastuzumab Concurrent or Sequential with an Anthracycline-Containing or Concurrent with an Anthracycline-Free Standard Regimen: A Randomized Phase II Study (TRYPHAENA). Cancer Research 2012; 71: S5-6 [DOI: 10.1158/0008-5472.SABCS11-S5-6]
-
(2012)
Cancer Research
, vol.71
, pp. S5-6
-
-
Schneeweiss, A.1
Chia, S.2
Hickish, T.3
Harvey, V.4
Eniu, A.5
Hegg, R.6
Tausch, C.7
Seo, J.8
Tsai, Y.9
Ackrill, A.10
Ross, G.11
Cortes, J.12
-
36
-
-
84883359410
-
Pertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline-containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer: A randomized phase II cardiac safety study (TRYPHAENA
-
PMID: 23704196
-
Schneeweiss A, Chia S, Hickish T, Harvey V, Eniu A, Hegg R, Tausch C, Seo JH, Tsai YF, Ratnayake J, McNally V, Ross G, Corts J. Pertuzumab plus trastuzumab in combination with standard neoadjuvant anthracycline-containing and anthracycline-free chemotherapy regimens in patients with HER2-positive early breast cancer: A randomized phase II cardiac safety study (TRYPHAENA). Ann Oncol 2013; 24: 2278-2284 [PMID: 23704196 DOI: 10.1093/annonc/mdt182]
-
(2013)
Ann Oncol
, vol.24
, pp. 2278-2284
-
-
Schneeweiss, A.1
Chia, S.2
Hickish, T.3
Harvey, V.4
Eniu, A.5
Hegg, R.6
Tausch, C.7
Seo, J.H.8
Tsai, Y.F.9
Ratnayake, J.10
McNally, V.11
Ross, G.12
Corts, J.13
-
37
-
-
84862893473
-
Pathological complete response and accelerated drug approval in early breast cancer
-
PMID: 22646508
-
Prowell TM, Pazdur R. Pathological complete response and accelerated drug approval in early breast cancer. N Engl J Med 2012; 366: 2438-2441 [PMID: 22646508 DOI: 10.1056/NEJMp1205737]
-
(2012)
N Engl J Med
, vol.366
, pp. 2438-2441
-
-
Prowell, T.M.1
Pazdur, R.2
-
38
-
-
39749116055
-
Preoperative chemotherapy for women with operable breast cancer
-
PMID: 17443564
-
Mieog JS, van der Hage JA, van de Velde CJ. Preoperative chemotherapy for women with operable breast cancer. Cochrane Database Syst Rev 2007; (2): CD005002 [PMID: 17443564 DOI: 10.1002/14651858.CD005002.pub2]
-
(2007)
Cochrane Database Syst Rev
, Issue.2
, pp. CD005002
-
-
Mieog, J.S.1
Van Der Hage, J.A.2
Van De Velde, C.J.3
-
39
-
-
84875187933
-
Meta-Analysis results from the collaborative trials in neoadjuvant breast cancer (CTNeoBC
-
Cortazar P, Zhang L, Untch M, Mehta K, Costantino J, Wolmark N, Bonnefoi H, Cameron D, Gianni L, Valagussa P, Zujewski J, Justice R, Loibl S, Wickerham L, Bogaerts J, Baselga J, Perou C, Blumenthal G, Blohmer J, Mamounas E, Bergh J, Semiglazov V, Prowell T, Eidtmann H, Paik S, Piccart M, Sridhara R, Fasching P, Swain S, Slaets L, Tang S, Gerber B, Geyer C, Pazdur R, Ditsch N, Rastogi P, Eiermann W, von Mincwitz G . Meta-Analysis Results from the Collaborative Trials in Neoadjuvant Breast Cancer (CTNeoBC). Cancer Research 2012; 72: S1-11 [DOI: 10.1158/0008-5472. SABCS12-S1-11]
-
(2012)
Cancer Research
, vol.72
, pp. S1-11
-
-
Cortazar, P.1
Zhang, L.2
Untch, M.3
Mehta, K.4
Costantino, J.5
Wolmark, N.6
Bonnefoi, H.7
Cameron, D.8
Gianni, L.9
Valagussa, P.10
Zujewski, J.11
Justice, R.12
Loibl, S.13
Wickerham, L.14
Bogaerts, J.15
Baselga, J.16
Perou, C.17
Blumenthal, G.18
Blohmer, J.19
Mamounas, E.20
Bergh, J.21
Semiglazov, V.22
Prowell, T.23
Eidtmann, H.24
Paik, S.25
Piccart, M.26
Sridhara, R.27
Fasching, P.28
Swain, S.29
Slaets, L.30
Tang, S.31
Gerber, B.32
Geyer, C.33
Pazdur, R.34
Ditsch, N.35
Rastogi, P.36
Eiermann, W.37
Von Mincwitz, G.38
more..
-
40
-
-
84862303759
-
Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes
-
PMID: 22508812
-
von Minckwitz G, Untch M, Blohmer JU, Costa SD, Eidtmann H, Fasching PA, Gerber B, Eiermann W, Hilfrich J, Huober J, Jackisch C, Kaufmann M, Konecny GE, Denkert C, Nekljudova V, Mehta K, Loibl S. Definition and impact of pathologic complete response on prognosis after neoadjuvant chemotherapy in various intrinsic breast cancer subtypes. J Clin Oncol 2012; 30: 1796-1804 [PMID: 22508812 DOI: 10.1200/JCO.2011.38.8595]
-
(2012)
J Clin Oncol
, vol.30
, pp. 1796-1804
-
-
Von Minckwitz, G.1
Untch, M.2
Blohmer, J.U.3
Costa, S.D.4
Eidtmann, H.5
Fasching, P.A.6
Gerber, B.7
Eiermann, W.8
Hilfrich, J.9
Huober, J.10
Jackisch, C.11
Kaufmann, M.12
Konecny, G.E.13
Denkert, C.14
Nekljudova, V.15
Mehta, K.16
Loibl, S.17
-
41
-
-
84877948642
-
Predictive factors of response in her2-positive breast cancer treated by neoadjuvant therapy
-
PMID: 23737784
-
Guiu S, Mouret Reynier MA, Toure M, Coudert B. Predictive Factors of Response in HER2-Positive Breast Cancer Treated by Neoadjuvant Therapy. J Oncol 2013; 2013: 854121 [PMID: 23737784 DOI: 10.1155/2013/854121]
-
(2013)
J Oncol 2013
, pp. 854121
-
-
Guiu, S.1
Mouret Reynier, M.A.2
Toure, M.3
Coudert, B.4
-
42
-
-
0032850677
-
Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease
-
PMID: 10561337
-
Cobleigh MA, Vogel CL, Tripathy D, Robert NJ, Scholl S, Fehrenbacher L, Wolter JM, Paton V, Shak S, Lieberman G, Slamon DJ. Multinational study of the efficacy and safety of humanized anti-HER2 monoclonal antibody in women who have HER2-overexpressing metastatic breast cancer that has progressed after chemotherapy for metastatic disease. J Clin Oncol 1999; 17: 2639-2648 [PMID: 10561337]
-
(1999)
J Clin Oncol
, vol.17
, pp. 2639-2648
-
-
Cobleigh, M.A.1
Vogel, C.L.2
Tripathy, D.3
Robert, N.J.4
Scholl, S.5
Fehrenbacher, L.6
Wolter, J.M.7
Paton, V.8
Shak, S.9
Lieberman, G.10
Slamon, D.J.11
-
43
-
-
11144357739
-
Efficacy and safety of trastuzumab as a single agent in heavily pretreated patients with HER-2/neu-overexpressing metastatic breast cancer
-
PMID: 15143970
-
Sawaki M, Ito Y, Tada K, Mizunuma N, Takahashi S, Horikoshi N, Kasumi F, Akiyama F, Sakamoto G, Imai T, Nakao A, Hatake K. Efficacy and safety of trastuzumab as a single agent in heavily pretreated patients with HER-2/neu-overexpressing metastatic breast cancer. Tumori 2004; 90: 40-43 [PMID: 15143970]
-
(2004)
Tumori
, vol.90
, pp. 40-43
-
-
Sawaki, M.1
Ito, Y.2
Tada, K.3
Mizunuma, N.4
Takahashi, S.5
Horikoshi, N.6
Kasumi, F.7
Akiyama, F.8
Sakamoto, G.9
Imai, T.10
Nakao, A.11
Hatake, K.12
-
44
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Norton PMID: 11248153
-
Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, Fleming T, Eiermann W, Wolter J, Pegram M, Baselga J, Norton L. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001; 344: 783-792 [PMID: 11248153 DOI: 10.1056/NEJM200103153441101]
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
Fleming, T.7
Eiermann, W.8
Wolter, J.9
Pegram, M.10
Baselga, J.L.11
-
45
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
PMID: 11821453
-
Vogel CL, Cobleigh MA, Tripathy D, Gutheil JC, Harris LN, Fehrenbacher L, Slamon DJ, Murphy M, Novotny WF, Burchmore M, Shak S, Stewart SJ, Press M. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002; 20: 719-726 [PMID: 11821453]
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
Gutheil, J.C.4
Harris, L.N.5
Fehrenbacher, L.6
Slamon, D.J.7
Murphy, M.8
Novotny, W.F.9
Burchmore, M.10
Shak, S.11
Stewart, S.J.12
Press, M.13
-
46
-
-
77949901499
-
Open-label, phase II, multicenter, randomized study of the efficacy and safety of two dose levels of Pertuzumab, a human epidermal growth factor receptor 2 dimerization inhibitor, in patients with human epidermal growth factor receptor 2-negative metastatic breast cancer
-
PMID: 20124183
-
Gianni L, Llad A, Bianchi G, Cortes J, Kellokumpu-Lehtinen PL, Cameron DA, Miles D, Salvagni S, Wardley A, Goeminne JC, Hersberger V, Baselga J. Open-label, phase II, multicenter, randomized study of the efficacy and safety of two dose levels of Pertuzumab, a human epidermal growth factor receptor 2 dimerization inhibitor, in patients with human epidermal growth factor receptor 2-negative metastatic breast cancer. J Clin Oncol 2010; 28: 1131-1137 [PMID: 20124183 DOI: 10.1200/JCO.2009.24.1661]
-
(2011)
J Clin Oncol
, vol.28
, pp. 1131-1137
-
-
Gianni, L.1
Llad, A.2
Bianchi, G.3
Cortes, J.4
Kellokumpu-Lehtinen, P.L.5
Cameron, D.A.6
Miles, D.7
Salvagni, S.8
Wardley, A.9
Goeminne, J.C.10
Hersberger, V.11
Baselga, J.12
-
47
-
-
61649118623
-
Single-Agent lapatinib for HER2-overexpressing advanced or metastatic breast cancer that progressed on first-or second-line trastuzumab-containing regimens
-
PMID: 19179558
-
Blackwell KL, Pegram MD, Tan-Chiu E, Schwartzberg LS, Arbushites MC, Maltzman JD, Forster JK, Rubin SD, Stein SH, Burstein HJ. Single-Agent lapatinib for HER2-overexpressing advanced or metastatic breast cancer that progressed on first-or second-line trastuzumab-containing regimens. Ann Oncol 2009; 20: 1026-1031 [PMID: 19179558 DOI: 10.1093/annonc/mdn759]
-
(2009)
Ann Oncol
, vol.20
, pp. 1026-1031
-
-
Blackwell, K.L.1
Pegram, M.D.2
Tan-Chiu, E.3
Schwartzberg, L.S.4
Arbushites, M.C.5
Maltzman, J.D.6
Forster, J.K.7
Rubin, S.D.8
Stein, S.H.9
Burstein, H.J.10
-
48
-
-
84863688392
-
A phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine
-
PMID: 22649126
-
Krop IE, LoRusso P, Miller KD, Modi S, Yardley D, Rodriguez G, Guardino E, Lu M, Zheng M, Girish S, Amler L, Winer EP, Rugo HS. A phase II study of trastuzumab emtansine in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer who were previously treated with trastuzumab, lapatinib, an anthracycline, a taxane, and capecitabine. J Clin Oncol 2012; 30: 3234-3241 [PMID: 22649126 DOI: 10.1200/JCO.2011.40.5902]
-
(2012)
J Clin Oncol
, vol.30
, pp. 3234-3241
-
-
Krop, I.E.1
LoRusso, P.2
Miller, K.D.3
Modi, S.4
Yardley, D.5
Rodriguez, G.6
Guardino, E.7
Lu, M.8
Zheng, M.9
Girish, S.10
Amler, L.11
Winer, E.P.12
Rugo, H.S.13
-
49
-
-
34548178720
-
Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: The trastuzumab and vinorelbine or taxane study
-
PMID: 17614302
-
Burstein HJ, Keshaviah A, Baron AD, Hart RD, Lambert-Falls R, Marcom PK, Gelman R, Winer EP. Trastuzumab plus vinorelbine or taxane chemotherapy for HER2-overexpressing metastatic breast cancer: The trastuzumab and vinorelbine or taxane study. Cancer 2007; 110: 965-972 [PMID: 17614302 DOI: 10.1002/cncr.22885]
-
(2007)
Cancer
, vol.110
, pp. 965-972
-
-
Burstein, H.J.1
Keshaviah, A.2
Baron, A.D.3
Hart, R.D.4
Lambert-Falls, R.5
Marcom, P.K.6
Gelman, R.7
Winer, E.P.8
-
50
-
-
33745530224
-
Randomized phase III study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with HER-2-overexpressing metastatic breast cancer
-
PMID: 16782917
-
Robert N, Leyland-Jones B, Asmar L, Belt R, Ilegbodu D, Loesch D, Raju R, Valentine E, Sayre R, Cobleigh M, Albain K, McCullough C, Fuchs L, Slamon D. Randomized phase III study of trastuzumab, paclitaxel, and carboplatin compared with trastuzumab and paclitaxel in women with HER-2-overexpressing metastatic breast cancer. J Clin Oncol 2006; 24: 2786-2792 [PMID: 16782917 DOI: 10.1200/JCO.2005.04.1764]
-
(2006)
J Clin Oncol
, vol.24
, pp. 2786-2792
-
-
Robert, N.1
Leyland-Jones, B.2
Asmar, L.3
Belt, R.4
Ilegbodu, D.5
Loesch, D.6
Raju, R.7
Valentine, E.8
Sayre, R.9
Cobleigh, M.10
Albain, K.11
McCullough, C.12
Fuchs, L.13
Slamon, D.14
-
51
-
-
77953426044
-
Role of lapatinib in the first-line treatment of patients with metastatic breast cancer
-
PMID: 21188093
-
Oakman C, Pestrin M, Zafarana E, Cantisani E, Di Leo A. Role of lapatinib in the first-line treatment of patients with metastatic breast cancer. Cancer Manag Res 2010; 2: 13-25 [PMID: 21188093]
-
(2011)
Cancer Manag Res
, vol.2
, pp. 13-25
-
-
Oakman, C.1
Pestrin, M.2
Zafarana, E.3
Cantisani, E.4
Di Leo, A.5
-
52
-
-
65349110371
-
Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: A German breast group 26/breast international group 03-05 study
-
PMID: 19289619
-
von Minckwitz G, du Bois A, Schmidt M, Maass N, Cufer T, de Jongh FE, Maartense E, Zielinski C, Kaufmann M, Bauer W, Baumann KH, Clemens MR, Duerr R, Uleer C, Andersson M, Stein RC, Nekljudova V, Loibl S. Trastuzumab beyond progression in human epidermal growth factor receptor 2-positive advanced breast cancer: A german breast group 26/breast international group 03-05 study. J Clin Oncol 2009; 27: 1999-2006 [PMID: 19289619 DOI: 10.1200/JCO.2008.19.6618]
-
(2009)
J Clin Oncol
, vol.27
, pp. 1999-2006
-
-
Von Minckwitz, G.1
Du Bois, A.2
Schmidt, M.3
Maass, N.4
Cufer, T.5
De Jongh, F.E.6
Maartense, E.7
Zielinski, C.8
Kaufmann, M.9
Bauer, W.10
Baumann, K.H.11
Clemens, M.R.12
Duerr, R.13
Uleer, C.14
Andersson, M.15
Stein, R.C.16
Nekljudova, V.17
Loibl, S.18
-
53
-
-
80053362290
-
Trastuzumab beyond progression: Overall survival analysis of the GBG 26/BIG 3-05 phase III study in HER2-positive breast cancer
-
PMID: 21741829
-
von Minckwitz G, Schwedler K, Schmidt M, Barinoff J, Mundhenke C, Cufer T, Maartense E, de Jongh FE, Baumann KH, Bischoff J, Harbeck N, Lck HJ, Maass N, Zielinski C, Andersson M, Stein RC, Nekljudova V, Loibl S. Trastuzumab beyond progression: overall survival analysis of the GBG 26/BIG 3-05 phase III study in HER2-positive breast cancer. Eur J Cancer 2011; 47: 2273-2281 [PMID: 21741829 DOI: 10.1016/j.ejca.2011.06.021]
-
(2011)
Eur J Cancer
, vol.47
, pp. 2273-2281
-
-
Von Minckwitz, G.1
Schwedler, K.2
Schmidt, M.3
Barinoff, J.4
Mundhenke, C.5
Cufer, T.6
Maartense, E.7
De Jongh, F.E.8
Baumann, K.H.9
Bischoff, J.10
Harbeck, N.11
Lck, H.J.12
Maass, N.13
Zielinski, C.14
Andersson, M.15
Stein, R.C.16
Nekljudova, V.17
Loibl, S.18
-
54
-
-
33845886440
-
Lapatinib plus capecitabine for HER2-positive advanced breast cancer
-
PMID: 17192538
-
Geyer CE, Forster J, Lindquist D, Chan S, Romieu CG, Pienkowski T, Jagiello-Gruszfeld A, Crown J, Chan A, Kaufman B, Skarlos D, Campone M, Davidson N, Berger M, Oliva C, Rubin SD, Stein S, Cameron D. Lapatinib plus capecitabine for HER2-positive advanced breast cancer. N Engl J Med 2006; 355: 2733-2743 [PMID: 17192538 DOI: 10.1056/NEJMoa064320]
-
(2006)
N Engl J Med
, vol.355
, pp. 2733-2743
-
-
Geyer, C.E.1
Forster, J.2
Lindquist, D.3
Chan, S.4
Romieu, C.G.5
Pienkowski, T.6
Jagiello-Gruszfeld, A.7
Crown, J.8
Chan, A.9
Kaufman, B.10
Skarlos, D.11
Campone, M.12
Davidson, N.13
Berger, M.14
Oliva, C.15
Rubin, S.D.16
Stein, S.17
Cameron, D.18
-
55
-
-
84868520609
-
Trastuzumab emtansine for HER2-positive advanced breast cancer
-
PMID: 23020162
-
Verma S, Miles D, Gianni L, Krop IE, Welslau M, Baselga J, Pegram M, Oh DY, Diras V, Guardino E, Fang L, Lu MW, Olsen S, Blackwell K. Trastuzumab emtansine for HER2-positive advanced breast cancer. N Engl J Med 2012; 367: 1783-1791 [PMID: 23020162 DOI: 10.1056/NEJMoa1209124]
-
(2012)
N Engl J Med
, vol.367
, pp. 1783-1791
-
-
Verma, S.1
Miles, D.2
Gianni, L.3
Krop, I.E.4
Welslau, M.5
Baselga, J.6
Pegram, M.7
Oh, D.Y.8
Diras, V.9
Guardino, E.10
Fang, L.11
Lu, M.W.12
Olsen, S.13
Blackwell, K.14
-
56
-
-
84876011018
-
Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer
-
PMID: 23382472
-
Hurvitz SA, Dirix L, Kocsis J, Bianchi GV, Lu J, Vinholes J, Guardino E, Song C, Tong B, Ng V, Chu YW, Perez EA. Phase II randomized study of trastuzumab emtansine versus trastuzumab plus docetaxel in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer. J Clin Oncol 2013; 31: 1157-1163 [PMID: 23382472 DOI: 10.1200/JCO.2012.44.9694]
-
(2013)
J Clin Oncol
, vol.31
, pp. 1157-1163
-
-
Hurvitz, S.A.1
Dirix, L.2
Kocsis, J.3
Bianchi, G.V.4
Lu, J.5
Vinholes, J.6
Guardino, E.7
Song, C.8
Tong, B.9
Ng, V.10
Chu, Y.W.11
Perez, E.A.12
-
57
-
-
84862914692
-
Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer
-
PMID: 22149875
-
Baselga J, Corts J, Kim SB, Im SA, Hegg R, Im YH, Roman L, Pedrini JL, Pienkowski T, Knott A, Clark E, Benyunes MC, Ross G, Swain SM. Pertuzumab plus trastuzumab plus docetaxel for metastatic breast cancer. N Engl J Med 2012; 366: 109-119 [PMID: 22149875 DOI: 10.1056/NEJMoa1113216]
-
(2012)
N Engl J Med
, vol.366
, pp. 109-119
-
-
Baselga, J.1
Corts, J.2
Kim, S.B.3
Im, S.A.4
Hegg, R.5
Im, Y.H.6
Roman, L.7
Pedrini, J.L.8
Pienkowski, T.9
Knott, A.10
Clark, E.11
Benyunes, M.C.12
Ross, G.13
Swain, S.M.14
-
58
-
-
84876970810
-
Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): Overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study
-
PMID: 23602601
-
Swain SM, Kim SB, Corts J, Ro J, Semiglazov V, Campone M, Ciruelos E, Ferrero JM, Schneeweiss A, Knott A, Clark E, Ross G, Benyunes MC, Baselga J. Pertuzumab, trastuzumab, and docetaxel for HER2-positive metastatic breast cancer (CLEOPATRA study): overall survival results from a randomised, double-blind, placebo-controlled, phase 3 study. Lancet Oncol 2013; 14: 461-471 [PMID: 23602601 DOI: 10.1016/S1470-2045(13)70130-X]
-
(2013)
Lancet Oncol
, vol.14
, pp. 461-471
-
-
Swain, S.M.1
Kim, S.B.2
Corts, J.3
Ro, J.4
Semiglazov, V.5
Campone, M.6
Ciruelos, E.7
Ferrero, J.M.8
Schneeweiss, A.9
Knott, A.10
Clark, E.11
Ross, G.12
Benyunes, M.C.13
Baselga, J.14
-
59
-
-
77949884661
-
Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer
-
PMID: 20124187
-
Blackwell KL, Burstein HJ, Storniolo AM, Rugo H, Sledge G, Koehler M, Ellis C, Casey M, Vukelja S, Bischoff J, Baselga J, OShaughnessy J. Randomized study of Lapatinib alone or in combination with trastuzumab in women with ErbB2-positive, trastuzumab-refractory metastatic breast cancer. J Clin Oncol 2010; 28: 1124-1130 [PMID: 20124187 DOI: 10.1200/JCO.2008.21.4437]
-
(2011)
J Clin Oncol
, vol.28
, pp. 1124-1130
-
-
Blackwell, K.L.1
Burstein, H.J.2
Storniolo, A.M.3
Rugo, H.4
Sledge, G.5
Koehler, M.6
Ellis, C.7
Casey, M.8
Vukelja, S.9
Bischoff, J.10
Baselga, J.11
OShaughnessy, J.12
-
60
-
-
84864066561
-
Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: Final results from the EGF104900 Study
-
PMID: 22689807
-
Blackwell KL, Burstein HJ, Storniolo AM, Rugo HS, Sledge G, Aktan G, Ellis C, Florance A, Vukelja S, Bischoff J, Baselga J, OShaughnessy J. Overall survival benefit with lapatinib in combination with trastuzumab for patients with human epidermal growth factor receptor 2-positive metastatic breast cancer: final results from the EGF104900 Study. J Clin Oncol 2012; 30: 2585-2592 [PMID: 22689807 DOI: 10.1200/JCO.2011.35.6725]
-
(2012)
J Clin Oncol
, vol.30
, pp. 2585-2592
-
-
Blackwell, K.L.1
Burstein, H.J.2
Storniolo, A.M.3
Rugo, H.S.4
Sledge, G.5
Aktan, G.6
Ellis, C.7
Florance, A.8
Vukelja, S.9
Bischoff, J.10
Baselga, J.11
OShaughnessy, J.12
-
61
-
-
77949903478
-
Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy
-
PMID: 20124182
-
Baselga J, Gelmon KA, Verma S, Wardley A, Conte P, Miles D, Bianchi G, Cortes J, McNally VA, Ross GA, Fumoleau P, Gianni L. Phase II trial of pertuzumab and trastuzumab in patients with human epidermal growth factor receptor 2-positive metastatic breast cancer that progressed during prior trastuzumab therapy. J Clin Oncol 2010; 28: 1138-1144 [PMID: 20124182 DOI: 10.1200/JCO.2009.24.2024]
-
(2011)
J Clin Oncol
, vol.28
, pp. 1138-1144
-
-
Baselga, J.1
Gelmon, K.A.2
Verma, S.3
Wardley, A.4
Conte, P.5
Miles, D.6
Bianchi, G.7
Cortes, J.8
McNally, V.A.9
Ross, G.A.10
Fumoleau, P.11
Gianni, L.12
-
62
-
-
0037440261
-
Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer
-
PMID: 12529347
-
Konecny G, Pauletti G, Pegram M, Untch M, Dandekar S, Aguilar Z, Wilson C, Rong HM, Bauerfeind I, Felber M, Wang HJ, Beryt M, Seshadri R, Hepp H, Slamon DJ. Quantitative association between HER-2/neu and steroid hormone receptors in hormone receptor-positive primary breast cancer. J Natl Cancer Inst 2003; 95: 142-153 [PMID: 12529347]
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 142-153
-
-
Konecny, G.1
Pauletti, G.2
Pegram, M.3
Untch, M.4
Dandekar, S.5
Aguilar, Z.6
Wilson, C.7
Rong, H.M.8
Bauerfeind, I.9
Felber, M.10
Wang, H.J.11
Beryt, M.12
Seshadri, R.13
Hepp, H.14
Slamon, D.J.15
-
63
-
-
73949105921
-
Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: Results from the randomized phase III TAnDEM study
-
PMID: 19786670
-
Kaufman B, Mackey JR, Clemens MR, Bapsy PP, Vaid A, Wardley A, Tjulandin S, Jahn M, Lehle M, Feyereislova A, Rvil C, Jones A. Trastuzumab plus anastrozole versus anastrozole alone for the treatment of postmenopausal women with human epidermal growth factor receptor 2-positive, hormone receptor-positive metastatic breast cancer: results from the randomized phase III TAnDEM study. J Clin Oncol 2009; 27: 5529-5537 [PMID: 19786670 DOI: 10.1200/JCO.2008.20.6847]
-
(2009)
J Clin Oncol
, vol.27
, pp. 5529-5537
-
-
Kaufman, B.1
Mackey, J.R.2
Clemens, M.R.3
Bapsy, P.P.4
Vaid, A.5
Wardley, A.6
Tjulandin, S.7
Jahn, M.8
Lehle, M.9
Feyereislova, A.10
Rvil, C.11
Jones, A.12
-
64
-
-
73149115341
-
Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for post-menopausal hormone receptor-positive metastatic breast cancer
-
PMID: 19786658
-
Johnston S, Pippen J, Pivot X, Lichinitser M, Sadeghi S, Dieras V, Gomez HL, Romieu G, Manikhas A, Kennedy MJ, Press MF, Maltzman J, Florance A, ORourke L, Oliva C, Stein S, Pegram M. Lapatinib combined with letrozole versus letrozole and placebo as first-line therapy for post-menopausal hormone receptor-positive metastatic breast cancer. J Clin Oncol 2009; 27: 5538-5546 [PMID: 19786658 DOI: 10.1200/JCO.2009.23.3734]
-
(2009)
J Clin Oncol
, vol.27
, pp. 5538-5546
-
-
Johnston, S.1
Pippen, J.2
Pivot, X.3
Lichinitser, M.4
Sadeghi, S.5
Dieras, V.6
Gomez, H.L.7
Romieu, G.8
Manikhas, A.9
Kennedy, M.J.10
Press, M.F.11
Maltzman, J.12
Florance, A.13
ORourke, L.14
Oliva, C.15
Stein, S.16
Pegram, M.17
-
65
-
-
84856319982
-
Higher efficacy of letrozole in combination with trastuzumab compared to letrozole monotherapy as first-line treatment in patients with HER2-positive, hormone-receptor-positive metastatic breast cancer-results of the eLEcTRA trial
-
PMID: 21862331
-
Huober J, Fasching PA, Barsoum M, Petruzelka L, Wallwiener D, Thomssen C, Reimer T, Paepke S, Azim HA, Ragosch V, Kubista E, Baumgrtner AK, Beckmann MW, May C, Nimmrich I, Harbeck N. Higher efficacy of letrozole in combination with trastuzumab compared to letrozole monotherapy as first-line treatment in patients with HER2-positive, hormone-receptor-positive metastatic breast cancer-results of the eLEcTRA trial. Breast 2012; 21: 27-33 [PMID: 21862331 DOI: 10.1016/j.breast.2011.07.006]
-
(2012)
Breast
, vol.21
, pp. 27-33
-
-
Huober, J.1
Fasching, P.A.2
Barsoum, M.3
Petruzelka, L.4
Wallwiener, D.5
Thomssen, C.6
Reimer, T.7
Paepke, S.8
Azim, H.A.9
Ragosch, V.10
Kubista, E.11
Baumgrtner, A.K.12
Beckmann, M.W.13
May, C.14
Nimmrich, I.15
Harbeck, N.16
-
66
-
-
84887461298
-
HER story: The next chapter in HER-2-directed therapy for advanced breast cancer
-
PMID: 24212500
-
Verma S, Joy AA, Rayson D, McLeod D, Brezden-Masley C, Boileau JF, Gelmon KA. HER story: The next chapter in HER-2-directed therapy for advanced breast cancer. Oncologist 2013; 18: 1153-1166 [PMID: 24212500 DOI: 10.1634/theoncologist. 2013-0217]
-
(2013)
Oncologist
, vol.18
, pp. 1153-1166
-
-
Verma, S.1
Joy, A.A.2
Rayson, D.3
McLeod, D.4
Brezden-Masley, C.5
Boileau, J.F.6
Gelmon, K.A.7
-
67
-
-
84878430061
-
Incidence and risk of central nervous system metastases as site of first recurrence in patients with HER2-positive breast cancer treated with adjuvant trastuzumab
-
PMID: 23463626
-
Olson EM, Abdel-Rasoul M, Maly J, Wu CS, Lin NU, Shapiro CL. Incidence and risk of central nervous system metastases as site of first recurrence in patients with HER2-positive breast cancer treated with adjuvant trastuzumab. Ann Oncol 2013; 24: 1526-1533 [PMID: 23463626 DOI: 10.1093/annonc/mdt036]
-
(2013)
Ann Oncol
, vol.24
, pp. 1526-1533
-
-
Olson, E.M.1
Abdel-Rasoul, M.2
Maly, J.3
Wu, C.S.4
Lin, N.U.5
Shapiro, C.L.6
-
68
-
-
56549113680
-
A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: Updated efficacy and biomarker analyses
-
PMID: 18188694
-
Cameron D, Casey M, Press M, Lindquist D, Pienkowski T, Romieu CG, Chan S, Jagiello-Gruszfeld A, Kaufman B, Crown J, Chan A, Campone M, Viens P, Davidson N, Gorbounova V, Raats JI, Skarlos D, Newstat B, Roychowdhury D, Paoletti P, Oliva C, Rubin S, Stein S, Geyer CE. A phase III randomized comparison of lapatinib plus capecitabine versus capecitabine alone in women with advanced breast cancer that has progressed on trastuzumab: updated efficacy and biomarker analyses. Breast Cancer Res Treat 2008; 112: 533-543 [PMID: 18188694 DOI: 10.1007/s10549-007-9885-0]
-
(2008)
Breast Cancer Res Treat
, vol.112
, pp. 533-543
-
-
Cameron, D.1
Casey, M.2
Press, M.3
Lindquist, D.4
Pienkowski, T.5
Romieu, C.G.6
Chan, S.7
Jagiello-Gruszfeld, A.8
Kaufman, B.9
Crown, J.10
Chan, A.11
Campone, M.12
Viens, P.13
Davidson, N.14
Gorbounova, V.15
Raats, J.I.16
Skarlos, D.17
Newstat, B.18
Roychowdhury, D.19
Paoletti, P.20
Oliva, C.21
Rubin, S.22
Stein, S.23
Geyer, C.E.24
more..
-
69
-
-
84887245412
-
CEREBEL (EGF111438): An open label randomised phase III study comparing the incidence of CNS metastases in patients with HER2 metastatic breast cancer, treated with lapatinib plus capecitabine versus trastuzumab plus capecitabine
-
Abstract LBA11
-
Pivot X, Zurawski B, Allerton R, Fabi A, Ciruelos E, Parikh R, Desilvio M, Santillana S, Swaby R, Semig V. CEREBEL (EGF111438): An open label randomised phase III study comparing the incidence of CNS metastases in patients with HER2 metastatic breast cancer, treated with lapatinib plus capecitabine versus trastuzumab plus capecitabine. ESMO, 2012: Abstract LBA11
-
(2012)
ESMO
-
-
Pivot, X.1
Zurawski, B.2
Allerton, R.3
Fabi, A.4
Ciruelos, E.5
Parikh, R.6
Desilvio, M.7
Santillana, S.8
Swaby, R.9
Semig, V.10
-
70
-
-
84871722407
-
Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): A singlegroup phase 2 study
-
PMID: 23122784
-
Bachelot T, Romieu G, Campone M, Diras V, Cropet C, Dalenc F, Jimenez M, Le Rhun E, Pierga JY, Gonalves A, Leheurteur M, Domont J, Gutierrez M, Cur H, Ferrero JM, Labbe-Devilliers C. Lapatinib plus capecitabine in patients with previously untreated brain metastases from HER2-positive metastatic breast cancer (LANDSCAPE): A singlegroup phase 2 study. Lancet Oncol 2013; 14: 64-71 [PMID: 23122784 DOI: 10.1016/S1470-2045(12)70432-1]
-
(2013)
Lancet Oncol
, vol.14
, pp. 64-71
-
-
Bachelot, T.1
Romieu, G.2
Campone, M.3
Diras, V.4
Cropet, C.5
Dalenc, F.6
Jimenez, M.7
Le Rhun, E.8
Pierga, J.Y.9
Gonalves, A.10
Leheurteur, M.11
Domont, J.12
Gutierrez, M.13
Cur, H.14
Ferrero, J.M.15
Labbe-Devilliers, C.16
-
71
-
-
84867621201
-
Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ERBB family blocker
-
PMID: 22888144
-
Solca F, Dahl G, Zoephel A, Bader G, Sanderson M, Klein C, Kraemer O, Himmelsbach F, Haaksma E, Adolf GR. Target binding properties and cellular activity of afatinib (BIBW 2992), an irreversible ErbB family blocker. J Pharmacol Exp Ther 2012; 343: 342-350 [PMID: 22888144 DOI: 10.1124/jpet.112.197756]
-
(2012)
J Pharmacol Exp Ther
, vol.343
, pp. 342-350
-
-
Solca, F.1
Dahl, G.2
Zoephel, A.3
Bader, G.4
Sanderson, M.5
Klein, C.6
Kraemer, O.7
Himmelsbach, F.8
Haaksma, E.9
Adolf, G.R.10
-
72
-
-
84863715765
-
A phase II study of afatinib (BIBW 2992), an irreversible ERBB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab
-
PMID: 22418700
-
Lin NU, Winer EP, Wheatley D, Carey LA, Houston S, Mendelson D, Munster P, Frakes L, Kelly S, Garcia AA, Cleator S, Uttenreuther-Fischer M, Jones H, Wind S, Vinisko R, Hickish T. A phase II study of afatinib (BIBW 2992), an irreversible ErbB family blocker, in patients with HER2-positive metastatic breast cancer progressing after trastuzumab. Breast Cancer Res Treat 2012; 133: 1057-1065 [PMID: 22418700 DOI: 10.1007/s10549-012-2003-y]
-
(2012)
Breast Cancer Res Treat
, vol.133
, pp. 1057-1065
-
-
Lin, N.U.1
Winer, E.P.2
Wheatley, D.3
Carey, L.A.4
Houston, S.5
Mendelson, D.6
Munster, P.7
Frakes, L.8
Kelly, S.9
Garcia, A.A.10
Cleator, S.11
Uttenreuther-Fischer, M.12
Jones, H.13
Wind, S.14
Vinisko, R.15
Hickish, T.16
-
73
-
-
84867875487
-
On behalf of the LUX-Breast 1 Study Group, . LUX-breast 1: Randomized, phase III trial of afatinib and vinorelbine versus trastuzumab and vinorelbine in patients with HER2-overexpressing metastatic breast cancer (MBC) failing one prior trastuzumab treatment
-
Harbeck N, Im S, Huang C, Im Y, Xu B, Hurvitz SA, Lee K, Ahn J, Mehta AO, Arora RS, Sun Q, Qin S, Jacob LA, Jassem J, Staroslawka E, Sufliarsky J, Wojtukiewicz M, Lahogue A, Uttenreuther-Fischer MM, Piccart-Gebhart MJ, on behalf of the LUX-Breast 1 Study Group, . LUX-breast 1: Randomized, phase III trial of afatinib and vinorelbine versus trastuzumab and vinorelbine in patients with HER2-overexpressing metastatic breast cancer (MBC) failing one prior trastuzumab treatment. ASCO Meeting Abstracts 2012; 30: TPS649
-
(2012)
ASCO Meeting Abstracts
, vol.30
, pp. TPS649
-
-
Harbeck, N.1
Im, S.2
Huang, C.3
Im, Y.4
Xu, B.5
Hurvitz, S.A.6
Lee, K.7
Ahn, J.8
Mehta, A.O.9
Arora, R.S.10
Sun, Q.11
Qin, S.12
Jacob, L.A.13
Jassem, J.14
Staroslawka, E.15
Sufliarsky, J.16
Wojtukiewicz, M.17
Lahogue, A.18
Uttenreuther-Fischer, M.M.19
Piccart-Gebhart, M.J.20
more..
-
74
-
-
2542582261
-
Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase
-
PMID: 15173008
-
Rabindran SK, Discafani CM, Rosfjord EC, Baxter M, Floyd MB, Golas J, Hallett WA, Johnson BD, Nilakantan R, Overbeek E, Reich MF, Shen R, Shi X, Tsou HR, Wang YF, Wissner A. Antitumor activity of HKI-272, an orally active, irreversible inhibitor of the HER-2 tyrosine kinase. Cancer Res 2004; 64: 3958-3965 [PMID: 15173008 DOI: 10.1158/0008-5472.CAN-03-2868]
-
(2004)
Cancer Res
, vol.64
, pp. 3958-3965
-
-
Rabindran, S.K.1
Discafani, C.M.2
Rosfjord, E.C.3
Baxter, M.4
Floyd, M.B.5
Golas, J.6
Hallett, W.A.7
Johnson, B.D.8
Nilakantan, R.9
Overbeek, E.10
Reich, M.F.11
Shen, R.12
Shi, X.13
Tsou, H.R.14
Wang, Y.F.15
Wissner, A.16
-
75
-
-
77950497981
-
Neratinib, an irreversible ERBB receptor tyrosine kinase inhibitor, in patients with advanced ERBB2-positive breast cancer
-
PMID: 20142587
-
Burstein HJ, Sun Y, Dirix LY, Jiang Z, Paridaens R, Tan AR, Awada A, Ranade A, Jiao S, Schwartz G, Abbas R, Powell C, Turnbull K, Vermette J, Zacharchuk C, Badwe R. Neratinib, an irreversible ErbB receptor tyrosine kinase inhibitor, in patients with advanced ErbB2-positive breast cancer. J Clin Oncol 2010; 28: 1301-1307 [PMID: 20142587 DOI: 10.1200/JCO.2009.25.8707]
-
(2011)
J Clin Oncol
, vol.28
, pp. 1301-1307
-
-
Burstein, H.J.1
Sun, Y.2
Dirix, L.Y.3
Jiang, Z.4
Paridaens, R.5
Tan, A.R.6
Awada, A.7
Ranade, A.8
Jiao, S.9
Schwartz, G.10
Abbas, R.11
Powell, C.12
Turnbull, K.13
Vermette, J.14
Zacharchuk, C.15
Badwe, R.16
-
76
-
-
73849142191
-
Neratinib in combination with trastuzumab for the treatment of advanced breast cancer: A phase I/II study
-
Swaby R, Blackwell K, Jiang Z, Sun Y, Dieras V, Zaman K, Zacharchuk C, Powell C, Abbas R, Thakuria M . Neratinib in combination with trastuzumab for the treatment of advanced breast cancer: A phase I/II study. ASCO Meeting Abstracts 2009; 27: 1004
-
(2009)
ASCO Meeting Abstracts
, vol.27
, pp. 1004
-
-
Swaby, R.1
Blackwell, K.2
Jiang, Z.3
Sun, Y.4
Dieras, V.5
Zaman, K.6
Zacharchuk, C.7
Powell, C.8
Abbas, R.9
Thakuria, M.10
-
77
-
-
84878621801
-
Abstract P3-14-05: Safety and efficacy of neratinib (hki-272) plus vinorelbine in the treatment of patients with erbb2 metastatic breast cancer pretreated with anti-her2 therapy
-
Staroslawska E, Dirix L, Luu T, Dieras V, Manso L, Xu B, Yang J, Abbas R, Strahs A, Vo Van M, Berkenblit A, Agrapart V, Powell C, Awada A . Abstract P3-14-05: Safety and Efficacy of Neratinib (HKI-272) Plus Vinorelbine in the Treatment of Patients with ErbB2 Metastatic Breast Cancer Pretreated with Anti-HER2 Therapy. Cancer Research 2011; 70: P3-14-05 [DOI: 10.1158/0008-5472.SABCS10-P3-14-05]
-
(2011)
Cancer Research
, vol.70
, pp. P31405
-
-
Staroslawska, E.1
Dirix, L.2
Luu, T.3
Dieras, V.4
Manso, L.5
Xu, B.6
Yang, J.7
Abbas, R.8
Strahs, A.9
Van M, V.10
Berkenblit, A.11
Agrapart, V.12
Powell, C.13
Awada, A.14
-
78
-
-
84884707708
-
A phase I/II study of MM-111, a novel bispecific antibody that targets the ErB2/ErB3 heterodimer, in combination with trastuzumab in advanced refractory HER2-positive breast cancer
-
Higgins MJ, Gabrail NY, Miller K, Agresta SV, Sharma S, McDonagh C, Murray J, Andreas K, Frye S, Moyo VM, Niyikiza C, Ryan PD . A phase I/II study of MM-111, a novel bispecific antibody that targets the ErB2/ErB3 heterodimer, in combination with trastuzumab in advanced refractory HER2-positive breast cancer. ASCO Meeting Abstracts 2011; 29: TPS119
-
(2011)
ASCO Meeting Abstracts
, vol.29
, pp. TPS119
-
-
Higgins, M.J.1
Gabrail, N.Y.2
Miller, K.3
Agresta, S.V.4
Sharma, S.5
McDonagh, C.6
Murray, J.7
Andreas, K.8
Frye, S.9
Moyo, V.M.10
Niyikiza, C.11
Ryan, P.D.12
-
79
-
-
79951809074
-
A phase I/II and pharmacologic study of MM-111 in patients with advanced, refractory HER2-positive (HER2) cancers
-
Denlinger CS, Beeram M, Tolcher AW, Goldstein LJ, Slichenmyer WJ, Murray J, McDonagh C, Andreas K, Moyo VM. A phase I/II and pharmacologic study of MM-111 in patients with advanced, refractory HER2-positive (HER2) cancers. ASCO Meeting Abstracts 2010; 28: TPS169
-
(2011)
ASCO Meeting Abstracts
, vol.28
, pp. TPS169
-
-
Denlinger, C.S.1
Beeram, M.2
Tolcher, A.W.3
Goldstein, L.J.4
Slichenmyer, W.J.5
Murray, J.6
McDonagh, C.7
Andreas, K.8
Moyo, V.M.9
-
80
-
-
0034006703
-
Delayed-Type hypersensitivity response is a predictor of peripheral blood T-cell immunity after HER-2/neu peptide immunization
-
PMID: 10778962
-
Disis ML, Schiffman K, Gooley TA, McNeel DG, Rinn K, Knutson KL. Delayed-Type hypersensitivity response is a predictor of peripheral blood T-cell immunity after HER-2/neu peptide immunization. Clin Cancer Res 2000; 6: 1347-1350 [PMID: 10778962]
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1347-1350
-
-
Disis, M.L.1
Schiffman, K.2
Gooley, T.A.3
McNeel, D.G.4
Rinn, K.5
Knutson, K.L.6
-
81
-
-
0036605567
-
Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines
-
PMID: 12039923
-
Disis ML, Gooley TA, Rinn K, Davis D, Piepkorn M, Cheever MA, Knutson KL, Schiffman K. Generation of T-cell immunity to the HER-2/neu protein after active immunization with HER-2/neu peptide-based vaccines. J Clin Oncol 2002; 20: 2624-2632 [PMID: 12039923]
-
(2002)
J Clin Oncol
, vol.20
, pp. 2624-2632
-
-
Disis, M.L.1
Gooley, T.A.2
Rinn, K.3
Davis, D.4
Piepkorn, M.5
Cheever, M.A.6
Knutson, K.L.7
Schiffman, K.8
-
82
-
-
0036098003
-
Immunization of cancer patients with a HER-2/neu, HLA-A2 peptide, p369-377, results in short-lived peptide-specific immunity
-
PMID: 12006513
-
Knutson KL, Schiffman K, Cheever MA, Disis ML. Immunization of cancer patients with a HER-2/neu, HLA-A2 peptide, p369-377, results in short-lived peptide-specific immunity. Clin Cancer Res 2002; 8: 1014-1018 [PMID: 12006513]
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1014-1018
-
-
Knutson, K.L.1
Schiffman, K.2
Cheever, M.A.3
Disis, M.L.4
-
83
-
-
34548474070
-
Treatment with autologous antigen-presenting cells activated with the HER-2 based antigen Lapuleucel-T: Results of a phase i study in immunologic and clinical activity in HER-2 overexpressing breast cancer
-
PMID: 17704416
-
Park JW, Melisko ME, Esserman LJ, Jones LA, Wollan JB, Sims R. Treatment with autologous antigen-presenting cells activated with the HER-2 based antigen Lapuleucel-T: results of a phase I study in immunologic and clinical activity in HER-2 overexpressing breast cancer. J Clin Oncol 2007; 25: 3680-3687 [PMID: 17704416 DOI: 10.1200/JCO.2006.10.5718]
-
(2007)
J Clin Oncol
, vol.25
, pp. 3680-3687
-
-
Park, J.W.1
Melisko, M.E.2
Esserman, L.J.3
Jones, L.A.4
Wollan, J.B.5
Sims, R.6
-
84
-
-
70350435441
-
Concurrent trastuzumab and HER2/neu-specific vaccination in patients with metastatic breast cancer
-
PMID: 19720923
-
Disis ML, Wallace DR, Gooley TA, Dang Y, Slota M, Lu H, Coveler AL, Childs JS, Higgins DM, Fintak PA, dela Rosa C, Tietje K, Link J, Waisman J, Salazar LG. Concurrent trastuzumab and HER2/neu-specific vaccination in patients with metastatic breast cancer. J Clin Oncol 2009; 27: 4685-4692 [PMID: 19720923 DOI: 10.1200/JCO.2008.20.6789]
-
(2009)
J Clin Oncol
, vol.27
, pp. 4685-4692
-
-
Disis, M.L.1
Wallace, D.R.2
Gooley, T.A.3
Dang, Y.4
Slota, M.5
Lu, H.6
Coveler, A.L.7
Childs, J.S.8
Higgins, D.M.9
Fintak, P.A.10
Dela Rosa, C.11
Tietje, K.12
Link, J.13
Waisman, J.14
Salazar, L.G.15
-
85
-
-
84856773016
-
Phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2kinase inhibition [corrected
-
PMID: 22325452
-
Hamilton E, Blackwell K, Hobeika AC, Clay TM, Broadwater G, Ren XR, Chen W, Castro H, Lehmann F, Spector N, Wei J, Osada T, Lyerly HK, Morse MA. Phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2kinase inhibition [corrected]. J Transl Med 2012; 10: 28 [PMID: 22325452 DOI: 10.1186/1479-5876-10-28]
-
(2012)
J Transl Med
, vol.10
, pp. 28
-
-
Hamilton, E.1
Blackwell, K.2
Hobeika, A.C.3
Clay, T.M.4
Broadwater, G.5
Ren, X.R.6
Chen, W.7
Castro, H.8
Lehmann, F.9
Spector, N.10
Wei, J.11
Osada, T.12
Lyerly, H.K.13
Morse, M.A.14
-
86
-
-
35148885729
-
A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer
-
PMID: 17936563
-
Berns K, Horlings HM, Hennessy BT, Madiredjo M, Hijmans EM, Beelen K, Linn SC, Gonzalez-Angulo AM, Stemke-Hale K, Hauptmann M, Beijersbergen RL, Mills GB, van de Vijver MJ, Bernards R. A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer. Cancer Cell 2007; 12: 395-402 [PMID: 17936563 DOI: 10.1016/j.ccr.2007.08.030]
-
(2007)
Cancer Cell
, vol.12
, pp. 395-402
-
-
Berns, K.1
Horlings, H.M.2
Hennessy, B.T.3
Madiredjo, M.4
Hijmans, E.M.5
Beelen, K.6
Linn, S.C.7
Gonzalez-Angulo, A.M.8
Stemke-Hale, K.9
Hauptmann, M.10
Beijersbergen, R.L.11
Mills, G.B.12
Van De Vijver, M.J.13
Bernards, R.14
-
87
-
-
78650984926
-
Phase i study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab
-
PMID: 20975068
-
Andre F, Campone M, ORegan R, Manlius C, Massacesi C, Sahmoud T, Mukhopadhyay P, Soria JC, Naughton M, Hurvitz SA. Phase I study of everolimus plus weekly paclitaxel and trastuzumab in patients with metastatic breast cancer pretreated with trastuzumab. J Clin Oncol 2010; 28: 5110-5115 [PMID: 20975068 DOI: 10.1200/JCO.2009.27.8549]
-
(2011)
J Clin Oncol
, vol.28
, pp. 5110-5115
-
-
Andre, F.1
Campone, M.2
ORegan, R.3
Manlius, C.4
Massacesi, C.5
Sahmoud, T.6
Mukhopadhyay, P.7
Soria, J.C.8
Naughton, M.9
Hurvitz, S.A.10
-
88
-
-
84885420714
-
Phase III, Randomized, double-blind, placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant, advanced breast cancer (BOLERO-3
-
ORegan R, Ozguroglu M, Andre F, Toi M, Jerusalem GHM, Wilks S, Isaacs C, Xu B, Masuda N, Arena FP, Yardley DA, Yap YS, Mukhopadhyay P, Douma S, El-Hashimy M, Taran T, Sahmoud T, Lebwohl DE, Gianni L . Phase III, randomized, double-blind, placebo-controlled multicenter trial of daily everolimus plus weekly trastuzumab and vinorelbine in trastuzumab-resistant, advanced breast cancer (BOLERO-3). ASCO Meeting Abstracts 2013; 31: 505
-
(2013)
ASCO Meeting Abstracts
, vol.31
, pp. 505
-
-
ORegan, R.1
Ozguroglu, M.2
Andre, F.3
Toi, M.4
Jerusalem, G.H.M.5
Wilks, S.6
Isaacs, C.7
Xu, B.8
Masuda, N.9
Arena, F.P.10
Yardley, D.A.11
Yap, Y.S.12
Mukhopadhyay, P.13
Douma, S.14
El-Hashimy, M.15
Taran, T.16
Sahmoud, T.17
Lebwohl, D.E.18
Gianni, L.19
-
89
-
-
79958084461
-
A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer
-
PMID: 21559012
-
Munster PN, Thurn KT, Thomas S, Raha P, Lacevic M, Miller A, Melisko M, Ismail-Khan R, Rugo H, Moasser M, Minton SE. A phase II study of the histone deacetylase inhibitor vorinostat combined with tamoxifen for the treatment of patients with hormone therapy-resistant breast cancer. Br J Cancer 2011; 104: 1828-1835 [PMID: 21559012 DOI: 10.1038/bjc.2011.156]
-
(2011)
Br J Cancer
, vol.104
, pp. 1828-1835
-
-
Munster, P.N.1
Thurn, K.T.2
Thomas, S.3
Raha, P.4
Lacevic, M.5
Miller, A.6
Melisko, M.7
Ismail-Khan, R.8
Rugo, H.9
Moasser, M.10
Minton, S.E.11
-
90
-
-
12144266330
-
Hsp90 restrains ERBB-2/HER2 signalling by limiting heterodimer formation
-
PMID: 15568014
-
Citri A, Gan J, Mosesson Y, Vereb G, Szollosi J, Yarden Y. Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation. EMBO Rep 2004; 5: 1165-1170 [PMID: 15568014 DOI: 10.1038/sj.embor.7400300]
-
(2004)
EMBO Rep
, vol.5
, pp. 1165-1170
-
-
Citri, A.1
Gan, J.2
Mosesson, Y.3
Vereb, G.4
Szollosi, J.5
Yarden, Y.6
-
91
-
-
36849055007
-
Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: A phase i dose-escalation study
-
PMID: 18048823
-
Modi S, Stopeck AT, Gordon MS, Mendelson D, Solit DB, Bagatell R, Ma W, Wheler J, Rosen N, Norton L, Cropp GF, Johnson RG, Hannah AL, Hudis CA. Combination of trastuzumab and tanespimycin (17-AAG, KOS-953) is safe and active in trastuzumab-refractory HER-2 overexpressing breast cancer: A phase I dose-escalation study. J Clin Oncol 2007; 25: 5410-5417 [PMID: 18048823 DOI: 10.1200/JCO.2007.11.7960]
-
(2007)
J Clin Oncol
, vol.25
, pp. 5410-5417
-
-
Modi, S.1
Stopeck, A.T.2
Gordon, M.S.3
Mendelson, D.4
Solit, D.B.5
Bagatell, R.6
Ma, W.7
Wheler, J.8
Rosen, N.9
Norton, L.10
Cropp, G.F.11
Johnson, R.G.12
Hannah, A.L.13
Hudis, C.A.14
-
92
-
-
79960985354
-
HSP90 inhibition is effective in breast cancer: A phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab
-
PMID: 21558407
-
Modi S, Stopeck A, Linden H, Solit D, Chandarlapaty S, Rosen N, DAndrea G, Dickler M, Moynahan ME, Sugarman S, Ma W, Patil S, Norton L, Hannah AL, Hudis C. HSP90 inhibition is effective in breast cancer: A phase II trial of tanespimycin (17-AAG) plus trastuzumab in patients with HER2-positive metastatic breast cancer progressing on trastuzumab. Clin Cancer Res 2011; 17: 5132-5139 [PMID: 21558407 DOI: 10.1158/1078-0432.CCR-11-0072]
-
(2011)
Clin Cancer Res
, vol.17
, pp. 5132-5139
-
-
Modi, S.1
Stopeck, A.2
Linden, H.3
Solit, D.4
Chandarlapaty, S.5
Rosen, N.6
DAndrea, G.7
Dickler, M.8
Moynahan, M.E.9
Sugarman, S.10
Ma, W.11
Patil, S.12
Norton, L.13
Hannah, A.L.14
Hudis, C.15
-
93
-
-
28244432561
-
Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
-
PMID: 16322262
-
Nahta R, Yuan LX, Zhang B, Kobayashi R, Esteva FJ. Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 2005; 65: 11118-11128 [PMID: 16322262 DOI: 10.1158/0008-5472. CAN-04-3841]
-
(2005)
Cancer Res
, vol.65
, pp. 11118-11128
-
-
Nahta, R.1
Yuan, L.X.2
Zhang, B.3
Kobayashi, R.4
Esteva, F.J.5
-
94
-
-
79953745096
-
Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways
-
PMID: 21399647
-
Zhang S, Huang WC, Li P, Guo H, Poh SB, Brady SW, Xiong Y, Tseng LM, Li SH, Ding Z, Sahin AA, Esteva FJ, Hortobagyi GN, Yu D. Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nat Med 2011; 17: 461-469 [PMID: 21399647 DOI: 10.1038/nm.2309]
-
(2011)
Nat Med
, vol.17
, pp. 461-469
-
-
Zhang, S.1
Huang, W.C.2
Li, P.3
Guo, H.4
Poh, S.B.5
Brady, S.W.6
Xiong, Y.7
Tseng, L.M.8
Li, S.H.9
Ding, Z.10
Sahin, A.A.11
Esteva, F.J.12
Hortobagyi, G.N.13
Yu, D.14
-
95
-
-
79953207364
-
Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase
-
PMID: 21385943
-
Garrett JT, Olivares MG, Rinehart C, Granja-Ingram ND, Snchez V, Chakrabarty A, Dave B, Cook RS, Pao W, McKinely E, Manning HC, Chang J, Arteaga CL. Transcriptional and posttranslational up-regulation of HER3 (ErbB3) compensates for inhibition of the HER2 tyrosine kinase. Proc Natl Acad Sci USA 2011; 108: 5021-5026 [PMID: 21385943 DOI: 10.1073/pnas.1016140108]
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 5021-5026
-
-
Garrett, J.T.1
Olivares, M.G.2
Rinehart, C.3
Granja-Ingram, N.D.4
Snchez, V.5
Chakrabarty, A.6
Dave, B.7
Cook, R.S.8
Pao, W.9
McKinely, E.10
Manning, H.C.11
Chang, J.12
Arteaga, C.L.13
-
96
-
-
84866433516
-
RB-pathway disruption is associated with improved response to neoadjuvant chemotherapy in breast cancer
-
PMID: 22811582
-
Witkiewicz AK, Ertel A, McFalls J, Valsecchi ME, Schwartz G, Knudsen ES. RB-pathway disruption is associated with improved response to neoadjuvant chemotherapy in breast cancer. Clin Cancer Res 2012; 18: 5110-5122 [PMID: 22811582 DOI: 10.1158/1078-0432.CCR-12-0903]
-
(2012)
Clin Cancer Res
, vol.18
, pp. 5110-5122
-
-
Witkiewicz, A.K.1
Ertel, A.2
McFalls, J.3
Valsecchi, M.E.4
Schwartz, G.5
Knudsen, E.S.6
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