Codon swapping of zinc finger nucleases confers expression in primary cells and in vivo from a single lentiviral vector

Current Gene Therapy

Volumn 14, Issue 5, 2014, Pages 365-376

  Cécilia, Abarrategui Pontes ^a,b,c   Alison, Créneguy ^a,b,c   Reynald, Thinard ^a,b,c   Fine Eli, J ^d   Virginie, Thepenier ^a,b,c   Le Ray Laure, Fournier ^a,b,c   Cradick Thomas, J ^d   Gang, Bao ^d   Laurent, Tesson ^a,b,c   Guillaume, Podevin ^e   Ignacio, Anegon ^a,b,c   Huy, Nguyen T ^a,b,c  

^a Centre National de la Recherche Scientifique   (France)

^b HÔTEL DIEU   (France)

^c UNIVERSITÉ DE NANTES   (France)

^d Emory University   (United States)

^e Pediatric Hepatogastroenterology HIFIH laboratory UPRES 3859 SFR 4038   (France)

Author keywords

Codon swapping; Lentiviral vectors; Liver; Off target sites; Primary cells; Zinc finger nuclease

Indexed keywords

ENDONUCLEASE; ZINC FINGER NUCLEASE; CODON; GLUCURONOSYLTRANSFERASE; SMALL INTERFERING RNA; UGT1A1 PROTEIN, RAT; ZINC FINGER PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CODON SWAPPING; CONTROLLED STUDY; FLOW CYTOMETRY; GENE EXPRESSION; GENE MUTATION; GENE SEQUENCE; GENETIC RECOMBINATION; GENETIC TRANSFECTION; NEWBORN; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING; ADMINISTRATION AND DOSAGE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; CODON; CYTOLOGY; DOUBLE STRANDED DNA BREAK; GENE VECTOR; GENETIC ENGINEERING; GENETICS; GENOME; GLIOMA; LIVER CELL; LIVER CELL CARCINOMA; LIVER TUMOR; METABOLISM; PATHOLOGY; PROCEDURES; WISTAR RAT;

ANIMALS; ANIMALS, NEWBORN; CARCINOMA, HEPATOCELLULAR; CELLS, CULTURED; CODON; DNA BREAKS, DOUBLE-STRANDED; ENDONUCLEASES; GENETIC ENGINEERING; GENETIC VECTORS; GENOME; GLIOMA; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; LIVER NEOPLASMS; RATS; RATS, WISTAR; RNA, SMALL INTERFERING; ZINC FINGERS;

EID: 84911461632     PISSN: 15665232     EISSN: 18755631     Source Type: Journal    
DOI: 10.2174/156652321405140926161748     Document Type: Article

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