Reduced cerebrospinal fluid levels of brain-derived neurotrophic factor is associated with cognitive impairment in late-life major depression

Journals of Gerontology - Series B Psychological Sciences and Social Sciences

Volumn 69, Issue 6, 2014, Pages 845-851

  Diniz, Breno S ^a,b,c   Teixeira, Antonio L ^a   Machado Vieira, Rodrigo ^b,d   Talib, Leda L ^b   Radanovic, Marcia ^b   Gattaz, Wagner F ^b   Forlenza, Orestes V ^b  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c National Institute of Science and Technology Molecular Medicine (INCT MM)   (Brazil)

^d NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Alzheimers disease; Amyloid 42; BDNF; Cerebrospinal fluid; Cognition; Late life depression

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID BETA-PROTEIN (1-42); BRAIN DERIVED NEUROTROPHIC FACTOR; PEPTIDE FRAGMENT; TAU PROTEIN;

AGED; AGING; CEREBROSPINAL FLUID; HUMAN; MAJOR DEPRESSION; MALE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; ONSET AGE; PATHOPHYSIOLOGY;

AGE OF ONSET; AGED; AGING; AMYLOID BETA-PEPTIDES; BRAIN-DERIVED NEUROTROPHIC FACTOR; DEPRESSIVE DISORDER, MAJOR; HUMANS; MALE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; PEPTIDE FRAGMENTS; TAU PROTEINS;

EID: 84911446832     PISSN: 10795014     EISSN: None     Source Type: Journal    
DOI: 10.1093/geronb/gbu096     Document Type: Article

References (30)

1. Brunoni, A. R., Lopes, M., and Fregni, F. (2008). A systematic review and meta-analysis of clinical studies on major depression and BDNF levels: Implications for the role of neuroplasticity in depression. International Journal of Neuropsychopharmacology, 11, 1169-1180. doi:10.1017/S1461145708009309
2. Butters, M. A., Klunk, W. E., Mathis, C. A., Price, J. C., Ziolko, S. K., Hoge, J. A., and Meltzer, C. C. (2008). Imaging Alzheimer pathology in latelife depression with PET and Pittsburgh Compound-B. Alzheimer Disease and Associated Disorders, 22, 261-268. doi:10.1097/WAD.0b013e31816c92bf
3. A., Mulsant, B. H., and Becker, J. T. (2004). The nature and determinants of neuropsychological functioning in late-life depression. Archives of General Psychiatry, 61, 587-595.
4. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders - 4th edition (DSM-IV). Washington, DC: American Psychiatric Association.
5. F. 3rd. (2013). Late-life depression and risk of vascular dementia and Alzheimers disease: Systematic review and meta-analysis of community-based cohort studies. British Journal of Psychiatry, 202, 329-335.
6. Diniz, B. S., Reynolds, C. F. 3rd, Begley, A., Dew, M. A., Anderson, S. J., Lotrich, F., and Butters, M. A. (2014). Brain-derived neurotrophic factor levels in late-life depression and comorbid mild cognitive impairment: A longitudinal study. Journal of Psychiatric Research, 49, 96-101.
7. Diniz, B. S., Talib, L. L., Joaquim, H. P., de Paula, V. R., Gattaz, W. F., and Forlenza, O. V. (2011). Platelet GSK3B activity in patients with late-life depression: Marker of depressive episode severity and cognitive impairment? World Journal of Biological Psychiatry, 12, 216-222.
8. Diniz, B. S., Teixeira, A. L., Machado-Vieira, R., Talib, L. L., Gattaz, W. F., and Forlenza, O. V. (2013). Reduced serum nerve growth factor in patients with late-life depression. The American Journal of Geriatric Psychiatry, 21, 493-496.
9. Diniz, B. S., Teixeira, A. L., Miranda, A. S., Talib, L. L., Gattaz, W. F., and Forlenza, O. V. (2012). Circulating Glial-derived neurotrophic factor is reduced in late-life depression. Journal of Psychiatric Research, 46, 135-139.
10. Diniz, B. S., Teixeira, A. L., Talib, L. L., Mendona, V. A., Gattaz, W. F., and Forlenza, O. V. (2010a). Increased soluble TNF receptor 2 in antidepressant-free patients with late-life depression. Journal of Psychiatric Research, 44, 917-920.
11. Diniz, B. S., Teixeira, A. L., Talib, L. L., Mendona, V. A., Gattaz, W. F., and Forlenza, O. V. (2010b). Serum brain-derived neurotrophic factor level is reduced in antidepressant-free patients with late-life depression. The World Journal of Biological Psychiatry, 11, 550-555.
12. Fernandes, B. S., Gama, C. S., Ceresér, K. M., Yatham, L. N., Fries, G. R., Colpo, G., and Kapczinski, F. (2011). Brain-derived neurotrophic factor as a state-marker of mood episodes in bipolar disorders: A systematic review and meta-regression analysis. Journal of Psychiatric Research, 45, 995-1004. doi:10.1016/j. jpsychires.2011.03.002.
13. First, M. B., Spitzer, R. L., Gibbon, M., and Williams, J. B. W. (2002). Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition. (SCID-I/P). New York: Biometrics Research, New York State Psychiatric Institute.
14. Folstein, M. F., Folstein, S. E., and McHugh, P. R. (1975). "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. Journal of Psychiatric Research, 12, 189-198.
15. Forlenza, O. V., Diniz, B. S., Talib, L. L., Radanovic, M., Yassuda, M. S., Ojopi, E. B., and Gattaz, W. F. (2010a). Clinical and biological predictors of Alzheimers disease in patients with amnestic mild cognitive impairment. Revista brasileira de psiquiatria (São Paulo, Brazil: 1999), 32, 216-222.
16. Forlenza, O. V., Diniz, B. S., Teixeira, A. L., Ojopi, E. B., Talib, L. L., Mendona, V. A., and Gattaz, W. F. (2010b). Effect of brainderived neurotrophic factor Val66Met polymorphism and serum levels on the progression of mild cognitive impairment. World Journal of Biological Psychiatry, 11, 774-780.
17. Gudmundsson, P., Skoog, I., Waern, M., Blennow, K., Plsson, S., Rosengren, L., and Gustafson, D. (2007). The relationship between cerebrospinal fluid biomarkers and depression in elderly women. The American Journal of Geriatric Psychiatry, 15, 832-838.
18. Hamilton, M. (1960). A rating scale for depression. Journal of Neurology Neurosurgery and Psychiatry, 23, 56-62.
19. Hansson, O., Zetterberg, H., Buchhave, P., Londos, E., Blennow, K., and Minthon, L. (2006). Association between CSF biomarkers and incipient Alzheimers disease in patients with mild cognitive impairment: A follow-up study. Lancet Neurology, 5, 228-234.
20. Kumar, A., Kepe, V., Barrio, J. R., Siddarth, P., Manoukian, V., Elderkin- Thompson, V., and Small, G. W. (2011). Protein binding in patients with late-life depression. Archives of General Psychiatry, 68, 1143-1150.
21. McKinney, B. C., and Sibille, E (2013). The age-by-disease interaction hypothesis of late-life depression. American Journal of Geriatric Psychiatry, 21, 418-432.
22. Modrego, P. J., and Ferrndez, J. (2004) Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: A prospective cohort study. Archives of Neurology, 61, 1290-1293.
23. Naismith, S. L., Norrie, L. M., Mowszowski, L., and Hickie, I. B. (2012). The neurobiology of depression in later-life: Clinical, neuropsychological, neuroimaging and pathophysiological features. Progress in Neurobiology, 98, 99-143. doi:10.1016/j. pneurobio.2012.05.009
24. Petersen, R. C., Stevens, J. C., Ganguli, M., Tangalos, E. G., Cummings, J. L., and DeKosky, S. T. (2001). Practice parameter: Early detection of dementia: Mild cognitive impairment (an evidence-based review). Report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology, 56, 1133-1142.
25. Pomara, N., Bruno, D., Sarreal, A. S., Hernando, R. T., Nierenberg, J., Petkova, E., and Blennow, K. (2012). Lower CSF amyloid beta peptides and higher F2-isoprostanes in cognitively intact elderly individuals with major depressive disorder. American Journal of Psychiatry, 169, 523-530.
26. Reiber, H. (2001). Dynamics of brain-derived proteins in cerebrospinal fluid. Clinica Chimica Acta, 310, 173-186.
27. Reis, T., Brandão, C. O., Freire Coutinho, E. S., Engelhardt, E., and Laks, J. (2012). Cerebrospinal fluid biomarkers in Alzheimers disease and geriatric depression: Preliminary findings from Brazil. CNS Neuroscience and Therapeutics, 18, 524-529.
28. Roth, M., Tym, E., Mountjoy, C. Q., Huppert, F. A., Hendrie, H., Verma, S., and Goddard, R. (1986). CAMDEX. A standardised instrument for the diagnosis of mental disorder in the elderly with special reference to the early detection of dementia. The British Journal of Psychiatry, 149, 698-709.
29. Sibille, E. (2013). Molecular aging of the brain, neuroplasticity, and vulnerability to depression and other brain-related disorders. Dialogues in Clinical Neurosciences, 15, 53-65.
30. Tsopelas, C., Stewart, R., Savva, G. M., Brayne, C., Ince, P., Thomas, A., and Matthews, F. E.; Medical Research Council Cognitive Function and Ageing Study. (2011). Neuropathological correlates of late-life depression in older people. The British Journal of Psychiatry, 198, 109-114.