Encapsulation of beraprost sodium in nanoparticles: analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension

Journal of controlled release : official journal of the Controlled Release Society

Volumn 197, Issue , 2015, Pages 97-104

  Ishihara, Tomoaki ^a   Hayashi, Erika ^a   Yamamoto, Shuhei ^a   Kobayashi, Chisa ^a   Tamura, Yuichi ^a   Sawazaki, Ryoichi ^a   Tamura, Fumiya ^a   Tahara, Kayoko ^a   Kasahara, Tadashi ^a   Ishihara, Tsutomu ^a   Takenaga, Mitsuko ^a   Fukuda, Keiichi ^a   Mizushima, Tohru ^a  

^a KEIO UNIVERSITY   (Japan)

Author keywords

Beraprost sodium; Biodegradable nanoparticle; Encapsulation; Prostaglandin I(2); Pulmonary arterial hypertension

Indexed keywords

BERAPROST; DELAYED RELEASE FORMULATION; DRUG CARRIER; LACTIC ACID; MACROGOL DERIVATIVE; MONOCROTALINE; MONOMETHOXYPOLYETHYLENEGLYCOL-POLYLACTIDE BLOCK COPOLYMER; NANOPARTICLE; POLYLACTIC ACID; POLYMER; PROSTACYCLIN; RHODAMINE;

ADMINISTRATION AND DOSAGE; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CAPILLARY PERMEABILITY; CHEMISTRY; DELAYED RELEASE FORMULATION; DISEASE MODEL; DRUG EFFECTS; HYPERTENSION, PULMONARY; MALE; METABOLISM; PATHOLOGY; PHARMACOKINETICS; PULMONARY ARTERY; WISTAR RAT;

ANIMALS; CAPILLARY PERMEABILITY; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; DRUG CARRIERS; EPOPROSTENOL; HYPERTENSION, PULMONARY; LACTIC ACID; MALE; MICE, INBRED C57BL; MONOCROTALINE; NANOPARTICLES; POLYETHYLENE GLYCOLS; POLYMERS; PULMONARY ARTERY; RATS, WISTAR; RHODAMINES;

EID: 84911443774     PISSN: None     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2014.10.029     Document Type: Article

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