Saffron and retina: Neuroprotection and pharmacokinetics

Visual Neuroscience

Volumn 31, Issue 4-5, 2014, Pages 355-361

  Bisti, Silvia ^a   Maccarone, Rita ^a   Falsini, Benedetto ^b  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b CATHOLIC UNIVERSITY   (Italy)

Author keywords

Age related macular degeneration; Focal electroretinogram; Neuroprotection; Photoreceptors; Saffron

Indexed keywords

CROCUS SATIVUS EXTRACT; METHYLDOPA; PLACEBO; NEUROPROTECTIVE AGENT;

AGE RELATED MACULAR DEGENERATION; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CONTROLLED STUDY; CROCUS SATIVUS; DEGENERATIVE DISEASE; DIET SUPPLEMENTATION; ELECTRORETINOGRAM; INFLAMMATION; LIGHT EXPOSURE; MORPHOLOGY; NEUROPROTECTION; NONHUMAN; PATHOGENESIS; PHOTORECEPTOR; PRIORITY JOURNAL; RAT; REVIEW; RISK FACTOR; UPREGULATION; ANIMAL; CROCUS; DRUG EFFECTS; HUMAN; MACULAR DEGENERATION; METABOLISM; PATHOLOGY; PHYTOTHERAPY; RETINA;

ANIMALS; CROCUS; HUMANS; MACULAR DEGENERATION; NEUROPROTECTIVE AGENTS; PHYTOTHERAPY; RETINA;

EID: 84911427280     PISSN: 09525238     EISSN: 14698714     Source Type: Journal    
DOI: 10.1017/S0952523814000108     Document Type: Review

References (42)

1. Abdullaev, F.I., Riveròn-Negrete, L., Caballero-Ortega, H., Manuel Hernàndez, J., Pérez-Lòpez, I., Pereda-Miranda, R. & Espinosa-Aguirre, J.J. (2003). Use of in vitro assays to assess the potential antigenotoxic and cytotoxic effects of saffron (Crocus sati v us L.). Toxicology in Vitro 17, 731-736.
2. Age-Related Eye Disease Study 2 Research Group (2013). Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: The agerelated eye disease study 2 (AREDS2) randomized clinical trial. The Journal of the American Medical Association 309, 2005-2015.
3. Akhondzadeh, S., Sabet, M.S., Harirchian, M.H., Togha, M., Cheraghmakani, H., Razeghi, S., Hejazi, S., Yousefi, M.H., Alimardani, R., Jamshidi, A., Zare, F. & Moradi, A. (2010). Saffron in the treatment of patients with mild to moderate Alzheimers disease: A 16-week, randomized and placebo-controlled trial. Journal of Clinical Pharmacy and Therapeutics 35, 581-588.
4. Akhondzadeh, S., Shafiee Sabet, M., Harirchian, M.H., Togha, M., Cheraghmakani, H., Razeghi, S., Hejazi, S.S., Yousefi, M.H., Alimardani, R., Jamshidi, A., Rezazadeh, S.A., Yousefi, A., Zare, F., Moradi, A. & Vossoughi, A. (2009). A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimers disease. Psychopharmacology (Berl) 207, 637-643.
5. Akhondzadeh, S., Tahmacebi-Pour, N., Noorbala, A.A., Amini, H., Fallah-Pour, H., Jamshidi, A.H. & Khani, M. (2005). Crocus sativus L. in the treatment of mild to moderate depression: A double-blind, randomized and placebo-controlled trial. Phytotherapy Research 19, 148-151.
6. Amin, A., Hamza, A.A., Bajbouj, K., Ashraf, S.S. & Daoud, S. (2011). Saffron: A potential candidate for a novel anticancer drug against hepatocellular carcinoma. Hepatology 54, 857-867.
7. Asai, A., Nakano, T., Takahashi, M. & Nagao, A. (2005). Orally administered crocetin and crocins are absorbed into blood plasma as crocetin and its glucuronide conjugates in mice. Journal of Agricultural and Food Chemistry 53, 7302-7306.
8. Ayatollahi, H., Javan, A.O., Khajedaluee, M., Shahroodian, M. & Hosseinzadeh, H. (2013 June 3). Effect of Crocus sativus L. (Saffron) on coagulation and anticoagulation systems in healthy volunteers. Phytotherapy Research DOI: 10.1002/ptr.5021.
9. Bowers, F., Valter, K., Chan, S., Walsh, N., Maslim, J. & Stone, J. (2001). Effects of oxygen and bFGF on the vulnerability of photoreceptors to light damage. Investigative Ophthalmology & Visual Science 42, 804-815.
10. Bird, A.C., Bressler, N.M., Bressler, S.B., Bressler, S.B., Chisholm, I.H., Coscas, G., Davis, M.D., de Jong, P.T., Klaver, C.C., Klein, B.E., Klein, R. (1995). The International ARM Epidemiological Study Group. An international classifi cation and grading system for age-related maculopathy and age-related macular degeneration. Survey of Ophthalmology 39, 367-374.
11. Beatty, S., Koh, H., Phil, M., Henson, D. & Boulton, M. (2000). The role of oxidative stress in the pathogenesis of age-related macular degeneration. Survey of Ophthalmology 45, 115-134.
12. Buschini, E., Piras, A., Nuzzi, R. & Vercelli, A. (2011). Age related macular degeneration and drusen: Neuroinfl ammation in the retina. Progress in Neurobiology 95, 14-25.
13. Di Marco, F., Romeo, S., Nandasena, C., Purushothuman, S., Adams, C., Bisti, S. & Stone, J. (2013). The time course of action of two neuroprotectants, dietary saffron and photobiomodulation, assessed in the rat retina. American Journal of Neurodegenerative Disease 2, 208-220.
14. Falsini, B., Fadda, A., Iarossi, G., Piccardi, M., Canu, D., Minnella, A., Serrao, S. & Scullica, L. (2000 May). Retinal sensitivity to fl icker modulation: Reduced by early age-related maculopathy. Investigative Ophthalmology & Visual Science 41, 1498-1506.
15. Falsini, B., Piccardi, M., Iarossi, G., Fadda, A., Merendino, E. & Valentini, P. (2003 Jan). Influence of short-term antioxidant supplementation on macular function in age-related maculopathy: A pilot study including electrophysiologic assessment. Ophthalmology 110, 51-60.
16. Falsini, B., Piccardi, M., Minnella, A., Savastano, C., Capoluongo, E., Fadda, A., Balestrazzi, E., Maccarone, R. & Bisti, S. (2010). Infl uence of saffron supplementation on retinal fl icker sensitivity in early age related macular degeneration. Investigative Ophthalmology & Visual Science 51, 6118-6124.
17. Fernndez-Snchez, L., Lax, P., Esquiva, G., Martn-Nieto, J., Pinilla, I. & Cuenca, N. (2012). Safranal, a saffron constituent, attenuates retinal degeneration in P23H rats. PLoS One 7, e43074.
18. Garcà -Olmo, D.C., Riese, H.H., Escribano, J., Ontanòn, J., Fernandez, J.A., Atinzar, M. & Garcà -Olmo, D. (1999). Effects of longterm treatment of colon adenocarcinoma with crocin, a carotenoid from saffron (Crocus sativus L.): An experimental study in the rat. Nutrition and Cancer 35, 120-126.
19. Giaccio, M. (2004). Crocetin from saffron: An active component of an ancient spice. Critical Reviews in Food Science and Nutrition 44, 155-172.
20. Hollyfield, J.G. (2010). Age-related macular degeneration: the molecular link between oxidative damage, tissue-specifi c infl ammation and outer retinal disease: The Proctor lecture. Investigative Ophthalmology & Visual Science 51, 1275-1281.
21. Hosseinzadeh, H., Sadeghnia, H.R., Ghaeni, F.A., Motamedshariaty, V.S. & Mohajeri, S.A. (2012). Effects of saffron (Crocus sativus L) and its active constituent, crocin, on recognition and spatial memory after chronic cerebral hypoperfusion in rats. Phytotherapy Research 26, 381-386.
22. Iarossi, G., Falsini, B. & Piccardi, M. (2003). Regional cone dysfunction in retinitis pigmentosa evaluated by fl icker ERGs: Relationship with perimetric sensitivity losses. Investigative Ophthalmology & Visual Science 44, 866-874.
23. Jarrett, S.G. & Boulton, M.E. (2012). Consequences of oxidative stress in age-related macular degeneration. Molecular Aspects of Medicine 33, 399-417.
24. Kanakis, C.D., Tarantilis, P.A., Tajimir-Riahi, H.A. & Polissiou, M.G. (2007). Crocetin, dimethylcrocetin, and safranal bind humanserum albumin: Stability and antioxidative properties. Journal of Agricultural and Food Chemistry 55, 970-977.
25. Maccarone, R., Di Marco, S. & Bisti, S. (2008). Saffron supplement maintains morphology and function after exposure to damaging light in mammalian retina. Investigative Ophthalmology & Visual Science 49, 1254-1261.
26. Marangoni, D., Falsini, B., Piccardi, M., Ambrosio, L., Minnella, A.M., Savastano, M.C., Bisti, S., Maccarone, R., Fadda, A., Mello, E., Concolino, P. & Capoluongo, E. (2013 Sept). Functional effect of saffron supplementation and risk genotypes in early age-related macular degeneration: A preliminary report. Journal of Translational Medicine 11, 228.
27. Nam, K.N., Park, Y.M., Jung, H.J., Lee, J.Y., Min, B.D., Park, S.U., Jung, W.S., Cho, K.H., Park, J.H., Kang, I., Hong, J.W. & Lee, E.H. (2010) Anti-infl ammatory effects of crocin and crocetin in rat brain microglial cells. European Journal of Pharmacology 648, 110-116.
28. Natoli, R., Zhu, Y., Valter, K., Bisti, S., Eells, J. & Stone, J. (2010). Gene and noncoding RNA regulation underlying photoreceptor protection: Microarray study of dietary antioxidant saffron and photobiomodulation in rat retina. Molecular Vision 16, 1801-1822.
29. Ochiai, T., Shimeno, H., Mishima, K., Iwasaki, K., Fujiwara, M., Tanaka, H., Shoyama, Y., Toda, A., Eyanagi, R. & Soeda, S. (2007). Protective effects of carotenoids from saffron on neuronal injury in vitro and in vivo. Biochemica Biophysica Acta 1770, 578-584.
30. Ohno, Y., Nakanishi, T., Umigai, N., Tsuruma, K., Shimazawa, M. & Hara, H. (2012). Oral administration of crocetin prevents inner retinal damage induced by N-methyl-D-aspartate in mice. European Journal of Pharmacology 690, 84-89.
31. Organisciak, D.T. & Vaughan, D.K. (2010). Retinal light damage: Mechanisms and protection. Progress in Retinal Eye Research 29, 113-134.
32. Piccardi, M., Marangoni, D., Minnella, A.M., Savastano, M.C., Valentini, P., Ambrosio, L., Capoluongo, E., Maccarone, R., Bisti, S. & Falsini, B. (2012). A longitudinal follow-up study of saffron supplementation in early age-related macular degeneration: Sustained benefi ts to central retinal function. Evidence Based Complement Alternat Med. 2012, 429124.
33. Piccardi, M., Ziccardi, L., Stifano, G., Montrone, L., Iarossi, G., Minnella, A., Fadda, A., Balestrazzi, E. & Falsini, B. (2009). Regional cone-mediated dysfunction in age-related maculopathy evaluated by focal electroretinograms: Relationship with retinal morphology and perimetric sensitivity. Ophthalmic Research 41, 194-202.
34. Purushothuman, S., Nandasena, C., Peoples, C.L., El Massri, N., Johnstone, D.M., Mitrofanis, J. & Stone, J. (2013). Saffron pretreatment offers neuroprotection to Nigral and retinal dopaminergic cells of MPTP-treated mice. Journal of Parkinsons Disease 3, 77-83. doi: 10.3233/JPD-130173.
35. Ratnapriya, R. & Chew, E.Y. (2013 Aug). Age-related macular degenerationclinical review and genetics update. Clinical Genetics 84, 160-166.
36. Rutar, M., Provis, J.M. & Valter, K. (2010). Brief exposure to damaging light causes focal recruitment of macrophages, and long-term destabilization of photoreceptors in the albino rat retina. Current Eye Research 35, 631-643.
37. Stone, J., Mervin, K., Walsh, N., Valter, K., Provis, J. & Penfold, P. (2005). Photoreceptor stability and degeneration in mammalian retina: Lessons from the edge. In Macular Degeneration: Science and Medicine in Practice, ed. Penfold, P. & Provis, J., pp. 149-165. Heidelberg Germany Springer Verlag
38. Swaroop, A., Chew, E.Y., Rickman, C.B. & Abecasis, G.R. (2009). Unraveling a multifactorial late-onset disease: From genetic susceptibility to disease mechanisms for age-related macular degeneration. Annual Review of Genomics and Human Genetics 10, 19-43.
39. Umigai, N., Murakami, K., Ulit, M.V., Antonio, L.S., Shirotori, M., Morikawa, H. & Nakano, T. (2011). The pharmacokinetic profi le of crocetin in healthy adult human volunteers after a single oral administration. Phytomedicine 18, 575-578.
40. Xi, L., Qian, Z., Du, P. & Fu, J. (2007). Pharmacokinetic properties of crocin (crocetin digentiobiose ester) following oral administration in rats. Phytomedicine 14, 633-636.
41. Xuan, B., Zhou, Y.H., Li, N., Min, Z.D. & Chiou, G.C. (1999). Effects of crocin analogues on ocular blood fl ow and retinal function. Journal of Ocular Pharmacology and Therapeutics 15, 143-152.
42. Yamauchi, M., Tsuruma, K., Imai, S., Nakanishi, T., Umigai, N., Shimazawa, M. & Hara, H. (2011). Crocetin prevents retinal degeneration induced by oxidative and endoplasmic reticulum stresses via inhibition of caspase activity. European Journal of Pharmacology 650, 110-119.