Acid sphingomyelinase serum activity predicts mortality in Intensive Care Unit Patients after Systemic Inflammation: A Prospective Cohort Study

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Matthias, Kott ^a   Gunnar, Elke ^a   Maike, Reinicke ^a   Supi, Winoto Morbach ^a   Dirk, Schaä Dler ^a   Guünther, Zick ^a   Iné, Z Frerichs ^a   Norbert, Weiler ^a   Stefan, Schuütze ^a  

^a UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; PROCALCITONIN; SPHINGOMYELIN PHOSPHODIESTERASE;

ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; COMORBIDITY; CONTROLLED STUDY; CRITICALLY ILL PATIENT; ELECTIVE SURGERY; FEMALE; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INTENSIVE CARE UNIT; MALE; MORTALITY; PROGNOSIS; PROSPECTIVE STUDY; RECEIVER OPERATING CHARACTERISTIC; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 84911401050     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0112323     Document Type: Article

References (27)

1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermon G, Carcillo J, et al. (2001) Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 7: 1303-1310.
2. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, et al. (2001) Early goaldirected therapy in the treatment of severe sepsis and septic shock. NEJM 19: 1368-1377.
3. Wacker C, Prkno A, Brunkhorst FM, Schlattmann P (2013) Procalcitonin as a diagnostic marker for sepsis: a systematic review and meta-analysis. Lancet Infect Dis 13: 426-35.
4. Prkno A, Wacker C, Brunkhorst FM, Schlattmann P (2013) Procalcitoninguided therapy in intensive care unit patients with severe sepsis and septic shock -a systematic review and meta-analysis. Crit Care 17: R291.
5. Reinhart K, Brunkhorst FM, Bone HG, Bardutzky J, Dempfle CE, et al. (2010) Prevention, diagnosis, treatment, and follow-up care of sepsis. First revision of the S2k Guidelines of the German Sepsis Society (DSG) and the German Interdisciplinary Association for Intensive and Emergency Care Medicine (DIVI). Anaesthesist 59: 347-370.
6. Meisner M, Adina H, Schmidt J (2006) Correlation of procalcitonin and Creactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients. Crit Care 10: R1.
7. Castelli GP, Pognani C, Meisner M, Stuani A, Bellomi D, et al. (2004) Procalcitonin and C-reactive protein during systemic inflammatory response syndrome, sepsis and organ dysfunction. Crit Care 4: R234-242.
8. Herrmann W, Ecker D, Quast S, Klieden M, Rose S, et al. (2000) Comparison of procalcitonin, sCD14 and interleukin-6 values in septic patients. Clin Chem Lab Med 38: 41-46.
9. Uzzan B, Cohen R, Nicolas P, Cucherat M, Perret GY (2006) Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med 34: 1996-2003.
10. Jenkins RW, Canals D, Hannun YA (2009) Roles and regulation of secretory and lysosomal acid sphingomyelinase. Cell Signal 21: 836-46.
11. Grassmé H, Riethmu? ller J, Gulbins E (2007) Biological aspects of ceramideenriched membrane domains. Prog Lipid Res 46: 161-70.
12. Claus RA, Bunck AC, Bockmeyer CL, Brunkhorst FM, Lo?sche W, et al. (2005) Role of increased sphingomyelinase activity in apoptosis and organ failure of patients with severe sepsis. FASEB J. 19: 1719-1721.
13. Jbeily N, Suckert I, Gonnert FA, Acht B, Bockmeyer CL, et al. (2013) Hyperresponsiveness of mice deficient in plasma-secreted sphingomyelinase reveals its pivotal role in early phase of host response. J Lipid Res 54: 410-424.
14. Levy MM, Fink MP, Marshall JC, Abrahams E, Angus D, et al. (2003) 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 4: 1250-1256.
15. Kornhuber J, Tripal P, Reichel M, Muhle C, Rhein C, et al. (2010) Functional Inhibitors of Acid Sphingomyelinase (FIASMAs): a novel pharmacological group of drugs with broad clinical applications. Cell Physiol Biochem 26: 9-20.
16. Le Gall JR, Lemeshow S, Saulnier F (1993) A new simplified acute physiology score (SAPS II) based on a European/North American multicenter study. JAMA 2957-2963.
17. Cullen DJ, Civetta JM, Briggs BA, Ferrara LC (1974) Therapeutic Intervention Scoring System: a method for quantitative comparison of patient care. Crit Care Med 2: 57-60.
18. Vincent JL, Moreno R, Takala J, Willatts S, De Mendonça A, et al. (1996) The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine. Intensive Care Med 22: 707-710.
19. Edelmann B, Bertsch U, Tchikov V, Winoto-Morbach S, Jakob M, et al. (2011) Caspase-8 and caspase-7 sequentially mediate proteolytic activation of acid sphingomyelinase in TNF-R1-receptosomes. EMBO-J 30: 379-394.
20. Drobnik W, Liebisch G, Audebert FX, Frohlich D, Gluck T, et al. (2003) Plasma ceramide and lysophosphatidylcholine inversely correlate with mortality in sepsis patients. J Lipid Res 44: 754-761.
21. Bozza FA, Salluh JI, Japiassu AM, Soares M, Assis EF, et al. (2007) Cytokine profiles as markers of disease severity in sepsis: a multiplex analysis. Crit Care 11: R49.
22. Castillo SS, Levy M, Wang C, Thaikoottathil JV, Khan E, et al. (2007) Nitric oxide-enhanced caspase-3 and acidic sphingomyelinase interaction: a novel mechanism by which airway epithelial cells escape ceramide-induced apoptosis. Exp Cell Res 313: 816-823.
23. Corda S, Laplace C, Vicaut E, Duranteau J (2001) Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide. Am J Resp Cell Mol Biol 24: 762-768.
24. Garcia-Ruiz C, Colell A, Mari M, Morales A, Calvo M, et al. (2003) Defective TNF-alpha-mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice. J Clin Invest 111: 197-208.
25. Tokuda H, Kozawa O, Harada A, Uematsu T (1999) Extracellular sphingomyelinase induces interleukin-6 synthesis in osteoblasts. J Bio Chem 262-268.
26. Go?ggel R, Winoto-Morbach S, Vielhaber G, Imai Y, Lindner K, et al. (2004) PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. Nat Med 10: 155-160.
27. Gudz TI, Tserng KY, Hoppel CL (1997) Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide. J Biol Chem 272: 24154-24158.