Pathophysiology of Apnea of Prematurity

Fetal and Neonatal Physiology: Third Edition

Volumn 1-2, Issue , 2003, Pages 905-918

  Miller, Martha J ^a,b   Martin, Richard J ^a,b  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84911137811     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-0-7216-9654-6.50092-8     Document Type: Chapter

References (125)

1. Task Force on Prolonged Apnea Prolonged apnea. Pediatrics 1978, 61:651.
2. Rigatto H, Brady JP Periodic breathing and apnea in preterm infants, evidence for hypoventilation possibly due to central respiratory depression. Pediatrics 1972, 50:202.
3. Thach BT, Stark AR Spontaneous neck flexion and airway obstruction during apneic spells in preterm infants. J Pediatr 1979, 94:275.
4. Milner AD, et al. Upper airway obstruction and apnea in preterm babies. Arch Dis Child 1980, 55:22.
5. Mathew OP, et al. Pharyngeal airway obstruction in preterm infants during mixed and obstructive apnea. J Pediatr 1982, 100:964.
6. Miller MJ, et al. Continuous positive airway pressure selectively reduces obstructive apnea in preterm infants. J Pediatr 1985, 106:91.
7. Butcher-Puech MC, et al. Relation between apnoea duration and type and neurological status of preterm infants. Arch Dis Child 1985, 60:953.
8. Bolivar J, et al. Mechanisms for episodes of hypoxemia in mechanically ventilated preterm infants. Pediatr Res 1994, 35:A1287.
9. Miller MJ, et al. Changes in resistance and ventilatory timing that accompany apnea in premature infants. J Appl Physiol 1993, 75:720.
10. Dimaguila MAVT, et al. Characteristics of hypoxemic episodes in intubated very low birthweight infants. J Pediatr 1997, 130:577.
11. Lehtonen L, et al. Relationship of sleep state to hypoxemic episodes in ventilated ELBW infants. J Pediatr 2002, 141:363-369.
12. Kahn A, et al. Effects of obstructive sleep apneas on transcutaneous oxygen pressure in control infants, siblings of sudden infant death syndrome victims and near miss infants: comparison with the effects of central sleep apneas. Pediatrics 1982, 70:852.
13. Kitchen WH, et al. Collaborative study of very-low-birth-weight infants. Am J Dis Child 1983, 137:555.
14. Haddad GG, et al. Heart rate pattern during respiratory pauses in normal infants during sleep. J Dev Physiol 1984, 6:329.
15. Valimaki I, Tarlo PA Heart rate patterns and apnea in newborn infants. Am J Obstet Gynecol 1971, 110:343.
16. Henderson-Smart DJ, et al. Incidence and mechanism of bradycardia during apnoea in preterm infants. Arch Dis Child 1986, 61:227.
17. Daly M de B, Scott MJ The effects of stimulation of the carotid body chemoreceptors on heart rate in the dog. J Physiol (Lond) 1958, 144:148.
18. Davidson NS, et al. Respiratory modulation of baroreceptor and chemoreceptor reflexes affecting heart rate and cardiac vagal efferent nerve activity. J Physiol (Lond) 1976, 259:523.
19. Angell-James JE, et al. Lung inflation: effects on heart rate, respiration, and vagal afferent activity in seals. Am J Physiol 1981, 240:H190.
20. Girling DJ Changes in heart rate, blood pressure, and pulse pressure during apnoeic attacks in newborn babies. Arch Dis Child 1972, 7:405.
21. Perlman JM, Volpe JJ Episodes of apnea and bradycardia in the preterm newborn: impact on cerebral circulation. Pediatrics 1985, 76:333.
22. Ramalkers VT, et al. Cerebral hyperperfusion following episodes of bradycardia in the preterm infant. Early Hum Dev 1993, 34:199.
23. Alden ER, et al. Morbidity and mortality of infants weighing less than 1000 grams in an intensive care nursery. Pediatrics 1972, 50:40.
24. Carlo WA, et al. The effect of respiratory distress syndrome on chest wall movements and respiratory pauses in preterm infants. Am Rev Respir Dis 1982, 126:103.
25. Ramanathan R, et al. Cardiorespiratory events recorded on home monitors: Comparison of healthy infants with those at increased risk for SIDS. JAMA 2001, 285:2199.
26. Adickes ED, et al. Familial lethal sleep apnea. Hum Genet 1986, 73:39.
27. Brazy JE, et al. Central nervous system structure lesions causing apnea at birth. J Pediatr 1987, 111:163.
28. Pickens DL, et al. Characterization of prolonged apneic episodes associated with respiratory syncytial virus infection. Pediatr Pulmonol 1989, 6:195.
29. Welborn LG, et al. Postoperative apnea in former premature infants: prospective comparison of spinal and general anaesthesia. Anaesthesiology 1990, 72:838.
30. Martin RJ, et al. Pathogenesis of apnea in preterm infants. J Pediatr 1986, 109:733.
31. Henderson-Smart DJ, et al. Clinical apnea and brainstem neural function in preterm infants. N Engl J Med 1983, 308:353.
32. Gauda EB, et al. Genioglossus and diaphragm activity during obstructive apnea and airway occlusion in infants. Pediatr Res 1989, 26:583.
33. Abu-Shaweesh JM, et al. Changes in respiratory timing induces by hypercapnia in maturing rats. J Appl Physiol 1999, 87:484.
34. Abu-Shaweesh JM, et al. Central GABAergic mechanisms are involved in apnea induced by SLN stimulation in piglets. J Appl Physiol 2001, 90:1570.
35. Miller MJ, et al. Recurrent hypoxic exposure and reflex responses during development in the piglet. Respir Physiol 2000, 123:51.
36. Suguihara C, et al. Effect of dopamine on hypoxic ventilatory response of sedated piglets with intact and denervated carotid bodies. J Appl Physiol 1994, 77:285.
37. Long WA, Lawson EE Developmental aspects of the effect of naloxone on control of breathing in piglets. Respir Physiol 1983, 51:119.
38. Mayock DE, et al. Role of endogenous opiates in hypoxic ventilatory response in the newborn primate. J Appl Physiol 1986, 60:2015.
39. Chernick V, et al. Clinical trial of naloxone in birth asphyxia. J Pediatr 1988, 113:519.
40. Hoppenbrouwers T, et al. Polygraphic studies of normal infants during the first six months of life. III. Incidence of apnea and periodic breathing. Pediatrics 1977, 60:418.
41. Haddad GG, et al. Determination of sleep state in infants using respiratory variability. Pediatr Res 1987, 21:556.
42. Curzi-Dascalova L Thoracico-abdominal respiratory correlations in infants: constancy and variability in different sleep states. Early Hum Dev 1978, 2:25.
43. Bryan AC, Bryan MH Control of respiration in the newborn. Clin Perinatol 1978, 5:269.
44. Martin RJ, et al. Arterial oxygen tension during active and quiet sleep in the normal neonate. J Pediatr 1979, 94:271.
45. Muller N, et al. Diaphragmatic muscle fatigue in the newborn. J Appl Physiol 1979, 46:688.
46. Thach BT The role of pharyngeal airway obstruction in prolonging infantile apneic spells. Sudden Infant Death Syndrome 1983, 279. Academic Press, New York. J.T. Tilden (Ed.).
47. Rigatto H, et al. Chemoreceptor reflexes in preterm infants. II. The effect of gestational and postnatal age on the ventilatory response to inhaled carbon dioxide. Pediatrics 1975, 55:614.
48. Noble LM, et al. Transient changes in expiratory time during hypercapnia in premature infants. J Appl Physiol 1987, 62:1010.
49. Gerhardt T, Bancalari E Apnea of prematurity. I. Lung function and regulation of breathing. Pediatrics 1984, 74:58.
50. Martin RJ, et al. Hypoglossal and phrenic responses to central respiratory inhibition in piglets. Respir Physiol 1994, 97:93.
51. Martin RJ, et al. Role of the ventral medullary surface in modulating respiratory responses to reflex stimulation in piglets. Ventral Brainstem Mechanisms and Control of Respiration and Blood Pressure 1995, 625. Marcel Dekker, New York. O.L. Trouth (Ed.).
52. Cross KW, Oppe TE The effect of inhalation of high and low concentrations of oxygen on the respiration of the premature infant. J Physiol 1952, 117:38.
53. 2 in preterm infants. J Appl Physiol 1975, 39:896.
54. Martin RJ, et al. Persistence of the biphasic ventilatory response to hypoxia in preterm infants. J Pediatr 1998, 132:960.
55. Martin RJ, et al. Effect of lung volume on expiratory time in the newborn infant. J Appl Physiol 1978, 45:18.
56. Carlo WA, et al. Differential response of respiratory muscles to airway occlusion in infants. J Appl Physiol 1985, 59:847.
57. Gerhardt T, Bancalari E Apnea of prematurity. II: respiratory reflexes. Pediatrics 1984, 74:63.
58. Waggener TB, et al. Oscillatory breathing patterns leading to apneic spells in infants. J Appl Physiol 1982, 52:1288.
59. Fenner A, et al. Periodic breathing in premature and neonatal babies: incidence, breathing pattern, respiratory gas tensions, response to changes in the composition of ambient air. Pediatr Res 1973, 7:174.
60. Miller MJ, et al. Airway obstruction during periodic breathing in premature infants. J Appl Physiol 1988, 64:2496.
61. 2 threshold of respiratory muscles in preterm infants. J Appl Physiol 1988, 65:2434.
62. Haxhiu MA, et al. Responses to chemical stimulation of upper airway muscles and diaphragm in awake cats. J Appl Physiol 1984, 56:397.
63. van Lunteren E, et al. Phasic volume-related feedback on upper airway muscle activity. J Appl Physiol 1984, 56:730.
64. Gauda EB, et al. Genioglossus response to airway obstruction in apneic versus nonapneic infants. Pediatr Res 1987, 22:683.
65. Long WA, Lawson EE Maturation of the superior laryngeal nerve inhibiting effect. Am Rev Respir Dis 1981, 123:A166.
66. Abu-Osba YK, et al. An animal model for airway sensory deprivation producing obstructive apnea with postmortem findings of sudden infant death syndrome. Pediatrics 1981, 68:796.
67. Al-Shway S, Mortola JP Respiratory effects of airflow through the upper airways in newborn kittens and puppies. J Appl Physiol 1982, 53:805.
68. Thach BT, et al. Negative upper airway pressure decreases inspiratory airflow and tidal volume in tracheostomized sleeping human infants. Am Rev Respir Dis 1985, 131:A295.
69. Mathew OP, Farber JP Effect of upper airway negative pressure on respiratory timing. Respir Physiol 1983, 54:259.
70. Gauda EG, et al. Mechano- and chemoreceptor modulation of respiratory muscles in response to upper airway negative pressure. J Appl Physiol 1994, 76:2656.
71. Menon AP, et al. Apnea associated with regurgitation in infants. J Pediatr 1985, 106:625.
72. Storey T, Johnson P Laryngeal water receptors initiating apnea in the lamb. Exp Neurol 1975, 47:42.
73. Menon AP, et al. Frequency and significance of swallowing during prolonged apnea in infants. Am Rev Respir Dis 1984, 130:969.
74. Miller MJ, DiFiore JM A comparison of swallowing during apnea and periodic breathing in premature infants. Pediatr Res 1995, 37:796.
75. Pickens DL, et al. Prolonged apnea associated with upper airway protective reflexes in apnea of prematurity. Am Rev Respir Dis 1988, 137:113.
76. Arad-Cohen N, et al. The relationship between gastroesophageal reflux and apnea in infants. J Pediatr 2000, 137:321.
77. Peter CS, et al. Gastroesophageal reflux and apnea of prematurity: no temporal relationship. Pediatrics 2002, 109:8.
78. Kiatchoosakun P, et al. Effects of hypoxia on respiratory neural output and lower esophageal sphincter pressure in piglets. Pediatr Res 2002, 52:50-55.
79. Kimball AL, Carlton DP Gastroesophageal reflux medications in the treatment of apnea in premature infants. J Pediatr 2001, 138:355.
80. Martin RJ, et al. The effect of a low continuous positive airway pressure on the reflex control of respiration in the preterm infants. J Pediatr 1977, 90:976.
81. Sreenan C, et al. High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure. Pediatrics 2001, 107:108.
82. Mathew OP, et al. Influence of upper airway pressure changes on genioglossus muscle respiratory activity. J Appl Physiol 1982, 52:438.
83. Henderson-Smart DJ, Steer P Methylxanthine treatment for apnea in preterm infants. Cochrane Database Syst Review 2001, 3:CD00140.
84. Aranda JV, et al. Effect of caffeine on control of breathing in infantile apnea. J Pediatr 1983, 103:975.
85. Gerhardt T, et al. Effect of aminophylline on respiratory center activity and metabolic rate in premature infants with idiopathic apnea. Pediatrics 1979, 63:537.
86. Bauer J, et al. Effect of caffeine on oxygen consumption and metabolic rate in very low birth weight infants with idiopathic apnea. Pediatrics 2001, 107:660.
87. Eldridge FL, et al. Mechanism of respiratory effects of methylxanthines. Respir Physiol 1983, 53:239.
88. Cattarossi L, et al. Aminophylline and increased activity of peripheral chemoreceptors in newborn infants. Arch Dis Child 1993, 69:52.
89. Darnall RA Aminophylline reduces hypoxic ventilatory depression: possible role of adenosine. Pediatr Res 1985, 19:706.
90. Murciano D, et al. Effects of theophylline on diaphragmatic strength and fatigue in patients with chronic obstructive pulmonary disease. N Engl J Med 1984, 311:349.
91. Aubier M, et al. Diaphragmatic contractility enhanced by aminophylline: role of extracellular calcium. J Appl Physiol 1983, 54:460.
92. Yamazaki T, et al. Low dose doxapram therapy for apnea of prematurity. Pediatr Int 2001, 43:124.
93. Barrington KJ, et al. Physiologic effects of doxapram in idiopathic apnea of prematurity. J Pediatr 1986, 108:124.
94. Schmidt B Methylxanthine therapy in premature infants: Sound practice, disaster, or fruitless byway. J Pediatr 1998, 135:526.
95. Naeye RL Brainstem and adrenal abnormalities in the sudden infant death syndrome. Am J Clin Pathol 1976, 66:526.
96. Naeye RL, et al. Carotid body in the sudden infant death syndrome. Science 1976, 191:567.
97. Cornwell AC, et al. Ambulatory and in-hospital continuous recording of sleep state and cardiorespiratory parameters in near-miss for the sudden infant death syndrome and control infants. Biotelemetry 1978, 5:113.
98. Guilleminault C, et al. Apneas during sleep in infants: possible relationship with sudden infant death syndrome. Science 1975, 190:677.
99. Shannon DC, et al. Abnormal regulation of ventilation in infants at risk for sudden infant death syndrome. N Engl J Med 1977, 297:747.
100. United States Department of Health and Human Services Infantile apnea and home monitoring: report of a consensus development conference 1987, National Institutes of Health, Bethesda, MD, NIH publication no. 87-2905.
101. Schwartz PJ, et al. Molecular diagnosis in a child with sudden infant death syndrome. Lancet 2001, 358:1342.
102. Ackerman MJ, et al. Postmortem molecular analysis of SCN5A defects in sudden infant death syndrome. JAMA 2001, 286:2264.
103. Willinger M, et al. Infant sleep position and risk for sudden infant death syndrome: report of meeting held January 13 and 14, 1994, National Institutes of Health, Bethesda, MD. Pediatrics 1994, 93:814.
104. 2 dispersal and factors affecting rebreathing in bedding. J Appl Physiol 1995, 78:740.
105. Fleming PJ, et al. Interactions between thermoregulation and the control of respiration in infants: possible relationship to sudden infant death. Acta Paediatr Suppl 1993, 389:57.
106. Martin RJ, et al. Arterial oxygen tension during active and quiet sleep in the normal neonate. J Pediatr 1979, 94:271.
107. Brackbill Y, et al. Psychophysiologic effects in the neonate of prone versus supine placement. J Pediatr 1973, 82:82.
108. Masterson J, et al. Prone and supine positioning effects on energy expenditure and behavior of low birth weight neonates. Pediatrics 1987, 80:689.
109. Heimler R, et al. Effect of positioning on the breathing pattern of preterm infants. Arch Dis Child 1992, 67:312.
110. Martin RJ, et al. Vulnerability of respiratory control in healthy preterm infants placed supine. J Pediatr 1995, 127:609.
111. Sundell H Why does maternal smoke exposure increase the risk of sudden infant death syndrome?. Acta Pediatr 2001, 90:718.
112. Upton CJ, et al. Apnoea, bradycardia, and oxygen saturation in preterm infants. Arch Dis Child 1991, 66:381.
113. Poets CF, et al. Prolonged episodes of hypoxemia in preterm infants undetectable by cardiorespiratory monitors. Pediatrics 1995, 95:860.
114. DiFiore JM, et al. Cardiorespiratory events in preterm infants referred for apnea monitoring studies. Pediatrics 2001, 108:1304.
115. Taylor HG, et al. Predictors of early school age outcomes in very low birth weight children. J Dev Behav Pediatr 1998, 19:235.
116. Cheung P-Y, et al. Early childhood neurodevelopment in very low birth weight infants with predischarge apnea. Pediatr Pulmonol 1999, 27:14.
117. Guilleminault C, Dement WC Sleep apnea syndrome and related sleep disorders. Sleep Disorders: Diagnosis and Treatment 1978, 9. John Wiley, New York. R.L. Williams, I. Koracan (Eds.).
118. Bradley TD, et al. Clinical and physiologic heterogeneity of the central sleep apnea syndrome. Am Rev Respir Dis 1986, 134:217.
119. Remmers JE, et al. Nasal airway positive pressure in patients with occlusive sleep apnea. Am Rev Respir Dis 1984, 130:1152.
120. Guilleminault C, Hayes B Naloxone, theophylline, bromocriptine, and obstructive sleep apnea: negative results. Bull Eur Physiopathol Respir 1983, 19:632.
121. Guilleminault C, et al. A review of 50 children with obstructive sleep apnea syndrome. Lung 1981, 159:275.
122. Cherniack NS, Longobardo GS Cheyne-Stokes breathing: an instability in physiologic control. N Engl J Med 1973, 288:952.
123. Schulte FJ, et al. Rapid eye movement sleep, motoneurone inhibition, and apneic spells in preterm infants. Pediatr Res 1977, 11:709.
124. Baker SB, Fewell JE Effects of hyperoxia on the arousal response to upper airway obstruction in lambs. Pediatr Res 1987, 21:116.
125. Fewell JE, Konduri G Repeated exposure to rapidly developing hypoxemia influences the interaction between oxygen and carbon dioxide in initiating arousal from sleep in lambs. Pediatr Res 1988, 24:28.