Prevalence of hypodontia and associated factors: A systematic review and meta-analysis

Journal of Orthodontics

Volumn 41, Issue 4, 2014, Pages 299-316

  Khalaf, Khaled ^a   Miskelly, John ^a   Voge, Elena ^a   Macfarlane, Tatiana V ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Congenitally absent teeth; Dental agenesis; Epidemiology; Hypodontia; Prevalence

Indexed keywords

ANCESTRY GROUP; ANODONTIA; CONGENITAL MALFORMATION; FEMALE; HEALTH; HUMAN; INCISOR; MALE; META ANALYSIS; PREMOLAR TOOTH; PREVALENCE; SEX DIFFERENCE; STATISTICS AND NUMERICAL DATA;

ANODONTIA; BICUSPID; CONTINENTAL POPULATION GROUPS; FEMALE; GLOBAL HEALTH; HUMANS; INCISOR; MALE; PREVALENCE; SEX FACTORS;

EID: 84910674993     PISSN: 14653125     EISSN: 14653133     Source Type: Journal    
DOI: 10.1179/1465313314Y.0000000116     Document Type: Review

References (100)

1. Abu Alhaija ES, Al-Khateeb SN, Al-Nimri KS. Prevalence of malocclusion in 13-15 year-old North Jordanian school children. Community Dent Health 2005; 22: 266-271.
2. Abu Shakra K, Alqaqaa S. Prevalence of hypodontia and oligodontia in a sample of orthodontic and pediatric dentistry patients at prince hashem bin al-hussein military hospital. J R Med Serv 2008; 15: 40-44.
3. Ahmad W, Brancolini V, ul Faiyaz MF, Lam H, ul Haque S, Haider M, et al. A locus for autosomal recessive hypodontia with associated dental anomalies maps to chromosome 16q12.1. Am J Hum Genet 1998; 62: 987-991.
4. Ajami BA, Shabzendedar M, Mehrjerdian M. Prevalence of hypodontia in nineto fourteen-year-old children who attended the Mashhad School of Dentistry. Indian J Dent Res 2010; 21: 549-551.
5. Aktan A, Kara I, Sener I, Bereket C, Ay S, C iftci M. Radiographic study of tooth agenesis in the Turkish population. Oral Radiol 2010; 26: 95-100.
6. Alaluusua S, Calderara P, Gerthoux PM, Lukinmaa PL, Kovero O, Needham L, et al. Developmental dental aberrations after the dioxin accident in Seveso. Environ Health Perspect 2004; 112: 1313-1318.
7. Albashaireh ZS, Khader YS. The prevalence and pattern of hypodontia of the permanent teeth and crown size and shape deformity affecting upper lateral incisors in a sample of Jordanian dental patients. Community Dent Health 2006; 23: 239-243.
8. Al-Moherat FH, Al-Ebrahim HM, Alshurman I, Shudefat N, Al-Tawareh Y. Hypodontia in orthodontic patients in southern Jordan. Pak Oral Dent J 2009; 29: 45-48.
9. Alvesalo L, Portin P. The inheritance pattern of missing, peg-shaped, and strongly mesio-distally reduced upper lateral incisors. Acta Odontol Scand 1969; 27: 563-575.
10. Amin F. Prevalence of hypodontia in orthodontic patients in a pakistani samplea study. Pak Oral Dent J 2010; 30: 142-145.
11. Arte S, Nieminen P, Apajalahti S, Haavikko K, Thesleff I, Pirinen S. Characteristics of incisor-premolar hypodontia in families. J Dent Res 2001; 80: 1445-1450.
12. Aslam A, Nadeem A, Arbab SS. Prevalence and distribution of hypodontia in pakistani orthodontic population. Pak Oral Dent J 2010; 30: 406-411.
13. Baccetti T. Tooth rotation associated with aplasia of nonadjacent teeth. Angle Orthod 1998; 68: 471-474.
14. Behr M, Proff P, Leitzmann M, Pretzel M, Handel G, Schmalz G, et al. Survey of congenitally missing teeth in orthodontic patients in Eastern Bavaria. Eur J Orthod 2011; 33: 32-36.
15. Bondemark L, Tsiopa J. Prevalence of ectopic eruption, impaction, retention and agenesis of the permanent second molar. Angle Orthod 2007; 77: 773-778.
16. Borenstein M, Hedges L, Higgins J, Rothstein H. Comprehensive Meta-analysis Version 2. Englewood, NJ: Biostat. 2005.
17. Boruchov MJ, Green LJ. Hypodontia in human twins and families. Am J Orthod 1971; 60: 165-174.
18. Brook AH. Dental anomalies of number, form and size: Their prevalence in British schoolchildren. J Int Ass Dent Child 1974; 5: 37-53.
19. Brook AH. A unifying aetiological explanation for anomalies of human tooth number and size. Arch Oral Biol 1984; 29: 373-378.
20. Brook AH, Elcock C, Aggarwal M, Lath DL, Russell JM, Patel PI, et al. Tooth dimensions in hypodontia with a known PAX9 mutation. Arch Oral Biol 2009b; 54(Suppl 1): S57-S62.
21. Brook AH, Griffin RC, Smith RN, Townsend GC, Kaur G, Davis GR, et al. Tooth size patterns in patients with hypodontia and supernumerary teeth. Arch Oral Biol 2009a; 54(Suppl 1): S63-S70.
22. Bud E, Popsor S, Jurca? AM, Suciu B, Cormos, Pacurar M. Statistical study on the prevalence of nonsyndromic hypodontia in youths. Acta Medica Transilvanica 2011; 16: 444-447.
23. Camporesi M, Baccetti T, Marinelli A, Defraia E, Franchi L. Maxillary dental anomalies in children with cleft lip and palate: A controlled study. Int J Paediatr Dent 2010; 20: 442-450.
24. Cantekin K, Dane A, Miloglu O, Kazanci F, Bayrakdar S, Celikoglu M. Prevalence and intra-oral distribution of agenesis of permanent teeth among Eastern Turkish children. Eur J Paediatr Dent 2012; 13: 53-56.
25. Celikoglu M, Kazanci F, Miloglu O, Oztek O, Kamak H, Ceylan I. Frequency and characteristics of tooth agenesis among an orthodontic patient population. Med Oral Patol Oral Cir Bucal 2010; 15: 797-801.
26. Chalothorn LA, Beeman CS, Ebersole JL, Kluemper GT, Hicks EP, Kryscio RJ, et al. Hypodontia as a risk marker for epithelial ovarian cancer: A casecontrolled study. J Am Dent Assoc 2008; 139: 163-169.
27. Chung CJ, Han JH, Kim KH. The pattern and prevalence of hypodontia in Koreans. Oral Dis 2008; 14: 620-625.
28. Cobourne MT. Familial human hypodontia-is it all in the genes? Br Dent J 2007; 203: 203-208.
29. Davis PJ. Hypodontia and hyperdontia of permanent teeth in Hong Kong schoolchildren. Community Dent Oral Epidemiol 1987; 15: 218-220.
30. Eidelman E, Chosack A, Rosenzweig KA. Hypodontia: Prevalence amongst Jewish populations of different origin. Am J Phys Anthropol 1973; 39: 129-133.
31. Endo T, Ozoe R, Kubota M, Akiyama M, Shimooka S. A survey of hypodontia in Japanese orthodontic patients. Am J Orthod Dentofacial Orthop 2006; 129: 29-35.
32. Erpenstein H, Pfeiffer RA. Sex-linked-dominant hereditary reduction in number of teeth. Humangenetik 1967; 4: 280-293.
33. Fekonja A. Hypodontia in orthodontically treated children. Eur J Orthod 2005; 27: 457-60.
34. Fujita Y, Hidaka A, Nishida I, Morikawa K, Hashiguchi D, Maki K. Developmental anomalies of permanent lateral incisors in young patients. J Clin Pediatr Dent 2009; 33: 211-215.
35. Gabris K, Fabian G, Kaan M, Rozsa N, Tarjan I. Prevalence of hypodontia and hyperdontia in paedodontic and orthodontic patients in Budapest. Community Dental Health 2006; 23: 80-82.
36. Goldenberg M, Das P, Messersmith M, Stockton DW, Patel PI, D'Souza RN. Clinical, radiographic, and genetic evaluation of a novel form of autosomal-dominant oligodontia. J Dent Res 2000; 79: 1469-1475.
37. Gomes RR, da Fonseca JA, Paula LM, Faber J, Acevedo AC. Prevalence of hypodontia in orthodontic patients in Brasilia, Brazil. Eur J Orthod 2010; 32: 302-306.
38. Goodman JR, Jones SP, Hobkirk JA, King PA. Hypodontia: 1. Clinical features and the management of mild to moderate hypodontia. Dent Update 1994; 21: 381-384.
39. Goren S, Tsoizner R, Dinbar A, Levin L, Brezniak N. Prevalence of congenitally missing teeth in Israeli recruits. Refuat Hapeh Vehashinayim 2005; 22: 49-53.
40. Gorlin RJ, Herman NG, Moss SJ. Complete absence of the permanent dentition: An autosomal recessive disorder. Am J Med Genet 1980; 5: 207-209.
41. Goya HA, Tanaka S, Maeda T, Akimoto Y. An orthopantomographic study of hypodontia in permanent teeth of Japanese pediatric patients. J Oral Sci 2008; 50: 143-150.
42. Grahnen H. Hypodontia in the permanent dentition. Odontol Revy 1956; 7: 1-100.
43. Gupta SK, Saxena P, Jain S, Jain D. Prevalence and distribution of selected developmental dental anomalies in an Indian population. J Oral Sci 2011; 53: 231-238.
44. Haavikko K. Hypodontia of permanent teeth. Proc Finn Dent Soc 1971; 67: 219-225.
45. Harris EF, Clark LL. Hypodontia: An epidemiologic study of American black and white people. Am J Orthod Dentofacial Orthop 2008; 134: 761-767.
46. Hu XL, Li JH, Luo J, Qiu LX, Lin Y. Multidisciplinary management of congenitally missing teeth with osseointegrated dental implants: A longterm report. Chin J Dent Res 2011; 14: 29-36.
47. Hunstadbraten K. Hypodontia in the permanent dentition. J Dent Child 1973; 40: 115-117.
48. Keene H. The relationship between maternal age and parity, birth weight and hypodontia in naval recruits. J Dent Child 1966; 33: 135-147.
49. Keller JM, Huet-Hudson YM, Leamy LJ. Qualitative effects of dioxin on molars vary among inbred mouse strains. Arch Oral Biol 2007; 52: 450-454.
50. Kim YH. Investigation of hypodontia as clinically related dental anomaly: Prevalence and characteristics. ISRN Dent 2011; 2001: 246135.
51. Kirziog?lu Z, Koseler Sentut T, Ozay Erturk MS, Karayilmaz H. Clinical features of hypodontia and associated dental anomalies: A retrospective study. Oral Dis 2005; 11: 399-404.
52. Kuchler EC, Risso PA, Costa Mde C, Modesto A, Vieira AR. Studies of dental anomalies in a large group of school children. Arch Oral Biol 2008; 53: 941-946.
53. Larmour CJ, Mossey PA, Thind BS, Forgie AH, Stirrups DR. Hypodontia-a retrospective review of prevalence and etiology. Part I. Quintessence Int 2005; 36: 263-70.
54. Maatouk F, Baaziz A, Ghnima S, Masmoudi F, Ghedira H. Survey on hypodontia in Sayada, Tunisia. Quintessence Int 2008; 39: 115-120.
55. Mahaney MC, Fujiwara TM, Morgan K. Dental agenesis in the Dariusleut Hutterite Brethren: Comparisons to selected Caucasoid population surveys. Am J Phys Anthropol 1990; 82: 165-177.
56. Marec-Berard P, Azzi D, Chaux-Bodard AG, Lagrange H, Gourmet R, Bergeron C. Long-term effects of chemotherapy on dental status in children treated for nephroblastoma. Pediatr Hematol Oncol 2005; 22: 581-588.
57. Mattheeuws N, Dermaut L, Martens G. Has hypodontia increased in Caucasians during the 20th century? A meta-analysis. Eur J Orthod 2004; 26: 99-103.
58. McNamara C, Foley T, McNamara CM. Multidisplinary management of hypodontia in adolescents: Case report. J Can Dent Assoc 2006; 72: 740-746.
59. Meaney S, Anweigi L, Ziada H, Allen F. The impact of hypodontia: A qualitative study on the experiences of patients. Eur J Orthod 2012; 34: 547-552.
60. Medina AC. Radiographic study of prevalence and distribution of hypodontia in a pediatric orthodontic population in Venezuela. Pediatr Dent 2012; 34: 113-116.
61. Moher D, Liberati A, Tetzlaff J, Altman DG. PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. J Clin Epidemiol 2009; 62: 1006-1012.
62. Muller TP, Hill IN, Petersen AC, Blayney JR. A survey of congenitally missing permanent teeth. J Am Dent Assoc 1970; 81: 101-109.
63. Murdock S, Lee JY, Guckes A, Wright JT. A costs analysis of dental treatment for ectodermal dysplasia. J Am Dent Assoc 2005; 136: 1273-1276.
64. Neal JJ, Bowden DE. The diagnostic value of panoramic radiographs in children aged nine to ten years. Br J Orthod 1988; 15: 193-197.
65. Nieminen P, Arte S, Pirinen S, Peltonen L, Thesleff I. Gene defect in hypodontia: Exclusion of MSX1 and MSX2 as candidate genes. Hum Genet. 1995; 96: 305-308.
66. Nieminen P. Genetic basis of tooth agenesis. J Exp Zool B Mol Dev Evol 2009; 312B: 320-342.
67. Niswander JD, Sujaku C. Congenital anomalies of teeth in Japanese children. J Phys Anthropol 1963; 21: 569-574.
68. Nordgarden H, Jensen JL, Storhaug K. Reported prevalence of congenitally missing teeth in two Norwegian counties. Community Dent Health 2002; 19: 258-261.
69. Parkin N, Elcock C, Smith RN, Griffin RC, Brook AH. The aetiology of hypodontia: The prevalence, severity and location of hypodontia within families. Arch Oral Biol 2009; 54(Suppl 1): S52-S56.
70. Peck S, Peck L, Kataja M. Site-specificity of tooth agenesis in subjects with maxillary canine malpositions. Angle Orthod 1996; 66: 473-476.
71. Peck S, Peck L, Kataja M. Concomitant occurrence of canine malposition and tooth agenesis: Evidence of orofacial genetic fields. Am J Orthod Dentofacial Orthop 2002; 122: 657-660.
72. Pedersen LB, Clausen N, Schrøder H, Schmidt M, Poulsen S. Microdontia and hypodontia of premolars and permanent molars in childhood cancer survivors after chemotherapy. Int J Paediatr Dent 2012; 22: 239-243.
73. Peker I, Kaya E, Darendeliler-Yaman S. Clinic and radiographical evaluation of non-syndromic hypodontia and hyperdontia in permanent dentition. Med Oral Patol Oral Cir Bucal 2009; 14: 393-397.
74. Pirinen S, Kentala A, Nieminen P, Varilo T, Thesleff I, Arte S. Recessively inherited lower incisor hypodontia. J Med Genet 2001; 38: 551-556.
75. Polder BJ, Van't Hof MA, Van der Linden FPGM, Kuijpers-Jagtman AM. A meta-analysis of the prevalence of dental agenesis of permanent teeth. Community Dent Oral Epidemiol 2004; 32: 217-226.
76. Rahardjo P. Prevalence of hypodontia in Chinese orthodontic patients. Dent J (Maj. Ked. Gigi) 2006; 39: 47-50.
77. Ringqvist M, Thilander B. The frequency of hypodontia in an orthodontic material. Sven Tandlaek Tidskr 1969; 62: 535-541.
78. Rølling S, Poulsen S. Agenesis of permanent teeth in 8138 Danish schoolchildren: Prevalence and intra-oral distribution according to gender. Int J Paediatr Dent 2009; 19: 172-175.
79. Rose JS. A survey of congenitally missing teeth, excluding third molars, in 6000 orthodontic patients. Dent Pract Dent Rec 1966; 17: 107-114.
80. Rosenzweig KA, Garbarski D. Numerical aberrations in the permanent teeth of grade school children in Jerusalem. Am J Phys Anthropol 1965; 23: 277-283.
81. Saeves R, Nordgarden H, Storhaug K, Sandvik L, Espelid I. Salivary flow rate and oral findings in Prader-Willi syndrome: A case-control study. Int J Paediatr Dent 2012; 22: 27-36.
82. Schalk-van der Weide Y, Steen WH, Bosman F. Distribution of missing teeth and toothmorphology in patients with oligodontia.JDent Child 1992; 59: 133-140.
83. Silva Meza R. Radiographic assessment of congenitally missing teeth in orthodontic patients. Int J Paediatr Dent 2003; 13: 112-116.
84. Simons AL, Stritzel F, Stamatiou J. Anomalies associated with hypodontia of the permanent lateral incisors and second premolar. J Clin Pediatr Dent 1993; 17: 109-111.
85. Sisman Y, Uysal T, Gelgor IE. Hypodontia. Does the prevalence and distribution pattern differ in orthodontic patients? Eur J Dent 2007; 1: 167-173.
86. Sogra Y, Mahdjoube GM, Elham K, Shohre TM. Prevalence of dental anomalies in Iranian orthodontic patients. J Dent Oral Hygiene 2012; 4: 16-20.
87. Spahic-Dizdarevic M, Deljo E, Ganibegovic-Selimovic M. Evaluation of the prevalence of dental anomalies in children in the canton of Sarajevo. Acta Stomatol Croat 2011; 45: 24-30.
88. S tefania D, Elisabeta B. Prevalence of hypodontia in orthodontic patients. Med Evolut 2010; XVI: 31-36.
89. Tavajohi-Kermani H, Kapur R, Sciote JJ. Tooth agenesis and craniofacial morphology in an orthodontic population. Am J Orthod Dentofacial Orthop 2002; 122: 39-47.
90. Thesleff I. The genetic basis of tooth development and dental defects. Am J Med Genet Part A 2006; 140: 2530-2535.
91. Thilander B, Myrberg N. The prevalence of malocclusion in Swedish schoolchildren. Scand J Dent Res 1973; 81: 12-21.
92. Thorlund K, Imberger G, Johnston BC, Walsh M, Awad T, Thabane L, et al. Evolution of Heterogeneity (I2) Estimates and Their 95% Confidence Intervals in Large Meta-Analyses. PLoS ONE 2012; 7: E39471.
93. Topkara A, Sari Z. Prevalence and distribution of hypodontia in a Turkish orthodontic patient population: Results from a large academic cohort. Eur J Paediatr Dent 2011; 12: 123-127.
94. Uslu O, Akcam MO, Evirgen S, Cebeci I. Prevalence of dental anomalies in various malocclusions. Am J Orthod Dentofacial Orthop 2009; 135: 328-335.
95. Vahid-Dastjerdi E, Borzabadi-Farahani A, Mahdian M, Amini N. Nonsyndromic hypodontia in an Iranian orthodontic population. J Oral Sci 2010; 52: 455-461.
96. Valle AL, Lorenzoni FC, Martins LM, Valle CV, Henriques JF, Almeida AL, et al. A multidisciplinary approach for the management of hypodontia: Case report. J Appl Oral Sci 2011; 19: 544-548.
97. Vastardis H, Karimbux N, Guthua SW, Seidman JG, Seidman CE. A human MSX1 homeodomain missense mutation causes selective tooth agenesis. Nat Genet 1996; 13: 417-421.
98. von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. STROBE Initiative. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: Guidelines for reporting observational studies. Epidemiology 2007; 18: 800-804.
99. Winter GB. Amelogenesis imperfecta with enamel opacities and taurodontism: An alternative diagnosis for idiopathic dental fluorosis. Br Dent J 1996; 181: 167-172.
100. Yamaguchi T, Tomoyasu Y, Nakadate T, Oguchi K, Maki K. Allergy as a possible predisposing factor for hypodontia. Eur J Orthod 2008; 30: 641-644.