Biodistribution studies of polymeric nanoparticles for drug delivery in mice

Human Gene Therapy

Volumn 25, Issue 11, 2014, Pages 927-928

  Falzarano, Maria Sofia ^a   Bassi, Elena ^a   Passarelli, Chiara ^b   Braghetta, Paola ^c   Ferlini, Alessandra ^a  

^a UNIVERSITY OF FERRARA   (Italy)

^b BAMBINO GESÙ CHILDREN S HOSPITAL   (Italy)

^c UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

2'OMEPS ANTISENSE OLIGONUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE; DRUG CARRIER; DYSTROPHIN; N ISOPROPIL ACRYLAMIDE NANOPARTICLE; NANOPARTICLE; POLY(METHYL METHACRYLATE); QUATERNARY AMMONIUM DERIVATIVE; UNCLASSIFIED DRUG; ZM4 NANOPARTICLE; POLYMETHACRYLIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIODEGRADABILITY; BLOOD BRAIN BARRIER; BRAIN VENTRICLE; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG DOSE REGIMEN; DUCHENNE MUSCULAR DYSTROPHY; FLUORESCENCE ANALYSIS; HEART MUSCLE; IMAGING SYSTEM; IN VIVO STUDY; MOUSE; NONHUMAN; PERITONEAL CAVITY; POLYMERIZATION; SKELETAL MUSCLE; ANIMAL; GENE THERAPY; HUMAN; MUSCULAR DYSTROPHY, DUCHENNE; TISSUE DISTRIBUTION; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

ANIMALS; GENETIC THERAPY; HUMANS; MICE, INBRED MDX; MUSCULAR DYSTROPHY, DUCHENNE; NANOPARTICLES; OLIGORIBONUCLEOTIDES, ANTISENSE; POLYMETHACRYLIC ACIDS; TISSUE DISTRIBUTION;

EID: 84910664811     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2014.073     Document Type: Article

References (4)

1. Bassi, E., Falzarano, S., Fabris, M., et al. (2012). Persistent dystrophin protein restoration 90 days after a course of intraperitoneally administered naked 2¢OMePS AON and ZM2 NP-AON complexes in mdx mice. J. Biomed. Biotechnol. 2012, 897076.
2. Falzarano, M.S., Passarelli, C., and Ferlini, A. (2014). Nanoparticle delivery of antisense oligonucleotides and their application in the exon skipping strategy for Duchenne muscular dystrophy. Nucleic Acid Ther. 24, 87-100.
3. Ferlini, A., Sabatelli, P., Fabris, M., et al. (2010). Dystrophin restoration in skeletal, heart and skin arrector pili smooth muscle of mdxmice byZM2NP-AONcomplexes. Gene Ther. 17, 432-438.
4. Rimessi, P., Sabatelli, P., Fabris, M., et al. (2009). Cationic PMMA nanoparticles bind and deliver antisense oligoribonucleotides allowing restoration of dystrophin expression in the mdx mouse. Mol. Ther. 17, 820-827.