Tn4401 Carrying blaKPC is inserted within another insertion in pKpQIL and related plasmids

Journal of Clinical Microbiology

Volumn 52, Issue 12, 2014, Pages 4448-4449

  Partridge, Sally R ^a  

^a WESTMEAD HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BLAKPC GENE; CHINA; GENE; GENE IDENTIFICATION; GENE INSERTION; GREECE; ISRAEL; LETTER; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; PKPQIL GENE; PLASMID; TN4401; TRANSPOSON; UNITED STATES; ANALYSIS; ANTIBIOTIC RESISTANCE; BACTERIUM IDENTIFICATION; CLASSIFICATION; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; EPIDEMIC; HUMAN; MASS SPECTROMETRY; PROCEDURES;

BACTERIAL TYPING TECHNIQUES; BETA-LACTAM RESISTANCE; DISEASE OUTBREAKS; ENTEROBACTERIACEAE; ENTEROBACTERIACEAE INFECTIONS; HUMANS; PLASMIDS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84910151161     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.02426-14     Document Type: Letter

References (12)

1. Nordmann P, Naas T, Poirel L. 2011. Global spread of carbapenemase-producing Enterobacteriaceae. Emerg. Infect. Dis. 17:1791-1798. http://dx.doi.org/10.3201/eid1710.110655.
2. Naas T, Cuzon G, Villegas MV, Lartigue MF, Quinn JP, Nordmann P. 2008. Genetic structures at the origin of acquisition of the β-lactamase blaKPC gene. Antimicrob. Agents Chemother. 52:1257-1263. http://dx.doi.org/10.1128/AAC.01451-07.
3. Leavitt A, Chmelnitsky I, Carmeli Y, Navon-Venezia S. 2010. Complete nucleotide sequence of KPC-3-encoding plasmid pKpQIL in the epidemic Klebsiella pneumoniae sequence type 258. Antimicrob. Agents Chemother. 54:4493-4496. http://dx.doi.org/10.1128/AAC.00175-10.
4. Gootz TD, Lescoe MK, Dib-Hajj F, Dougherty BA, He W, Della-Latta P, Huard RC. 2009. Genetic organization of transposase regions surrounding blaKPC carbapenemase genes on plasmids from Klebsiella strains isolated in a New York City hospital. Antimicrob. Agents Chemother. 53:1998-2004. http://dx.doi.org/10.1128/AAC.01355-08.
5. Chen L, Chavda KD, Al Laham N, Melano RG, Jacobs MR, Bonomo RA, Kreiswirth BN. 2013. Complete nucleotide sequence of a blaKPC-harboring IncI2 plasmid and its dissemination in New Jersey and New York hospitals: a hidden threat. Antimicrob. Agents Chemother. 57: 5019-5025. http://dx.doi.org/10.1128/AAC.01397-13.
6. Ho PL, Cheung YY, Lo WU, Li Z, Chow KH, Lin CH, Chan JF, Cheng VC. 2013. Molecular characterization of an atypical IncX3 plasmid pKPCNY79 carrying blaKPC-2 in a Klebsiella pneumoniae. Curr. Microbiol. 67: 493-498. http://dx.doi.org/10.1007/s00284-013-0398-2.
7. Lau AF, Wang H, Weingarten RA, Drake SK, Suffredini AF, Garfield MK, Chen Y, Gucek M, Youn JH, Stock F, Tso H, DeLeo J, Cimino JJ, Frank KM, Dekker JP. 2014. A rapid matrix-assisted laser desorption ionization-time of flight mass spectrometry-based method for single plasmid tracking in an outbreak of carbapenem-resistant Enterobacteriaceae. J. Clin. Microbiol. 52:2804-2812. http://dx.doi.org/10.1128/JCM.00694-14.
8. Moura A, Pereira C, Henriques I, Correia A. 2012. Novel gene cassettes and integrons in antibiotic-resistant bacteria isolated from urban wastewaters. Res. Microbiol. 163:92-100. http://dx.doi.org/10.1016/j.resmic.2011.10.010.
9. Siguier P, Perochon J, Lestrade L, Mahillon J, Chandler M. 2006. ISfinder: the reference centre for bacterial insertion sequences. Nucleic Acids Res. 34:D32-D36. http://dx.doi.org/10.1093/nar/gkj014.
10. Poirel L, Lartigue MF, Decousser JW, Nordmann P. 2005. ISEcp1Bmediated transposition of blaCTX-M in Escherichia coli. Antimicrob. Agents Chemother. 49:447-450. http://dx.doi.org/10.1128/AAC.49.1.447-450.2005.
11. Naas T, Bonnin RA, Cuzon G, Villegas MV, Nordmann P. 2013. Complete sequence of two KPC-harbouring plasmids from Pseudomonas aeruginosa. J. Antimicrob. Chemother. 68:1757-1762. http://dx.doi.org/10.1093/jac/dkt094.
12. Frasson I, Lavezzo E, Franchin E, Toppo S, Barzon L, Cavallaro A, Richter SN, Palu G. 2012. Antimicrobial treatment and containment measures for an extremely drug-resistant Klebsiella pneumoniae ST101 isolate carrying pKPN101-IT, a novel fully sequenced blaKPC-2 plasmid. J. Clin. Microbiol. 50:3768-3772. http://dx.doi.org/10.1128/JCM.01892-12.