Impact of homocysteine-thiolactone on plasma fibrin networks

Journal of Thrombosis and Thrombolysis

Volumn 38, Issue 4, 2014, Pages 540-545

  Genoud, Valeria ^a   Lauricella, Ana María ^a   Kordich, Lucía C ^a   Quintana, Irene ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Fibrin formation; Fibrin network structure; Homocysteine thiolactone; Scanning electron microscopy

Indexed keywords

FIBRIN; HOMOCYSTEINE; LYSINE; THIOLACTONE; HOMOCYSTEINE THIOLACTONE;

ACYLATION; ARTICLE; BLOOD CLOTTING TEST; BLOOD CLOTTING TIME; DISEASE ASSOCIATION; ELECTRON MICROSCOPY; ENZYME KINETIC ASSAY; FIBRIN FORMATION; FIBRINOLYSIS; HUMAN; HYPERHOMOCYSTEINEMIA; MAXIMUM REACTION VELOCITY; OPTICAL DENSITY; PARTIAL THROMBOPLASTIN TIME; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTHROMBIN TIME; RISK FACTOR; SCANNING ELECTRON MICROSCOPY; THROMBIN TIME; VASCULAR DISEASE; ANALOGS AND DERIVATIVES; ANIMAL; BLOOD CLOTTING; BOVINE; CHEMISTRY; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; PLASMA;

ANIMALS; BLOOD COAGULATION; CATTLE; FIBRIN; HOMOCYSTEINE; HUMANS; PLASMA;

EID: 84910140789     PISSN: 09295305     EISSN: 1573742X     Source Type: Journal    
DOI: 10.1007/s11239-014-1063-8     Document Type: Article

References (32)

1. Guba SC, Fonseca V, Fink LM (1999) Hyperhomocysteinemia and thrombosis. Semin Thromb Hemost 25:291–309
2. D´Angelo A, Selhub J (1997) Homocysteine and thrombotic disease. Blood 90:1–11
3. Van Guldener C, Stehouwer CD (2000) Hyperhomocysteinemia, vascular pathology, and endothelial dysfunction. Semin Thromb Hemost 26:281–289
4. Perła-Kaján J, Twardowski T, Jakubowski H (2007) Mechanisms of homocysteine toxicity in humans. Amino Acids 32:561–572
5. Castañon MM, Lauricella AM, Kordich L, Quintana I (2007) Plasma homocysteine cutoff values for venous thrombosis. Clin Chem Lab Med 45:232–236
6. Refsum H, Smith AD, Ueland PM, Nexo E, Clarke R, McPartlin J, Johnston C, Engbaek F, Schneede J, McPartlin C, Scott JM (2004) Facts and recommendations about total homocysteine determinations: an expert opinion. Clin Chem 50:3–32
7. Jakubowski H, Goldman E (1993) Synthesis of homocysteine thiolactone by methionyl-tRNA synthetase in cultured mammalian cells. FEBS Lett 317:237–240
8. Blom HJ (2000) Consequences of homocysteine export and oxidation in the vascular system. Semin Thromb Hemost 26:227–232
9. Jakubowski H (1999) Protein homocysteinylation: possible mechanism underlying pathological consequences of elevated homocysteine levels. FASEB J 13:2277–2283
10. Glushchenko AV, Jacobsen DW (2007) Molecular targeting of proteins by L-homocysteine: mechanistic implications for vascular disease. Antioxid Redox Signal 9(11):1883–1898
11. Jakubowski H (2007) The molecular basis of homocysteine thiolactone-mediated vascular disease. Clin Chem Lab Med 45:1704–1716
12. Yang X, Gao Y, Zhou J, Zhen Y, Yang Y, Wang J, Song L, Liu Y, Xu H, Chen Z, Hui R (2006) Plasma homocysteine thiolactone adducts associated with risk of coronary heart disease. Clin Chim Acta 364:230–234
13. Weisel JW (2007) Structure of fibrin: impact on clot stability. J Thromb Haemost 5(suppl 1):116–124
14. Hoffman M (2008) Alterations of fibrinogen structure in human disease. Cardiovasc Hematol Agents Med Chem 6:206–211
15. Sauls DL, Wolberg AS, Hoffman M (2003) Elevated plasma homocysteine leads to alterations in fibrin clot structure and stability: implications for the mechanism of thrombosis in hyperhomocysteinemia. J Thromb Haemost 1:300–306
16. Lauricella AM, Quintana IL, Kordich LC (2002) Effects of homocysteine thiol group on fibrin networks: another possible mechanism of harm. Thromb Res 107:75–79
17. Rojas AM, Kordich L, Lauricella AM (2009) Homocysteine modifies fibrin clot deformability: another possible explanation of harm. Biorheology 46:379–387
18. Quintana IL, Oberholzer MV, Kordich L, Lauricella AM (2009) Impaired fibrin gel permeability by high homocysteine levels. Thromb Res 127:35–38
19. Lauricella AM, Quintana I, Castañon M, Sassetti B, Kordich L (2006) Influence of homocysteine on fibrin network lysis. Blood Coagul Fibrinolysis 17:181–186
20. Olas B, Kolodziejczyk J, Malinowska J (2010) May modifications of human plasma proteins stimulated by homocysteine and its thiolactone induce changes of hemostatic function of plasma in vitro? Gen Physiol Biophys 29:186–193
21. Malinowska J, Nowak P, Olas B (2011) Comparison of the effect of homocysteine in the reduced form, its thiolactone and protein homocysteinylation on hemostatic properties of plasma. Thromb Res 127:214–219
22. Mosesson MW (1999) Dysfibrinogenemia and thrombosis. Semin Thromb Hemost 25:311–319
23. Wolberg AS, Gabriel DA, Hoffman M (2002) Analyzing fibrin clot structure using a microplate reader. Blood Coagul Fibrinolysis 13:533–539
24. Meh DA, Mosesson MW, DiOrio JP, Siebenlist KR, Hernandez I, Amrani DL, Stojanovich L (2001) Disintegration and reorganization of fibrin networks during tissue-type plasminogen activator-induced clot lysis. Blood Coagul Fibrinolysis 12:627–637
25. Collet JP, Park D, Lesty C, Soria J, Soria C, Montalescot G, Weisel JW (2000) Influence of fibrin network conformation and fibrin fiber diameter on fibrinolysis speed: dynamic and structural approaches by confocal microscopy. Arterioscler Thromb Vasc Biol 20:1354–1361
26. Wu JH, Siddiqui K, Diamond SL (1994) Transport phenomena and clot dissolving therapy: an experimental investigation of diffusion-controlled and permeation-enhanced fibrinolysis. Thromb Haemost 72:105–112
27. Collet JP, Lesty C, Montalescot G, Weisel JW (2003) Dynamic changes of fibrin architecture during fibrin formation and intrinsic fibrinolysis of fibrin-rich clots. J Biol Chem 278:21331–21335
28. Carr ME, Alving BM (1995) Effect of fibrin structure on plasmin-mediated dissolution of plasma clots. Blood Coagul Fibrinolysis 6:567–573
29. Kolev K, Machovich R (2003) Molecular and cellular modulation of fibrinolysis. Thromb Haemost 89:610–621
30. Sauls DL, Lockhart E, Warren ME, Lenkowski A, Wilhelm SE, Hoffman M (2006) Modification of fibrinogen by homocysteine thiolactone increases resistance to fibrinolysis: a potential mechanism of the thrombotic tendency in hyperhomocysteinemia. Biochemistry 45:2480–2487
31. Undas A, Brozek J, Jankowski M, Siudak Z, Szczeklik A, Jakubowski H (2006) Plasma homocysteine affects fibrin clot permeability and resistance to lysis in human subjects. Arterioscler Thromb Vasc Biol 26:1397–1404
32. Cellai AP, Lami D, Antonucci E, Liotta AA, Rogolino A, Fedi S, Fiorillo C, Becatti M, Cenci C, Marcucci R, Abbate R, Prisco D (2013) Hyperhomocysteinemia in patients with pulmonary embolism is associated with impaired plasma fibrinolytic capacity. J Thromb Thrombolysis. doi:10.1007/s11239-013-0981-1