Do vascular smooth muscle cells differentiate to macrophages in atherosclerotic lesions?

Circulation Research

Volumn 115, Issue 7, 2014, Pages 605-606

  Swirski, Filip K ^a   Nahrendorf, Matthias ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN E; BETA GALACTOSIDASE; CD11B ANTIGEN; CD45 ANTIGEN; CD68 ANTIGEN; CRE RECOMBINASE; GALECTIN 3; GREEN FLUORESCENT PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ALLELE; AORTA ROOT; ATHEROSCLEROSIS; BONE MARROW CELL; CELL DIFFERENTIATION; CELL EXPANSION; CELL MIGRATION; CELL TRANSDIFFERENTIATION; EDITORIAL; GENE EXPRESSION; GENE LOCUS; MACROPHAGE; MONOCYTE; MONONUCLEAR PHAGOCYTE; NONHUMAN; PRIORITY JOURNAL; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; ANIMAL; ATHEROSCLEROTIC PLAQUE; EDITORIALS; NOTE; PATHOLOGY; VASCULAR SMOOTH MUSCLE CELLS;

ATHEROSCLEROSIS; EDITORIALS; MACROPHAGES; VASCULAR SMOOTH MUSCLE CELLS;

ANIMALS; CELL TRANSDIFFERENTIATION; MACROPHAGES; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; PLAQUE, ATHEROSCLEROTIC;

EID: 84910123575     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.114.304925     Document Type: Editorial

References (11)

1. Swirski FK, Nahrendorf M. Leukocyte behavior in atherosclerosis, myocardial infarction, and heart failure. Science. 2013;339:161-166.
2. van Furth R, Cohn ZA. The origin and kinetics of mononuclear phagocytes. J Exp Med. 1968;128:415-435.
3. Davies LC, Jenkins SJ, Allen JE, Taylor PR. Tissue-resident macrophages. Nat Immunol. 2013;14:986-995.
4. Epelman S, Lavine KJ, Randolph GJ. Origin and functions of tissue macrophages. Immunity. 2014;41:21-35.
5. Sieweke MH, Allen JE. Beyond stem cells: self-renewal of differentiated macrophages. Science. 2013;342:1242974.
6. Ginhoux F, Jung S. Monocytes and macrophages: developmental pathways and tissue homeostasis. Nat Rev Immunol. 2014;14:392-404.
7. Gomez D, Owens GK. Smooth muscle cell phenotypic switching in atherosclerosis. Cardiovasc Res. 2012;95:156-164.
8. Allahverdian S, Chehroudi AC, McManus BM, Abraham T, Francis GA. Contribution of intimal smooth muscle cells to cholesterol accumulation and macrophage-like cells in human atherosclerosis. Circulation. 2014;129:1551-1559.
9. Rong JX, Shapiro M, Trogan E, Fisher EA. Transdifferentiation of mouse aortic smooth muscle cells to a macrophage-like state after cholesterol loading. Proc Natl Acad Sci U S A. 2003;100:13531-13536.
10. Feil S, Fehrenbacher B, Lukowski R, Essmann F, Schulze-Osthoff, Schaller M, Feil R. Transdifferentiation of vascular smooth muscle cells to macrophage-like cells druing atherogenesis. Circ Res. 2014;115:662-667.
11. Robbins CS, Hilgendorf I, Weber GF, et al. Local proliferation dominates lesional macrophage accumulation in atherosclerosis. Nat Med. 2013;19:1166-1172.