TERT gene amplification is associated with poor outcome in acral lentiginous melanoma

Journal of the American Academy of Dermatology

Volumn 71, Issue 4, 2014, Pages 839-841

  Diaz, Alba ^a   Puig Butillé, Joan Anton ^a,d   Muñoz, Concha ^a   Costa, Dolors ^a   Díez, Anna ^b   Garcia Herrera, Adriana ^a   Carrera, Cristina ^a,c   Badenas, Celia ^a,d   Solé, Francesc ^c   Malvehy, Josep ^a,d   Puig, Susana ^a,d   Alos, Llucia ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b Institute of Predictive and Personalized Medicine of Cancer (IMPPC)   (Spain)

^c UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^d INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; TELOMERASE REVERSE TRANSCRIPTASE; TELOMERASE; TERT PROTEIN, HUMAN;

ACRAL LENTIGINOUS MELANOMA; ADULT; AGED; BACTERIAL ARTIFICIAL CHROMOSOME; CANCER GROWTH; CANCER PROGNOSIS; CANCER SURVIVAL; CELL PROLIFERATION; CELL SURVIVAL; CENTROMERE; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; FOLLOW UP; GENE ACTIVATION; GENE AMPLIFICATION; GENE DOSAGE; GENE FREQUENCY; HUMAN; LETTER; MALE; MELANOMA; ONCOGENE; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PRIORITY JOURNAL; PROMOTER REGION; SKIN CARCINOGENESIS; SOMATIC MUTATION; SUN EXPOSURE; TELOMERASE REVERSE TRANSCRIPTASE GENE; EPIDEMIOLOGY; GENE EXPRESSION REGULATION; GENETICS; HISTOLOGY; IMMUNOHISTOCHEMISTRY; MALIGNANT LENTIGO; MIDDLE AGED; MORTALITY; NEEDLE BIOPSY; NONPARAMETRIC TEST; PATHOLOGY; PROGNOSIS; SKIN TUMOR; SURVIVAL; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY, NEEDLE; FEMALE; GENE AMPLIFICATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HUTCHINSON'S MELANOTIC FRECKLE; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; MALE; MELANOMA; MIDDLE AGED; PROGNOSIS; SAMPLING STUDIES; SKIN NEOPLASMS; STATISTICS, NONPARAMETRIC; SURVIVAL ANALYSIS; TELOMERASE; TISSUE EMBEDDING;

EID: 84910116494     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2014.05.035     Document Type: Article

References (5)

1. Curtin JA, Fridlyand J, Kageshita T, Patel HN, Busam KJ, Kutzner H, et al. Distinct sets of genetic alterations in melanoma. N Engl J Med 2005;353:2135-47.
2. Puig-Butille JA, Badenas C, Ogbah Z, Carrera C, Aguilera P, Malvehy J, et al. Genetic alterations in RAS-regulated pathway in acral lentiginous melanoma. Exp Dermatol 2013;22:148-50.
3. Diaz A, Puig-Butillé JA, Valera A, Muñoz C, Costa D, Garcia-Herrera A, et al. TERT and AURKA gene copy number gains enhance the detection of acral lentiginous melanomas by fluorescence in situ hybridization. J Mol Diagn 2014;16:198-206.
4. Zhu CQ, Cutz JC, Liu N, Lau D, Shepherd FA, Squire JA, et al. Amplification of telomerase (hTERT) gene is a poor prognostic marker in non-small-cell lung cancer. Br J Cancer 2006;94:1452-9.
5. Liau JY, Tsai JH, Jeng YM, Chu CY, Kuo KT, Liang CW. TERT promoter mutation is uncommon in acral lentiginous melanoma. J Cutan Pathol 2014;41:504-8.