Diminazene aceturate (Berenil) modulates LPS induced pro-inflammatory cytokine production by inhibiting phosphorylation of MAPKs and STAT proteins

Innate Immunity

Volumn 20, Issue 7, 2014, Pages 760-773

  Kuriakose, Shiby ^a   Muleme, Helen ^a   Onyilagha, Chukwunonso ^a   Okeke, Emeka ^a   Uzonna, Jude E ^a  

^a UNIVERSITY OF MANITOBA   (Canada)

Author keywords

diminazene aceturate; immunomodulation; inflammation; intracellular signaling; proinflammatory cytokines; Trypanosoma congolense

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; DIMINAZENE ACETURATE; ESCHERICHIA COLI LIPOPOLYSACCHARIDE; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; POLYINOSINIC POLYCYTIDYLIC ACID; STAT1 PROTEIN; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 3; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; ANTITRYPANOSOMAL AGENT; CYTOKINE; DIMINAZENE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; TOLL LIKE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG MECHANISM; ENZYME INHIBITION; FEMALE; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROMOTER REGION; PROTEIN PHOSPHORYLATION; TRANSIENT TRANSFECTION; UPREGULATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CHEMICALLY INDUCED; DRUG EFFECTS; INFLAMMATION; MACROPHAGE; METABOLISM; PHOSPHORYLATION;

ANIMALS; CYTOKINES; DIMINAZENE; DOWN-REGULATION; FEMALE; INFLAMMATION; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; PHOSPHORYLATION; STAT TRANSCRIPTION FACTORS; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; TOLL-LIKE RECEPTORS; TRYPANOCIDAL AGENTS;

EID: 84910092795     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425913507488     Document Type: Article

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