Nonparametric tests for evaluation of biosimilarity in variability of follow-on biologics

Journal of Biopharmaceutical Statistics

Volumn 24, Issue 6, 2014, Pages 1239-1253

  Zhang, Nan ^a   Yang, Jun ^a   Chow, Shein Chung ^b   Chi, Eric ^a  

^a AMGEN INC   (United States)

^b DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Biosimilarity in variability; Biosimilars; Conover's squared rank test; F test; Follow on biologics; Levene's test; Nonparametric test for variances

Indexed keywords

BIOLOGICAL PRODUCT; BIOSIMILAR AGENT;

ARTICLE; BIOEQUIVALENCE; CROSSOVER PROCEDURE; EVALUATION STUDY; HUMAN; NONPARAMETRIC TEST; NORMAL DISTRIBUTION; NULL HYPOTHESIS; PARALLEL DESIGN; SIMULATION; CLINICAL TRIAL (TOPIC); COMPUTER SIMULATION; PROCEDURES; STATISTICAL MODEL; STATISTICS AND NUMERICAL DATA; THERAPEUTIC EQUIVALENCE;

BIOSIMILAR PHARMACEUTICALS; CLINICAL TRIALS AS TOPIC; COMPUTER SIMULATION; CROSS-OVER STUDIES; HUMANS; MODELS, STATISTICAL; STATISTICS, NONPARAMETRIC; THERAPEUTIC EQUIVALENCY;

EID: 84910055479     PISSN: 10543406     EISSN: 15205711     Source Type: Journal    
DOI: 10.1080/10543406.2014.941991     Document Type: Article

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