Severe experimental folate deficiency in a human subject - a longitudinal investigation of red-cell folate immunoassay errors as megaloblastic anaemia develops

SpringerPlus

Volumn 3, Issue 1, 2014, Pages

  Golding, Paul Henry ^a  

^a Unit 5   (Australia)

Author keywords

Diagnosis of folate deficiency; Immunoassay errors; Megaloblastic anaemia; Red cell folate immunoassays

Indexed keywords

EID: 84910009625     PISSN: None     EISSN: 21931801     Source Type: Journal    
DOI: 10.1186/2193-1801-3-441     Document Type: Article

References (42)

1. Bailey LB (Ed): Folate in Health and Disease. Marcel Dekker, New York; 1995.
2. Bailey LB (Ed): Folate in Health and Disease. 2nd edition. CRC Press, Boca Raton; 2009.
3. Bates I, Lewis S: Reference ranges and normal values. In Dacie and Lewis Practical Haematology, 11th edn. Churchill Livingstone; 2012:11–22.
4. Beckman Coulter: Access Immunoassay Systems Folate WB A33383E. Beckman Coulter, Fullerton; 2008.
5. Bland JM, Altman DG: Statistical methods for assessing agreement between two methods of clinical measurement.Lancet 1986, 8476:307–310.
6. Brouwer DA, Welten HT, Reijngoud DJ, van Doormaal JJ, Muskiet FA: Plasma folic acid cutoff value, derived from its relationship with homocyst(e)ine.Clin Chem 1998,44(7):1545–1550.
7. Callen S: Red cell folate QAP review. Australasian Association of Clinical Biochemists. 2010. Internet: http://oldsite.aacb.asn.au/ (accessed 02 August 2013)
8. Clifford AJ, Noceti EM, Block-Joy A, Block T, Block G: Erythrocyte folate and its response to folic acid supplementation is assay dependent in women.J Nutr 2005,135(1):137–143.
9. Food Standards Australia and New Zealand: NUTTAB 2010 Online Searchable Database. Foods that Contain Dietary Folate Equivalents. 2011. Internet: http://www.foodstandards.gov.au/science/monitoringnutrients/nutrientables/nuttab/Pages/default.aspx
10. Gilois CR, Stone J, Lai AP, Wierzbicki AS: Effect of haemolysate preparation on measurement of red cell folate by a radioisotopic method.J Clin Pathol 1990,43(2):160–162. 10.1136/jcp.43.2.160
11. Golding PH: Severe experimental folate deficiency in a human subject - a longitudinal study of biochemical and haematological responses as megaloblastic anaemia develops.SpringerPlus 2014, 3:442. 10.1186/2193-1801-3-442
12. Gregory JF 3rd: The bioavailability of folate. In Folate in Health and Disease. New York: Marcel Dekker; 1995:195–236.
13. Gunter EW, Bowman BA, Caudill SP, Twite DB, Adams MJ, Sampson EJ: Results of an international round robin for serum and whole-blood folate.Clin Chem 1996,42(10):1689–1694.
14. Herbert V: Experimental nutritional folate deficiency in man.Trans Assoc Am Physicians 1962, 75:307–320.
15. Herbert V: A palatable diet for producing experimental folate deficiency in man.Am J Clin Nutr 1963, 12:17–20.
16. Institute of Medicine, National Academy of Sciences: Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and its Panel on Folate, Other B Vitamins, and Choline: Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. National Academies Press (US), Washington (DC); 1998.
17. Jacobsen DW: Serum and erythrocyte folates: a matter of life and premature death.Clin Chem 1996,42(10):1579–1581.
18. Kricka LJ: Interferences in immunoassay: still a threat.Clin Chem 2000,46(8 Pt 1):1037–1038.
19. McNulty H, Pentieva K: Folate Bioavailability. In Folate in Health and Disease. 2nd edition. Boca Raton: CRC Press; 2009:25–47.
20. Nakazato M, Maeda T, Emura K, Maeda M, Tamura T: Blood folate concentrations analyzed by microbiological assay and chemiluminescent immunoassay methods.J Nutr Sci Vitaminol (Tokyo) 2012,58(1):59–62. 10.3177/jnsv.58.59
21. Netteland B, Bakke OM: Inadequate sample-preparation technique as a source of error in determination of erythrocyte folate by competitive binding radioassay.Clin Chem 1977,23(8):1505–1506.
22. O’Broin S, Kelleher B: Microbiological assay on microtitre plates of folate in serum and red cells.J Clin Pathol 1992,45(4):344–347. 10.1136/jcp.45.4.344
23. Omer A: Factors influencing the release of assayable folate from erythrocytes.J Clin Pathol 1969,22(2):217–221. 10.1136/jcp.22.2.217
24. Owen WE, Roberts WL: Comparison of five automated serum and whole blood folate assays.Am J Clin Pathol 2003,120(1):121–126. 10.1309/L2U6HH5KAYG48L40
25. Petersen PH, Stöckl D, Blaabjerg O, Pedersen B, Birkemose E, Thienpont L, Lassen JF, Kjeldsen J: Graphical interpretation of analytical data from comparison of a field method with reference method by use of difference plots.Clin Chem 1997,43(11):2039–2046.
26. Pfeiffer CM, Fazili Z, Zhang M: Folate analytical methodology. In Folate in Health and Disease. 2nd edition. Boca Raton: CRC Press; 2009:517–574.
27. RCPA: Allowable Limits of Performance. RCPA Quality Assurance Programs, Chemical Pathology. 2013. Internet: http://www.rcpaqap.com.au/ (accessed 02 August 2013)
28. Ricos C, Alvarez V, Cava F, Garcia-Lario JV, Hernandez A, Jimenez CV, Minchinela J, Perich C, Simon M: Desirable Specifications for Total Error, Imprecision, and Bias, Derived from Intra- and Inter-individual Biologic Variation. 2012. Internet: http://www.westgard.com (accessed 02 August 2013)
29. Roche Diagnostics: Folate RBC 2011–10, V 1 English. Roche Diagnostics, Mannheim; 2011.
30. Scott JM, Weir DG: The methyl folate trap. A physiological response in man to prevent methyl group deficiency in kwashiorkor (methionine deficiency) and an explanation for folic-acid induced exacerbation of subacute combined degeneration in pernicious anaemia.Lancet 1981,2(8242):337–340.
31. Selby C: Interference in immunoassay.Ann Clin Biochem 1999,36(6):704–721. 10.1177/000456329903600603
32. Siemens: ADVIA Centaur Assay Manual Folate 19514 Rev. E, 2004–02. Bayer HealthCare; 2004.
33. Smulders YM, Smith DE, Kok RM, Teerlink T, Swinkels DW, Stehouwer CD, Jakobs C: Cellular folate vitamer distribution during and after correction of vitamin B12 deficiency: a case for the methylfolate trap.Br J Haematol 2006,132(5):623–629. 10.1111/j.1365-2141.2005.05913.x
34. Stanger O, Herrmann W, Pietrzik K, Fowler B, Geisel J, Dierkes J, Weger M: Clinical use and rational management of homocysteine, folic acid, and B vitamins in cardiovascular and thrombotic diseases.Z Kardiol 2004,93(6):439–453.
35. Tate J, Ward G: Interferences in immunoassay.Clin Biochem Rev 2004,25(2):105–120.
36. Tisman G, Herbert V: B12 dependence of cell uptake of serum folate: an explanation for high serum folate and cell folate depletion in B 12 deficiency.Blood 1973,41(3):465–469.
37. Westgard JO, Hunt MR: Use and interpretation of common statistical tests in method-comparison studies.Clin Chem 1973,19(1):49–57.
38. Wickramasinghe SN: Diagnosis of megaloblastic anaemias.Blood Rev 2006,20(6):299–318. 10.1016/j.blre.2006.02.002
39. World Health Organization: Haemoglobin Concentrations For The Diagnosis Of Anaemia And Assessment Of Severity. Vitamin and Mineral Nutrition Information System. World Health Organization, Geneva; 2011. Internet: http://www.who.int/vmnis/indicators/haemoglobin.pdf (accessed 3 July 2013)
40. Wright AJ, Finglas PM, Southon S: Erythrocyte folate analysis: a cause for concern?Clin Chem 1998,44(9):1886–1891.
41. Wright AJ, Finglas PM, Southon S: Erythrocyte folate analysis: saponin added during lysis of whole blood can increase apparent folate concentrations, depending on hemolysate pH.Clin Chem 2000,46(12):1978–1986.
42. Zhang M, Pfeiffer CM, Sampson EJ: Laboratory Procedure Manual. Total Folate Serum/Whole Blood Microbiological Assay. Method Code 4000.02. Inorganic Toxicology and Nutrition Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention; 2008.