Biomechanics and inflammation in atherosclerotic plaque erosion and plaque rupture: Implications for cardiovascular events in women

PLoS ONE

Volumn 9, Issue 11, 2014, Pages

  Campbell, Ian C ^a   Suever, Jonathan D ^a   Timmins, Lucas H ^a,b   Veneziani, Alessandro ^a,c   Vito, Raymond P ^a,d   Virmani, Renu ^e   Oshinski, John N ^a,b   Taylor, W Robert ^a,b,f  

^a Emory University   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c EMORY UNIVERSITY   (United States)

^d GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^e CVPATH INSTITUTE   (United States)

^f ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 8; CD31 ANTIGEN; CD38 ANTIGEN; CHLORDANE; GELATINASE B; INTERSTITIAL COLLAGENASE; SMOOTH MUSCLE ACTIN;

ADULT; APOPTOSIS; ARTICLE; ATHEROMA; ATHEROSCLEROTIC PLAQUE; BIOMECHANICS; CARDIOVASCULAR DISEASE; CARDITIS; COMPUTER MODEL; DISEASE ASSOCIATION; ENDOTHELIUM CELL; FEMALE; HEART MUSCLE; HISTOLOGY; HUMAN; HUMAN TISSUE; IMAGE ANALYSIS; MALE; MUSCLE STRAIN; MUSCLE STRESS; PLAQUE EROSION; PLAQUE RUPTURE; PROTEIN EXPRESSION; SEX DIFFERENCE; THICK CAP FIBROATHEROMA; AGED; BIOLOGICAL MODEL; CORONARY ARTERY THROMBOSIS; CORONARY BLOOD VESSEL; INFLAMMATION; METABOLISM; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; SEXUAL DEVELOPMENT;

ADULT; AGED; CORONARY THROMBOSIS; CORONARY VESSELS; FEMALE; HUMANS; INFLAMMATION; MALE; MIDDLE AGED; MODELS, CARDIOVASCULAR; PLAQUE, ATHEROSCLEROTIC; SEX CHARACTERISTICS;

EID: 84909594931     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0111785     Document Type: Article

References (41)

1. Farb A, Burke AP, Tang AL, Liang TY, Mannan P, et al. (1996) Coronary plaque erosion without rupture into a lipid core. A frequent cause of coronary thrombosis in sudden coronary death. Circulation 93:1354-1363.
2. van der Wal AC, Becker AE, van der Loos CM, Das PK (1994) Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation 89:36-44.
3. Virmani R, Burke AP, Farb A, Kolodgie FD (2006) Pathology of the vulnerable plaque. J Am Coll Cardiol 47:C13-18.
4. Durand E, Scoazec A, Lafont A, Boddaert J, Al Hajzen A, et al. (2004) In vivo induction of endothelial apoptosis leads to vessel thrombosis and endothelial denudation: a clue to the understanding of the mechanisms of thrombotic plaque erosion. Circulation 109:2503-2506.
5. Sumi T, Yamashita A, Matsuda S, Goto S, Nishihira K, et al. (2010) Disturbed blood flow induces erosive injury to smooth muscle cell-rich neointima and promotes thrombus formation in rabbit femoral arteries. J Thromb Haemost 8:1394-1402.
6. Kolodgie FD, Burke AP, Wight TN, Virmani R (2004) The accumulation of specific types of proteoglycans in eroded plaques: a role in coronary thrombosis in the absence of rupture. Curr Opin Lipidol 15:575-582.
7. Cheng GC, Loree HM, Kamm RD, Fishbein MC, Lee RT (1993) Distribution of circumferential stress in ruptured and stable atherosclerotic lesions. A structural analysis with histopathological correlation. Circulation 87:1179-1187.
8. Hallow KM, Taylor WR, Rachev A, Vito RP (2009) Markers of inflammation collocate with increased wall stress in human coronary arterial plaque. Biomech Model Mechanobiol 8:473-486.
9. Lee RT, Schoen FJ, Loree HM, Lark MW, Libby P (1996) Circumferential stress and matrix metalloproteinase 1 in human coronary atherosclerosis. Implications for plaque rupture. Arterioscler Thromb Vasc Biol 16:1070-1073.
10. Farb A, Tang AL, Burke AP, Sessums L, Liang Y, et al. (1995) Sudden coronary death. Frequency of active coronary lesions, inactive coronary lesions, and myocardial infarction. Circulation 92:1701-1709.
11. Shoelson B (2006) clusterImg. 2.0 ed: The MathWorks, Inc., http://www.mathworks.com/matlabcentral/fileexchange/12979-%20clusterimg.
12. Chodorowski A, Mattsson U, Langille M, Hamarneh G (2005) Color Lesion Boundary Detection Using Live Wire. In: Fitzpatrick JM, editor; Bellingham, WA. pp. 1589-1596.
13. Campbell IC, Weiss D, Suever JD, Virmani R, Veneziani A, et al. (2013) Biomechanical modeling and morphology analysis indicates plaque rupture due to mechanical failure unlikely in atherosclerosis-prone mice. Am J Physiol Heart Circ Physiol 304:H473-486.
14. Beattie D, Xu C, Vito R, Glagov S, Whang MC (1998) Mechanical analysis of heterogeneous, atherosclerotic human aorta. J Biomech Eng 120:602-607.
15. Fung YC (1997) Biomechanics: Circulation: Springer.
16. Fung YC, Fronek K, Patitucci P (1979) Pseudoelasticity of arteries and the choice of its mathematical expression. Am J Physiol 237:H620-631.
17. Canfeld T, Dobrin P (1987) Static Elastic Properties of Blood Vessels. In: Skalak R, Chen S, editors. Handbook of Bioengineering: McGraw-Hill.
18. Holzapfel GA, Sommer G, Gasser CT, Regitnig P (2005) Determination of layer-specific mechanical properties of human coronary arteries with nonatherosclerotic intimal thickening and related constitutive modeling. Am J Physiol Heart Circ Physiol 289:H2048-2058.
19. Holzapfel GA, Weizsacker HW (1998) Biomechanical behavior of the arterial wall and its numerical characterization. Comput Biol Med 28:377-392.
20. Humphrey JD, Rajagopal KR (2002) A constrained mixture model for growth and remodeling of soft tissues. Mathematical Models & Methods in Applied Sciences 12:407-430.
21. Yezzi AJ Jr, Prince JL (2003) An Eulerian PDE approach for computing tissue thickness. IEEE Trans Med Imaging 22:1332-1339.
22. Timmins LH, Suever JD, Eshtehardi P, McDaniel MC, Oshinski JN, et al. (2013) Framework to Co-register Longitudinal Virtual Histology-Intravascular Ultrasound Data in the Circumferential Direction. IEEE Trans Med Imaging.
23. Ridker PM, Thuren T, Zalewski A, Libby P (2011) Interleukin-1beta inhibition and the prevention of recurrent cardiovascular events: rationale and design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS). Am Heart J 162:597-605.
24. Everett BM, Pradhan AD, Solomon DH, Paynter N, Macfadyen J, et al. (2013) Rationale and design of the Cardiovascular Inflammation Reduction Trial: a test of the inflammatory hypothesis of atherothrombosis. Am Heart J 166:199-207 e115.
25. Ridker PM, MacFadyen J, Cressman M, Glynn RJ (2010) Efficacy of rosuvastatin among men and women with moderate chronic kidney disease and elevated high-sensitivity C-reactive protein: a secondary analysis from the JUPITER (Justification for the Use of Statins in Prevention-an Intervention Trial Evaluating Rosuvastatin) trial. J Am Coll Cardiol 55:1266-1273.
26. Rosenson RS, Hislop C, Elliott M, Stasiv Y, Goulder M, et al. (2010) Effects of varespladib methyl on biomarkers and major cardiovascular events in acute coronary syndrome patients. J Am Coll Cardiol 56:1079-1088.
27. Weber M, Bhatt DL, Brennan DM, Hankey GJ, Steinhubl SR, et al. (2011) High-sensitivity C-reactive protein and clopidogrel treatment in patients at high risk of cardiovascular events: a substudy from the CHARISMA trial. Heart 97:626-631.
28. Mayranpaa MI, Resendiz JC, Heikkila HM, Lindstedt KA, Kovanen PT (2007) Improved identification of endothelial erosion by simultaneous detection of endothelial cells (CD31/CD34) and platelets (CD42b). Endothelium 14:81-87.
29. Campbell IC, Timmins LH, Giddens DP, Virmani R, Veneziani A, et al. (2013) Computational Fluid Dynamics Simulations of Hemodynamics in Plaque Erosion. Cardiovasc Eng Tech 4:464-473.
30. Fuster V, Chesebro JH (1996) Atherosclerosis - A. Pathogenesis: initiation, progression, acute coronary syndromes, and regression. In: Giuliani E, Gersh B, McGoon M, Hayes D, Schaff H, editors. Mayo Clinic Practice of Cardiology. 3 ed. St. Louis: Mosby. pp. 1056-1081.
31. Shah PK (2009) Inflammation and plaque vulnerability. Cardiovasc Drugs Ther 23:31-40.
32. Lindstedt KA, Leskinen MJ, Kovanen PT (2004) Proteolysis of the pericellular matrix: a novel element determining cell survival and death in the pathogenesis of plaque erosion and rupture. Arterioscler Thromb Vasc Biol 24:1350-1358.
33. Kilpatrick D, Goudet C, Sakaguchi Y, Bassiouny HS, Glagov S, et al. (2001) Effect of plaque composition on fibrous cap stress in carotid endarterectomy specimens. J Biomech Eng 123:635-638.
34. Ohayon J, Finet G, Gharib AM, Herzka DA, Tracqui P, et al. (2008) Necrotic core thickness and positive arterial remodeling index: emergent biomechanical factors for evaluating the risk of plaque rupture. Am J Physiol Heart Circ Physiol 295:H717-727.
35. Virmani R, Kolodgie FD, Burke AP, Farb A, Schwartz SM (2000) Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler Thromb Vasc Biol 20:1262-1275.
36. Finet G, Ohayon J, Rioufol G (2004) Biomechanical interaction between cap thickness, lipid core composition and blood pressure in vulnerable coronary plaque: impact on stability or instability. Coron Artery Dis 15:13-20.
37. Huang H, Virmani R, Younis H, Burke AP, Kamm RD, et al. (2001) The impact of calcification on the biomechanical stability of atherosclerotic plaques. Circulation 103:1051-1056.
38. Lee RT (2000) Atherosclerotic lesion mechanics versus biology. Z Kardiol 89 Suppl 2:80-84.
39. Li ZY, Howarth SP, Tang T, Gillard JH (2006) How critical is fibrous cap thickness to carotid plaque stability? A flow-plaque interaction model. Stroke 37:1195-1199.
40. Maldonado N, Kelly-Arnold A, Vengrenyuk Y, Laudier D, Fallon JT, et al. (2012) A mechanistic analysis of the role of microcalcifications in atherosclerotic plaque stability: potential implications for plaque rupture. Am J Physiol Heart Circ Physiol 303:H619-628.
41. Kramer MC, Rittersma SZ, de Winter RJ, Ladich ER, Fowler DR, et al. (2010) Relationship of thrombus healing to underlying plaque morphology in sudden coronary death. J Am Coll Cardiol 55:122-132.