OVOL2 is a critical regulator of ER71/ETV2 in generating FLK1+, hematopoietic, and endothelial cells from embryonic stem cells

Blood

Volumn 124, Issue 19, 2014, Pages 2948-2952

  Kim, Ju Young ^a,b   Lee, Ra Ham ^c   Kim, Tae Min ^b   Kim, Dong Wook ^c,g   Jeon, Young Joo ^c   Huh, Sung Ho ^d   Oh, Se Yeong ^a   Kyba, Michael ^e   Kataoka, Hiroshi ^f   Choi, Kyunghee ^d   Ornitz, David M ^d   Chae, Jung Il ^c   Park, Changwon ^a,b  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ILLINOIS   (United States)

^c Chonbuk National University   (South Korea)

^d WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^f RIKEN Center for Biosystems Dynamics Research   (Japan)

^g UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ER71 PROTEIN; ETV2 PROTEIN; OVOL 2 PROTEIN; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 2; ZINC FINGER PROTEIN; ER71 PROTEIN, MOUSE; MOVO PROTEIN, MOUSE; SMALL INTERFERING RNA; VEGFR2 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CELL LINEAGE; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENDOTHELIUM CELL; HEMATOPOIETIC CELL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN INTERACTION; ANIMAL; CELL CULTURE; CYTOLOGY; GENE SILENCING; GENETICS; HEMATOPOIETIC STEM CELL; METABOLISM; PHYSIOLOGY; PROTEOMICS; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINEAGE; CELLS, CULTURED; EMBRYONIC STEM CELLS; ENDOTHELIAL CELLS; GENE KNOCKDOWN TECHNIQUES; HEMATOPOIETIC STEM CELLS; MICE; PROTEOMICS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84909592642     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-03-556332     Document Type: Article

References (25)

1. Hirschi KK. Hemogenic endothelium during development and beyond. Blood. 2012;119(21):4823-4827.
2. Park C, Ma YD, Choi K. Evidence for the hemangioblast. Exp Hematol. 2005;33(9):965-970.
3. Carmeliet P, Ferreira V, Breier G, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature. 1996;380(6573):435-439.
4. Shalaby F, Rossant J, Yamaguchi TP, et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 1995;376(6535):62-66.
5. Lee D, Park C, Lee H, et al. ER71 acts downstream of BMP, Notch, and Wnt signaling in blood and vessel progenitor specification. Cell Stem Cell. 2008;2(5):497-507.
6. Kataoka H, Hayashi M, Nakagawa R, et al. Etv2/ER71 induces vascular mesoderm from Flk1+PDGFRα+ primitive mesoderm. Blood. 2011;118(26):6975-6986.
7. Ferdous A, Caprioli A, Iacovino M, et al. Nkx2-5 transactivates the Ets-related protein 71 gene and specifies an endothelial/endocardial fate in the developing embryo. Proc Natl Acad Sci USA. 2009;106(3):814-819.
8. Liu F, Kang I, Park C, et al. ER71 specifies Flk-1+ hemangiogenic mesoderm by inhibiting cardiac mesoderm and Wnt signaling. Blood. 2012;119(14):3295-3305.
9. De Val S, Chi NC, Meadows SM, et al. Combinatorial regulation of endothelial gene expression by ets and forkhead transcription factors. Cell. 2008;135(6):1053-1064.
10. Koyano-Nakagawa N, Kweon J, Iacovino M, et al. Etv2 is expressed in the yolk sac hematopoietic and endothelial progenitors and regulates Lmo2 gene expression. Stem Cells. 2012;30(8):1611-1623.
11. Neuhaus H, Müller F, Hollemann T. Xenopus er71 is involved in vascular development. Dev Dyn. 2010;239(12):3436-3445.
12. Sumanas S, Lin S. Ets1-related protein is a key regulator of vasculogenesis in zebrafish. PLoS Biol. 2006;4(1):e10.
13. Dejana E, Taddei A, Randi AM. Foxs and Ets in the transcriptional regulation of endothelial cell differentiation and angiogenesis. Biochim Biophys Acta. 2007;1775(2):298-312.
14. Sharrocks AD. The ETS-domain transcription factor family. Nat Rev Mol Cell Biol. 2001;2(11):827-837.
15. De Haro L, Janknecht R. Cloning of the murine ER71 gene (Etsrp71) and initial characterization of its promoter. Genomics. 2005;85(4):493-502.
16. Knebel J, De Haro L, Janknecht R. Repression of transcription by TSGA/Jmjd1a, a novel interaction partner of the ETS protein ER71. J Cell Biochem. 2006;99(1):319-329.
17. Unezaki S, Horai R, Sudo K, Iwakura Y, Ito S. Ovol2/Movo, a homologue of Drosophila ovo, is required for angiogenesis, heart formation and placental development in mice. Genes Cells. 2007;12(6):773-785.
18. Iacovino M, Hernandez C, Xu Z, Bajwa G, Prather M, Kyba M. A conserved role for Hox paralog group 4 in regulation of hematopoietic progenitors. Stem Cells Dev. 2009;18(5):783-792.
19. Kim JH, Lee SR, Li LH, et al. High cleavage efficiency of a 2A peptide derived from porcine teschovirus-1 in human cell lines, zebrafish and mice. PLoS ONE. 2011;6(4):e18556.
20. Mackay DR, Hu M, Li B, Rhéaume C, Dai X. The mouse Ovol2 gene is required for cranial neural tube development. Dev Biol. 2006;291(1):38-52.
21. Elvert G, Kappel A, Heidenreich R, et al. Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1). J Biol Chem. 2003;278(9):7520-7530.
22. Kappel A, Schlaeger TM, Flamme I, Orkin SH, Risau W, Breier G. Role of SCL/Tal-1, GATA, and ets transcription factor binding sites for the regulation of flk-1 expression during murine vascular development. Blood. 2000;96(9):3078-3085.
23. Fujiwara Y, Browne CP, Cunniff K, Goff SC, Orkin SH. Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1. Proc Natl Acad Sci USA. 1996;93(22):12355-12358.
24. Bondue A, Tännler S, Chiapparo G, et al. Defining the earliest step of cardiovascular progenitor specification during embryonic stem cell differentiation. J Cell Biol. 2011;192(5):751-765.
25. Zhang T, Zhu Q, Xie Z, et al. The zinc finger transcription factor Ovol2 acts downstream of the bone morphogenetic protein pathway to regulate the cell fate decision between neuroectoderm and mesendoderm. J Biol Chem. 2013;288(9):6166-6177.