Urokinase versus VATS for treatment of empyema: A randomized multicenter clinical trial

Pediatrics

Volumn 134, Issue 5, 2014, Pages e1301-e1307

  Marhuenda, Claudia ^a   Barceló, Concepció ^a   Fuentes, Inmaculada ^a   Guillén, Gabriela ^a   Cano, Indalecio ^b   López, María ^b   Hernández, Francisco ^c   Pérez Yarza, Eduardo G ^d,e,f   Matute, José A ^g   García Casillas, María A ^g   Álvarez, Víctor ^h   Moreno Galdó, Antonio ^a  

^a HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^c HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^d UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^e HOSPITAL DONOSTIA   (Spain)

^f INSTITUTO DE SALUD CARLOS III   (Spain)

^g HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

^h HOSPITAL UNIVERSITARIO CENTRAL DE ASTURIAS   (Spain)

Author keywords

Children; Empyema; Fibrinolytics; Parapneumonic effusions; Randomized clinical trial; Urokinase; VATS; Video assisted thoracoscopic surgery

Indexed keywords

UROKINASE;

ADOLESCENT; ARTICLE; BRONCHOPLEURAL FISTULA; BRONCHOSPASM; CHEST TUBE; CLINICAL EFFECTIVENESS; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DISEASE DURATION; EMPYEMA; FEMALE; FEVER; HUMAN; INTERMETHOD COMPARISON; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; OUTCOME ASSESSMENT; PARAPNEUMONIC EMPYEMA; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; THORACOSCOPY; TREATMENT FAILURE; VIDEO ASSISTED THORACOSCOPIC SURGERY; CHILD; CLINICAL TRIAL; COMPARATIVE STUDY; EMPYEMA, PLEURAL; INFANT; PILOT STUDY; PRESCHOOL CHILD; PROCEDURES;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; EMPYEMA, PLEURAL; FEMALE; HUMANS; INFANT; MALE; PILOT PROJECTS; PROSPECTIVE STUDIES; THORACIC SURGERY, VIDEO-ASSISTED; UROKINASE-TYPE PLASMINOGEN ACTIVATOR;

EID: 84908890446     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2013-3935     Document Type: Article

References (30)

1. Durbin WJ, Stille C. Pneumonia. Pediatr Rev. 2008;29(5):147-158, quiz 159-160
2. Andrews NC, Parker EF, Shaw RR, et al Management of nontuberculous empyema: a statement of the Subcommittee on Surgery. Am Rev Respir Dis. 1962;85:935-936
3. Martinón-Torres F, Bernaola Iturbe E, Giménez Sánchez F, et al. Why are pediatric empyemas on the increase in Spain? [in Spanish]. An Pediatr (Barc). 2008;68(2):158-164
4. Tan TQ, Mason EO Jr, Wald ER, et al. Clinical characteristics of children with complicated pneumonia caused by Streptococcus pneumoniae. Pediatrics. 2002;110(1 pt 1):1-6
5. Grijalva CG, Nuorti JP, Zhu Y, Griffin MR. Increasing incidence of empyema complicating childhood community-acquired pneumonia in the United States. Clin Infect Dis. 2010;50(6):805-813
6. Byington CL, Spencer LY, Johnson TA, et al. An epidemiological investigation of a sustained high rate of pediatric parapneumonic empyema: risk factors and microbiological associations. Clin Infect Dis. 2002;34(4):434-440
7. Obando I, Muñoz-Almagro C, Arroyo LA, et al. Pediatric parapneumonic empyema, Spain. Emerg Infect Dis. 2008;14(9):1390-1397
8. Calbo E, Díaz A, Cañadell E, et al; Spanish Pneumococcal Infection Study Network. Invasive pneumococcal disease among children in a health district of Barcelona: early impact of pneumococcal conjugate vaccine. Clin Microbiol Infect. 2006;12(9):867-872
9. Chan W, Keyser-Gauvin E, Davis GM, Nguyen LT, Laberge JM. Empyema thoracis in children: a 26-year review of the Montreal Children's Hospital experience. J Pediatr Surg. 1997;32(6):870-872
10. Mayo P, Saha SP, McElvein RB. Acute empyema in children treated by open thoracotomy and decortication. Ann Thorac Surg. 1982;34(4):401-407
11. Carey JA, Hamilton JR, Spencer DA, Gould K, Hasan A. Empyema thoracis: a role for open thoracotomy and decortication. Arch Dis Child. 1998;79(6):510-513
12. Khakoo GA, Goldstraw P, Hansell DM, Bush A. Surgical treatment of parapneumonic empyema. Pediatr Pulmonol. 1996;22(6):348-356
13. Balfour-Lynn IM, Abrahamson E, Cohen G, et al; Paediatric Pleural Diseases Sub-committee of the BTS Standards of Care Committee. BTS guidelines for the management of pleural infection in children. Thorax. 2005;60(suppl 1):i1-i21
14. Thomson AH, Hull J, Kumar MR, Wallis C, Balfour Lynn IM. Randomised trial of intrapleural urokinase in the treatment of childhood empyema. Thorax. 2002;57(4):343-347
15. Singh M, Mathew JL, Chandra S, Katariya S, Kumar L. Randomized controlled trial of intrapleural streptokinase in empyema thoracis in children. Acta Paediatr. 2004;93(11):1443-1445
16. Kern JA, Rodgers BM. Thoracoscopy in the management of empyema in children. J Pediatr Surg. 1993;28(9):1128-1132
17. Klena JW, Cameron BH, Langer JC, Winthrop AL, Perez CR. Timing of video-assisted thoracoscopic debridement for pediatric empyema. J Am Coll Surg. 1998;187(4):404-408
18. Stovroff M, Teague G, Heiss KF, Parker P, Ricketts RR. Thoracoscopy in the management of pediatric empyema. J Pediatr Surg. 1995;30(8):1211-1215
19. Grewal H, Jackson RJ, Wagner CW, Smith SD. Early video-assisted thoracic surgery in the management of empyema. Pediatrics. 1999;103(5). Available at: www.pediatrics.org/cgi/content/full/103/5/e63
20. Kercher KW, Attorri RJ, Hoover JD, Morton D Jr. Thoracoscopic decortication as firstline therapy for pediatric parapneumonic empyema. A case series. Chest. 2000;118(1):24-27
21. Merry CM, Bufo AJ, Shah RS, Schropp KP, Lobe TE. Early definitive intervention by thoracoscopy in pediatric empyema. J Pediatr Surg. 1999;34(1):178-180, discussion 180-181
22. Schneider CR, Gauderer MW, Blackhurst D, Chandler JC, Abrams RS. Video-assisted thoracoscopic surgery as a primary intervention in pediatric parapneumonic effusion and empyema. Am Surg. 2010;76(9):957-961
23. Islam S, Calkins CM, Goldin AB, et al; APSA Outcomes and Clinical Trials Committee, 2011-2012. The diagnosis and management of empyema in children: a comprehensive review from the APSA Outcomes and Clinical Trials Committee. J Pediatr Surg. 2012;47(11):2101-2110
24. Paraskakis E, Vergadi E, Chatzimichael A, Bouros D. Current evidence for the management of paediatric parapneumonic effusions. Curr Med Res Opin. 2012;28(7):1179-1192
25. Marhuenda C, Barceló C, Molino JA, Guillén G, Moreno A, Martínez X. Treatment of loculated parapneumonic empyema. Video assisted thoracoscopy or fibrinolytics? [in Spanish]. An Pediatr (Barc). 2011;75(5):307-313
26. Sonnappa S, Cohen G, Owens CM, et al. Comparison of urokinase and video-assisted thoracoscopic surgery for treatment of childhood empyema. Am J Respir Crit Care Med. 2006;174(2):221-227
27. St Peter SD, Tsao K, Spilde TL, et al. Thoracoscopic decortication vs tube thoracostomy with fibrinolysis for empyema in children: a prospective, randomized trial [published correction in J Pediatr Surg. 2009;44(9):1865]. J Pediatr Surg. 2009;44(1):106-111, discussion 111
28. Cobanoglu U, Sayir F, Bilici S, Melek M. Comparison of the methods of fibrinolysis by tube thoracostomy and thoracoscopic decortication in children with stage II and III empyema: a prospective randomized study. Pediatr Rep. 2011;3(4):e29
29. Avansino JR, Goldman B, Sawin RS, Flum DR. Primary operative versus nonoperative therapy for pediatric empyema: a meta-analysis. Pediatrics. 2005;115(6):1652-1659
30. Gasior AC, Knott EM, Sharp SW, Ostlie DJ, Holcomb GW III, St Peter SD. Experience with an evidence-based protocol using fibrinolysis as first line treatment for empyema in children. J Pediatr Surg. 2013;48(6):1312-1315