Endothelial insulin resistance protects the heart against prolonged ischemia-reperfusion injury but does not prevent insulin transport across the endothelium in a mouse langendorff model

Journal of Cardiovascular Pharmacology and Therapeutics

Volumn 19, Issue 6, 2014, Pages 586-591

  Sharma, Vikram ^a   Kearney, Mark T ^b   Davidson, Sean M ^a   Yellon, Derek M ^a  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

diabetes mellitus; endothelium; insulin resistance; insulin transport; myocardial infarction

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; GENE OVEREXPRESSION; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE; HEART PROTECTION; INSULIN RESISTANCE; ISOLATED HEART; MALE; MEMBRANE TRANSPORT; MOUSE; NONHUMAN; REPERFUSION INJURY; WESTERN BLOTTING; WILD TYPE; ANIMAL; DISEASE MODEL; DRUG EFFECTS; GENETICS; IN VITRO STUDY; METABOLISM; MUTATION; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; PERFUSION; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIME; TRANSGENIC MOUSE; TRANSPORT AT THE CELLULAR LEVEL; VASCULAR ENDOTHELIUM;

ANIMALS; BIOLOGICAL TRANSPORT; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; IN VITRO TECHNIQUES; INSULIN; INSULIN RESISTANCE; MALE; MICE, TRANSGENIC; MUTATION; MYOCARDIAL INFARCTION; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; PERFUSION; PHOSPHATIDYLINOSITOL 3-KINASE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 84908868763     PISSN: 10742484     EISSN: 19404034     Source Type: Journal    
DOI: 10.1177/1074248414525506     Document Type: Article

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