Retinal neurodegeneration on optical coherence tomography and cerebral atrophy

Neuroscience Letters

Volumn 584, Issue , 2015, Pages 12-16

  Ong, Yi Ting ^a,b,c   Hilal, Saima ^c,d,e   Cheung, Carol Y ^a,c,e   Venketasubramanian, Narayanaswamy ^f   Niessen, Wiro J ^g,h   Vrooman, Henri ^g,h   Anuar, Ainur R ^a   Chew, Merwyn ^a,c   Chen, Christopher ^d,e   Wong, Tien Yin ^a,c,e   Ikram, Mohammad Kamran ^a,d,e,i  

^a SINGAPORE EYE RESEARCH INSTITUTE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^f RAFFLES HOSPITAL   (Singapore)

^g ERASMUS MEDICAL CENTER   (Netherlands)

^h DELFT UNIVERSITY OF TECHNOLOGY   (Netherlands)

ⁱ Academy of Medicine Singapore   (Singapore)

Author keywords

Cerebral atrophy; Ganglion cell; Grey matter; Occipital lobe; Retina; Temporal lobe

Indexed keywords

AGED; ALZHEIMER DISEASE; ARTICLE; BRAIN ATROPHY; BRAIN SIZE; DEMENTIA; DIABETES MELLITUS; DISEASE ASSOCIATION; FEMALE; GRAY MATTER; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; OCCIPITAL LOBE; OPTICAL COHERENCE TOMOGRAPHY; RETINA DEGENERATION; RETINA GANGLION CELL; RETINA NERVE CELL; RETINAL NERVE FIBER LAYER THICKNESS; RISK FACTOR; TEMPORAL LOBE; WHITE MATTER; ADULT; ATROPHY; BRAIN; MIDDLE AGED; NERVE DEGENERATION; NERVE FIBER; PATHOLOGY; RETINA; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; ATROPHY; BRAIN; FEMALE; GRAY MATTER; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NERVE DEGENERATION; NERVE FIBERS; RETINA; RETINAL GANGLION CELLS; TOMOGRAPHY, OPTICAL COHERENCE; WHITE MATTER;

EID: 84908626239     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2014.10.010     Document Type: Article

References (28)

1. Berisha F., Feke G.T., Trempe C.L., McMeel J.W., Schepens C.L. Retinal abnormalities in early Alzheimer's disease. Invest. Ophthalmol. Vis. Sci. 2007, 48:2285-2289.
2. Buckner R.L., Snyder A.Z., Shannon B.J., LaRossa G., Sachs R., Fotenos A.F., Sheline Y.I., Klunk W.E., Mathis C.A., Morris J.C., Mintun M.A. Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory. J. Neurosci. 2005, 25:7709-7717.
3. Chang L.Y., et al. Alzheimer's disease in the human eye. Clinical tests that identify ocular and visual information processing deficit as biomarkers. Alzheimers Dement 2014, 10:251-261.
4. Cheung C.Y., Chen D., Wong T.Y., Tham Y.C., Wu R., Zheng Y., Cheng C.Y., Saw S.M., Baskaran M., Leung C.K., Aung T. Determinants of quantitative optic nerve measurements using spectral domain optical coherence tomography in a population-based sample of non-glaucomatous subjects. Invest. Ophthalmol. Vis. Sci. 2011, 52:9629-9635.
5. de Boer R., Vrooman H.A., Ikram M.A., Vernooij M.W., Breteler M.M., van der Lugt A., Niessen W.J. Accuracy and reproducibility study of automatic MRI brain tissue segmentation methods. NeuroImage 2010, 51:1047-1056.
6. Frisoni G.B., Testa C., Zorzan A., Sabattoli F., Beltramello A., Soininen H., Laakso M.P. Detection of grey matter loss in mild Alzheimer's disease with voxel based morphometry. J. Neurol. Neurosurg. Psychiatry 2002, 73:657-664.
7. Garcia-Martin E., Larrosa J.M., Polo V., Satue M., Marques M.L., Alarcia R., Seral M., Fuertes I., Otin S., Pablo L.E. Distribution of retinal layer atrophy in patients with Parkinson disease and association with disease severity and duration. Am. J. Ophthalmol. 2014, 157:470-478. e472.
8. Gordon-Lipkin E., Chodkowski B., Reich D.S., Smith S.A., Pulicken M., Balcer L.J., Frohman E.M., Cutter G., Calabresi P.A. Retinal nerve fiber layer is associated with brain atrophy in multiple sclerosis. Neurology 2007, 69:1603-1609.
9. Hämäläinen A., Tervo S., Grau-Olivares M., Niskanen E., Pennanen C., Huuskonen J., Kivipelto M., Hänninen T., Tapiola M., Vanhanen M., Hallikainen M., Helkala E.L., Nissinen A., Vanninen R., Soininen H. Voxel-based morphometry to detect brain atrophy in progressive mild cognitive impairment. NeuroImage 2007, 37:1122-1131.
10. Hilal S., Saini M., Tan C.S., Catindig J.A., Dong Y.H., Leon L.B., Niessen W.J., Vrooman H., Wong T.Y., Chen C., Venketasubramanian N., Ikram M.K. Ankle-brachial index, cognitive impairment and cerebrovascular disease in a chinese population. Neuroepidemiology 2014, 42:131-138.
11. Hof P.R., Morrison J.H. Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: II. Primary and secondary visual cortex. J. Comp. Neurol. 1990, 301:55-64.
12. Ikram M.K., Cheung C.Y., Wong T.Y., Chen C.P. Retinal pathology as biomarker for cognitive impairment and Alzheimer's disease. J. Neurol. Neurosurg. Psychiatry 2012, 83:917-922.
13. Iseri P.K., Altinas O., Tokay T., Yuksel N. Relationship between cognitive impairment and retinal morphological and visual functional abnormalities in Alzheimer disease. J. Neuroophthalmol. 2006, 26:18-24.
14. Karas G.B., Scheltens P., Rombouts S.A., Visser P.J., van Schijndel R.A., Fox N.C., Barkhof F. Global and local gray matter loss in mild cognitive impairment and Alzheimer's disease. NeuroImage 2004, 23:708-716.
15. Kesler A., Vakhapova V., Korczyn A.D., Naftaliev E., Neudorfer M. Retinal thickness in patients with mild cognitive impairment and Alzheimer's disease. Clin. Neurol. Neurosurg. 2011, 113:523-526.
16. Koh V.T., Tham Y.C., Cheung C.Y., Wong W.L., Baskaran M., Saw S.M., Wong T.Y., Aung T. Determinants of ganglion cell-inner plexiform layer thickness measured by high-definition optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2012, 53:5853-5859.
17. Leung K.K., Bartlett J.W., Barnes J., Manning E.N., Ourselin S., Fox N.C.A. A.S.D.N. initiative, cerebral atrophy in mild cognitive impairment and Alzheimer disease: rates and acceleration. Neurology 2013, 80:648-654.
18. Lewis D.A., Campbell M.J., Terry R.D., Morrison J.H. Laminar and regional distributions of neurofibrillary tangles and neuritic plaques in Alzheimer's disease: a quantitative study of visual and auditory cortices. J. Neurosci. 1987, 7:1799-1808.
19. London A., Benhar I., Schwartz M. The retina as a window to the brain-from eye research to CNS disorders. Nat. Rev. Neurol. 2013, 9:44-53.
20. Marziani E., Pomati S., Ramolfo P., Cigada M., Giani A., Mariani C., Staurenghi G. Evaluation of retinal nerve fiber layer and ganglion cell layer thickness in Alzheimer's disease using spectral-domain optical coherence tomography. Invest. Ophthalmol. Vis. Sci. 2013, 54:5953-5958.
21. McKee A.C., Au R., Cabral H.J., Kowall N.W., Seshadri S., Kubilus C.A., Drake J., Wolf P.A. Visual association pathology in preclinical Alzheimer disease. J. Neuropathol. Exp. Neurol. 2006, 65:621-630.
22. Paquet C., Boissonnot M., Roger F., Dighiero P., Gil R., Hugon J. Abnormal retinal thickness in patients with mild cognitive impairment and Alzheimer's disease. Neurosci. Lett. 2007, 420:97-99.
23. Rosman M., Zheng Y., Wong W., Lamoureux E., Saw S.M., Tay W.T., Wang J.J., Mitchell P., Tai E.S., Wong T.Y. Singapore Malay Eye Study: rationale and methodology of 6-year follow-up study (SiMES-2). Clin. Exp. Ophthal. 2012, 40:557-568.
24. Trivedi M.A., Wichmann A.K., Torgerson B.M., Ward M.A., Schmitz T.W., Ries M.L., Koscik R.L., Asthana S., Johnson S.C. Structural MRI discriminates individuals with mild cognitive impairment from age-matched controls: a combined neuropsychological and voxel based morphometry study. Alzheimers Dement. 2006, 2:296-302.
25. Vrooman H.A., Cocosco C.A., van der Lijn F., Stokking R., Ikram M.A., Vernooij M.W., Breteler M.M., Niessen W.J. Multi-spectral brain tissue segmentation using automatically trained k-nearest-neighbor classification. NeuroImage 2007, 37:71-81.
26. Whitwell J.L. Voxel-based morphometry: an automated technique for assessing structural changes in the brain. J. Neurosci. 2009, 29:9661-9664.
27. Whitwell J.L., Shiung M.M., Przybelski S.A., Weigand S.D., Knopman D.S., Boeve B.F., Petersen R.C., Jack C.R. MRI patterns of atrophy associated with progression to AD in amnestic mild cognitive impairment. Neurology 2008, 70:512-520.
28. Williams P.A., Thirgood R.A., Oliphant H., Frizzati A., Littlewood E., Votruba M., Good M.A., Williams J., Morgan J.E. Retinal ganglion cell dendritic degeneration in a mouse model of Alzheimer's disease. Neurobiol. Aging 2013, 34:1799-1806.