Mapping the pathophysiology of schizophrenia: Interactions between multiple cellular pathways

Frontiers in Cellular Neuroscience

Volumn 7, Issue NOV, 2013, Pages

  Deng, Chao ^a,b,c   Dean, Brian ^d,e  

^a ILLAWARRA HEALTH AND MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF WOLLONGONG   (Australia)

^c SCHIZOPHRENIA RESEARCH INSTITUTE   (Australia)

^d FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

^e UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Acetylcholine; Dopamine; ErbB4; GABA; Glutamate; NEUregulin 1; Neurodevelopment; Schizophrenia

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; BRAIN DERIVED NEUROTROPHIC FACTOR; CANNABINOID; CATECHOLAMINE; DOPAMINE; EPIDERMAL GROWTH FACTOR RECEPTOR 4; GLUTAMIC ACID; MICRORNA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEU DIFFERENTIATION FACTOR; POLYSIALIC ACID; SEROTONIN;

COGNITION; EDITORIAL; GABAERGIC TRANSMISSION; HUMAN; METABOLISM; MOLECULAR INTERACTION; NERVE CELL DIFFERENTIATION; NONHUMAN; OXIDATIVE STRES; PATHOPHYSIOLOGY; PROTEIN EXPRESSION; SCHIZOPHRENIA; SIGNAL TRANSDUCTION;

EID: 84908621871     PISSN: 16625102     EISSN: None     Source Type: Journal    
DOI: 10.3389/fncel.2013.00238     Document Type: Editorial

References (16)

1. Benes, F. M. (2009). Neural circuitry models of schizophrenia: is it dopamine, GABA, glutamate, or something else. Biol. Psychiatry 65, 1003–1005. doi: 10.1016/j.biopsych.2009.04.006
2. Catts, V. S., Fung, S. J., Long, L. E., Joshi, D., Vercammen, A., Allen, K. M., et al. (2013). Rethinking schizophrenia in the context of normal neurodevelopment. Front. Cell. Neurosci. 7:60. doi: 10.3389/fncel.2013.00060
3. Chana, G., Bousman, C. A., Money, T. T., Gibbons, A., Gillett, P., Dean, B., et al. (2013). Biomarker investigations related to pathophysiological pathways in schizophrenia and psychosis. Front. Cell. Neurosci. 7:95. doi: 10.3389/fncel.2013.00095
4. Furth, K. E., Mastwal, S., Wang, K. H., Buonanno, A., and Vullhorst, D. (2013). Dopamine, cognitive function, and gamma oscillations: role of D4 receptors. Front. Cell. Neurosci. 7:102. doi: 10.3389/fncel.2013.00102
5. Gibbons, A. S., Scarr, E., Boer, S., Money, T., Jeon, W.-J., Felder, C., et al. (2013). Widespread decreases in cortical muscarinic receptors in a subset of people with schizophrenia. Int. J. Neuropsychopharmacol. 16, 37–46. doi: 10.1017/S1461145712000028
6. Iwakura, Y., and Nawa, H. (2013). ErbB1-4-dependent EGF/neuregulin signals and their cross talk in the central nervous system: pathological implications in schizophrenia and Parkinson’s disease. Front. Cell. Neurosci. 7:4. doi: 10.3389/fncel.2013.00004
7. Karam, C. S., Ballon, J. S., Bivens, N. M., Freyberg, Z., Girgis, R. R., Lizardi-Ortiz, J. E., et al. (2010). Signaling pathways in schizophrenia: emerging targets and therapeutic strategies. Trends Pharmacol. Sci. 31, 381–390. doi: 10.1016/j.tips.2010.05.004
8. Karl, T., and Arnold, J. C. (2013). What does a mouse tell us about neuregulin 1—cannabis interactions. Front. Cell. Neurosci. 7:18. doi: 10.3389/fncel.2013.00018
9. Kesby, J. P., Cui, X., Burne, T. H. J., and Eyles, D. W. (2013). Altered dopamine ontogeny in the developmentally vitamin D deficient rat and its relevance to schizophrenia. Front. Cell. Neurosci. 7:111. doi: 10.3389/fncel.2013.00111
10. Manning, E. E., and van den Buuse, M. (2013). BDNF deficiency and young-adult methamphetamine induce sex-specific effects on prepulse inhibition regulation. Front. Cell. Neurosci. 7:92. doi: 10.3389/fncel.2013.00092
11. Sato, C., and Kitajima, K. (2013). Impact of structural aberrancy of polysialic acid and its synthetic enzyme ST8SIA2 in schizophrenia. Front. Cell. Neurosci. 7:61. doi: 10.3389/fncel.2013.00061
12. Scarr, E., Gibbons, A. S., Neo, J., Udawela, M., and Dean, B. (2013). Cholinergic connectivity: it’s implications for psychiatric disorders. Front. Cell. Neurosci. 7:55. doi: 10.3389/fncel.2013.00055
13. Snyder, M. A., and Gao, W.-J. (2013). NMDA hypofunction as a convergence point for progression and symptoms of schizophrenia. Front. Cell. Neurosci. 7:31. doi: 10.3389/fncel.2013.00031
14. Spencer, J. R., Darbyshire, K. M. E., Boucher, A. A., Kashem, M. A., Long, L. E., McGregor, I. S., et al. (2013). Novel molecular changes induced by Nrg1 hypomorphism and Nrg1-cannabinoid interaction in adolescence: A hippocampal proteomic study in mice. Front. Cell. Neurosci. 7:15. doi: 10.3389/fncel.2013.00015
15. Uhlhaas, P. J., and Singer, W. (2010). Abnormal neural oscillations and synchrony in schizophrenia. Nat. Rev. Neurosci. 11, 100–113. doi: 10.1038/nrn2774
16. Yao, J. K., Dougherty, G. G., Reddy, R. D., Matson, W. R., Kaddurah-Daouk, R., and Keshavan, M. S. (2013). Associations between purine metabolites and monoamine neurotransmitters in first-episode psychosis. Front. Cell. Neurosci. 7:90. doi: 10.3389/fncel.2013.00090