PIM inhibitors target CD25-positive AML cells through concomitant suppression of STAT5 activation and degradation of MYC oncogene.

Blood

Volumn 124, Issue 11, 2014, Pages 1777-1789

  Guo, Zhuyan ^a   Wang, Anlai ^a   Zhang, Weidong ^a   Levit, Mikhail ^a   Gao, Qiang ^a   Barberis, Claude ^a   Tabart, Michel ^a   Zhang, Jingxin ^a   Hoffmann, Dietmar ^a   Wiederschain, Dmitri ^a   Rocnik, Jennifer ^a   Sun, Fangxian ^a   Murtie, Josh ^a   Lengauer, Christoph ^a   Gross, Stefan ^a   Zhang, Bailin ^a   Cheng, Hong ^a   Patel, Vinod ^a   Schio, Laurent ^a   Adrian, Francisco ^a   Dorsch, Marion ^a   Garcia Echeverria, Carlos ^a   Huang, Shih Min A ^a   more..

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; IL2RA PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR ALPHA; MYC PROTEIN; MYC PROTEIN, HUMAN; PIM1 PROTEIN, HUMAN; PROTEIN KINASE PIM 1; STAT5 PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BLAST CELL CRISIS; CHEMISTRY; CLINICAL TRIAL; DRUG ANTAGONISM; DRUG EFFECT; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HL 60 CELL LINE; HUMAN; MALE; METABOLISM; MULTICENTER STUDY; PATHOLOGY; PROTEIN DEGRADATION;

ANTINEOPLASTIC AGENTS; BLAST CRISIS; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; HL-60 CELLS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LEUKEMIA, MYELOID, ACUTE; MALE; PROTEOLYSIS; PROTO-ONCOGENE PROTEINS C-MYC; PROTO-ONCOGENE PROTEINS C-PIM-1; STAT5 TRANSCRIPTION FACTOR;

MLCS; MLOWN;

EID: 84908615329     PISSN: None     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-01-551234     Document Type: Article

References (0)