Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo.

Blood

Volumn 124, Issue 11, 2014, Pages 1737-1747

  Yu, Hui ^a   Neale, Geoffrey ^b   Zhang, Hui ^a   Lee, Han M ^a   Ma, Zhijun ^b   Zhou, Sheng ^b   Forget, Bernard G ^a   Sorrentino, Brian P ^b  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; HOMEODOMAIN PROTEIN; HOXA10 PROTEIN, MOUSE; HOXB4 PROTEIN, MOUSE; MESSENGER RNA; PRDM16 PROTEIN, MOUSE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXA9; TUMOR PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL; ARTICLE; B LYMPHOCYTE; BIOSYNTHESIS; BONE MARROW CELL; CELL DIFFERENTIATION; CELL TRANSFORMATION; CYTOLOGY; DOWN REGULATION; FEMALE; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; GENETICS; HEMATOPOIETIC STEM CELL; HUMAN; METABOLISM; MOUSE; PHYSIOLOGY;

ANIMALS; B-LYMPHOCYTES; CELL DIFFERENTIATION; CELL TRANSFORMATION, NEOPLASTIC; DNA-BINDING PROTEINS; DOWN-REGULATION; FEMALE; GENE EXPRESSION REGULATION, LEUKEMIC; HEMATOPOIETIC STEM CELLS; HOMEODOMAIN PROTEINS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MICE; MYELOID CELLS; NEOPLASM PROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSDUCTION, GENETIC;

MLCS; MLOWN;

EID: 84908613134     PISSN: None     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2013-10-534735     Document Type: Article

References (0)