Impact of increased hematocrit on right ventricular afterload in response to chronic hypoxia

Journal of Applied Physiology

Volumn 117, Issue 8, 2014, Pages 833-839

  Schreier, David A ^a   Hacker, Timothy A ^b   Hunter, Kendall ^c   Eickoff, Jens ^b   Liu, Aiping ^a   Song, Gouqing ^b   Chesler, Naomi ^a,b  

^a University of Wisconsin Madison   (United States)

^b Medical Science   (United States)

^c The University of Colorado Denver   (United States)

Author keywords

Blood viscosity; Cardiopulmonary hemodynamics; Characteristic impedance; Chronic hypoxia; Pulmonary vascular impedance

Indexed keywords

ALTITUDE DISEASE; ANIMAL; ANOXIA; BLOOD PRESSURE; C57BL MOUSE; HEART OUTPUT; HEART RIGHT VENTRICLE FUNCTION; HEART VENTRICLE; HEMATOCRIT; LUNG; LUNG CIRCULATION; MALE; MOUSE; PATHOPHYSIOLOGY; PHYSIOLOGY; PULMONARY ARTERY; PULMONARY HYPERTENSION;

ALTITUDE SICKNESS; ANIMALS; ANOXIA; BLOOD PRESSURE; CARDIAC OUTPUT; HEART VENTRICLES; HEMATOCRIT; HYPERTENSION, PULMONARY; LUNG; MALE; MICE; MICE, INBRED C57BL; PULMONARY ARTERY; PULMONARY CIRCULATION; VENTRICULAR FUNCTION, RIGHT;

EID: 84908596054     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00059.2014     Document Type: Article

References (47)

1. Barbera J, Peinado V, Santos S. Pulmonary hypertension in chronic obstructive pulmonary disease. Eur Respir J 21: 892-905, 2003.
2. Barer G, Bee D, Wach RA, Sheffield S. Contribution of polycythaemia to pulmonary hypertension in simulated high altitude in rats. J Physiol 336: 27-38, 1983.
3. Cabrales P, Tsai AG, Intaglietta M. Resuscitation from hemorrhagic shock with hydroxyethyl starch and coagulation changes. Shock 28: 461-467, 2007.
4. Chien S, Usami S, Taylor H, Lundberg J, Gregersen M. Effects of hematocrit and plasma proteins on human blood rheology at low shear rates. J Appl Physiol 21: 81-87, 1966.
5. Cinar Y, Demir G, Paç M, Cinar A. Effect of hematocrit on blood pressure via hyperviscosity. Am J Hypertens 12: 739-743, 1999.
6. D'Alonzo G, Barst R. Survival in patients with primary pulmonary hypertension. Results from a national prospective registry. Ann Intern Med 115: 343-349, 1991.
7. Du HK, Lee YJ, Colice GL, Leiter JC, Ou LC. Pathophysiological effects of hemodilution in chronic mountain sickness in rats. J Appl Physiol 80: 574-582, 1996.
8. Effron B. Bootstrap methods: another look at the jackknife. Ann Stat 7: 1-26, 1979.
9. Fischer E, Armentano RL, Pessana FM, Graf S, Romero L, Christen AI, Simon A, Levenson J. Endothelium-dependent arterial wall tone elasticity modulated by blood viscosity. Am J Physiol Heart Circ Physiol 282: H389-H394, 2002.
10. Fraser KL, Tullis DE, Sasson Z, Hyland RH, Thornley KS, Hanly PJ. Pulmonary hypertension and cardiac function in adult cystic fibrosis: role of hypoxemia. Chest 115: 1321-1328, 1999.
11. Gan C, Lankhaar J, Westerhof N, Marcus J, Becker A, Twisk J, Boonstra A, Postmus PE, Vonk-Noordegraaf A. Noninvasively assessed pulmonary artery stiffness predicts mortality in pulmonary arterial hypertension. Chest 132: 1906-1912, 2007.
12. Graber S, Krantz S. Erythropoietin and the control of red cell production. Annu Rev Med 29: 51-66, 1978.
13. Guilot M, Ross-Ascuitto N, Ascuitto R. Fluid-flow energetics for curved or angulated pathways associated with staged operations for the modified Fontan procedure. Congentical Cardiol Today 10: 1-15, 2012.
14. Hemnes A, Champion HC. Right heart function and haemodynamics in pulmonary hypertension. Int J Clin Pract Suppl 62: 11-19, 2008.
15. Hiestand D, Phillips B. The overlap syndrome: chronic obstructive pulmonary disease and obstructive sleep apnea. Crit Care Clin 24: 551-563, 2008.
16. Hoffman JI. Pulmonary vascular resistance and viscosity: the forgotten factor. Pediatr Cardiol 32: 557-561, 2011.
17. Humbert M, Sitbon O, Chaouat A, Bertocchi M, Habib G, Gressin V, Yaïci A, Weitzenblum E, Cordier JF, Chabot F, Dromer C, Pison C, Reynaud-Gaubert M, Haloun A, Laurent M, Hachulla E, Cottin V, Degano B, Jaïs X, Montani D, Souza R, Simonneau G. Survival in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era. Circulation 122: 156-163, 2010.
18. Hunter KS, Lee P, Lanning CJ, Ivy DD, Kirby KS, Claussen LR, Chan KC. Pulmonary vascular input impedance is a combined measure of pulmonary vascular resistance and stiffness and predicts clinical outcomes better than pulmonary vascular resistance alone in pediatric patients with pulmonary hypertension. Am Heart J 155: 166-174, 2008.
19. León-Velarde F, Villafuerte FC, Richalet JP. Chronic mountain sickness and the heart. Prog Cardiovasc Dis 52: 540-9, 2010.
20. Levin M, Pincott JR, Hjelm M, Taylor F, Kay J, Hoizel H, Dinwiddie R, Matthew DJ. Hemorrhagic shock and encephalopathy: clinical, pathologic, and biochemical features. J Pediatr 114: 194-203, 1989.
21. Linde T, Sandhagen B, Hägg A. Blood viscosity and peripheral vascular resistance in patients with untreated essential hypertension. J Hypertens 11: 731-736, 1993.
22. Mahapatra S, Nishimura a R, Oh JK, McGoon MD. The prognostic value of pulmonary vascular capacitance determined by Doppler echocardiography in patients with pulmonary arterial hypertension. J Am Soc Echocardiogr 19: 1045-1050, 2006.
23. Milnor WR, Nichols WW. A new method of measuring propagation coefficients and characteristic impedance in blood vessels. Circ Res 36: 631-639, 1975.
24. Milnor WR. Hemodynamics. Baltimore, MD: Williams & Wilkins, 1982.
25. Mitchell G, Pfeffer M, Westerhof N, Pfeffer J. Measurement of aortic input impedance in rats. Am J Physiol Heart Circ Physiol 267: H1907-H1915, 1994.
26. Morpurgo M, Jezek V, Ostadal B. Pulmonary input impedance or pulmonary vascular resistance? Monaldi Arch Chest Dis 50: 282-285, 1995.
27. Moudgil R, Michelakis ED, Archer SL. Hypoxic pulmonary vasoconstriction. J Appl Physiol 98: 390-403, 2005.
28. Porterfield JE, Kottam A, Raghavan K, Escobedo D, Jenkins JT, Larson ER, Treviño RJ, Valvano JW, Pearce a J, Feldman MD. Dynamic correction for parallel conductance, GP, and gain factor, alpha, in invasive murine left ventricular volume measurements. J Appl Physiol 107: 1693-1703, 2009.
29. Pratali L, Allemann Y, Rimoldi SF, Faita F, Hutter D, Rexhaj E, Brenner R, Bailey DM, Sartori C, Salmon CS, Villena M, Scherrer U, Picano E, Sicari R. RV contractility and exercise-induced pulmonary hypertension in chronic mountain sickness: a stress echocardiographic and tissue Doppler imaging study. JACC Cardiovasc Imaging 6: 1287-1297, 2013.
30. Späni D, Arras M, König B, Rülicke T. Higher heart rate of laboratory mice housed individually vs. in pairs. Lab Anim 37: 54-62, 2003.
31. Stergiopulos N, Meister J, Westerhof N. Evaluation of methods for estimation of total arterial compliance. Am J Physiol Heart Circ Physiol 268: H1540-H1548, 1995.
32. Stone H, Thompson H, Schmidt-Nielsen K. Influence of erythrocytes on blood viscosity. Am J Physiol 214: 913-918, 1968.
33. Tabima DM, Hacker TA, Chesler NC. Measuring right ventricular function in the normal and hypertensive mouse hearts using admittancederived pressure-volume loops. Am J Physiol Heart Circ Physiol 299: H2069-H2075, 2010.
34. Tabima DM, Roldan-Alzate A, Wang Z, Hacker a T, Molthen RC, Chesler NC. Persistent vascular collagen accumulation alters hemodynamic recovery from chronic hypoxia. J Biomech 45: 799-804, 2012.
35. Tian L, Chesler NC. In vivo and in vitro measurements of pulmonary arterial stiffness: a brief review. Pulm Circ 2: 505-517, 2012.
36. Vanderpool RR, Chesler NC. Characterization of the isolated, ventilated, and instrumented mouse lung perfused with pulsatile flow. J. Vis. Exp.: 3-7, 2011.
37. Vanderpool RR, Kim AR, Molthen R, Chesler NC. Effects of acute Rho kinase inhibition on chronic hypoxia-induced changes in proximal and distal pulmonary arterial structure and function. J Appl Physiol 110: 188-198, 2011.
38. Vanderpool RR, Naeije R, Chesler NC. Impedance in isolated mouse lungs for the determination of site of action of vasoactive agents and disease. Ann Biomed Eng 38: 1854-1861, 2010.
39. Wang SH, Lee LP, Lee JS. A linear relation between the compressibility and density of blood. J Acoust Soc Am 109: 390, 2001.
40. Wang Z, Chesler NC. Pulmonary vascular wall stiffness: An important contributor to the increased ventricular afterload with pulmonary hypertension. Pulm Circ 1: 212-223, 2011.
41. Weed R, LaCelle P, Merrill E. Metabolic dependence of red cell deformability. J Clin Invest 48: 795-809, 1969.
42. Westerhof N, Sipkema P, Van Den Bos G, Elzinga G. Forward and backward waves in the arterial system. Cardiovasc Res 6: 648-656, 1972.
43. Van den Wijngaard J, Westerhof BE, Faber DJ, Ramsay MM, Westerhof N, van Gemert M. Abnormal arterial flows by a distributed model of the fetal circulation. Am J Physiol Regul Integr Comp Physiol 291: R1222-R1233, 2006.
44. Winslow RM, Monge CC, Brown EG, Klein HG, Sarnquist F, Winslow NJ, McKneally SS. Effects of hemodilution on O2 transport in high-altitude polycythemia. J Appl Physiol 59: 1495-1502, 1985.
45. Womersley J. The mathematical analysis of the arterial circulation in a state of oscillatory motion. Wright Air Development Center Technical Report WADC-TR-56-614. Dayton, OH, Wright Air Development Center, 1957.
46. Youmans JB. Mineral deficiencies. J Am Med Assoc 143: 1252-1259, 1950.
47. Zhou Y, Zhou T, Ouzhuluobu Qiao L, Wang X, Xu H, Liu H, Hua Y. Effect of polycythemia on hypoxia induced pulmonary hypertension and pulmonary vascular remodeling in rats. Sichuan Da Xue Xue Bao Yi Xue Ban 40: 619-622, 2009.