Statement on the safety of glucosamine for patients receiving coumarin anticoagulants

EFSA Journal

Volumn 9, Issue 12, 2011, Pages

[No Author Info available]

Author keywords

coumarin anticoagulants; Glucosamine; ingredient; novel food

Indexed keywords

EID: 84908575419     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2011.2473     Document Type: Article

References (10)

1. ADRAC/ADRU (Australian Drug Advisory Committee and the Adverse Drug Reaction Unit), 2008. Interaction between glucosamine and warfarin. Australian Adverse Drug reactions Bulletin 27.
2. AFSSA (French Food Safety Agency), 2008. La glucosamine, Avis de l'Agence française de sécurité sanitaire des aliments sur un project d'arrěté relatif à l'emploi des substances à but nutritionnel ou physiologique et de plantes et préparations de plantes dans la fabrication de compléments alimentaires (Afssa-Sasine No 2007-SA-0231)
3. BfR (German Federal Institute for Risk Assessment), 2009. Food supplements that contain glucosamine can constitute a health risk for patients who take coumarin anticoagulants as blood coagulation inhibitor. BfR Opinion No 004/2010, 14 August 2009.
4. EMEA (European Medicines Agency), 2006. Committee for Medicinal Products for Human Use (CHMP) Opinion Following an Article 29(4)1 Referral for Glucomed and Associated Names (EMEA/405628/2006) (Annex I: List of the Names, Pharmaceuticals, Form, Strength of the Medicinal Products, Route of Administration, Applicant, Marketing, Authorisation Holder in the member states; Annex II: Scientific Conclusions and Grounds for Amendment of the Summary of Product Characteristics, Labelling and Package Leaflet Presented by the EMEA; Annex III: Summary of Product Characteristics, Labelling and Package Leaflet).
5. Garcia MG, Pineiro MJI, Alvarez RM, Gonzalez JP, 2004. Interacción farmacológica del sulfato de glucosamina con acenocumarol. Atención Primaria, 33, 162–163.
6. Health Canada, 2008. Single Ingredient Monographs: Glucosamine. Available from: www.hc-sc.gc.ca/dhp-mps/prodnatur/applications/licen-prod/monograph/mono_glucosamine-eng.php
7. Knudson and Sokol, 2008. Potential glucosamine-warfarin interaction resulting in increased international normalized ratio: case report and review of the literature and MedWatch database. Pharmacotherapy, 28, 540–8.
8. MHRA (Medicines and Healthcare products Regulatory Agency), 2007. Cases of warfarin/glucosamine interaction reported in the May 2006 Current Problem in Pharmacovigilance series – Freedom of information disclosure. (06/330 request)
9. Wysowski DK, Nourjah P and Swartz L, 2007. Bleeding complications with warfarin use. A prevalent adverse effect resulting in regulatory action. Archives of Internal Medicine, 167, 1414–1419.
10. Yue Q-Y, Strandell J and Myrberg O, 2006. Concomitant use of glucosamine may potentiate the effect of warfarin. Poster, ISoP 2006.