Efficacy and safety of sugammadex (Org 25969) in reversing deep neuromuscular block induced by rocuronium or vecuronium in japanese patients

Japanese Journal of Anesthesiology

Volumn 63, Issue 10, 2014, Pages 1083-1088

  Takeda, Junzo ^a,b   Iwasaki, Hiroshi ^c   Otagiri, Tetsutaro ^d,e   Katoh, Takasumi ^f   Shingu, Koh ^g   Obara, Hidefumi ^h,i   Nakatsuka, Hideki ^j,k   Tomiyama, Yoshinobu ^l   Kasaba, Toshiharu ^m,n  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL HOSPITAL ORGANIZATION TOKYO MEDICAL CENTER   (Japan)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

^d SHINSHU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e Hokushin General Hospital   (Japan)

^f HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^g KANSAI MEDICAL UNIVERSITY   (Japan)

^h KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

ⁱ Hamasaka Public Hospital   (Japan)

^j OKAYAMA UNIVERSITY   (Japan)

^k KAWASAKI MEDICAL SCHOOL   (Japan)

^l TOKUSHIMA UNIVERSITY HOSPITAL   (Japan)

^m UNIVERSITY OF MIYAZAKI   (Japan)

ⁿ Hakodate Medical Association Hospital   (Japan)

more..

Author keywords

Non depolarizing muscle relaxant rocuronium; Selective relaxant binding agent; Sugammadex; Vecuronium

Indexed keywords

ROCURONIUM; SEVOFLURANE; SUGAMMADEX; VECURONIUM; ANDROSTANE DERIVATIVE; GAMMA CYCLODEXTRIN DERIVATIVE; NEUROMUSCULAR BLOCKING AGENT;

ARTICLE; HUMAN; JAPANESE (PEOPLE); MAJOR CLINICAL STUDY; NEUROMUSCULAR BLOCKING; ADULT; ANESTHETIC RECOVERY; ANTAGONISTS AND INHIBITORS; ASIAN CONTINENTAL ANCESTRY GROUP; CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; FEMALE; GENERAL ANESTHESIA; MALE; MIDDLE AGED; PHASE 2 CLINICAL TRIAL; RANDOMIZED CONTROLLED TRIAL;

ADULT; ANDROSTANOLS; ANESTHESIA RECOVERY PERIOD; ANESTHESIA, GENERAL; ASIAN CONTINENTAL ANCESTRY GROUP; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GAMMA-CYCLODEXTRINS; HUMANS; MALE; MIDDLE AGED; NEUROMUSCULAR BLOCKADE; NEUROMUSCULAR NONDEPOLARIZING AGENTS; VECURONIUM BROMIDE;

EID: 84908537411     PISSN: 00214892     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

1. Jones RK. Caldwell JE Brull SJ, Soto RG. Reversal of profound rocuronium-induced blockade with sugammadex : a randomized comparison with neostigmine. Anesthesiology 2008; 109 : 816-24.
2. Adam JM, Bennett DJ, Bom A, Clark JK, Feilden H, Hutchinson EJ, et al. Cyclodextrin-derived host molecules as reversal agents for the neuromuscular blocker rocuronium bromide : synthesis and structure-activity relationships. J Med Chem 2002; 45 : 1806-16.
3. Bom A, Bradley M, Cameron K, Clark JK, van Egmond J, Feilden H, et aL A novel concept of reversing neuromuscular block : chemical encapsulation of rocuronium bromide by a cyclodextrin-based synthetic host Angew Chem Int Ed 2002; 41 : 266-70.
4. Geldner G, Niskanen M. Laurila P, Mizikov V, Hübler M, Beck G, et aL A randomized controlled trial comparing sugammadex and neostigmine at different depth of neuromuscular blockade in patients undergoing laparoscopic surgery. Anaesthesia 2012; 67 : 991-8.
5. Groudine SB, Soto R, Lien C, Drover D, Roberts K. A randomized, dose-finding, Phase II study of the selective relaxant binding drug, sugammadex, capable of safely reversing profound rocuronium-induced neuromuscular block. Anesth Analg 2007; 104 : 555-62.
6. Duvaldestin P, Kuizenga K, Saldien V, Claudius C, Servin F, Klein J, et al. A randomized, doseresponse study of sugammadex given for the reversal of deep rocuronium-or vecuronium-induced neuromuscular blockade under sevoflurane anesthesia Anesth Analg 2010; 110 : 74-82.