Opioid-related mortality and filled prescriptions for buprenorphine and methadone

Drug and Alcohol Review

Volumn 33, Issue 5, 2014, Pages 491-498

  Wikner, Birgitta N ^a   Öhman, Inger ^a   Seldén, Tor ^b   Druid, Henrik ^a   Brandt, Lena ^a   Kieler, Helle ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b Department of Forensic Genetics and Forensic Toxicology National Board of Forensic Medicine ^*  (Sweden)

Author keywords

Buprenorphine; Methadone; Mortality; Opioid dependence; Overdose

Indexed keywords

BUPRENORPHINE; METHADONE;

ADOLESCENT; ADULT; ADVERSE EFFECTS; AGED; COMPARATIVE STUDY; EPIDEMIOLOGY; FACTUAL DATABASE; FEMALE; HEROIN DEPENDENCE; HUMAN; MALE; MIDDLE AGED; MORTALITY; OPIATE SUBSTITUTION TREATMENT; OPIOID-RELATED DISORDERS; REGISTER; SWEDEN; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; BUPRENORPHINE; DATABASES, FACTUAL; FEMALE; HEROIN DEPENDENCE; HUMANS; MALE; METHADONE; MIDDLE AGED; OPIATE SUBSTITUTION TREATMENT; OPIOID-RELATED DISORDERS; REGISTRIES; SWEDEN; YOUNG ADULT;

EID: 84908489400     PISSN: 09595236     EISSN: 14653362     Source Type: Journal    
DOI: 10.1111/dar.12143     Document Type: Article

References (33)

1. Weimer MB, Korthuis PT, Behonick GS, Wunsch MJ. The source of methadone in overdose deaths in western Virginia in 2004. J Addict Med 2011;5:188-202.
2. Huang CL, Lee CW. Factors associated with mortality among heroin users after seeking treatment with methadone: a population-based cohort study in Taiwan. J Subst Abuse Treat 2013;44:295-300.
3. Rosca P, Haklai Z, Goldberger N, Zohar P, Margolis A, Ponizovsky AM. Mortality and causes of death among users of methadone maintenance treatment in Israel, 1999-2008. Drug Alcohol Depend 2012;125:160-163.
4. Mattick RP, Kimber J, Breen C, Davoli M. Buprenorphine maintenance versus placebo or methadone maintenance for opioid dependence. Cochrane Database Syst Rev 2008;(2):CD002207.
5. Mattick RP, Breen C, Kimber J, Davoli M. Methadone maintenance therapy versus no opioid replacement therapy for opioid dependence. Cochrane Database Syst Rev 2009;(3):CD002209.
6. Kreek MJ, Borg L, Ducat E, Ray B. Pharmacotherapy in the treatment of addiction: methadone. J Addict Dis 2010;29:200-216.
7. Romelsjo A, Engdahl B, Stenbacka M, etal. Were the changes to Sweden's maintenance treatment policy 2000-06 related to changes in opioid-related mortality and morbidity? Addiction 2010;105:1625-1632.
8. Strang J, Hall W, Hickman M, Bird SM. Impact of supervision of methadone consumption on deaths related to methadone overdose (1993-2008): analyses using OD4 index in England and Scotland. BMJ 2010;341:c4851.
9. Seldén T, Ahlner J, Druid H, Kronstrand R. Toxicological and pathological findings in a series of buprenorphine related deaths. Possible risk factors for fatal outcome. Forensic Sci Int 2012;220:284-290.
10. Kapur BM, Hutson JR, Chibber T, Luk A, Selby P. Methadone: a review of drug-drug and pathophysiological interactions. Crit Rev Clin Lab Sci 2011;48:171-195.
11. Rouguieg K, Picard N, Sauvage FL, Gaulier JM, Marquet P. Contribution of the different UDP-glucuronosyltransferase (UGT) isoforms to buprenorphine and norbuprenorphine metabolism and relationship with the main UGT polymorphisms in a bank of human liver microsomes. Drug Metab Dispos 2010;38:40-45.
12. Socialstyrelsen [National Board of Health and Welfare]. Kartläggning av läkemedelsassisterad behandling vid opiatberoende. Stockholm: Socialstyrelsen, 2012.
13. Druid H, Strandberg JJ, Alkass K, Nystrom I, Kugelberg FC, Kronstrand R. Evaluation of the role of abstinence in heroin overdose deaths using segmental hair analysis. Forensic Sci Int 2007;168:223-226.
14. Darke S, Mills KL, Ross J, Teesson M. Rates and correlates of mortality amongst heroin users: findings from the Australian Treatment Outcome Study (ATOS), 2001-2009. Drug Alcohol Depend 2011;115:190-195.
15. Degenhardt L, Bucello C, Mathers B, etal. Mortality among regular or dependent users of heroin and other opioids: a systematic review and meta-analysis of cohort studies. Addiction 2011;106:32-51.
16. Ludvigsson JF, Otterblad-Olausson P, Pettersson BU, Ekbom A. The Swedish personal identity number: possibilities and pitfalls in healthcare and medical research. Eur J Epidemiol 2009;24:659-667.
17. Druid H, Holmgren P, Löwenhielm P. Computer-assisted systems for forensic pathology and forensic toxicology. J Forensic Sci 1996;41:830-836.
18. Wettermark B, Hammar N, Fored M, etal. The new Swedish Prescribed Drug Register-opportunities for pharmacoepidemiological research and experience from the first six months. Pharmacoepidemiol Drug Saf 2007;16:726-735.
19. Druid H, Holmgren P. Fatal injections of heroin. Interpretation of toxicological findings in multiple specimens. Int J Legal Med 1999;112:62-66.
20. Seldén T, Roman M, Druid H, Kronstrand R. LC-MS-MS analysis of buprenorphine and norbuprenorphine in whole blood from suspected drug users. Forensic Sci Int 2011;209:113-119.
21. Druid H, Holmgren P. A compilation of fatal and control concentrations of drugs in postmortem femoral blood. J Forensic Sci 1997;42:79-87.
22. Reis M, Aamo T, Ahlner J, Druid H. Reference concentrations of antidepressants. A compilation of postmortem and therapeutic levels. J Anal Toxicol 2007;31:254-264.
23. White JM, Irvine RJ. Mechanisms of fatal opioid overdose. Addiction 1999;94:961-972.
24. Shields LB, Hunsaker Iii JC, Corey TS, Ward MK, Stewart D. Methadone toxicity fatalities: a review of medical examiner cases in a large metropolitan area. J Forensic Sci 2007;52:1389-1395.
25. Simonsen KW, Normann PT, Ceder G, etal. Fatal poisoning in drug addicts in the Nordic countries in 2007. Forensic Sci Int 2011;207:170-176.
26. Auriacombe M, Franques P, Tignol J. Deaths attributable to methadone vs buprenorphine in France. JAMA 2001;285:45.
27. Bernard JP, Havnes I, Slørdal L, Waal H, Mørland J, Khiabani HZ. Methadone-related deaths in Norway. Forensic Sci Int 2013;224:111-116.
28. Winstock AR, Lea T, Sheridan J. What is diversion of supervised buprenorphine and how common is it? J Addict Dis 2009;28:269-278.
29. Bell JR, Butler B, Lawrance A, Batey R, Salmelainen P. Comparing overdose mortality associated with methadone and buprenorphine treatment. Drug Alcohol Depend 2009;104:73-77.
30. Darke S, Hall WJ. Heroin overdose: research and evidence-based intervention. Urban Health 2003;80:189-200.
31. Häkkinen M, Launiainen T, Vuori E, Ojanperä I. Benzodiazepines and alcohol are associated with cases of fatal buprenorphine poisoning. Eur J Clin Pharmacol 2012;68:301-309.
32. Kintz P. Deaths involving buprenorphine: a compendium of French cases. Forensic Sci Int 2001;121:65-69.
33. Paulozzi LJ, Kilbourne EM, Shah NG, etal. A history of being prescribed controlled substances and risk of drug overdose death. Pain Med 2012;13:87-95.