Alveolo-capillary diffusion of hyperpolarized 129Xe as a marker of pulmonary fibrosis

Journal of Applied Physiology

Volumn 117, Issue 6, 2014, Pages 573-574

  Hsia, Connie C W ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

XENON;

DIAGNOSTIC USE; FEMALE; HUMAN; LUNG FIBROSIS; MALE; PATHOLOGY;

FEMALE; HUMANS; MALE; PULMONARY FIBROSIS; XENON ISOTOPES;

EID: 84908405680     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00688.2014     Document Type: Editorial

References (6)

1. Borland CD, Higenbottam TW. A simultaneous single breath measurement of pulmonary diffusing capacity with nitric oxide and carbon monoxide. Eur Respir J 2: 56-63, 1989.
2. Cleveland ZI, Virgincar RS, Qi Y, Robertson SH, Degan S, Driehuys B. 3D MRI of impaired hyperpolarized Xe uptake in a rat model of pulmonary fibrosis. NMR Biomed 2014 May 12. doi: 10.1002/nbm.3127. [Epub ahead of print].
3. Driehuys B, Cofer GP, Pollaro J, Mackel JB, Hedlund LW, Johnson GA. Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. Proc Natl Acad Sci USA 103: 18278-18283, 2006.
4. Gehr P, Bachofen M, Weibel ER. The normal human lung: Ultrastructure and morphometric estimation of diffusion capacity. Respir Physiol 32: 121-140, 1978.
5. Kaushik SS, Freeman MS, Yoon SW, Liljeroth MG, Stiles JV, Roos JE, Foster WM, Rackley CR, McAdams HP, Driehuys B. Measuring diffusion-limitation with a perfusion-limited gas-Hyperpolarized 129Xe gas transfer spectroscopy in patients with idiopathic pulmonary fibrosis. J Appl Physiol (First published July 18, 2014) doi: 10.1152/japplphysiol.00326.2014.
6. Roughton FJW, Forster RE. Relative importance of diffusion and chemical reaction rates in determining the rate of exchange of gases in the human lung, with special reference to true diffusing capacity of the pulmonary membrane and volume of blood in lung capillaries. J Appl Physiol 11: 290-302, 1957.