Health assessment of gasoline and fuel oxygenate vapors: Immunotoxicity evaluation

Regulatory Toxicology and Pharmacology

Volumn 70, Issue 2, 2014, Pages S43-S47

  White, Kimber L ^a   Peachee, Vanessa L ^a   Armstrong, Sarah R ^b   Twerdok, Lorraine E ^c   Clark, Charles R ^d   Schreiner, Ceinwen A ^e  

^a ImmunoTox Inc   (United States)

^b Cambridge Environmental Inc   (United States)

^c Twerdok Consulting LLC   (United States)

^d Phillips 66 Co   (United States)

^e C and C Consulting in Toxicology   (United States)

Author keywords

Diisopropyl ether; Ethanol; Ethyl t butyl ether; Evaporative emissions; Gasoline vapor condensates; Immunotoxicity; Methyl tertiary butyl ether; Plaque assay; T Amyl methyl ether; T Butyl alcohol

Indexed keywords

ALCOHOL; CHEMICAL COMPOUND; DIISOPROPYL ETHER; ETHYL TERT BUTYL ETHER; FUEL; GASOLINE; IMMUNOGLOBULIN M; IMMUNOGLOBULIN M ANTIBODY; TERT AMYL METHYL ETHER; TERT BUTYL ALCOHOL; TERT BUTYL METHYL ETHER; UNCLASSIFIED DRUG; AIR POLLUTANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; B LYMPHOCYTE; CELLULAR IMMUNITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; FEMALE; HUMORAL IMMUNITY; IMMUNOTOXICITY; INNATE IMMUNITY; LONG TERM EXPOSURE; MACROPHAGE; NONHUMAN; RAT; SHEEP ERYTHROCYTE; SPLEEN CELL; SPLEEN WEIGHT; T LYMPHOCYTE; VAPOR; AIR POLLUTANT; ANIMAL; DRUG EFFECTS; IMMUNOGLOBULIN PRODUCING CELL; IMMUNOLOGY; INHALATION; RISK ASSESSMENT; SPRAGUE DAWLEY RAT; TOXICITY;

AIR POLLUTANTS; ANIMALS; ANTIBODY-PRODUCING CELLS; FEMALE; GASOLINE; IMMUNOGLOBULIN M; INHALATION; RATS; RATS, SPRAGUE-DAWLEY; RISK ASSESSMENT;

EID: 84908404029     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2014.04.010     Document Type: Article

References (27)

1. Bartlett M.S. Sub-sampling for attributes. J. R. Stat. Soc. 1937, (Suppl. 4: 13):1-35.
2. Benson J.M., Gigliotti A.P., March T.H., Barr E.B., Tibbetts B.M., Skipper B.J., Clark C.R., Twerdok L. Chronic carcinogenicity study of gasoline vapor condensate (GVC) and GVC containing methyl tertiary-butyl ether in F344 rats. J. Toxicol. Environ. Health 2011, 74:638-657.
3. Clark, C.R., Schreiner, C.A., Parker, C.M., Gray, T.M, Hoffman, G.M., 2014. Health assessment of gasoline and fuel oxygenate vapors: subchronic inhalation toxicity. Regul. Toxicol. Pharmacol. 70 (2S), S18-S28.
4. Dunnett C.W. A multiple comparison procedure for comparing several treatments with a control. J. Am. Stat. Assoc. 1955, 50:1096-1121.
5. European Chemicals Agency Registration Data for 2-ethoxy-2-methylpropane.
6. European Chemicals Agency Registration Data for diisopropyl ether.
7. Gray, T.M., Steup, D., O'Callaghan, J.P., Hoffman, G.M., Roberts, L.G., Schreiner, C.A., Clark, C.R., 2014. Health assessment of gasoline and fuel oxygenate vapors: reproductive toxicity. Regul.Toxicol. Pharmacol. 70 (2S), S48-S57.
8. Gross A.J., Clark V.A. Gehan-Wilcoxon Test. Survival Distributions: Reliability Applications in the Biomedical Sciences 1975, 225-256. John Wiley and Sons, New York. A.J. Gross, V.A. Clark (Eds.).
9. Henley, M., Daniel, J., Letinsky, D.J., Carr, J., Caro, M., Daughtrey, W., White, R., 2014. Health assessment of gasoline and fuel oxygenate vapors: generation and characterization of test materials. Regul. Toxicol. Pharmacol. 70 (2S), S13-S17. http://dx.doi.org/10.1016/j.yrtph.2014.05.012.
10. Hollander M., Wolfe D.A. Jonckheere's Test: Non-parametric Statistical Methods 1973, 120-123. John Wiley and Sons, New York. M. Hollander, D.A. Wolfe (Eds.).
11. Jerne N.K., Henry C., Nordin A.A., Fun H., Koros M.C., Lefkovits I. Plaque-forming cells: methodology and theory. Transplant Rev. 1974, 18:130-191.
12. Kruskal W.H., Wallis W.A. Use of ranks in one-criterion variance analysis. J. Am. Stat. Assoc. 1952, 47:583-621.
13. Loose L.D., Stege T., Diluzio N.R. The influence of acute and chronic ethanol or bourbon administration on phagocytic and immune responses in rats. Exp. Mol. Pathol. 1975, 23:159-172.
14. Luster M.I., Munson A.E., Thomas P., Holsapple M.P., Fenters J., White K.L., Lauer L.D., Dean J.D. Development of a testing battery to assess chemical-induced immunotoxicity. Fundam. Appl. Toxicol. 1988, 10:2-19.
15. Luster M.I., Portier C., Pait D.G., White K.L., Gennings C., Munson A.E., Rosenthal G.J. Risk assessment in immunotoxicology. I. Sensitivity and predictability of immune tests. Fundam. Appl. Toxicol. 1992, 18:200-210.
16. O'Callaghan, J.P., Felton, C.M., Billig, B.K., Daughtrey, W.C., Clark, C.R., Schreiner, C.A., White, R., 2014. Health assessment of gasoline and fuel oxygenate vapors: neurotoxicity evaluation. Regul. Toxicol. Pharmacol. 70 (2S), S35-S42. http://dx.doi.org/10.1016/j.yrtph.2014.05.002.
17. Razani-Boroujerdi S., Savage S.M., Sopori M.L. Alcohol-induced changes in the immune response: immunological effects of chronic ethanol intake are genetically regulated. Toxicol. Appl. Pharmacol. 1994, 127(1):37-43.
18. Roberts, L.G., Gray, T.M., Marr, M.C., Tyl, R.W., Trimmer, G.W., Hoffman, G.M., Murray, F.J., Clark, C.R., Schreiner, C.A., 2014a. Health assessment of gasoline and fuel oxygenate vapors: developmental toxicity in mice. Regul. Toxicol. Pharmacol. 70 (2S), S58-S68.
19. Roberts, L.G., Gray, T.M., Trimmer, G.W., Murray, F.J., Parker, R., Schreiner, C.A., Clark, C.R., 2014b. Health assessment of gasoline and fuel oxygenate vapors: developmental toxicity in rats. Regul. Toxicol. Pharmacol. 70 (2S), S69-S79. http://dx.doi.org/10.1016/j.yrtph.2014.05.009.
20. Schreiner, C., Hoffman, G.,Gudi, R., Clark, C.R., 2014. Health assessment of gasoline and fuel oxygenate vapors: micronucleus and sister chromatid exchange tests by inhalation exposure. Regul. Toxicol. Pharmacol. 70 (2S), S29-S34.
21. Sokal R.R., Rohlf F.J. Biometry 1981, 222-229. Freeman, San Francisco.
22. USDA, 1989. Animal Welfare Act Regulations: 9 CFR Parts 1 and 2 Final Rules, Federal Register, vol. 54, No. 168, August 31, 1989, pp. 36112-36163, effective October 30, 1989.
23. USDA, 1991. Animal Welfare Standards, 9 CFR Part 3; Final Rule, Federal Register, vol. 56, No. 32, February 15, 1991, pp. 6426-6505, effective March 18, 1991.
24. US EPA, 1994. Good Laboratory Practice Standards 79.60, CFR vol. 59, No. 122, 27 June 1994.
25. US EPA, 1998. OPPTS Health Effects Test Guidelines 870.3465, 90-Day Inhalation Toxicity, August 1998.
26. US EPA, 1998. OPPTS Health Effects Test Guidelines 870.7800, Immunotoxicity, August 1998.
27. White K.W., Musgrove D.L., Brown R.D. The sheep erythrocyte T-dependent antibody response (TDAR). Methods Mol. Biol. 2010, 598:173-184.