Left ventricular diastolic function in patients with type 2 diabetes treated with a dipeptidyl peptidase-4 inhibitor- a pilot study

Diabetology and Metabolic Syndrome

Volumn 6, Issue 1, 2014, Pages

  Nogueira, Katia Camarano ^a   Furtado, Meive ^a   Fukui, Rosa Tsuneshiro ^a   Correia, Marcia Regina Silva ^a   Dos Santos, Rosa Ferreira ^a   Andrade, José Lázaro ^a   Da Silva, Maria Elizabeth Rossi ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Bedtime NPH insulin; Cardiovascular function; Dypeptidil peptidase 4 inhibitor; Glucagon like peptide 1; Type 2 diabetes mellitus (T2DM)

Indexed keywords

C REACTIVE PROTEIN; GLIBENCLAMIDE PLUS METFORMIN; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; HEMOGLOBIN A1C; ISOPHANE INSULIN; LIPID; SITAGLIPTIN; TRIACYLGLYCEROL;

ADD ON THERAPY; ADULT; ARTICLE; BEDTIME DOSAGE; BLOOD PRESSURE MONITORING; CLINICAL ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DIABETES CONTROL; DIABETIC PATIENT; DIET RESTRICTION; ECHOCARDIOGRAPHY; FEMALE; GLUCAGON BLOOD LEVEL; GLUCOSE BLOOD LEVEL; HEART LEFT VENTRICLE FUNCTION; HEART PROTECTION; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPOGLYCEMIA; INSULIN TREATMENT; LEFT VENTRICULAR DIASTOLIC DYSFUNCTION; LEFT VENTRICULAR DIASTOLIC FUNCTION; LIPID BLOOD LEVEL; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PILOT STUDY; RANDOMIZED CONTROLLED TRIAL; TREATMENT RESPONSE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84908394848     PISSN: None     EISSN: 17585996     Source Type: Journal    
DOI: 10.1186/1758-5996-6-103     Document Type: Article

References (29)

1. American Diabetes Association: Diagnosis and classification of diabetes mellitus. Diabetes Care 2004, 27:S5-S10.
2. Martin JH, Deacon CF, Gorrell MD, Prins JB: Incretin-based therapies - review of the physiology, pharmacology and emerging clinical experience. Intern Med J 2011, 41:299-307.
3. Turner RC, Cull CA, Frigh V, Holman RR: Glycaemic control with diet, sulphonylurea, metformin or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). JAMA 1999, 281:2005-2012.
4. Scheen AJ: Cardiovascular effects of dipeptidyl peptidase-4 inhibitors: from risk factors to clinical outcomes. Postgrad Med 2011, 125:7-20.
5. Sokos GG, Bolukoglu H, German J, Hentosz T, Magovern GJ Jr, Maher TD, Dean DA, Bailey SH, Marrone G, Benckart DH, Elahi D, Shannon RP: Effect of glucagon-like peptide-1 (GLP-10 on glycemic control and left ventricular function in patients undergoing coronary artery bypass grafting. Am J Cardiol 2007, 100:824-829.
6. Nikolaidis AL, Mankad S, Sokos GG, Miske G, Shah A, Elahi D, Shannon RP: Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004, 109:962-965.
7. Sonne DP, Engstrom T, Treiman M: Protective effects of GLP-1 analogues exendin-4 and GLP-1 (9-36) amide against ischemia-reperfusion injury in rat heart. Regul Pept 2008, 146:243-249.
8. Picatoste B, Ramírez E, Caro-Vadillo A, Iborra C, Egido J, Tuñón J, Lorenzo O: Sitagliptin reduces cardiac apoptosis, hypertrophy and fibrosis primarily by insulin-dependent mechanisms in experimental type-II diabetes. Potential roles of GLP-1 isoforms. PLoS One 2013, 8:e78330.
9. Read PA, Khan FZ, Heck PM, Hoole SP, Dutka DP: DPP-4 inhibition by sitagliptin improves the myocardial response to dobutamine stress and mitigates stunning in a pilot study of patients with coronary artery disease. Circ Cardiovasc Imaging 2010, 3:195-201.
10. Patil HR, Al Badarin FJ, Al Shami HA, Bhatti SK, Lavie CJ, Bell DS, O'Keefe JH: Meta-analysis of effect of dipeptidyl peptidase-4 inhibitors on cardiovascular risk in type 2 diabetes mellitus. Am J Cardiol 2010, 110:826-833.
11. Monami M, Ahrén B, Dicembrini I: Dipeptidyl peptidase-4 inhibitors and cardiovascular risk: a meta-analysis of randomized clinical trials. Diabetes Obes Metab 2013, 15:112-120.
12. Mor-Avi V, Lang RM, Badano LP, Belohlavek M, Cardim NM, Derumeaux G, Galderisi M, Marwick T, Nagueh SF, Sengupta PP, Sicari R, Smiseth OA, Smulevitz B, Takeuchi M, Thomas JD, Vannan M, Voigt JU, Zamorano JL: Current and evolving echocardiographic techniques for the quantitative evaluation of cardiac mechanics: ASE/EAE consensus statement on methodology and indications. J Am Soc Echocardiogr 2011, 24:277-313.
13. Nagueh SF, Appleton CP, Gillebert TC, Marino PN, Oh JK, Waggoner AD, Flachskampf FA, Pellikka PA, Evangelista A, Smiseth OA: Recommendations for the evaluation of left ventricular diastolic function by echocardiography. J Am Soc Echocardiogr 2009, 22:107-133.
14. Boyer JK, Thanigaraj S, Schechtman KB, Pérez JE: Prevalence of ventricular diastolic dysfunction in asymtomatic, normotensive patients with diabetes mellitus. Am Cardiol 2004, 93:870-875.
15. Cosson S, Kevorkian J: Left ventricular diastolic dysfunction: an early sign of diabetic cardiomypathy? Diabetes Metab 2003, 29:455-466.
16. Raev DC: Which left ventricular function is impaired earlier in the evolution of diabetic cardiomyopathy? An echocardiographic study of young type 1 diabetic patients. Diabetes Care 1994, 17:633-639.
17. Cohn JN, Johnson G, The Veterans Administration Cooperative Study Group: Heart failure with normal ejection: the V-HeFT study. Circulation 1990, 81(Suppl2):III48-III53.
18. Hiramatsu K, Ohara N, Shigematsu S, Aizawa T, Ishihara F, Niwa A, Yamada T, Naka M, Momose A, Yoshizawa K: Left ventricular filling abnormalities in non-insulin-dependent diabetes mellitus and improvement by a short-term glycemic control. Am J Cardiol 1992, 70:1185.
19. Ye Y, Keyes KT, Zhang C, Perez-Polo JR, Lin Y, Birnbaum Y: The myocardial infarct size-limiting effect of sitagliptin is PKA-dependent, whereas the protective effect of pioglitazone is partially dependent on PKA. Am J Physiol Heart Circ Physiol 2010, 298:H1454-H1465.
20. Saxena A, Fish JE, White MD: Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction. Circulation 2008, 117:224-231.
21. Theiss HD, Gross L, Vallaster, David R, Brunner S, Brenner C, Nathan P, Assmann G, Mueller-Hoecker J, Vogeser M, Steinbeck G, Franz WM: Antidiabetic gliptins in combination with G-CSF enhances myocardial function and survival after acute myocardial infarction. Int J Cardiol 2013, 168:3359-3369.
22. Chang G, Zhang P, Ye L, Lu K, Wang Y, Duan Q, Zheng A, Qin S, Zhang D: Protective effects of sitagliptin on myocardial injury and cardiac function in an ischemia/reperfusion rat model. Eur J Pharmacol 2013, 718:105-113.
23. Post S, van den Broek AJ, Rensing BJ, Pasterkamp G, Goumans MJ, Doevendans PA: Reduced CD26 expression is associated with improved cardiac function after acute myocardial infarction: insights from the REPERATOR study. J Mol Cell Cardiol 2012, 53:899-905.
24. dos Santos L, Salles TA, Arruda-Junior DF, Campos LC, Pereira AC, Barreto AL, Antonio EL, Mansur AJ, Tucci PJ, Krieger JE, Girardi AC: Circulating dipeptidyl peptidase IV activity correlates with cardiac dysfunction in human and experimental heart failure. Circ Heart Fail 2013, 6:1029-1038.
25. Marney A, Kunchakarra S, Byrne L, Brown NJ: Interactive hemodynamic effects of dipeptidyl peptidase-IV inhibition and angiotensin-converting enzyme inhibition in humans. Hypertension 2010, 56:728-733.
26. Currie CJ, Poole CD, Evans M, Peters JR, Morgan CL: Mortality and other important diabetes-related outcomes with insulin vs other antihyperglycemic therapies in type 2 diabetes. J Clin Endocrinol Metab 2013, 98:668-677.
27. Shimabukuro M, Higa N, Asahi T, Yamakawa K, Oshiro Y, Higa M, Masuzaki H: Impaired glucose tolerance, but not impaired fasting glucose, underlies left ventricular diastolic dysfunction. Diabetes Care 2011, 34:686-690.
28. Dinh W, Lankisch M, Nickl W, Scheyer D, Scheffold T, Kramer F, Klein RM, Barroso MC, Futh R: Insulin resistance and glycemic abnormalities are associated with deterioration of left ventricular diastolic function: a cross-sectional study. Cardiovasc Diabetol 2010, 9:63.
29. Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mozenzon O, McGuire DK, Ray KK, Leiter LA, Raz I, SAVOR-TIMI 53 Steering Committee and Investigators: Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes. N Engl J Med 2013, 369:1317-1326.